Adrenergic Signaling-Induced Ultrastructural Strengthening of Intercalated Discs via Plakoglobin Is Crucial for Positive Adhesiotropy in Murine Cardiomyocytes.

abstract：:Background: Acute mountain sickness (AMS) is a common disabling condition in individuals experiencing high altitudes, which may progress to life-threatening high altitude cerebral edema. Today, no established biomarkers are available for prediction the susceptibility of AMS. MicroRNAs emerge as promising sensitive and...

journal_title：Frontiers in physiology

authors： Liu B,Huang H,Wu G,Xu G,Sun BD,Zhang EL,Chen J,Gao YQ

更新日期：2017-02-08 00:00:00

abstract：:Electronic cigarettes (ECs) are a modern nicotine delivery system that rapidly grew in widespread use, particularly in younger populations. Given the long history of the comorbidity of alcohol and nicotine use, the rising prevalence of ECs raises the question as to their role in the consumption of alcohol. Of the nume...

journal_title：Frontiers in physiology

authors： Wetzel TJ,Wyatt TA

更新日期：2020-11-02 00:00:00

abstract：:Advances in high-performance computing are enabling a new generation of software tools that employ computational modeling for surgical planning. Surgical management of laryngeal paralysis is one area where such computational tools could have a significant impact. The current paper describes a comprehensive effort to d...

journal_title：Frontiers in physiology

authors： Mittal R,Zheng X,Bhardwaj R,Seo JH,Xue Q,Bielamowicz S

更新日期：2011-05-02 00:00:00

abstract：:Many studies have investigated the physiological response to microgravity in both astronauts and animals. However, while space agencies have sought to deploy more women on their missions; animal models rarely include females studies or comparisons between males and females. Therefore, we exposed adult female rats to 2...

journal_title：Frontiers in physiology

authors： Semple C,Riveros D,Nagy JA,Rutkove SB,Mortreux M

更新日期：2020-04-03 00:00:00

abstract：:Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human ventricular myocytes (HVMs) were investigated using the mathematical model developed by ten Tusscher and Panfilov (Am J Physiol Heart Circ Physiol 2...

journal_title：Frontiers in physiology

authors： Kurata Y,Tsumoto K,Hayashi K,Hisatome I,Kuda Y,Tanida M

更新日期：2020-01-10 00:00:00

abstract：:Obesity is characterized by an excessive increase in body mass, leading to endothelial damage that may favor the development of erectile dysfunction (ED). ED is defined as the inability to achieve or maintain a penile erection long enough to have a sexual intercourse. In this context, different ED models were develope...

journal_title：Frontiers in physiology

authors： de Souza ILL,Barros BC,de Oliveira GA,Queiroga FR,Toscano LT,Silva AS,Silva PM,Interaminense LFL,Cavalcante FA,da Silva BA

更新日期：2017-10-04 00:00:00

abstract：:Co-expressed genes often share similar functions, and gene co-expression networks have been widely used in studying the functionality of gene modules. Previous analysis indicated that genes are more likely to be co-expressed if they are either regulated by the same transcription factors, forming protein complexes or s...

journal_title：Frontiers in physiology

authors： Zhang C,Lee S,Mardinoglu A,Hua Q

更新日期：2016-05-02 00:00:00

abstract：:Background: Whole-body electromyostimulation (WB-EMS) gained increasing interest in sports within recent years. However, few intervention studies have examined the effects of WB-EMS on trained subjects in comparison to conventional strength training. Objective: The aim of the present mini-meta-analysis of 5 recently c...

journal_title：Frontiers in physiology

authors： Wirtz N,Dörmann U,Micke F,Filipovic A,Kleinöder H,Donath L

更新日期：2019-11-08 00:00:00

abstract：INTRODUCTION:Severe dengue hemorrhagic fever (DHF) is a viral infection that acts to increase permeability of capillaries, resulting in internal hemorrhage. Linear frequency domain Fourier spectral analysis represents the most published noninvasive tool for diagnosing and assessing health status via calculated heart ra...

journal_title：Frontiers in physiology

authors： Carter R 3rd,Hinojosa-Laborde C,Convertino VA

更新日期：2014-02-25 00:00:00

abstract：:Neuromuscular training in young athletes improves performance and decreases the risk of injuries during sports activities. These effects are primarily ascribed to the enhancement of muscle strength and power but also balance, speed and agility. However, most studies have failed to demonstrate significant improvement i...

journal_title：Frontiers in physiology

authors： Zemková E,Hamar D

更新日期：2018-04-11 00:00:00

abstract：:We examined structural properties of the marine mammal respiratory system, and tested Scholander's hypothesis that the chest is highly compliant by measuring the mechanical properties of the respiratory system in five species of pinniped under anesthesia (Pacific harbor seal, Phoca vitulina; northern elephant seal, Mi...

journal_title：Frontiers in physiology

authors： Fahlman A,Loring SH,Johnson SP,Haulena M,Trites AW,Fravel VA,Van Bonn WG

更新日期：2014-11-10 00:00:00

abstract：:Alpine skiing has been an Olympic event since the first Winter Games in 1936. Nowadays, skiers compete in four main events: slalom, giant slalom, super-G and downhill. Here, we present an update on the biomechanics of alpine ski racers and their equipment. The technical and tactical ability of today's world-class skie...

journal_title：Frontiers in physiology

authors： Supej M,Holmberg HC

更新日期：2019-02-20 00:00:00

abstract：:Pancreatic cancer shows a characteristic tissue structure called desmoplasia, which consists of dense fibrotic stroma surrounding cancer cells. Interactions between pancreatic cancer cells and stromal cells promote invasive growth of cancer cells and establish a specific microenvironment such as hypoxia which further ...

journal_title：Frontiers in physiology

authors： Hamada S,Masamune A,Shimosegawa T

更新日期：2013-11-01 00:00:00

abstract：:Previous studies report greater activation in the cortical motor network in controlling eccentric contraction (EC) than concentric contraction (CC) of human skeletal muscles despite lower activation level of the muscle associated with EC. It is unknown, however, whether the strength of functional coupling between the ...

journal_title：Frontiers in physiology

authors： Yao WX,Jiang Z,Li J,Jiang C,Franlin CG,Lancaster JL,Huang Y,Yue GH

更新日期：2016-11-15 00:00:00

abstract：:This study aims to present complex network models which analyze professional swimmers of 50-m freestyle Olympic competitions, comparing characteristics and variables that are considered performance determinants. This comparative research includes Olympic medalists' versus non-medalists' behavior. Using data from 40 at...

journal_title：Frontiers in physiology

authors： Pereira-Ferrero VH,Lewis TG,Ferrero LGP,Duarte LT

更新日期：2019-09-03 00:00:00

abstract：:The two forms of inorganic arsenic, arsenate (AsV) and arsenite (AsIII), are easily taken up by the cells of the plant root. Once in the cell, AsV can be readily converted to AsIII, the more toxic of the two forms. AsV and AsIII both disrupt plant metabolism, but through distinct mechanisms. AsV is a chemical analog o...

journal_title：Frontiers in physiology

authors： Finnegan PM,Chen W

更新日期：2012-06-06 00:00:00

abstract：:Huanglian Jiedu decoction (HLJDD) has been used in the clinical treatment of inflammatory conditions. To clarify the mechanism of its comprehensive anti-inflammatory activities, the correlation between lipid homeostasis and the TLR4/MyD88 signaling pathway in zebrafish was established in the present study. In the lipo...

journal_title：Frontiers in physiology

authors： Zhou J,Gu X,Fan X,Zhou Y,Wang H,Si N,Yang J,Bian B,Zhao H

更新日期：2019-09-26 00:00:00

abstract：:Arboviruses are emerging/reemerging infectious agents worldwide. The factors within this scenario include vector and host population fluctuations, climatic changes, anthropogenic activities that disturb ecosystems, an increase in international flights, human mobility, and genetic mutations that allow spill-over phenom...

journal_title：Frontiers in physiology

authors： Diaz LA,Flores FS,Quaglia A,Contigiani MS

更新日期：2013-01-11 00:00:00

abstract：:We explored the metagenomic, metabolomic and trace metal makeup of intestinal microbiota and environment in healthy male participants during the run-in (5 day) and the following three 21-day interventions: normoxic bedrest (NBR), hypoxic bedrest (HBR) and hypoxic ambulation (HAmb) which were carried out within a contr...

journal_title：Frontiers in physiology

authors： Šket R,Debevec T,Kublik S,Schloter M,Schoeller A,Murovec B,Vogel Mikuš K,Makuc D,Pečnik K,Plavec J,Mekjavić IB,Eiken O,Prevoršek Z,Stres B

更新日期：2018-03-13 00:00:00

abstract：:Background: The superior cervical ganglion (SCG) of the autonomic nervous system plays an important role in different cardiovascular diseases. In this study, we investigated the effects of ischemia and fluvastatin treatment on the ion channel characteristics of SCG neurons in a rabbit myocardial ischemia (MI) model. M...

journal_title：Frontiers in physiology

authors： Cheng L,Wang X,Liu T,Tse G,Fu H,Li G

更新日期：2018-09-10 00:00:00

abstract：Background:Sickle cell disease (SCD) patients with asthma have an increased rate of vaso-occlusive crisis (VOC) and acute chest syndrome (ACS) episodes when compared to those without asthma. We hypothesized that either asthma diagnosis or bronchodilator treatment might aggravate SCD via their modulating effect on the a...

journal_title：Frontiers in physiology

authors： Bokov P,El Jurdi H,Denjoy I,Peiffer C,Medjahdi N,Holvoet L,Benkerrou M,Delclaux C

更新日期：2020-02-26 00:00:00

abstract：:Signaling pathways of red blood cells' (RBCs) micromechanics regulation, which are responsible for maintaining microcirculation, constitute an important property of RBC physiology. Selective control over these processes may serve as an indispensable tool for correction of hemorheological disorders, which accompany a n...

journal_title：Frontiers in physiology

authors： Semenov AN,Shirshin EA,Muravyov AV,Priezzhev AV

更新日期：2019-08-14 00:00:00

abstract：:Hyperbilirubinemia (HB) occurs in 90% of preterm newborns. Moderate HB can induce acute neurological disorders while severe HB has been linked to a higher incidence of apneas of prematurity. The present study aimed to test the hypothesis that even moderate HB disrupts cardiorespiratory control in preterm lambs. Two gr...

journal_title：Frontiers in physiology

authors： Specq ML,Bourgoin-Heck M,Samson N,Corbin F,Gestreau C,Richer M,Kadhim H,Praud JP

更新日期：2016-09-30 00:00:00

abstract：:Extracellular ATP acts on the P2X family of ligand-gated ion channels and several members of the P2Y family of G protein-coupled receptors to mediate intercellular communication among many cell types including bone-forming osteoblasts. It is known that multiple P2 receptors are expressed on osteoblasts (P2X2,5,6,7 and...

journal_title：Frontiers in physiology

authors： Xing S,Grol MW,Grutter PH,Dixon SJ,Komarova SV

更新日期：2016-07-13 00:00:00

abstract：:The pea aphid, Acyrthosiphon pisum (Harris) (Hemiptera: Aphididae), shows wing polyphenism (winged and wingless morphs) in its life cycle. The winged morph is adapted for dispersal; its two developmental adult stages (for dispersal and reproduction) are based on its breeding periods. The two morphs show different phot...

journal_title：Frontiers in physiology

authors： Zhang Y,Wang XX,Jing X,Tian HG,Liu TX

更新日期：2016-08-02 00:00:00

abstract：:Minimizing central nervous system (CNS) injury from preterm birth depends upon identification of the critical pathways that underlie essential neurodevelopmental and CNS pathophysiology. While chorioamnionitis (CHORIO), is a leading cause of preterm birth, the precise mechanism linking prenatal brain injury and long-t...

journal_title：Frontiers in physiology

authors： Yellowhair TR,Newville JC,Noor S,Maxwell JR,Milligan ED,Robinson S,Jantzie LL

更新日期：2019-04-02 00:00:00

abstract：:Studies have revealed a robust and independent correlation between chronic kidney disease (CKD) and cardiovascular (CV) events, including death, heart failure, and myocardial infarction. Recent clinical trials extend this range of adverse CV events, including malignant ventricular arrhythmias and sudden cardiac death ...

journal_title：Frontiers in physiology

authors： Kiuchi MG,Ho JK,Nolde JM,Gavidia LML,Carnagarin R,Matthews VB,Schlaich MP

更新日期：2020-01-14 00:00:00

abstract：Objective:To explore the correlation between in vivo placental volumetric parameters in the first trimester of pregnancy and ex vivo parameters of fetoplacental vascular function after delivery. Methods:In ten singleton physiological pregnancies, placental volume (PV) and uteroplacental vascular volume (uPVV) were mea...

journal_title：Frontiers in physiology

authors： Hitzerd E,Reijnders IF,Mulders AGMGJ,Koning AHJ,Reiss IKM,Danser AHJ,Steegers-Theunissen RPM,Simons SHP,Koster MPH

更新日期：2020-01-24 00:00:00

abstract：:Current cardiac drug safety assessments focus on hERG channel block and QT prolongation for evaluating arrhythmic risks, whereas the optogenetic approach focuses on the action potential (AP) waveform generated by a monolayer of human cardiomyocytes beating synchronously, thus assessing the contribution of several ion ...

journal_title：Frontiers in physiology

authors： Björk S,Ojala EA,Nordström T,Ahola A,Liljeström M,Hyttinen J,Kankuri E,Mervaala E

更新日期：2017-11-02 00:00:00

abstract：:Stable gait requires active control of the mediolateral (ML) kinematics of the body center of mass (CoM) and the base of support (BoS) in relation to each other. Stance leg hip abductor (HA) muscle spindle afference may be used to guide contralateral swing foot placement and adequately position the BoS in relation to ...

journal_title：Frontiers in physiology

authors： Arvin M,Hoozemans MJM,Pijnappels M,Duysens J,Verschueren SM,van Dieën JH

更新日期：2018-08-21 00:00:00