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Neurons and tumor suppressors.

Abstract：

:Neurons choose growth pathways with half hearted reluctance, behavior that may be appropriate to maintain fixed long lasting connections but not to regenerate them. We now recognize that intrinsic brakes on regrowth are widely expressed in these hesitant neurons and include classical tumor suppressor molecules. Here, we review how two brakes, PTEN (phosphatase and tensin homolog deleted on chromosome 10) and retinoblastoma emerge as new and exciting knockdown targets to enhance neuron plasticity and improve outcome from damage or disease.

journal_name

ACS Chem Neurosci

journal_title

ACS chemical neuroscience

authors

Zochodne DW

doi

10.1021/cn500110p

subject

Has Abstract

pub_date

2014-08-20 00:00:00

pages

618-20

issue

8

issn

1948-7193

journal_volume

5

pub_type

杂志文章,评审

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