Abstract:
:The causal role of midline thalamus in the initiation and early organization of mesial temporal lobe seizures is studied. Three patients undergoing stereoelectroencephalography were enrolled for the placement of an additional depth electrode targeting the midline thalamus. The midline thalamus was recruited in all three patients at varying points of seizure initiation (0-13 sec) and propagation (9-60 sec). Stimulation of either thalamus or hippocampus induced similar habitual seizures. Seizure-induced in the hippocampus rapidly recruited the thalamus. Evoked potentials demonstrated stronger connectivity from the hippocampus to the thalamus than in the opposite direction. The midline thalamus can be within the seizure initiation and symptomatogenic circuits.
journal_name
Ann Clin Transl Neuroljournal_title
Annals of clinical and translational neurologyauthors
Romeo A,Issa Roach AT,Toth E,Chaitanya G,Ilyas A,Riley KO,Pati Sdoi
10.1002/acn3.50835subject
Has Abstractpub_date
2019-08-01 00:00:00pages
1552-1558issue
8issn
2328-9503journal_volume
6pub_type
杂志文章abstract::FBXO7 is implicated in the ubiquitin-proteasome system and parkin-mediated mitophagy. FBXO7defects cause a levodopa-responsive parkinsonian-pyramidal syndrome(PPS). METHODS:We investigated the disease molecular bases in a child with PPS and brain iron accumulation. RESULTS:A novel homozygous c.368C>G (p.S123*) FBXO7...
journal_title:Annals of clinical and translational neurology
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journal_title:Annals of clinical and translational neurology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,随机对照试验
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journal_title:Annals of clinical and translational neurology
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pub_type: 杂志文章
doi:10.1002/acn3.523
更新日期:2018-02-26 00:00:00
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doi:10.1002/acn3.620
更新日期:2018-08-15 00:00:00
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更新日期:2016-04-20 00:00:00
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pub_type: 杂志文章
doi:10.1002/acn3.218
更新日期:2015-09-01 00:00:00
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journal_title:Annals of clinical and translational neurology
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pub_type: 杂志文章
doi:10.1002/acn3.666
更新日期:2018-10-31 00:00:00
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pub_type: 杂志文章
doi:10.1002/acn3.50833
更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/acn3.50966
更新日期:2020-01-01 00:00:00
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journal_title:Annals of clinical and translational neurology
pub_type: 杂志文章
doi:10.1002/acn3.186
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Annals of clinical and translational neurology
pub_type: 杂志文章
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更新日期:2019-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Annals of clinical and translational neurology
pub_type: 杂志文章
doi:10.1002/acn3.203
更新日期:2015-06-01 00:00:00
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journal_title:Annals of clinical and translational neurology
pub_type: 杂志文章
doi:10.1002/acn3.733
更新日期:2019-02-21 00:00:00
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journal_title:Annals of clinical and translational neurology
pub_type: 杂志文章,评审
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更新日期:2017-08-10 00:00:00
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pub_type: 杂志文章
doi:10.1002/acn3.503
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journal_title:Annals of clinical and translational neurology
pub_type: 杂志文章
doi:10.1002/acn3.719
更新日期:2019-01-22 00:00:00
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journal_title:Annals of clinical and translational neurology
pub_type: 杂志文章
doi:10.1002/acn3.51050
更新日期:2020-05-01 00:00:00