The long noncoding RNA AK002107 negatively modulates miR-140-5p and targets TGFBR1 to induce epithelial-mesenchymal transition in hepatocellular carcinoma.

abstract：:Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer. This review summarizes the current state of knowledge on rare high penetrance mutations, as well as moderate and low-penetrance genetic variants implicated in breast cancer aetiology. We summarize recent discoveries from larg...

journal_title：Molecular oncology

authors： Mavaddat N,Antoniou AC,Easton DF,Garcia-Closas M

更新日期：2010-06-01 00:00:00

abstract：:Enumeration and characterization of circulating tumor cells (CTC) hold the promise of a real time liquid biopsy. They are however present in a large background of hematopoietic cells making their isolation technically challenging. In 2004, the CellSearch system was introduced as the first and only FDA cleared method d...

journal_title：Molecular oncology

authors： Andree KC,van Dalum G,Terstappen LW

更新日期：2016-03-01 00:00:00

abstract：:The above article, published online on 28 February 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article (https://doi.org/10.1002/1878-0261.12656), has been withdrawn at the authors' request, and in agreement between the authors, the journal Editors in Chief J. E. Celis and K. Ryan, and John Wil...

journal_title：Molecular oncology

authors：

更新日期：2020-12-01 00:00:00

abstract：:The elevated expression and activation of human telomerase reverse transcriptase (hTERT) is associated with the unlimited proliferation of cancer cells. However, the excise mechanism of hTERT regulation during carcinogenesis is not well understood. In this study, we discovered cleavage and polyadenylation specific fac...

journal_title：Molecular oncology

authors： Chen W,Qin L,Wang S,Li M,Shi D,Tian Y,Wang J,Fu L,Li Z,Guo W,Yu W,Yuan Y,Kang T,Huang W,Deng W

更新日期：2014-05-01 00:00:00

abstract：:Triple negative breast cancer (TNBC) is a very aggressive subgroup of breast carcinoma, still lacking specific markers for an effective targeted therapy and with a poorer prognosis compared to other breast cancer subtypes. In this study we investigated the possibility that TNBC cells contribute to the establishment of...

journal_title：Molecular oncology

authors： Plantamura I,Casalini P,Dugnani E,Sasso M,D'Ippolito E,Tortoreto M,Cacciatore M,Guarnotta C,Ghirelli C,Barajon I,Bianchi F,Triulzi T,Agresti R,Balsari A,Campiglio M,Tripodo C,Iorio MV,Tagliabue E

更新日期：2014-07-01 00:00:00

abstract：:Transient receptor potential melastatin-4 channel (TRPM4) dysregulation contributes to heart conditions, immune diseases, and cervical and prostate cancer. Up to now, the involvement of TRPM4 in colorectal cancer (CRC) pathophysiology remains unknown. Here, we investigated tumor tissue microarrays from 379 CRC patient...

journal_title：Molecular oncology

authors： Kappel S,Stokłosa P,Hauert B,Ross-Kaschitza D,Borgström A,Baur R,Galván JA,Zlobec I,Peinelt C

更新日期：2019-11-01 00:00:00

abstract：:Short arm of chromosome 8 is a hot spot for chromosomal breaks, losses and amplifications in breast cancer. Although such genetic changes may have phenotypic consequences, the identity of candidate gene(s) remains to be clearly defined. Pol β gene is localized to chromosome 8p12-p11 and encodes a key DNA base excision...

journal_title：Molecular oncology

authors： Abdel-Fatah TM,Russell R,Agarwal D,Moseley P,Abayomi MA,Perry C,Albarakati N,Ball G,Chan S,Caldas C,Ellis IO,Madhusudan S

更新日期：2014-05-01 00:00:00

abstract：:Around 50% of all human microRNAs reside within introns of coding genes and are usually co-transcribed. Gene expression datasets, therefore, should contain a wealth of miRNA-relevant latent information, exploitable for many basic and translational research aims. The present study was undertaken to investigate this pos...

journal_title：Molecular oncology

authors： Monterisi S,D'Ario G,Dama E,Rotmensz N,Confalonieri S,Tordonato C,Troglio F,Bertalot G,Maisonneuve P,Viale G,Nicassio F,Vecchi M,Di Fiore PP,Bianchi F

更新日期：2015-02-01 00:00:00

abstract：:Targeted therapy for patients with HER2-positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor (ER) and HER2 expression has been proposed to play a key role in treatment failure, but little work...

journal_title：Molecular oncology

authors： Rye IH,Trinh A,Saetersdal AB,Nebdal D,Lingjaerde OC,Almendro V,Polyak K,Børresen-Dale AL,Helland Å,Markowetz F,Russnes HG

更新日期：2018-11-01 00:00:00

abstract：:Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be 'BRCA1-like' or 'non-BRCA1-like', which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approximately one third of ...

journal_title：Molecular oncology

authors： Schouten PC,Grigoriadis A,Kuilman T,Mirza H,Watkins JA,Cooke SA,van Dyk E,Severson TM,Rueda OM,Hoogstraat M,Verhagen CV,Natrajan R,Chin SF,Lips EH,Kruizinga J,Velds A,Nieuwland M,Kerkhoven RM,Krijgsman O,Vens C,Pe

更新日期：2015-08-01 00:00:00

abstract：:Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor-associated chronic inflammation is a hallmark of cancer that fosters progression to a metastatic stage, as has been extensively reviewed lately. Indeed, inflammatory cells persisting in the tu...

journal_title：Molecular oncology

authors： Suarez-Carmona M,Lesage J,Cataldo D,Gilles C

更新日期：2017-07-01 00:00:00

abstract：:Deregulation of microRNAs contributes to the aberrant growth of hepatocellular carcinoma (HCC). Here, we showed that miR-634 expression was frequently decreased in HCC. Low miR-634 expression was significantly associated with larger tumor size, poorer tumor differentiation, advanced TNM stage, vascular invasion, absen...

journal_title：Molecular oncology

authors： Zhang CZ,Cao Y,Fu J,Yun JP,Zhang MF

更新日期：2016-12-01 00:00:00

abstract：:Histone methyltransferases (HMTs) catalyze the methylation of lysine and arginine residues on histone tails and non-histone targets. These important post-translational modifications are exquisitely regulated and affect chromatin compaction and transcriptional programs leading to diverse biological outcomes. There is a...

journal_title：Molecular oncology

authors： Michalak EM,Visvader JE

更新日期：2016-12-01 00:00:00

abstract：:Patient derived xenografts (PDXs) are increasingly appreciated models in cancer research, particularly for preclinical testing, as they reflect the patient's tumor biology more accurately than cancer cell lines. We have established a collection of 20 breast PDXs and characterized their biological and clinical features...

journal_title：Molecular oncology

authors： du Manoir S,Orsetti B,Bras-Gonçalves R,Nguyen TT,Lasorsa L,Boissière F,Massemin B,Colombo PE,Bibeau F,Jacot W,Theillet C

更新日期：2014-03-01 00:00:00

abstract：:Estrogen receptor-alpha (ERα)-positive breast cancer is often treated with antihormonal regimens. However, resistance to treatment is common, leading to metastatic disease. ERα activity requires the functional involvement of pioneer factors FOXA1 and GATA3, which enable ERα-chromatin binding and are crucial for ERα-dr...

journal_title：Molecular oncology

authors： Schrijver W,Schuurman K,van Rossum A,Droog M,Jeronimo C,Salta S,Henrique R,Wesseling J,Moelans C,Linn SC,van den Heuvel M,van Diest P,Zwart W

更新日期：2018-11-01 00:00:00

abstract：:Tumour suppressor p53, a master transcriptional regulator determines cell fate through preferential activation/repression of a myriad of genes during stress. Till date, activation and preferential binding of p53 on different promoters was reported to be influenced by the nature, strength and duration of stress which m...

journal_title：Molecular oncology

authors： Thakur B,Ray P

更新日期：2016-10-01 00:00:00

abstract：:Hypoxia is a feature of the microenvironment of many cancers and can trigger epithelial-mesenchymal transition (EMT), a process by which cells acquire a more invasive phenotype with enriched survival. A remodeling of adenosine 5'-triphosphate (ATP)-induced Ca(2+) signaling via purinergic receptors is associated with e...

journal_title：Molecular oncology

authors： Azimi I,Beilby H,Davis FM,Marcial DL,Kenny PA,Thompson EW,Roberts-Thomson SJ,Monteith GR

更新日期：2016-01-01 00:00:00

abstract：:Resistance to HER2-targeted therapies remains a major obstacle in the treatment of HER2-overexpressing breast cancer. Understanding the molecular pathways that contribute to the development of drug resistance is needed to improve the clinical utility of novel agents, and to predict the success of targeted personalized...

journal_title：Molecular oncology

authors： Boulbes DR,Arold ST,Chauhan GB,Blachno KV,Deng N,Chang WC,Jin Q,Huang TH,Hsu JM,Brady SW,Bartholomeusz C,Ladbury JE,Stone S,Yu D,Hung MC,Esteva FJ

更新日期：2015-03-01 00:00:00

abstract：:Pancreatic cancer is one of the most lethal human cancers, and radiotherapy is often implemented for locally advanced pancreatic ductal adenocarcinoma. Tumor cell repopulation is a major challenge in treating cancers after radiotherapy. In order to address the problem of tumor repopulation, our previous studies have d...

journal_title：Molecular oncology

authors： Cheng J,Tian L,Ma J,Gong Y,Zhang Z,Chen Z,Xu B,Xiong H,Li C,Huang Q

更新日期：2015-01-01 00:00:00

abstract：:C13ORF18 is frequently hypermethylated in cervical cancer but not in normal cervix and might serve as a biomarker for the early detection of cervical cancer in scrapings. As hypermethylation is often observed for silenced tumor suppressor genes (TSGs), hypermethylated biomarker genes might exhibit tumor suppressive ac...

journal_title：Molecular oncology

authors： Huisman C,Wisman GB,Kazemier HG,van Vugt MA,van der Zee AG,Schuuring E,Rots MG

更新日期：2013-06-01 00:00:00

abstract：:Protein inhibitor of activated STAT3 (PIAS3) is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. We previous...

journal_title：Molecular oncology

authors： He T,McColl K,Sakre N,Chen Y,Wildey G,Dowlati A

更新日期：2018-12-01 00:00:00

abstract：:Gain-of-function (GOF) mutants of p53 upregulate genes implicated in cell proliferation and oncogenesis. Here, we report that GOF p53 induces tumorigenicity through simultaneous activation of key oncogenic pathways including those controlling putative tumor-initiating cell functions. We determined that in cells expres...

journal_title：Molecular oncology

authors： Vaughan CA,Singh S,Grossman SR,Windle B,Deb SP,Deb S

更新日期：2017-06-01 00:00:00

abstract：:Lung metastasis is the major cause of death in osteosarcoma patients. However, molecular mechanisms underlying this metastasis remain poorly understood. To identify key molecules related with pulmonary metastasis of pediatric osteosarcomas, we analyzed high-throughput miRNA expression in a cohort of 11 primary tumors ...

journal_title：Molecular oncology

authors： Berlanga P,Muñoz L,Piqueras M,Sirerol JA,Sánchez-Izquierdo MD,Hervás D,Hernández M,Llavador M,Machado I,Llombart-Bosch A,Cañete A,Castel V,Font de Mora J

更新日期：2016-08-01 00:00:00

abstract：:Ewing sarcomas (ES) are highly malignant, osteolytic bone or soft tissue tumors, which are characterized by EWS-ETS translocations and early metastasis to lung and bone. In this study, we investigated the role of the BRICHOS chaperone domain-containing endochondral bone protein chondromodulin I (CHM1) in ES pathogenes...

journal_title：Molecular oncology

authors： von Heyking K,Calzada-Wack J,Göllner S,Neff F,Schmidt O,Hensel T,Schirmer D,Fasan A,Esposito I,Müller-Tidow C,Sorensen PH,Burdach S,Richter GHS

更新日期：2017-09-01 00:00:00

abstract：:It has been hypothesized based on accumulated data that a class of small noncoding RNAs, termed microRNAs, are key factors in intercellular communication. Here, microRNAs present in interstitial breast tumor fluids have been analyzed to identify relevant markers for a diagnosis of breast cancer and to elucidate the cr...

journal_title：Molecular oncology

authors： Halvorsen AR,Helland Å,Gromov P,Wielenga VT,Talman MM,Brunner N,Sandhu V,Børresen-Dale AL,Gromova I,Haakensen VD

更新日期：2017-02-01 00:00:00

abstract：:Ovarian cancer is the most lethal gynecologic malignancy. About 75% of ovarian cancer patients relapse and/or develop chemo-resistant disease after initial response to standard-of-care treatment with platinum-based therapies. HER2 amplifications and overexpression in ovarian cancer are reported to vary, and responses ...

journal_title：Molecular oncology

authors： Harris FR,Zhang P,Yang L,Hou X,Leventakos K,Weroha SJ,Vasmatzis G,Kovtun IV

更新日期：2019-02-01 00:00:00

abstract：:Mouse models of human cancers may provide a valuable resource for the discovery of cancer biomarkers. We have developed a practical strategy for profiling specific proteins in mouse plasma using low-volume sandwich-immunoassays. We used this method to profile the levels of 14 different cytokines, acute-phase reactants...

journal_title：Molecular oncology

authors： Forrester S,Hung KE,Kuick R,Kucherlapati R,Haab BB

更新日期：2007-09-01 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) is an important process in embryonic development, fibrosis, and cancer metastasis. During cancer progression, the activation of EMT permits cancer cells to acquire migratory, invasive, and stem-like properties. A growing body of evidence supports the critical link between EMT an...

journal_title：Molecular oncology

authors： Liao TT,Yang MH

更新日期：2017-07-01 00:00:00

abstract：:It is well known that different racial groups have significantly different incidence and mortality rates for certain cancers. It has been suggested that biological factors play a major role in these cancer racial disparities. Previous studies on the biological factors contributing to cancer racial disparity have gener...

journal_title：Molecular oncology

authors： Li Y,Pang X,Cui Z,Zhou Y,Mao F,Lin Y,Zhang X,Shen S,Zhu P,Zhao T,Sun Q,Zhang J

更新日期：2020-09-13 00:00:00

abstract：:Molecular characterization of cancers is important in dictating prognostic factors and directing therapy. Next-generation sequencing of plasma circulating tumor DNA (ctDNA) offers less invasive, more convenient collection, and a more real-time representation of a tumor and its molecular heterogeneity than tissue. Howe...

journal_title：Molecular oncology

authors： Charo LM,Eskander RN,Okamura R,Patel SP,Nikanjam M,Lanman RB,Piccioni DE,Kato S,McHale MT,Kurzrock R

更新日期：2021-01-01 00:00:00