Abstract：
:In this paper, a formula for estimating the prevalence ratio of a disease in a population that is tested with imperfect tests is given. The formula is in terms of the fraction of positive test results and test parameters, i.e., probability of true positives (sensitivity) and the probability of true negatives (specificity). The motivation of this work arises in the context of the COVID-19 pandemic in which estimating the number of infected individuals depends on the sensitivity and specificity of the tests. In this context, it is shown that approximating the prevalence ratio by the ratio between the number of positive tests and the total number of tested individuals leads to dramatically high estimation errors, and thus, unadapted public health policies. The relevance of estimating the prevalence ratio using the formula presented in this work is that precision increases with the number of tests. Two conclusions are drawn from this work. First, in order to ensure that a reliable estimation is achieved with a finite number of tests, testing campaigns must be implemented with tests for which the sum of the sensitivity and the specificity is sufficiently different than one. Second, the key parameter for reducing the estimation error is the number of tests. For a large number of tests, as long as the sum of the sensitivity and specificity is different than one, the exact values of these parameters have very little impact on the estimation error.
journal_name
Int J Environ Res Public Healthauthors
Altman E,Mounir I,Najid FZ,Perlaza SMdoi
10.3390/ijerph17155328subject
Has Abstractpub_date
2020-07-24 00:00:00issue
15eissn
1661-7827issn
1660-4601pii
ijerph17155328journal_volume
17pub_type
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