Abstract：
:Recently, ionizing radiation has been shown to decrease the proliferative response to injury in animal models of restenosis. The Scripps Coronary Radiation to Inhibit Proliferation Post-Stenting (SCRIPPS) trial was a double-blind, placebo-controlled, randomized trial to test this new treatment modality in restenotic stented human coronary arteries. Patients with previous restenosis and stent implantation were randomized to receive catheter-based radiation with Iridium-192 or a placebo using a catheter-based delivery system. Fifty-five patients were enrolled; 26 were assigned to Iridium-192 and 29 to the placebo. Follow-up angiography was obtained in 96% of patients. Restenosis was observed in 53.6% of placebo patients compared with only 16.7% of treated patients (P = 0.025). Late luminal loss was also significantly lower in the Iridium-192 group (0.38 +/- 1.06 mm vs 1.03 +/- 0.97 mm, P = 0.009). Clinical outcome also revealed a significant reduction in the need for target lesion revascularization in the Iridium-192 group (44.8% vs 11.5%, P = 0.008). In this preliminary study, catheter-based intracoronary radiotherapy substantially reduced the rate of subsequent restenosis. Clinical trials using gamma emitters, beta emitters, and beta-emitting radioactive stents are ongoing.
journal_name
Tex Heart Inst Jjournal_title
Texas Heart Institute journalauthors
Teirstein PSsubject
Has Abstractpub_date
1998-01-01 00:00:00pages
30-3issue
1eissn
0730-2347issn
1526-6702journal_volume
25pub_type
临床试验,杂志文章,随机对照试验abstract：:Because of physiologic R-R interval variability and arrhythmia, frame-mode acquisition of gated images may produce erroneous left ventricular volume curves, particularly in the diastolic filling phase. Eighteen patients in sinus rhythm underwent gated imaging in which both frame-mode and list-mode acquisitions were us...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1984-09-01 00:00:00
abstract：:Acquired long QT syndrome is typically caused by medications, electrolyte disturbances, bradycardia, or catastrophic central nervous system events. We report a case of myocardial infarction-related acquired long QT syndrome in a 58-year-old woman that had no clear cause and progressed to torsades de pointes requiring ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-18-6872
更新日期：2020-04-01 00:00:00
abstract：:Percutaneous coronary intervention in tortuous or calcified vessels poses a substantial challenge for interventional cardiologists. Many techniques have been described to overcome the challenge, including the use of stiffer wires, buddy wires, the anchor balloon technique, and deep seating of the guide catheter. Herei...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2011-01-01 00:00:00
abstract：:The rupture of a mycotic femoral artery pseudoaneurysm in an intravenous drug abuser is a limb- and life-threatening condition that necessitates emergency intervention. Emergency stent-grafting appears to be a viable, minimally invasive alternative, or a bridge, to subsequent open surgery. Caution is required in cases...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3882
更新日期：2014-12-01 00:00:00
abstract：:The Bentall procedure is the standard operation for patients who have lesions of the ascending aorta associated with aortic valve disease. In many cases, however, mechanical prosthetic conduits are not suitable. There are few reports in the English-language medical literature concerning the mid- to long-term outcome o...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:The glutaraldehyde-preserved stented porcine xenograft valve has been durable in adult patients with a low incidence of valve-related complications. In children, however, early degeneration and calcification of this valve is now being reported. The etiology of the early degeneration is still unclear but may be related...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1982-03-01 00:00:00
abstract：:Hemangiomas of the heart are extremely rare. The prognosis is quite variable, because this benign tumor may grow, involute, or stop growing; therefore, resection is usually the treatment of choice. In patients with tumors of the left atrium, percutaneous balloon mitral valvulotomy is generally contraindicated. Yet for...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:The benefit of defibrillator therapy has been well established for patients with LV dysfunction (ejection fraction less than 35%), coronary artery disease, NSVT, and inducible and nonsuppressible ventricular tachycardia. Implantable cardioverter-defibrillator therapy is also indicated for all CHF patients in NYHA func...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：1999-01-01 00:00:00
abstract：:We report the case of a 65-year-old man with a 6-year history of hypertension who presented with dilated cardiomyopathy, a transient cerebrovascular event, paroxysmal sweating, and intractable hypertension. Coronary angiography revealed no abnormality, but diagnostic testing was pursued because of the severe sweating ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2007-01-01 00:00:00
abstract：:Apical akinesis and dilation in the absence of obstructive coronary artery disease is a typical feature of stress-induced (takotsubo) cardiomyopathy, whereas apical hypertrophy is seen in apical-variant hypertrophic cardiomyopathy. We report the cases of 2 patients who presented with takotsubo cardiomyopathy and were ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3191
更新日期：2014-04-01 00:00:00
abstract：:During his work, an 18-year-old carpenter-in-training overbalanced and shot himself in the left median thorax with a nail gun. The patient was delivered to our thoracic surgery unit with a tentative diagnosis of penetrating lung trauma. An emergent computed tomogram showed a heart-penetrating nail injury. The patient ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-13-3405
更新日期：2014-08-01 00:00:00
abstract：:Celiac artery aneurysms are rare and typically warrant surgical treatment. Atherosclerosis is their chief cause. Symptomatic patients usually present with abdominal pain. Surgical resection of celiac artery aneurysms is associated with low morbidity and mortality rates. We report the case of a patient whose 2.2-cm cel...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-16-5802
更新日期：2017-02-01 00:00:00
abstract：:Ischemic mitral regurgitation, a complication of myocardial infarction, is associated with a poor prognosis and can result in postinfarction congestive heart failure. The preferred treatment of its chronic form is a matter of debate. Herein, we report the early and midterm results in 44 patients with chronic ischemic ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:The consequences of deep wound infections before, during, and after coronary artery bypass grafting have prompted research to clarify risk factors and explore preventive measures to keep infection rates at an irreducible minimum. An analysis of 42 studies in which investigators used multivariate logistic regression an...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：2013-01-01 00:00:00
abstract：:Permanent junctional reciprocating tachycardia, or atrioventricular reentrant tachycardia utilizing a slowly conducting posteroseptal accessory pathway, is a rare form of reentrant supraventricular tachycardia in children and adults. The characteristic features of this narrow complex tachycardia are a long RP interval...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:We report the case of a 58-year-old man who presented with ventricular fibrillation. The serum potassium level was 1.8 mEq/L after successful cardioversion. Coronary angiography showed a normal heart with no structural defects, but 12-lead electrocardiography showed indications of left ventricular hypertrophy, which w...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Aortoventricular fistula, a rare congenital or acquired defect of the aortic wall, is characterized by an abnormal connection between the aorta and one of the ventricles. Symptom severity correlates with the diameter of the fistula and with the acute or chronic timing of presentation. The diagnosis is usually made by ...
journal_title：Texas Heart Institute journal
pub_type：
doi：10.14503/THIJ-17-6332
更新日期：2019-04-01 00:00:00
abstract：:This report summarizes results of the first 453 consecutive patients who had 491 low profile bioprostheses implanted at the Italian Hospital in Buenos Aires over a 5-year period. During this time, with the goal of long-term durability, the valve mounting technique was slightly modified, whereas the materials and desig...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1982-06-01 00:00:00
abstract：:Heart valve repair is a biomaterial-dependent procedure, yet autogenous tissue for valvular reconstruction has to date been obtained mostly from the pericardium and fascia lata. Most clinical studies recommend valve repair as an alternative to replacement. We now put forward a hypothesis, extrapolated from hand surger...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Our goal was to investigate the efficacy of degradable poly(D,L-lactic-coglycolic acid) (PLGA) scaffolds loaded with basic fibroblast growth factor (bFGF) in inducing cardiac neovascularization, increasing perfusion, and improving cardiac function.For ease of scaffold implantation into the ventricular wall, we develop...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：:We report a case of an 11-year-old girl who presented with a slowly enlarging mass in the right posterolateral chest wall. Computed tomography showed a soft-tissue mass 8.5 × 7.5 × 5.5 cm in size, arising from the right posterolateral 9th, 10th, and 11th intercostal spaces. Magnetic resonance imaging confirmed a vascu...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:In order to determine the comparative merits of antegrade cardioplegia at moderate systemic hypothermia versus retrograde cardioplegia at systemic normothermia, we performed coronary artery bypass grafting using intermittent oxygenated blood cardioplegia in 2 sets of 50 consecutive patients with triple-vessel disease ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Anomalous origin of the right coronary artery from the pulmonary artery, a rare congenital cardiac defect, is typically not diagnosed during infancy. On the other hand, Turner syndrome is usually diagnosed early, and it is classically associated with bicuspid aortic valve and aortic coarctation. Individuals with Turne...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-17-6521
更新日期：2019-06-01 00:00:00
abstract：:No data are available on the long-term outcome of coronary-coronary venous bypass grafting. We describe a case in which we successfully stented a discrete, critical stenosis of a coronary-coronary venous graft that had been placed 19 years earlier to minimize manipulation of a severely calcified ascending aorta. Coron...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:Few orthotopic heart transplantations have been performed in patients infected with the human immunodeficiency virus since the first such case was reported in 2001. Since that time, advances in highly active antiretroviral therapy have resulted in potent and durable suppression of the causative human immunodeficiency ...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：10.14503/THIJ-14-4746
更新日期：2016-02-01 00:00:00
abstract：:Because of the variety of their anatomy and clinical implications, coronary anomalies tend to confuse many observers. Recently, our group and other investigators have proposed that only 1 specific type of anomaly, by means of a specific mechanism, is able to cause both symptoms of myocardial ischemia and sudden death....
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2010-01-01 00:00:00
abstract：:We present a series of 4 patients in whom mechanical trauma was identified as a factor in the development of late complications after AneuRx Stent Graft placement for repair of abdominal aortic aneurysms. In all 4 patients, Type I or III endoleaks (and pseudoaneurysms in 2 patients) were discovered several months afte...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:We describe our experience with the transseptal approach for mitral valve replacement, a technique that we applied especially in cases of 3rd and 4th operations wherein numerous adhesions made the usual left atrial approach difficult. We report 39 cases of mitral procedures in which we used 3 slightly different transs...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:We present a case of aortic valve replacement combined with aortic root enlargement, performed on an achondroplastic dwarf with severe calcific aortic stenosis. There are no data about the incidence of valvular diseases in achondroplastic patients. To our knowledge, this is the 1st time that an aortic valve replacemen...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章
doi：
更新日期：2005-01-01 00:00:00
abstract：:We report the case of a 65-year-old man who presented with an infrarenal aortic aneurysm in association with a congenital right pelvic kidney vascularized by 2 aortic arteries, 1 of which arose from the aneurysmal aorta and the other from the common right iliac artery. Successful surgery consisted of excising the aneu...
journal_title：Texas Heart Institute journal
pub_type： 杂志文章,评审
doi：
更新日期：1997-01-01 00:00:00
