Abstract：
:The interaction between HPV E6 and p53 protein is known as the most important event in HPV-associated carcinogenesis. Some in vitro studies suggested that p53 genetic variants are targeted for ubiquitin-proteasome degradation induced by E6 with different abilities. A common p53 variant at position 72 (R72P) has leaded to the development of several studies regarding its role on cervical cancer development. However, only few reports have shown an association between the Arginine (R) variant at position 52 of p53 and increased susceptibility to HPV E6 mediated degradation and thus to increased cancer susceptibility. We revised the literature in order to obtain plausible data to discuss about these evidences for cervical cancer susceptibility. The more recent studies, including meta-analysis reviews, point out that there is no association of this p53 variant and cervical cancer development. This variant seems to be differently segregated in different ethnic/geographical locations; therefore, there might be a possible role of this genetic variant associated with a certain genetic background, which can explain why some studies reveal increased risk of cervical cancer development associated with Arginine p53 variant.
journal_name
Acta Med Portjournal_title
Acta medica portuguesaauthors
Sousa H,Santos AM,Pinto D,Medeiros Rsubject
Has Abstractpub_date
2011-01-01 00:00:00pages
127-34issue
1eissn
0870-399Xissn
1646-0758journal_volume
24pub_type
杂志文章,评审abstract：:In about 28% of patients, dyslipidemia has a secondary cause. Many times, the treatment of these causes can lead to the total correction of dyslipidemia. We describe the case of a 50-year-old female patient with class II obesity and primary biliary cirrhosis, evaluated for mixed dyslipidemia with poor control (statins...
journal_title：Acta medica portuguesa
pub_type：
doi：10.20344/amp.9944
更新日期：2020-03-02 00:00:00
abstract：:This paper summons to contest some of the bonds that will be severed, probably, by the new eugenics, and may be repaired by narrative-based medicine, two of the most extreme and contradictory challenges to today's--and tomorrow's--medical practice. Accordingly, I intend to frame its development into the unbounded math...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2005-09-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to evaluate the efficacy of post-caesarean analgesia comparing three techniques most frequently used. PATIENTS AND METHODS:For three months all pregnant women submitted to elective or urgent caesarean section, under general or regional anaesthesia, were evaluate with a total of 129 ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2001-07-01 00:00:00
abstract：:The aim of this study was to evaluate the accuracy of ultrasound biometric and hemodynamic fetal parameters for the prenatal diagnosis of intrauterine retardation in a sample of 438 pregnant women who had their first visit before the 16th week of gestation at the outpatient clinic of the Department of Obstetrics and G...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1996-02-01 00:00:00
abstract：INTRODUCTION:The purpose of postoperative surveillance programs after curative treatment for colorectal cancer is to detect asymptomatic recurrences with the premise that an important rate will be eligible for curative resection, improving overall survival. We have implemented a surveillance program for patients with c...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.7889
更新日期：2017-09-29 00:00:00
abstract：:The authors present a clinical case of an intracranial dural arteriovenous malformation with clinical manifestations of a prefrontal syndrome, documented with its respective diagnostic tests, including imaging studies. A number of considerations are being enlarged upon, concerning possible pathophysiological mechanism...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-10-01 00:00:00
abstract：:The occurrence of metastases is documented in a varied number of hepato-cellular carcinomas (HCC). The indicative metastasis is very rarely the form of clinical presentation of the disease. Two cases of HCC which were clinically presented in a secondary location, in the bone and skeletal muscle respectively, are descr...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-04-01 00:00:00
abstract：INTRODUCTION:The surgical management of complete ureteral duplication anomalies is not consensual. OBJECTIVE:To characterize the pediatric population who underwent surgery for complete ureteral duplication and assess the outcomes of different approaches. MATERIAL AND METHODS:Clinical records from patients treated bet...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.6329
更新日期：2016-04-01 00:00:00
abstract：:Modern medicine has many roots on greco-roman practice of the medical art. The authors analyse the work De Medicina by Aulus Cornelius Celsus. They look upon the nature of the medical knowledge, the principles of ethics, causality and describe the mental disorders (phrenitis, depression, third insanity, seizure disord...
journal_title：Acta medica portuguesa
pub_type： 传,历史文章,杂志文章
doi：
更新日期：2007-09-01 00:00:00
abstract：:In Portugal the screening for phenylketonuria (PKU) and congenital hypothyroidism (CH) was begun towards the end of 1979, and by 1990 59 cases of PKU and 227 cases of CH had been detected. The early initiation of treatment and the observed mental and motor development, point towards a normal development in these child...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1992-03-01 00:00:00
abstract：:The case of a 31 man with acute disautonomia envolving the parasympathetic and sympathetic systems but sparing sympathetic cholinergic division is presented. A Hodgkin lymphoma was diagnosed allowing the diagnosis of a paraneoplastic syndrome. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2002-03-01 00:00:00
abstract：:Spontaneous ileopsoas hematoma is a rare and potentially lethal complication of liver cirrhosis, with exceptional mention in medical literature. In this article we present a clinical case diagnosed in a patient with alcoholic liver cirrhosis. ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2012-01-01 00:00:00
abstract：:Our study centred on the research of Pelvic Endometriosis prevalence, in 134 women, who were submitted to diagnostic or surgical laparoscopy in our department, from April 1991 to November 1994. According to the admission causes, the women were divided in four groups: Pelvic pain/infertility/Anexial tumours/Optional tu...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1997-10-01 00:00:00
abstract：INTRODUCTION:Menopause is a biological process that occurs as part of aging in women. The increase in average life expectancy and the decline in mortality have caused the aging of global population and, currently, women live about a third of their life in postmenopausal. The General Physician (GP) is usually the first ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：2010-03-01 00:00:00
abstract：INTRODUCTION:Multiacinar regenerative nodules are benign hepatocellular nodules related to vascular disturbances of the liver. They strongly resemble conventional focal nodular hyperplasia but are connected to different clinical settings, typically chronic liver disease. The purpose of the present study was to describe...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.10259
更新日期：2018-09-28 00:00:00
abstract：:The female varicocile is associated to the pelvic congestion syndrome that is described. Five patients 31 to 52 years old are presented. Four of them have continuous pelvic pain and the fifth had huge vaginal and vulvar varices. Flebography of the left ovarian vein showed retrograde flux of the dilated vein. Sclerothe...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:Maturity-onset diabetes of the young (MODY) is a rare form of juvenile diabetes mellitus, defined by early onset, absence of ketosis, non-insulin-dependent diabetes and autosomal dominant inheritance. Advances in molecular genetic analysis have identified mutations accounting for different MODY subtypes, all of them a...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
abstract：:The authors, using the Cancer Registry data of S. Antonio General Hospital in Oporto, selected the cancer cases from 1981 to 1993. Distribution according to age, sex, topography and morphology is presented. Seven point nine percent of the 12,124 cases mentioned in the Registry were skin cancers (n = 883). They were mo...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1998-06-01 00:00:00
abstract：:Essencial Thrombocytemia is a rare chronic myeloproliferative disease of unknown etiology, characterized by markedly elevated platelet production (> 600,000/ml). It is more frequent among women above 50 years of age and may be associated with hemorrhagic or thrombotic tendencies. The authors report a case of Essencial...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-03-01 00:00:00
abstract：:A case of oesophageal basaloid carcinoma is reported. The disease was revealed as a brain metastasis and was found ad initium to be in an advanced stage, with evidence of brain, lung and liver metastasis. The treatment performed was palliative subtotal oesophagectomy followed by roentgen therapy. A year and a half lat...
journal_title：Acta medica portuguesa
pub_type： 杂志文章,评审
doi：
更新日期：1995-09-01 00:00:00
abstract：INTRODUCTION:The use of adequate assessment tools in health care is crucial for the management of care. The lack of specific tools in Portugal for assessing the performance of children who use cochlear implants motivated the translation and adaptation of the EARS (Evaluation of Auditory Responses to Speech) test batter...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2014-01-01 00:00:00
abstract：:Helicobacter pylori infection is a risk factor for gastric adenocarcinoma. Identification of individuals with this infection and its eradication may be considered as a primary prevention strategy to reduce the incidence of gastric adenocarcinoma; however, the magnitude of benefit and the effectiveness of this strategy...
journal_title：Acta medica portuguesa
pub_type： 评论,杂志文章
doi：
更新日期：2015-11-01 00:00:00
abstract：:The recent improvement in surgical of therapy of carriers of hepatocellular carcinoma is due to both an early diagnosis of the illness and in the evaluation of set of prognostic and resectability factors. On describing a clinical case of a hepatocellular carcinoma localized on the left lobe of a healthy liver, the imp...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1989-05-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the safety and efficacy in the first sixteen patients operated by endoscopic third ventriculostomy for triventricular obstructive hydrocephalus in the Hospital of S. João-Porto. METHODS:Operated from December 1998 to December 1999, there were one adult, one teenager...
journal_title：Acta medica portuguesa
pub_type： 临床试验,杂志文章
doi：
更新日期：2002-09-01 00:00:00
abstract：INTRODUCTION:Disciplinary actions may have a significant impact in medical doctors' and patients' lives. The objective of this study was the assessment of the disciplinary actions in Obstetrics and Gynecology that occurred in the north of Portugal in years 2008 to 2012. MATERIAL AND METHODS:Retrospective descriptive s...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2015-03-01 00:00:00
abstract：INTRODUCTION:To evaluate the safety and impact on visual acuity, retinal and choroidal morphology of simultaneous cataract surgery and intravitreal anti-vascular endothelial growth factor on patients with visually significant cataracts and previously treated exudative age-related macular degeneration. MATERIAL AND MET...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：10.20344/amp.7850
更新日期：2017-02-27 00:00:00
abstract：:In adults, endogenous hyperinsulinemic hypoglycaemia is almost invariably due to insulinoma. The authors describe a 29 year old patient with repeated postprandial symptomatic hypoglycaemias and negative prolonged fast test. Distal pancreatectomy was performed, directed by positive arteriographic testing. Histological ...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：2003-11-01 00:00:00
abstract：:An opinion article of health care programmes questioning the effects and benefits of their management. The AA, based on their experience in management/administration, present suggestions to identify, quantify and analyse a problem in health care. After characterising a health care problem, the AA point out the fundame...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1995-03-01 00:00:00
abstract：:Selected medical students for undergraduate medical courses in Portugal exhibit each year substantial deficiencies in chemistry. The group of students admitted to the Faculty of Medicine of Lisbon in 1989/1990 were selected by admission criteria apparently more restrictive than before. The aim of this study was to eva...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:Statistics is the science that studies variability in all its forms and, in essence, is an instrument that allows us to analyze variable phenomena and detect small, but nevertheless important, differences. The instrumental character of this science made Statistics a fundamental tool for the study of biological and cli...
journal_title：Acta medica portuguesa
pub_type： 杂志文章
doi：
更新日期：1996-10-01 00:00:00
