Abstract:
:Candida infection is an important cause of morbidity and mortality in immunocompromised patients. The increase in its incidence has been associated with resistance to antimicrobial therapy and biofilm formation. The aim of this study was to evaluate the efficacy of tea tree oil (TTO) and its main component - terpinen-4-ol - against resistant Candida albicans strains (genotypes A and B) identified by molecular typing and against C. albicans ATCC 90028 and SC 5314 reference strains in planktonic and biofilm cultures. The minimum inhibitory concentration, minimum fungicidal concentration, and rate of biofilm development were used to evaluate antifungal activity. Results were obtained from analysis of the biofilm using the cell proliferation assay 2,3-Bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) and confocal laser scanning microscopy (CLSM). Terpinen-4-ol and TTO inhibited C. albicans growth. CLSM confirmed that 17.92 mg/mL of TTO and 8.86 mg/mL of terpinen-4-ol applied for 60 s (rinse simulation) interfered with biofilm formation. Hence, this in vitro study revealed that natural substances such as TTO and terpinen-4-ol present promising results for the treatment of oral candidiasis.
journal_name
Braz Oral Resjournal_title
Brazilian oral researchauthors
Francisconi RS,Huacho PMM,Tonon CC,Bordini EAF,Correia MF,Sardi JCO,Spolidorio DMPdoi
10.1590/1807-3107bor-2020.vol34.0050subject
Has Abstractpub_date
2020-06-05 00:00:00pages
e050eissn
1806-8324issn
1807-3107pii
S1806-83242020000100236journal_volume
34pub_type
杂志文章abstract::School and family together play an important role in the individual development of children. Therefore, this study aimed at evaluating the practices and attitudes towards oral health care of 245 education professionals working in 24 public municipal pre-schools in Niterói, State of Rio de Janeiro, Brazil. The data wer...
journal_title:Brazilian oral research
pub_type: 杂志文章
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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journal_title:Brazilian oral research
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