Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro.

abstract：:Human 15-lipoxygenase (h15-LO) is present on chromosome 17p13.3 in close proximity to the tumor-suppressor gene, p53. 15-LO is implicated in antiinflammation, membrane remodeling, and cancer development/metastasis. The murine BALB/c embryo fibroblast cell line, (10)1val, expresses p53 in mutant (mt) conformation when ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelavkar UP,Badr KF

更新日期：1999-04-13 00:00:00

abstract：:Recombinant DNA techniques have been combined with somatic cell genetic methods to identify, isolate, and amplify fragments of human DNA localized at specific regions of human chromosome 11 selected as a model system. A library of genomic DNA segments has been constructed, in lambda Charon 4A bacteriophage, from the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gusella JF,Keys C,VarsanyiBreiner A,Kao FT,Jones C,Puck TT,Housman D

更新日期：1980-05-01 00:00:00

abstract：:Primary prostate cancer is the most common malignancy in men but has highly variable outcomes, highlighting the need for biomarkers to determine which patients can be managed conservatively. Few large prostate oncogenome resources currently exist that combine the molecular and clinical outcome data necessary to discov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hieronymus H,Schultz N,Gopalan A,Carver BS,Chang MT,Xiao Y,Heguy A,Huberman K,Bernstein M,Assel M,Murali R,Vickers A,Scardino PT,Sander C,Reuter V,Taylor BS,Sawyers CL

更新日期：2014-07-29 00:00:00

abstract：:Previous studies have shown that the immunosuppressive and carcinogenic polycyclic aromatic hydrocarbon 7,12-dimethylbenz(a)anthracene (DMBA) impairs Ca(2+)-dependent transmembrane signaling in human and murine lymphocytes. The purpose of the present studies was to analyze potential mechanisms of immunosuppression by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Archuleta MM,Schieven GL,Ledbetter JA,Deanin GG,Burchiel SW

更新日期：1993-07-01 00:00:00

abstract：:We have previously shown that chronic activation of mitogenic signaling induced by over-expression of c-myc and transforming growth factor-alpha (TGFalpha) transgenes in mouse liver induces a state of oxidative stress. We therefore proposed that increased reactive oxygen species (ROS) generation might be responsible f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Factor VM,Laskowska D,Jensen MR,Woitach JT,Popescu NC,Thorgeirsson SS

更新日期：2000-02-29 00:00:00

abstract：:Most transmissible spongiform encephalopathies arise either spontaneously or by infection. Mutations of PRNP, which encodes the prion protein, PrP, segregate with phenotypically similar diseases. Here we report that moderate overexpression in transgenic mice of mPrP(170N,174T), a mouse PrP with two point mutations tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sigurdson CJ,Nilsson KP,Hornemann S,Heikenwalder M,Manco G,Schwarz P,Ott D,Rülicke T,Liberski PP,Julius C,Falsig J,Stitz L,Wüthrich K,Aguzzi A

更新日期：2009-01-06 00:00:00

abstract：:Glucose is a fundamental metabolite, yet how cells sense and respond to changes in extracellular glucose concentration is not completely understood. We recently reported that the MondoA:Mlx dimeric transcription factor directly regulates glycolysis. In this article, we consider whether MondoA:Mlx complexes have a broa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoltzman CA,Peterson CW,Breen KT,Muoio DM,Billin AN,Ayer DE

更新日期：2008-05-13 00:00:00

abstract：:The core protein of a small chondroitin/dermatan sulfate proteoglycan expressed by human fibroblasts and present in extracellular matrices in association with collagen has been cloned from a lambda gt11 fibroblast cDNA library. cDNA clones were isolated by use of antibodies specific for the intact proteoglycan and ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krusius T,Ruoslahti E

更新日期：1986-10-01 00:00:00

abstract：:After males of Lasioglossum zephyrum (Hymenoptera: Halictidae) have first been exposed to a conspecific female, the attractiveness of a second female diminishes with increasing genealogical relationship between the two females. The most parsimonious explanation for this is a polygenically controlled female sex pheromo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith BH

更新日期：1983-07-01 00:00:00

abstract：:Cell clones nonproductively transformed by the replication-defective Abelson strain of murine leukemia virus (AbLV) were analyzed for type C viral antigen expression by competition immunoassay. AbLV-transformed mink non-producer lines were found to express a 110,000- to 130,000-molecular weight polyprotein containing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reynolds FH Jr,Sacks TL,Deobagkar DN,Stephenson JR

更新日期：1978-08-01 00:00:00

abstract：:Clostridium ljungdahlii is an anaerobic homoacetogen, able to ferment sugars, other organic compounds, or CO(2)/H(2) and synthesis gas (CO/H(2)). The latter feature makes it an interesting microbe for the biotech industry, as important bulk chemicals and proteins can be produced at the expense of CO(2), thus combining...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Köpke M,Held C,Hujer S,Liesegang H,Wiezer A,Wollherr A,Ehrenreich A,Liebl W,Gottschalk G,Dürre P

更新日期：2010-07-20 00:00:00

abstract：:Heat shock locus V (HslV; also called ClpQ) is the proteolytic core of the ATP-dependent protease HslVU in Escherichia coli. It has sequence similarity with the beta-type subunits of the eukaryotic and archaebacterial proteasomes. Unlike these particles, which display 72-point symmetry, it is a dimer of hexamers with ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bochtler M,Ditzel L,Groll M,Huber R

更新日期：1997-06-10 00:00:00

abstract：:Treatment of C57BL/6 or NOD mice with a monoclonal antibody to the CSF-1 receptor resulted in depletion of the resident macrophages of pancreatic islets of Langerhans that lasted for several weeks. Depletion of macrophages in C57BL/6 mice did not affect multiple parameters of islet function, including glucose response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrero JA,McCarthy DP,Ferris ST,Wan X,Hu H,Zinselmeyer BH,Vomund AN,Unanue ER

更新日期：2017-11-28 00:00:00

abstract：:Fe(CN)6(-3) oxidation of the aerobically isolated 7Fe Azotobacter vinelandii ferredoxin I, (7Fe)FdI, is a degradative reaction. Destruction of the [4Fe-4S] cluster occurs first, followed by destruction of the [3Fe-3S] cluster. At a Fe(CN)6(-3)/(7Fe)FdI concentration ratio of 20, the product is a mixture of apoprotein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephens PJ,Morgan TV,Devlin F,Penner-Hahn JE,Hodgson KO,Scott RA,Stout CD,Burgess BK

更新日期：1985-09-01 00:00:00

abstract：:The nodZ gene, which is present in various soil bacteria such as Bradyrhizobium japonicum, Azorhizobium caulinodans, and Rhizobium loti, is involved in the addition of a fucosyl residue to the reducing N-acetylglucosamine residue of lipochitin oligosaccharide (LCO) signal molecules. Using an Escherichia coli strain th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quinto C,Wijfjes AH,Bloemberg GV,Blok-Tip L,López-Lara IM,Lugtenberg BJ,Thomas-Oates JE,Spaink HP

更新日期：1997-04-29 00:00:00

abstract：:Excited states of proteins may play important roles in function, yet are difficult to study spectroscopically because of their sparse population. High hydrostatic pressure increases the equilibrium population of excited states, enabling their characterization [Akasaka K (2003) Biochemistry 42:10875-85]. High-pressure ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lerch MT,Horwitz J,McCoy J,Hubbell WL

更新日期：2013-12-03 00:00:00

abstract：:The design, realization, and test performances of an electronic junction based on single-electron phenomena that works in the air at room temperature are hereby reported. The element consists of an electrochemically etched sharp tungsten stylus over whose tip a nanometer-size crystal was synthesized. Langmuir-Blodgett...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Facci P,Erokhin V,Carrara S,Nicolini C

更新日期：1996-10-01 00:00:00

abstract：:Cold-water conditions have excluded durophagous (skeleton-breaking) predators from the Antarctic seafloor for millions of years. Rapidly warming seas off the western Antarctic Peninsula could now facilitate their return to the continental shelf, with profound consequences for the endemic fauna. Among the likely first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aronson RB,Smith KE,Vos SC,McClintock JB,Amsler MO,Moksnes PO,Ellis DS,Kaeli J,Singh H,Bailey JW,Schiferl JC,van Woesik R,Martin MA,Steffel BV,Deal ME,Lazarus SM,Havenhand JN,Swalethorp R,Kjellerup S,Thatje S

更新日期：2015-10-20 00:00:00

abstract：:To adapt to habitat temperature, vertebrates have developed sophisticated physiological and ecological mechanisms through evolution. Transient receptor potential melastatin 8 (TRPM8) serves as the primary sensor for cold. However, how cold activates TRPM8 and how this sensor is tuned for thermal adaptation remain larg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang S,Lu X,Wang Y,Xu L,Chen X,Yang F,Lai R

更新日期：2020-04-14 00:00:00

abstract：:Circadian timekeeping by intracellular molecular clocks is evident widely in prokaryotes and eukaryotes. The clockworks are driven by autoregulatory feedback loops that lead to oscillating levels of components whose maxima are in fixed phase relationships with one another. These phase relationships are the key metric ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirsky HP,Liu AC,Welsh DK,Kay SA,Doyle FJ 3rd

更新日期：2009-07-07 00:00:00

abstract：:Store-operated calcium entry (SOCE), an important mechanism of Ca2+ signaling in a wide range of cell types, is mediated by stromal interaction molecule (STIM), which senses the depletion of endoplasmic reticulum Ca2+ stores and binds and activates Orai channels in the plasma membrane. This inside-out mechanism of Ca2...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim KM,Wijerathne T,Hur JH,Kang UJ,Kim IH,Kweon YC,Lee AR,Jeong SJ,Lee SK,Lee YY,Sim BW,Lee JH,Baig C,Kim SU,Chang KT,Lee KP,Park CY

更新日期：2018-05-15 00:00:00

abstract：:Influenza viruses contain segmented, negative-strand RNA genomes. Genome segmentation facilitates reassortment between different influenza virus strains infecting the same cell. This phenomenon results in the rapid exchange of RNA segments. In this study, we have developed a method to prevent the free reassortment of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao Q,Palese P

更新日期：2009-09-15 00:00:00

abstract：:Human aging is accompanied by dramatic changes in daily sleep-wake behavior: Activity shifts to an earlier phase, and the consolidation of sleep and wake is disturbed. Although this daily circadian rhythm is brain-controlled, its mechanism is encoded by cell-autonomous circadian clocks functioning in nearly every cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pagani L,Schmitt K,Meier F,Izakovic J,Roemer K,Viola A,Cajochen C,Wirz-Justice A,Brown SA,Eckert A

更新日期：2011-04-26 00:00:00

abstract：:Insects living in the temperate zone enter a physiological state of arrested or slowed development to overcome an adverse season, such as winter. Developmental arrest, called diapause, occurs at a species-specific developmental stage, and embryonic and pupal diapauses have been extensively studied in mostly holometabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miki T,Shinohara T,Chafino S,Noji S,Tomioka K

更新日期：2020-03-10 00:00:00

abstract：:We propose a model for DNA polymerase fidelity in which free energy differences, delta delta G, between matched and mismatched nucleotides are magnified at the enzyme's active site. Both hydrogen bonding and stacking components of the interaction energy are amplified, with the most profound effect being on the magnitu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Petruska J,Sowers LC,Goodman MF

更新日期：1986-03-01 00:00:00

abstract：:Maintaining the fidelity of nascent peptide chain (NP) synthesis is essential for proteome integrity and cellular health. Ribosome-associated quality control (RQC) serves to resolve stalled translation, during which untemplated Ala/Thr residues are added C terminally to stalled peptide, as shown during C-terminal Ala ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li S,Wu Z,Tantray I,Li Y,Chen S,Dong J,Glynn S,Vogel H,Snyder M,Lu B

更新日期：2020-10-06 00:00:00

abstract：:Cytokines such as interleukin 4 (IL-4) play a key role in the regulation of immune responses, but little is known about how their multiple activities are regulated in vivo. In this report, we demonstrated that an IL-4-binding protein (IL-4BP) is constitutively present in the biological fluids of mice (serum, ascites, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernandez-Botran R,Vitetta ES

更新日期：1990-06-01 00:00:00

abstract：:Although recent studies have shown that brown adipose tissue (BAT) arises from progenitor cells that also give rise to skeletal muscle, the developmental signals that control the formation of BAT remain largely unknown. Here, we show that brown preadipocytes possess primary cilia and can respond to Hedgehog (Hh) signa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nosavanh L,Yu DH,Jaehnig EJ,Tong Q,Shen L,Chen MH

更新日期：2015-04-21 00:00:00

abstract：:In this report we identify the specific isozymes of protein kinase C (PKC) that are involved in c-fos and c-jun mRNA accumulation in the rat basophilic leukemia cell line RBL-2H3. These cells could be largely depleted of the endogenous PKC isozymes by chronic treatment with phorbol 12-myristate 13-acetate followed by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Razin E,Szallasi Z,Kazanietz MG,Blumberg PM,Rivera J

更新日期：1994-08-02 00:00:00

abstract：:The heterodimeric antimicrobial peptide distinctin is composed of 2 linear peptide chains of 22- and 25-aa residues that are connected by a single intermolecular S-S bond. This heterodimer has been considered to be a unique example of a previously unrecorded class of bioactive peptides. Here the 2 distinctin chains we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Resende JM,Moraes CM,Munhoz VH,Aisenbrey C,Verly RM,Bertani P,Cesar A,Piló-Veloso D,Bechinger B

更新日期：2009-09-29 00:00:00