Abstract：
:The evaluation of new therapy poses a formidable challenge in intensive care medicine. When therapy evaluation cannot be double-blinded, as in the evaluation of extracorporeal support, the problem becomes more difficult. The result of the extracorporeal clinical trial, like that of the ECMO trial in the 1970s, is a potent reminder of the importance of concurrent controls in such evaluations. We should view with caution ethical objections to controlled trials of therapies that are not supported by credible data. A stronger ethical argument may frequently be mounted in favor of a randomized, controlled clinical trial. This is particularly pertinent in the high-technology ICU environment in which information overload is intense. The establishment of ICU human laboratories should enable the medical community to make much needed progress and help us identify the useful elements in our therapeutic armamentarium.
journal_name
Respir Carejournal_title
Respiratory careauthors
Morris AHkeywords:
subject
Has Abstractpub_date
1993-07-01 00:00:00pages
829-38; discussion 838-41issue
7eissn
0020-1324issn
1943-3654journal_volume
38pub_type
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