Abstract：
:New generation oral anticoagulants - rivaroxaban, apixaban and edoxaban - represent an important medical achievement. Their therapeutic effectiveness and ease of use make them essential in the management of thromboembolic conditions. However, as warfarin, they have known haemorrhagic risks. This paper reports the case of a 50-year-old female who presented with ear pain and spontaneous blood discharge in her right ear, after a two-week treatment with rivaroxaban. The physical examination revealed a spontaneous tympanic haematoma in the inferior quadrants, adjacent to the umbus. She denied any manipulation of the ear canal. Our goal is to alert for a presumable side effect of this drug in clinical practise. :A nova geração de anti-coagulantes orais — rivaroxabano, apixabano e edoxabano — constitui um avanço significativo na medicina. Estes fármacos têm, atualmente, um papel fundamental no tratamento de doenças tromboembólicas, pela sua facilidade de administração. No entanto, tal como a varfarina, têm efeitos adversos, nomeadamente aqueles relacionados com o risco hemorrágico. Neste artigo, apresentamos o caso de uma doente de 50 anos de idade, do género feminino, que se apresentou no serviço de urgência com otalgia e otorragia espontânea à direita, após duas semanas de tratamento com rivaroxabano em dose profilática. No exame objetivo, destacava-se a presença de hematoma nos quadrantes inferiores do tímpano, adjacente ao umbus. Não havia história de manipulação do ouvido. O nosso objetivo é alertar para um provável efeito adverso deste fármaco, na prática clínica.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Saldanha I,Matos R,Órfão T,Santos Mdoi
10.20344/amp.9397subject
Has Abstractpub_date
2019-06-28 00:00:00pages
469-470issue
6eissn
0870-399Xissn
1646-0758journal_volume
32pub_type
abstract：BACKGROUND:Meningitis is an uncommon clinical manifestation of invasive infection by Streptococcus pyogenes. CASE REPORT:A four years-old female child, previously healthy, started a history of high fever, associated to right otorrhea, prostration and vomiting. On admission she was haemodynamically stable but prostrate...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-12-01 00:00:00
abstract：:Gastrointestinal Bleeding (GIB) is a complication in patients with Chronic Renal Failure (CRF) on regular hemodialysis (HD). To analyse the importance of GIB we studied, retrospectively, the causes of hospitalization in 301 patients, all on HD in the same Unit in January 1990. The average age was 57.4 +/- 14.2 years (...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-02-01 00:00:00
abstract：BACKGROUND:In experimental ageing models an inverse relationship between age and alkaline phosphatase activity has been observed. OBJECTIVE:To characterize serum levels of alkaline phosphatase activity in humans according to age and gender. METHODS:Serum alkaline phosphatase was determined in a random sample of 203 c...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:The authors join the celebrations of the Centenary of the establishment of the Faculdade de Medicina da Universidade de Lisboa, on the 22(nd) April 2011, through the historical account of one of its main pilasters, the Institute of Anatomy. It is discussed the scope of its creation at the time, the important work done...
journal_title：Acta medica portuguesa
pub_type： 历史文章,杂志文章
doi：
更新日期：2011-07-01 00:00:00
abstract：:In recent years, the time for motherhood has been postponed, which is related to social aspects and can lead to health problems for the pregnant women and the child. An appropriate follow-up of the pregnancy is essential for identification and early treatment of possible complications. The purpose of this study was to...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2011-11-01 00:00:00
abstract：:The accurate treatment of a dyslipidaemia is based on correct diagnosis. Together with the laboratory values. A good clinical interview, focusing on the family history, is the bases for a good diagnosis strategy. The author schematze the rules of etiological diagnosis of inherited defects of lipid metabolism. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-02-01 00:00:00
abstract：INTRODUCTION:Respiratory tract infections represent the most frequent conditions in pediatric clinical practice that motivate antibiotic prescribing. The objective was to identify the frequency and pattern of antibacterial prescribing in respiratory diseases. MATERIAL AND METHODS:Over a period of two years (divided by...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.11111
更新日期：2019-02-28 00:00:00
abstract：INTRODUCTION:Since dysphagia may be one of the brain post-stroke consequences, the objective of this study was to analyze the average recovery time of patients with cerebrovascular accident and dysphagia subjected to speech therapy in a hospital bed. MATERIAL AND METHODS:Systematic review performed following the 'Pref...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：10.20344/amp.9183
更新日期：2017-12-29 00:00:00
abstract：:Our study centred on the research of Pelvic Endometriosis prevalence, in 134 women, who were submitted to diagnostic or surgical laparoscopy in our department, from April 1991 to November 1994. According to the admission causes, the women were divided in four groups: Pelvic pain/infertility/Anexial tumours/Optional tu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：:The female varicocile is associated to the pelvic congestion syndrome that is described. Five patients 31 to 52 years old are presented. Four of them have continuous pelvic pain and the fifth had huge vaginal and vulvar varices. Flebography of the left ovarian vein showed retrograde flux of the dilated vein. Sclerothe...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Multiple risk factors for cardiovascular disorders, particularly hypercholesterolemia, are often present in hypertensive patients. Several studies have shown that antihypertensive drugs affect the lipid profile, increasing the risk of cardiovascular diseases. Here, it was investigated the lipoprotein metabolism altera...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2008-11-01 00:00:00
abstract：:The Portuguese population is affected by the highest mortality rates in all the countries of the European Union. The highest mortality rates occur in some districts on the north coast where, in 1995, the rates standardised by age were above 200/100,000/annum, with the lowest figures in some districts in the interior a...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1997-08-01 00:00:00
abstract：:The sacroiliitis accounts for about 1.5% - 10% of all cases of septic arthritis and it is strongly associated with gynaecological infections, pelvic trauma or drug abuse (3.4% - 12.8% of cases occur during the postpartum period). Early diagnosis is difficult because the symptoms are nonspecific in pregnancy and in the...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.7062
更新日期：2016-08-01 00:00:00
abstract：:Ankle injuries are the most frequently encountered injuries in clinical practice. They are often managed by general practicians, and not only by orthopaedic or physiatric physicians. This injury is usually non-complicated, but some care should be taken to assure an adequate management and to exclude severe lesions. Th...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2008-05-01 00:00:00
abstract：:Several infectious, neoplastic or inflammatory skin diseases, may be early manifestations of HIV infection. We reviewed the clinical data of 226 HIV seropositive male patients with cutaneous disease, from a total of 337 inpatients at the Infectious Diseases Unit--Department of Medicine 1--Curry Cabral Hospital, from 1...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1994-03-01 00:00:00
abstract：:Endoscopic interventional techniques have created a wide new perspective for non-surgical treatment of chronic pancreatitis (CP). Surgery and endoscopy differ in their techniques, but are comparable with regard to tactics. The aim of methods in CP is to relieve pain and/or local complications. The preliminary results ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-06-01 00:00:00
abstract：:Modern medicine has many roots on greco-roman practice of the medical art. The authors analyse the work De Medicina by Aulus Cornelius Celsus. They look upon the nature of the medical knowledge, the principles of ethics, causality and describe the mental disorders (phrenitis, depression, third insanity, seizure disord...
journal_title：Acta medica portuguesa
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:After defining U.I. as a symptom, sign and condition, the author claims, through epidemiological studies, that this reflects a major medical, social and economic problem. On the other hand the physiopathology of U.I. can be explained in a context of balance between the retention and emptying forces during the filling ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:Free radicals are highly reactive molecules, and therefore transient, which have an odd number of electrons and are generated in vivo as byproducts of normal metabolism. In this review we survey basic concepts on the chemistry of oxygen free radicals, their cellular sources and the reactions they can undergo. We also ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1989-05-01 00:00:00
abstract：:We describe a case report of a 69 year old woman with atrial myxoma, presented as a cerebellar syndrome caused by ischemic infarctions of the posterior circulation. The transthoracic 2D echocardiogram provided the diagnosis of a left atrial myxoma. Seven months after surgical removal of the cardiac tumor, the cerebell...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-12-01 00:00:00
abstract：:The authors present a clinical case of an intracranial dural arteriovenous malformation with clinical manifestations of a prefrontal syndrome, documented with its respective diagnostic tests, including imaging studies. A number of considerations are being enlarged upon, concerning possible pathophysiological mechanism...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:Biomedical simulation is an effective educational complement for healthcare training, both at undergraduate and postgraduate level. It enables knowledge, skills and attitudes to be acquired in a safe, educationally orientated and efficient manner. In this context, simulation provides skills and experience that facilit...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.8403
更新日期：2016-12-30 00:00:00
abstract：OBJECTIVE:To assess in diabetic nephropathy, the accuracy of estimated creatinine clearance (calculated with the Cockroft Gault formula) and the clearance of the Tc99m-DTPA, to measure the glomerular filtration rate (GFR). PATIENTS AND METHODS:We analysed the GFR measure by Tc99m-DTPA method and the estimated by the C...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2007-03-01 00:00:00
abstract：INTRODUCTION:Telemedicine is the provision of health services, where distance is a critical factor, using information and communication technologies. Cape Verde has bet on using this tool to increase access of the population of its islands to specialized care. MATERIAL AND METHODS:Qualitative study, covering the perio...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.7578
更新日期：2017-04-28 00:00:00
abstract：INTRODUCTION:Creatine deficiency syndromes are a recently described group of diseases characterized by inborn errors of creatine metabolism. Clinical features include a spectrum of neurodevelopment disorders of diverse severity. They are characterized by low levels of cerebral creatine caused by different pathogenic mu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2012-11-01 00:00:00
abstract：:Schistosomiasis is a major cause of liver damage and portal hypertension, especially in tropical countries, affecting about 200 million people in the world. We report the cases of two patients presenting persistent alterations of serum liver enzymes. We enhance the importance of considering the history of past travels...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-10-01 00:00:00
abstract：:Fabry disease (FD) is a rare disorder resulting from mutations of the alpha-Galactosidase A lysosomal enzyme gene. Accumulation of enzyme substrates leads to multisystemic clinical manifestations and multiorgan progressive damage with high morbidity and mortality. Recombinant enzyme replacement therapy (RERT) now avai...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2010-05-01 00:00:00
abstract：:The interaction between HPV E6 and p53 protein is known as the most important event in HPV-associated carcinogenesis. Some in vitro studies suggested that p53 genetic variants are targeted for ubiquitin-proteasome degradation induced by E6 with different abilities. A common p53 variant at position 72 (R72P) has leaded...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-01-01 00:00:00
abstract：:As far as we know, there is no experience of quality management in mental health care in Portugal. This study fills a gap in the area of consultation-liaison psychiatry. Due to its multidisciplinarity and to the complexity of the problems it deals with, consultation-liaison psychiatry seems a privileged field for the ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1997-12-01 00:00:00
abstract：:Because the metabolic syndrome (MS) poses a growing public health problem, it is crucial to identify related modifiable risk factors. The MS is a multifaceted syndrome, however, physical activity (PA) is thought to be one of the protective factors in MS occurrence. The purpose of this study is to analyse recent litera...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2011-09-01 00:00:00
