Serine Supports IL-1β Production in Macrophages Through mTOR Signaling.

abstract：:γ9δ2T cells play a critical role in daily cancer immune surveillance by sensing cancer-mediated metabolic changes. However, a major limitation of the therapeutic application of γ9δ2T cells is their diversity and regulation through innate co-receptors. In order to overcome natural obstacles of γ9δ2T cells, we have deve...

journal_title：Frontiers in immunology

authors： Straetemans T,Kierkels GJJ,Doorn R,Jansen K,Heijhuurs S,Dos Santos JM,van Muyden ADD,Vie H,Clemenceau B,Raymakers R,de Witte M,Sebestyén Z,Kuball J

更新日期：2018-05-30 00:00:00

abstract：:Cytokines are known to shape the tumor microenvironment and although progress has been made in understanding their role in carcinogenesis, much remains to learn regarding their role in tumor growth and progression. We have identified granulocyte colony-stimulating factor (G-CSF) as one such cytokine, showing that G-CS...

journal_title：Frontiers in immunology

authors： Karagiannidis I,Jerman SJ,Jacenik D,Phinney BB,Yao R,Prossnitz ER,Beswick EJ

更新日期：2020-09-15 00:00:00

abstract：:Nijmegen breakage syndrome (NBS) is a DNA repair disorder characterized by combined immunodeficiency and a high predisposition to lymphoid malignancies. The majority of NBS patients are identified with a homozygous five base pair deletion in the Nibrin (NBN) gene (c.657_661del5, p.K219fsX19) with a founder effect obse...

journal_title：Frontiers in immunology

authors： Sharapova SO,Pashchenko OE,Bondarenko AV,Vakhlyarskaya SS,Prokofjeva T,Fedorova AS,Savchak I,Mareika Y,Valiev TT,Popa A,Tuzankina IA,Vlasova EV,Sakovich IS,Polyakova EA,Rumiantseva NV,Naumchik IV,Kulyova SA,Aleshkevich

更新日期：2021-01-08 00:00:00

abstract：:Laboratory of genetics and physiology 2 (LGP2) is a key component of RIG-I-like receptors (RLRs). However, the lack of the caspase recruitment domains (CARDs) results in its controversial functional performance as a negative or positive regulator in antiviral responses. Especially, no sufficient evidence uncovers the ...

journal_title：Frontiers in immunology

authors： Rao Y,Wan Q,Yang C,Su J

更新日期：2017-03-27 00:00:00

abstract：:Recent studies suggest an important role of immunoglobulin E (IgE) as an alternative pathogenic pathway in the development of bullous pemphigoid (BP), as the most frequent subepidermal blistering disease of the skin Use of IgE targeted therapies, such as omalizumab, has been shown promising in recent studies. The aim ...

journal_title：Frontiers in immunology

authors： Seyed Jafari SM,Gadaldi K,Feldmeyer L,Yawalkar N,Borradori L,Schlapbach C

更新日期：2019-08-14 00:00:00

abstract：:Prolonged shedding of viral RNA occurs in some individuals following SARS-CoV-2 infection. We perform comprehensive immunologic evaluation of one individual with prolonged shedding. The case subject recovered from severe COVID-19 and tested positive for SARS-CoV-2 viral RNA repeatedly as many as 87 days after the firs...

journal_title：Frontiers in immunology

authors： Turner JS,Day A,Alsoussi WB,Liu Z,O'Halloran JA,Presti RM,Patterson BK,Whelan SPJ,Ellebedy AH,Mudd PA

更新日期：2021-01-08 00:00:00

abstract：:Candida is a dominant fungal pathogen in immunocompromised hosts, leading to opportunistic infections. Complement with its multifaceted functions is involved in the immune defense against this yeast, and recently several novel aspects have emerged in this old battle. It is clear that Candida can adopt both roles as a ...

journal_title：Frontiers in immunology

authors： Harpf V,Rambach G,Würzner R,Lass-Flörl C,Speth C

更新日期：2020-07-14 00:00:00

abstract：:Sialic acids, a group of acidic sugars abundantly expressed in the tissues of deuterostome animals but rarely found in microbes, serve as a "signature of self" for these animals. Cognate sensors for sialic acids include Siglecs, a family of transmembrane lectins of vertebrate immune systems that recognize glycans cont...

journal_title：Frontiers in immunology

authors： Angata T

更新日期：2018-12-04 00:00:00

abstract：:Among all T and NK cell subsets, regulatory T (Treg) cells typically respond to the lowest concentrations of IL-2 due to elevated surface expression of the IL-2R alpha chain (IL2RA; CD25) and the high affinity IL-2 receptor (IL-2R) complex. This enhanced sensitivity forms the basis for low-dose (LD) IL-2 therapy for t...

journal_title：Frontiers in immunology

authors： Ghelani A,Bates D,Conner K,Wu MZ,Lu J,Hu YL,Li CM,Chaudhry A,Sohn SJ

更新日期：2020-06-05 00:00:00

abstract：:Respiratory syncytial virus (RSV) is a common pathogen that infects virtually all children by 2 years of age and is the leading cause of hospitalization of infants worldwide. While most children experience mild symptoms, some children progress to severe lower respiratory tract infection. Those children with severe dis...

journal_title：Frontiers in immunology

authors： Fonseca W,Lukacs NW,Ptaschinski C

更新日期：2018-02-19 00:00:00

abstract：:Toll-like receptors (TLR) triggering of B cells are known to promote B cell expansion, differentiation of B cells into antibody-producing and memory cells, but the TLR responses of porcine B cells is poorly characterized. Therefore, this study investigated the response pattern of porcine B cell subsets to a large coll...

journal_title：Frontiers in immunology

authors： Braun RO,Python S,Summerfield A

更新日期：2017-08-25 00:00:00

abstract：:Hepatitis B virus (HBV) infection is regarded as the main etiological risk factor in the process of hepatocellular carcinoma (HCC), as it promotes an immunosuppressive microenvironment that is partially mediated by the programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) signaling pathway. The tumo...

journal_title：Frontiers in immunology

authors： Li B,Yan C,Zhu J,Chen X,Fu Q,Zhang H,Tong Z,Liu L,Zheng Y,Zhao P,Jiang W,Fang W

更新日期：2020-05-28 00:00:00

abstract：:The heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli display adjuvant effects to coadministered antigens, leading to enhanced production of serum antibodies. Despite extensive knowledge of the adjuvant properties of LT derivatives, including in vitro-generated non-toxic mutant forms, little is know...

journal_title：Frontiers in immunology

authors： Maeda DLNF,Batista MT,Pereira LR,de Jesus Cintra M,Amorim JH,Mathias-Santos C,Pereira SA,Boscardin SB,Silva SDR,Faquim-Mauro EL,Silveira VB,Oliveira DBL,Johnston SA,Ferreira LCS,Rodrigues JF

更新日期：2017-09-25 00:00:00

abstract：:A major limitation to the translation of tolerogenic therapies to clinical transplantation is a lack of biomarkers that can be used as surrogate measures for predicting the successful induction of immune tolerance which would allow for the safe withdrawal of immunosuppression. We have used three different mouse models...

journal_title：Frontiers in immunology

authors： Cobbold SP,Adams E,Waldmann H

更新日期：2011-04-06 00:00:00

abstract：:Functional impairment of T-cells and a concomitant augmented expression of programmed death-1 (PD-1) have been observed in visceral leishmaniasis patients, as well as in experimental models for visceral and cutaneous leishmaniasis. The PD-1/PD-1-ligand (PD-1/PD-L) interaction negatively regulates T-cell effector funct...

journal_title：Frontiers in immunology

authors： Filippis C,Arens K,Noubissi Nzeteu GA,Reichmann G,Waibler Z,Crauwels P,van Zandbergen G

更新日期：2017-12-22 00:00:00

abstract：:Myeloid cells play an important role in the pathogenesis of multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). Monocytes, macrophages, and microglia can adopt two distinct phenotypes, with M1-polarized cells being more related to inflammation and autoimmunity while M2-polariz...

journal_title：Frontiers in immunology

authors： Montes-Cobos E,Schweingruber N,Li X,Fischer HJ,Reichardt HM,Lühder F

更新日期：2017-10-13 00:00:00

abstract：:MicroRNAs (miRNAs) are a class of small, non-coding RNAs that are recognized as critical regulators of immune gene expression during infection. Many immunologically significant human miRNAs have been found to be conserved in agriculturally important species, including cattle. Discovering how bovine miRNAs mediate the ...

journal_title：Frontiers in immunology

authors： Lawless N,Vegh P,O'Farrelly C,Lynn DJ

更新日期：2014-11-27 00:00:00

abstract：:Rheumatoid arthritis (RA) associated anti-citrullinated protein autoantibodies (ACPA) target a wide range of modified proteins. Citrullination occurs during physiological processes such as apoptosis, yet little is known about the interaction of ACPA with nuclear antigens or apoptotic cells. Since uncleared apoptotic c...

journal_title：Frontiers in immunology

authors： Lloyd KA,Wigerblad G,Sahlström P,Garimella MG,Chemin K,Steen J,Titcombe PJ,Marklein B,Zhou D,Stålesen R,Ossipova E,Lundqvist C,Ekwall O,Rönnelid J,Mueller DL,Karlsson MCI,Kaplan MJ,Skriner K,Klareskog L,Wermeling F

更新日期：2019-01-04 00:00:00

abstract：:Immunoglobulin G (IgG), a glycoprotein secreted by plasma B-cells, plays a major role in the human adaptive immune response and are associated with a wide range of diseases. Glycosylation of the Fc binding region of IgGs, responsible for the antibody's effector function, is essential for prompting a proper immune resp...

journal_title：Frontiers in immunology

authors： Wahl A,van den Akker E,Klaric L,Štambuk J,Benedetti E,Plomp R,Razdorov G,Trbojević-Akmačić I,Deelen J,van Heemst D,Slagboom PE,Vučković F,Grallert H,Krumsiek J,Strauch K,Peters A,Meitinger T,Hayward C,Wuhrer M,Beekm

更新日期：2018-02-26 00:00:00

abstract：:Complement factor H (CFH) has a pivotal role in regulating alternative complement activation through its ability to inhibit the cleavage of the central complement component C3, which links innate and humoral immunity. However, insights into the role of CFH in B cell biology are limited. Here, we demonstrate that defic...

journal_title：Frontiers in immunology

authors： Kiss MG,Ozsvár-Kozma M,Porsch F,Göderle L,Papac-Miličević N,Bartolini-Gritti B,Tsiantoulas D,Pickering MC,Binder CJ

更新日期：2019-07-11 00:00:00

abstract：:Immunotherapy using checkpoint inhibitor targeting PD-1 and PD-L1 revolutionized the treatment of microsatellite instable metastatic colon cancer. Such treatment is now a standard of care for these patients. However, when used as monotherapy checkpoint inhibitors targeting PD-1 and PD-L1 are not effective in metastati...

journal_title：Frontiers in immunology

authors： Ghiringhelli F,Fumet JD

更新日期：2019-08-06 00:00:00

abstract：Objectives:Granulocyte monocyte colony-stimulating factor (GM-CSF) is currently considered a crucial inflammatory mediator and a novel therapeutic target in rheumatoid arthritis (RA), despite the fact that its precise cellular sources remain uncertain. We studied the expression of GM-CSF in peripheral lymphocytes from ...

journal_title：Frontiers in immunology

authors： Makris A,Adamidi S,Koutsianas C,Tsalapaki C,Hadziyannis E,Vassilopoulos D

更新日期：2018-01-10 00:00:00

abstract：:The COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has generated a significant repercussion on the administration of adoptive cell therapies, including chimeric antigen receptor (CAR) T-cells. The closing of borders, the reduction of people transit and the confinement of the...

journal_title：Frontiers in immunology

authors： Ortiz de Landazuri I,Egri N,Muñoz-Sánchez G,Ortiz-Maldonado V,Bolaño V,Guijarro C,Pascal M,Juan M

更新日期：2020-10-15 00:00:00

abstract：:Background: Variants in recombination-activating genes (RAG) are common genetic causes of autosomal recessive forms of combined immunodeficiencies (CID) ranging from severe combined immunodeficiency (SCID), Omenn syndrome (OS), leaky SCID, and CID with granulomas and/or autoimmunity (CID-G/AI), and even milder present...

journal_title：Frontiers in immunology

authors： Sharapova SO,Skomska-Pawliszak M,Rodina YA,Wolska-Kuśnierz B,Dabrowska-Leonik N,Mikołuć B,Pashchenko OE,Pasic S,Freiberger T,Milota T,Formánková R,Szaflarska A,Siedlar M,Avčin T,Markelj G,Ciznar P,Kalwak K,Kołtan S,Ja

更新日期：2020-06-10 00:00:00

abstract：:The influence of CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Tregs) on cancer progression has been demonstrated in a large number of preclinical models and confirmed in several types of malignancies. Neoplastic processes trigger an increase of Treg numbers in draining lymph nodes, spleen, blood, and tumors, leading to t...

journal_title：Frontiers in immunology

authors： Darrasse-Jèze G,Podsypanina K

更新日期：2013-09-26 00:00:00

abstract：:Due to limited sepsis patient cohort size and extreme heterogeneity, only one significant locus and suggestive associations at several independent loci were implicated by three genome-wide association studies. However, genes from such suggestive loci may also provide crucial information to unravel genetic mechanisms t...

journal_title：Frontiers in immunology

authors： Le KTT,Matzaraki V,Netea MG,Wijmenga C,Moser J,Kumar V

更新日期：2019-08-14 00:00:00

abstract：:Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk associated with RA. Methods: The frequencies of monocyte subpopula...

journal_title：Frontiers in immunology

authors： Ruiz-Limon P,Ortega-Castro R,Barbarroja N,Perez-Sanchez C,Jamin C,Patiño-Trives AM,Luque-Tevar M,Ibáñez-Costa A,Perez-Sanchez L,de la Rosa IA,Abalos-Aguilera M,Jimenez-Gomez Y,Calvo-Gutierrez J,Font P,Escudero-Contreras A,A

更新日期：2019-05-21 00:00:00

abstract：:The diversity of the immune repertoire is important for the adaptive immune system's ability to detect pathogens. Much of this diversity is generated in two steps, first through the recombination of germline gene segments and second through hypermutation during an immune response. While both steps are to some extent b...

journal_title：Frontiers in immunology

authors： Schwartz GW,Hershberg U

更新日期：2013-11-08 00:00:00

abstract：:The autoimmune regulator AIRE controls the negative selection of self-reactive T-cells as well as the induction of regulatory T-cells in the thymus by mastering the transcription and presentation of tissue restricted antigens (TRAs) in thymic cells. However, extrathymic AIRE expression of hitherto unknown clinical sig...

journal_title：Frontiers in immunology

authors： Bergström B,Lundqvist C,Vasileiadis GK,Carlsten H,Ekwall O,Ekwall AH

更新日期：2019-06-18 00:00:00

abstract：:Background: Iron deficiency may impair adaptive immunity and is common among African infants at time of vaccination. Whether iron deficiency impairs vaccine response and whether iron supplementation improves humoral vaccine response is uncertain. Methods: We performed two studies in southern coastal Kenya. In a birth ...

journal_title：Frontiers in immunology

authors： Stoffel NU,Uyoga MA,Mutuku FM,Frost JN,Mwasi E,Paganini D,van der Klis FRM,Malhotra IJ,LaBeaud AD,Ricci C,Karanja S,Drakesmith H,King CH,Zimmermann MB

更新日期：2020-07-13 00:00:00