Could Artesunate Have a Positive Effect on the Neurological Complications Related to Infection When It Is Used in the Treatment of COVID-19?

abstract：:The molecular pathogenesis of Alzheimer's disease (AD) is complex and sparsely understood. The relationship between AD's amyloid β (Aβ) peptides and neuronal membranes is central to Aβ's cytotoxicity and is directly modulated by the composition of the lipid headgroups. Molecular studies of the insertion of model Aβ40 ...

journal_title：ACS chemical neuroscience

authors： Tofoleanu F,Brooks BR,Buchete NV

更新日期：2015-03-18 00:00:00

abstract：:Calcitonin gene-related peptide (α-CGRP) released from perivascular sensory nerves induces decreases in diastolic blood pressure (DBP). Experimentally, this can be shown by spinal thoracic (T9-T12) electrical stimulation of these afferent fibers. Because ergotamine inhibits these neurogenic vascular responses and disp...

journal_title：ACS chemical neuroscience

authors： González-Hernández A,Marichal-Cancino BA,Lozano-Cuenca J,MaassenVanDenBrink A,Villalón CM

更新日期：2019-07-17 00:00:00

abstract：:Ca(2+)/calmodulin-dependent protein kinase IIα (CaMKIIα) autophosphorylation at Thr286 and Thr305/Thr306 regulates kinase activity and modulates subcellular targeting and is critical for normal synaptic plasticity and learning and memory. Here, a mass spectrometry-based approach was used to identify Ca(2+)-dependent a...

journal_title：ACS chemical neuroscience

authors： Baucum AJ 2nd,Shonesy BC,Rose KL,Colbran RJ

更新日期：2015-04-15 00:00:00

abstract：:The pathogenesis of Parkinson's disease (PD) is multifactorial event. Combination therapies might be more effective in controlling the disease. Thus, the studies reported were designed to test the hypothesis that gastrodin (GAS)-induced de novo synthesis of nuclear factor E2-related factor 2 (Nrf2) and isorhynchophyll...

journal_title：ACS chemical neuroscience

authors： Li Q,Niu C,Zhang X,Dong M

更新日期：2018-03-21 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, with a 10% genetic linkage, of which 20% of these cases may be attributed to mutations in superoxide dismutase (SOD1). Specific mutations in SOD1 have been associated with disease duration, which can be highly variable ranging from a life...

journal_title：ACS chemical neuroscience

authors： Abu-Hamad S,Kahn J,Leyton-Jaimes MF,Rosenblatt J,Israelson A

更新日期：2017-10-18 00:00:00

abstract：:We previously reported on the synthesis of substituted phenyl-4-hydroxy-1-piperidyl indole analogues with nanomolar affinity at D2 dopamine receptors, ranging from 10- to 100-fold selective for D2 compared to the D3 dopamine receptor subtype. More recently, we evaluated a panel of aripiprazole analogues, identifying s...

journal_title：ACS chemical neuroscience

authors： Luedtke RR,Mishra Y,Wang Q,Griffin SA,Bell-Horner C,Taylor M,Vangveravong S,Dillon GH,Huang RQ,Reichert DE,Mach RH

更新日期：2012-12-19 00:00:00

abstract：:The effect of the bis-sulfonated iron(III) corrole (1-Fe), a potent decomposition catalyst of reactive oxygen species, on rescuing SN4741 cells that were damaged by 6-hydroxydopamine (6-OHDA) was investigated as an in vitro model system for studying cell death of dopaminergic neurons in the substantia nigra. Important...

journal_title：ACS chemical neuroscience

authors： Soll M,Bar Am O,Mahammed A,Saltsman I,Mandel S,Youdim MB,Gross Z

更新日期：2016-10-19 00:00:00

abstract：:Modulation of the neuropeptide S (NPS) system has been linked to a variety of CNS disorders such as panic disorder, anxiety, sleeping disorders, asthma, obesity, PTSD, and substance abuse. In this study, a series of diphenyltetrahydro-1H-oxazolo[3,4-α]pyrazin-3(5H)-ones were synthesized and evaluated for antagonist ac...

journal_title：ACS chemical neuroscience

authors： Hassler C,Zhang Y,Gilmour B,Graf T,Fennell T,Snyder R,Deschamps JR,Reinscheid RK,Garau C,Runyon SP

更新日期：2014-08-20 00:00:00

abstract：:Carboranes have been extensively investigated as potential drugs for the treatment of malignant human brain tumors by boron neutron capture therapy (BNCT). This noninvasive treatment modality utilizes compounds containing the nonradioactive isotope 10B which has a high propensity to capture slow neutrons. In response,...

journal_title：ACS chemical neuroscience

authors： He T,Chittur SV,Musah RA

更新日期：2019-03-20 00:00:00

abstract：:1-Methyl-4-phenylpyridinium (MPP+) induces microglial activation and degeneration of dopaminergic (DAergic) neurons. Donepezil is a well-known acetylcholinesterase inhibitor used clinically to treat cognitive dysfunction in Alzheimer's disease (AD). In the present study, we tested the hypothesis that MPP+ promotes mic...

journal_title：ACS chemical neuroscience

authors： Chen T,Hou R,Xu S,Wu C

更新日期：2015-10-21 00:00:00

abstract：:The distribution and density of neurons within the brain poses many challenges when making quantitative measurements of neurotransmission in the extracellular space. A volume neurotransmitter is released into the synapse during chemical communication and must diffuse through the extracellular space to an implanted sen...

journal_title：ACS chemical neuroscience

authors： Atcherley CW,Laude ND,Monroe EB,Wood KM,Hashemi P,Heien ML

更新日期：2015-09-16 00:00:00

abstract：:Amyloid formation and neuroinflammation are major features of Alzheimer's disease pathology. Proinflammatory mediator S100A9 was shown to act as a link between the amyloid and neuroinflammatory cascades in Alzheimer's disease, leading together with Aβ to plaque formation, neuronal loss and memory impairment. In order ...

journal_title：ACS chemical neuroscience

authors： Iashchishyn IA,Gruden MA,Moskalenko RA,Davydova TV,Wang C,Sewell RDE,Morozova-Roche LA

更新日期：2018-06-20 00:00:00

abstract：:High levels of histamine H3 receptors (H3Rs) are found in the globus pallidus (GP), a neuronal nucleus in the basal ganglia involved in the control of motor behavior. By using rat GP isolated nerve terminals (synaptosomes), we studied whether H3R activation modified the previously reported enhancing action of adenosin...

journal_title：ACS chemical neuroscience

authors： Morales-Figueroa GE,Márquez-Gómez R,González-Pantoja R,Escamilla-Sánchez J,Arias-Montaño JA

更新日期：2014-08-20 00:00:00

abstract：:Dopamine (DA) is a neurotransmitter implicated in multiple functions, including movement, cognition, motivation, and reward. The DA transporter (DAT) is responsible for clearing extracellular DA, thereby terminating DA neurotransmission. Previously, it has been shown that insulin signaling through protein kinase B/Akt...

journal_title：ACS chemical neuroscience

authors： Speed NK,Matthies HJ,Kennedy JP,Vaughan RA,Javitch JA,Russo SJ,Lindsley CW,Niswender K,Galli A

更新日期：2010-07-21 00:00:00

abstract：:Vesicular acetylcholine transporter (VAChT) is a member of the major facilitator superfamily (MFS). It contains conserved sequence motifs originally defined in the bacterial multidrug resistance transporter family of the MFS. Motif C (GSLV(227) A(228)PPFGGIL) is located at the C-terminal end of transmembrane helix 5 (...

journal_title：ACS chemical neuroscience

authors： Luo J,Parsons SM

更新日期：2010-05-19 00:00:00

abstract：:Central norepinephrine (NE) and dopamine (DA) are involved in a variety of physiological functions and behaviors. Accumulating evidence suggests that NE neurons originating from the locus coeruleus (LC) innervate DA neurons of the ventral tegmental area (VTA) and influence VTA-DA neural activity. However, the underlyi...

journal_title：ACS chemical neuroscience

authors： Park JW,Bhimani RV,Park J

更新日期：2017-09-20 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) protects the embryo from endogenous and xenobiotic-enhanced oxidative DNA damage and embryopathies. Here we show in aged mice that G6PD similarly protects against endogenous reactive oxygen species (ROS)-mediated neurodegeneration. In G6PD-normal (G6PD(+/+)) and heterozygous (G...

journal_title：ACS chemical neuroscience

authors： Jeng W,Loniewska MM,Wells PG

更新日期：2013-07-17 00:00:00

abstract：:With roughly 2 billion people infected, the neurotropic protozoan Toxoplasma gondii remains one of the most pervasive and infectious parasites. Toxoplasma infection is the second leading cause of death due to foodborne illness in the United States, causes severe disease in immunocompromised patients, and is correlated...

journal_title：ACS chemical neuroscience

authors： Zwicker JD,Smith D,Guerra AJ,Hitchens JR,Haug N,Vander Roest S,Lee P,Wen B,Sun D,Wang L,Keep RF,Xiang J,Carruthers VB,Larsen SD

更新日期：2020-08-19 00:00:00

abstract：:The dorsal raphe nucleus contains one of the largest groups of serotonergic neurons in the mammalian brain and is the main site of origin of the serotonergic projection to the cerebral cortex. Early electrophysiological studies suggested that serotonergic neurons in this cell group formed a homogeneous cell class. Mor...

journal_title：ACS chemical neuroscience

authors： Andrade R,Haj-Dahmane S

更新日期：2013-01-16 00:00:00

abstract：:The glycine receptor (GlyR) is a ligand-activated chloride channel, whose mutations are the major cause of hereditary hyperekplexia. The hyperekplexia-causing R271Q mutation, which is located at the extracellular outer mouth of the channel pore, dramatically impairs the GlyR function manifesting a reduced sensitivity ...

journal_title：ACS chemical neuroscience

authors： Han L,Shan Q

更新日期：2020-10-21 00:00:00

abstract：:Currently, anti-AD drug discovery using target-based approaches is extremely challenging due to unclear etiology of AD and absence of validated therapeutic protein targets. Neuronal death, regardless of causes, plays a key role in AD progression, and it is directly linked to neuroinflammation. Meanwhile, phenotypic sc...

journal_title：ACS chemical neuroscience

authors： Zhou W,Zhong G,Fu S,Xie H,Chi T,Li L,Rao X,Zeng S,Xu D,Wang H,Sheng G,Ji X,Liu X,Ji X,Wu D,Zou L,Tortorella M,Zhang K,Hu W

更新日期：2016-11-16 00:00:00

abstract：:Neurons choose growth pathways with half hearted reluctance, behavior that may be appropriate to maintain fixed long lasting connections but not to regenerate them. We now recognize that intrinsic brakes on regrowth are widely expressed in these hesitant neurons and include classical tumor suppressor molecules. Here, ...

journal_title：ACS chemical neuroscience

authors： Zochodne DW

更新日期：2014-08-20 00:00:00

abstract：:Amyloid-β (Aβ) is a peptide fragment that is prone to aggregate into large fibrils under physiological conditions. Many techniques have been developed to quickly monitor the transition from a primarily monomeric peptide into fibrils. Here we propose a novel method for both incubating and monitoring changes in Aβ aggre...

journal_title：ACS chemical neuroscience

authors： Cook NP,Martí AA

更新日期：2012-11-21 00:00:00

abstract：:Gangliosides are biologically important glycolipids widely distributed in vertebrate cells. An important member of the ganglioside family is the monosialylganglioside GM1, which has been suggested as a potential therapeutic for Parkinson's disease. In the current study, a late-stage radiofluorination protocol was deve...

journal_title：ACS chemical neuroscience

authors： Revunov E,Johnström P,Arakawa R,Malmquist J,Jucaite A,Defay T,Takano A,Schou M

更新日期：2020-05-06 00:00:00

abstract：:We recently found that tamoxifen suppresses l-glutamate transport activity of cultured astrocytes. Here, in an attempt to separate the l-glutamate transporter-inhibitory activity from the estrogen receptor-mediated genomic effects, we synthesized several compounds structurally related to tamoxifen. Among them, we iden...

journal_title：ACS chemical neuroscience

authors： Sato K,Kuriwaki J,Takahashi K,Saito Y,Oka J,Otani Y,Sha Y,Nakazawa K,Sekino Y,Ohwada T

更新日期：2012-02-15 00:00:00

abstract：:Parkinson's disease (PD) has long been seen as a disorder caused by degeneration of the dopaminergic system, leading to the classic motor manifestations of the disease. However, there is now overwhelming evidence that PD is more than a disease merely caused by dopamine depletion. It is well-known that a myriad of othe...

journal_title：ACS chemical neuroscience

authors： Huot P,Sgambato-Faure V,Fox SH,McCreary AC

更新日期：2017-05-17 00:00:00

abstract：:Exposure to di-(2-ethylhexyl) phthalate (DEHP), a widely used kind of plasticizer, can result in neurodevelopment impairments and learning and memory disorders. We studied the effects and possible mechanisms of maternal DEHP treatment on hippocampal synaptic plasticity in offspring. Pregnant Wistar rats were randomly ...

journal_title：ACS chemical neuroscience

authors： Dong J,Fu H,Fu Y,You M,Li X,Wang C,Leng K,Wang Y,Chen J

更新日期：2021-01-20 00:00:00

abstract：:Neurotensin (NT) exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2. This opioid-independent antinociception represents a potential alternative for pain management. While activation of NTS1 also induces a drop in blood pressure and body temperature, NTS2 appears to be an a...

journal_title：ACS chemical neuroscience

authors： Eiselt E,Gonzalez S,Martin C,Chartier M,Betti C,Longpré JM,Cavelier F,Tourwé D,Gendron L,Ballet S,Sarret P

更新日期：2019-11-20 00:00:00

abstract：:In humans, genetic defects of the synthesis or regeneration of tetrahydrobiopterin (BH4), an essential cofactor in hydroxylation reactions, are associated with severe neurological disorders. The diagnosis of these conditions relies on the determination of BH4, dihydrobiopterin (BH2), and dihydroneopterin (NH2) in cere...

journal_title：ACS chemical neuroscience

authors： Guibal P,Lévêque N,Doummar D,Giraud N,Roze E,Rodriguez D,Couderc R,Billette De Villemeur T,Moussa F

更新日期：2014-07-16 00:00:00

abstract：:Photochromic blockers of voltage gated ion channels are powerful tools for the control of neuronal systems with high spatial and temporal precision. We now introduce fotocaine, a new type of photochromic channel blocker based on the long-lasting anesthetic fomocaine. Fotocaine is readily taken up by neurons in brain s...

journal_title：ACS chemical neuroscience

authors： Schoenberger M,Damijonaitis A,Zhang Z,Nagel D,Trauner D

更新日期：2014-07-16 00:00:00