Low-volume, high-throughput sandwich immunoassays for profiling plasma proteins in mice: identification of early-stage systemic inflammation in a mouse model of intestinal cancer.

abstract：:Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylatio...

journal_title：Molecular oncology

authors： Ji X,Lin L,Shen S,Dong X,Chen C,Li Y,Zhu Y,Huang H,Chen J,Chen X,Wei L,He J,Duan W,Su L,Jiang Y,Fan J,Guan J,You D,Shafer A,Bjaanæs MM,Karlsson A,Planck M,Staaf J,Helland Å,Esteller M,Wei Y,Zhang R,C

更新日期：2020-11-01 00:00:00

abstract：:cMet is a well-characterized oncogene that is the target of many drugs including small molecule and biologic pathway inhibitors, and, more recently, antibody-drug conjugates (ADCs). However, the clinical benefit from cMet-targeted therapy has been limited. We developed a novel cMet-targeted 'third-generation' ADC, TR1...

journal_title：Molecular oncology

authors： Gymnopoulos M,Betancourt O,Blot V,Fujita R,Galvan D,Lieuw V,Nguyen S,Snedden J,Stewart C,Villicana J,Wojciak J,Wong E,Pardo R,Patel N,D'Hooge F,Vijayakrishnan B,Barry C,Hartley JA,Howard PW,Newman R,Coronella J

更新日期：2020-01-01 00:00:00

abstract：:It has been hypothesized based on accumulated data that a class of small noncoding RNAs, termed microRNAs, are key factors in intercellular communication. Here, microRNAs present in interstitial breast tumor fluids have been analyzed to identify relevant markers for a diagnosis of breast cancer and to elucidate the cr...

journal_title：Molecular oncology

authors： Halvorsen AR,Helland Å,Gromov P,Wielenga VT,Talman MM,Brunner N,Sandhu V,Børresen-Dale AL,Gromova I,Haakensen VD

更新日期：2017-02-01 00:00:00

abstract：:The PI3K/Akt signaling pathway, the most frequently altered signaling system in human cancer, is a crucial inducer of dysregulated proliferation and neoplastic processes; however, few therapeutic strategies using PI3K/Akt inhibitors singly have been shown to be effective. The purpose of this paper was to underline the...

journal_title：Molecular oncology

authors： Fabi F,Adam P,Parent S,Tardif L,Cadrin M,Asselin E

更新日期：2020-12-18 00:00:00

abstract：:Triple-negative breast cancer (TNBC), the most refractory subtype of breast cancer to current treatments, accounts disproportionately for the majority of breast cancer-related deaths. This is largely due to cancer plasticity and the development of cancer stem cells (CSCs). Recently, distinct yet interconvertible mesen...

journal_title：Molecular oncology

authors： Sulaiman A,McGarry S,Li L,Jia D,Ooi S,Addison C,Dimitroulakos J,Arnaout A,Nessim C,Yao Z,Ji G,Song H,Gadde S,Li X,Wang L

更新日期：2018-04-01 00:00:00

abstract：:JS-2 is a novel gene located at 5p15.2 and originally detected in primary oesophageal cancer. There is no study on the role of JS-2 in colorectal cancer. The aim of this study is to determine the gene copy number and expression of JS-2 in a large cohort of patients with colorectal tumours and correlate these to the cl...

journal_title：Molecular oncology

authors： Lam AK,Gopalan V,Nassiri MR,Kasim K,Dissanayake J,Tang JC,Smith RA

更新日期：2011-10-01 00:00:00

abstract：:The presence of circulating tumor cells (CTCs) in the blood of ovarian cancer patients was shown to correlate with decreased overall survival, whereby CTCs with epithelial-mesenchymal-transition (EMT) or stem-like traits are supposed to be involved in metastatic progression and recurrence. Thus, investigating the tran...

journal_title：Molecular oncology

authors： Blassl C,Kuhlmann JD,Webers A,Wimberger P,Fehm T,Neubauer H

更新日期：2016-08-01 00:00:00

abstract：:The above article, published online on 28 February 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article (https://doi.org/10.1002/1878-0261.12656), has been withdrawn at the authors' request, and in agreement between the authors, the journal Editors in Chief J. E. Celis and K. Ryan, and John Wil...

journal_title：Molecular oncology

authors：

更新日期：2020-12-01 00:00:00

abstract：:The interferon-inducible transcription factor STAT1 is a tumor suppressor in various malignancies. We investigated sex-specific STAT1 functions in colitis and colitis-associated colorectal cancer (CRC) using mice with specific STAT1 deletion in intestinal epithelial cells (STAT1∆IEC ). Male but not female STAT1∆IEC mi...

journal_title：Molecular oncology

authors： Crnčec I,Modak M,Gordziel C,Svinka J,Scharf I,Moritsch S,Pathria P,Schlederer M,Kenner L,Timelthaler G,Müller M,Strobl B,Casanova E,Bayer E,Mohr T,Stöckl J,Friedrich K,Eferl R

更新日期：2018-04-01 00:00:00

abstract：:Although mutations in the phosphoinositide 3-kinase catalytic subunit (PIK3CA) are common in breast cancer, PI3K inhibitors alone have shown modest efficacy. We sought to identify additional pathways altered in PIK3CA-mutant tumors that might be targeted in combination with PI3K inhibitors. We generated two transgenic...

journal_title：Molecular oncology

authors： Merino VF,Cho S,Liang X,Park S,Jin K,Chen Q,Pan D,Zahnow CA,Rein AR,Sukumar S

更新日期：2017-05-01 00:00:00

abstract：:ATR-CHEK1 signalling is critical for genomic stability. ATR-CHEK1 signalling may be deregulated in breast cancer and have prognostic, predictive and therapeutic significance. We investigated ATR, CHEK1 and phosphorylated CHEK1 (Ser345) protein (pCHEK1) levels in 1712 breast cancers. ATR and CHEK1 mRNA expression was e...

journal_title：Molecular oncology

authors： Abdel-Fatah TM,Middleton FK,Arora A,Agarwal D,Chen T,Moseley PM,Perry C,Doherty R,Chan S,Green AR,Rakha E,Ball G,Ellis IO,Curtin NJ,Madhusudan S

更新日期：2015-03-01 00:00:00

abstract：:PKN3 is an AGC-family protein kinase implicated in growth of metastatic prostate cancer cells with phosphoinositide 3-kinase pathway deregulation. The molecular mechanism, however, by which PKN3 contributes to malignant growth and tumorigenesis is not well understood. Using orthotopic mouse tumor models, we now show t...

journal_title：Molecular oncology

authors： Unsal-Kacmaz K,Ragunathan S,Rosfjord E,Dann S,Upeslacis E,Grillo M,Hernandez R,Mack F,Klippel A

更新日期：2012-06-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored a promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), a demethylating agent, in combina...

journal_title：Molecular oncology

authors： Vitale G,Dicitore A,Pepe D,Gentilini D,Grassi ES,Borghi MO,Gelmini G,Cantone MC,Gaudenzi G,Misso G,Di Blasio AM,Hofland LJ,Caraglia M,Persani L

更新日期：2017-08-01 00:00:00

abstract：:Protein inhibitor of activated STAT3 (PIAS3) is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. We previous...

journal_title：Molecular oncology

authors： He T,McColl K,Sakre N,Chen Y,Wildey G,Dowlati A

更新日期：2018-12-01 00:00:00

abstract：:Brain metastases are life-threatening complications of triple-negative breast cancer, melanoma, and a few other tumor types. Poor outcome of cerebral secondary tumors largely depends on the microenvironment formed by cells of the neurovascular unit, among which pericytes are the least characterized. By using in vivo a...

journal_title：Molecular oncology

authors： Molnár K,Mészáros Á,Fazakas C,Kozma M,Győri F,Reisz Z,Tiszlavicz L,Farkas AE,Nyúl-Tóth Á,Haskó J,Krizbai IA,Wilhelm I

更新日期：2020-09-01 00:00:00

abstract：:Genetic alterations responsible for the initiation of cancer may serve as immediate biomarkers for early diagnosis. Plasma levels of cell-free DNA (cfDNA) in patients with cancer are higher than those in healthy individuals; however, the major technical challenge for the widespread implementation of cfDNA genotyping a...

journal_title：Molecular oncology

authors： Ono Y,Sugitani A,Karasaki H,Ogata M,Nozaki R,Sasajima J,Yokochi T,Asahara S,Koizumi K,Ando K,Hironaka K,Daito T,Mizukami Y

更新日期：2017-10-01 00:00:00

abstract：:Germ cell cancers (GCC) are the most frequent malignancy in young Caucasian males. GCC can consist of seminomas (SE) and non-seminomas (malignant NS: embryonal carcinoma (EC), yolk sac tumor (YS), choriocarcinoma (CH) and teratoma (TE)). Current serum-markers used for diagnosis and follow-up (AFP, hCG) are predominant...

journal_title：Molecular oncology

authors： Gillis AJ,Rijlaarsdam MA,Eini R,Dorssers LC,Biermann K,Murray MJ,Nicholson JC,Coleman N,Dieckmann KP,Belge G,Bullerdiek J,Xu T,Bernard N,Looijenga LH

更新日期：2013-12-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of human cancer for which there are no effective therapies. Deep sequencing of PDAC tumors has revealed the presence of a high number of mutations (>50) that affect at least a dozen key signaling pathways. This scenario highlights the urgent need ...

journal_title：Molecular oncology

authors： Guerra C,Barbacid M

更新日期：2013-04-01 00:00:00

abstract：:Pancreatic cancer is one of the most lethal human cancers, and radiotherapy is often implemented for locally advanced pancreatic ductal adenocarcinoma. Tumor cell repopulation is a major challenge in treating cancers after radiotherapy. In order to address the problem of tumor repopulation, our previous studies have d...

journal_title：Molecular oncology

authors： Cheng J,Tian L,Ma J,Gong Y,Zhang Z,Chen Z,Xu B,Xiong H,Li C,Huang Q

更新日期：2015-01-01 00:00:00

abstract：:Breast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A ), and α-1,3/4-fucosyltransferases (FUTs) in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their...

journal_title：Molecular oncology

authors： Carrascal MA,Silva M,Ramalho JS,Pen C,Martins M,Pascoal C,Amaral C,Serrano I,Oliveira MJ,Sackstein R,Videira PA

更新日期：2018-05-01 00:00:00

abstract：:Glioblastoma (GBM) is an incurable brain tumor for which new treatment strategies are urgently needed. Next-generation sequencing of GBM has most often been performed retrospectively and on archival tissue from both diagnostic and relapse surgeries with limited knowledge of clinical information, including treatment gi...

journal_title：Molecular oncology

authors： Nørøxe DS,Yde CW,Østrup O,Michaelsen SR,Schmidt AY,Kinalis S,Torp MH,Skjøth-Rasmussen J,Brennum J,Hamerlik P,Poulsen HS,Nielsen FC,Lassen U

更新日期：2020-09-04 00:00:00

abstract：:Cancer is a multifactorial and heterogeneous disease. The corresponding complexity appears at multiple levels: from the molecular and the cellular constitution to the macroscopic phenotype, and at the diagnostic and therapeutic management stages. The overall complexity can be approximated to a certain extent, e.g. cha...

journal_title：Molecular oncology

authors： Dominietto M,Tsinoremas N,Capobianco E

更新日期：2015-01-01 00:00:00

abstract：:The abnormal expression of long noncoding RNAs (lncRNAs) is associated with human carcinoma. The present study aimed to investigate the mechanisms underlying the function of lncRNA AK002107 in the progression of hepatocellular carcinoma (HCC). The differential expression of lncRNAs between HCC and paired nontumor tiss...

journal_title：Molecular oncology

authors： Tang YH,He GL,Huang SZ,Zhong KB,Liao H,Cai L,Gao Y,Peng ZW,Fu SJ

更新日期：2019-05-01 00:00:00

abstract：:The elevated expression and activation of human telomerase reverse transcriptase (hTERT) is associated with the unlimited proliferation of cancer cells. However, the excise mechanism of hTERT regulation during carcinogenesis is not well understood. In this study, we discovered cleavage and polyadenylation specific fac...

journal_title：Molecular oncology

authors： Chen W,Qin L,Wang S,Li M,Shi D,Tian Y,Wang J,Fu L,Li Z,Guo W,Yu W,Yuan Y,Kang T,Huang W,Deng W

更新日期：2014-05-01 00:00:00

abstract：:Patient derived xenografts (PDXs) are increasingly appreciated models in cancer research, particularly for preclinical testing, as they reflect the patient's tumor biology more accurately than cancer cell lines. We have established a collection of 20 breast PDXs and characterized their biological and clinical features...

journal_title：Molecular oncology

authors： du Manoir S,Orsetti B,Bras-Gonçalves R,Nguyen TT,Lasorsa L,Boissière F,Massemin B,Colombo PE,Bibeau F,Jacot W,Theillet C

更新日期：2014-03-01 00:00:00

abstract：:Standard treatments for advanced high-grade serous ovarian carcinomas (HGSOCs) show significant side-effects and provide only short-term survival benefits due to disease recurrence. Thus, identification of novel prognostic and predictive biomarkers is urgently needed. We have used 42 paraffin-embedded HGSOCs, to evalu...

journal_title：Molecular oncology

authors： Kamieniak MM,Rico D,Milne RL,Muñoz-Repeto I,Ibáñez K,Grillo MA,Domingo S,Borrego S,Cazorla A,García-Bueno JM,Hernando S,García-Donas J,Hernández-Agudo E,Y Cajal TR,Robles-Díaz L,Márquez-Rodas I,Cusidó M,Sáez R,Lacambr

更新日期：2015-02-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma interaction in PD...

journal_title：Molecular oncology

authors： Veenstra VL,Damhofer H,Waasdorp C,Steins A,Kocher HM,Medema JP,van Laarhoven HW,Bijlsma MF

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:Lobular carcinoma in situ (LCIS) is both a risk indicator and non-obligate precursor of invasive lobular carcinoma (ILC). We sought to characterize the transcriptomic features of LCIS and ILC, with a focus on the identification of intrinsic molecular subtypes of LCIS and the changes involved in the progression ...

journal_title：Molecular oncology

authors： Andrade VP,Morrogh M,Qin LX,Olvera N,Giri D,Muhsen S,Sakr RA,Schizas M,Ng CK,Arroyo CD,Brogi E,Viale A,Morrow M,Reis-Filho JS,King TA

更新日期：2015-04-01 00:00:00

abstract：:ERBB2 amplification and overexpression are strongly associated with invasive cancer with high recurrence and poor prognosis. Enhanced ErbB2 signaling induces cysteine cathepsin B and L expression leading to their higher proteolytic activity (zFRase activity), which is crucial for the invasion of ErbB2-positive breast ...

journal_title：Molecular oncology

authors： Brix DM,Rafn B,Bundgaard Clemmensen K,Andersen SH,Ambartsumian N,Jäättelä M,Kallunki T

更新日期：2014-12-01 00:00:00

abstract：:High throughput gene expression profiling has showed great promise in providing insight into molecular mechanisms. Metastasis-related mRNAs may potentially enrich genes with the ability to predict cancer recurrence, therefore we attempted to build a recurrence-associated gene signature to improve prognostic prediction...

journal_title：Molecular oncology

authors： Tian X,Zhu X,Yan T,Yu C,Shen C,Hu Y,Hong J,Chen H,Fang JY

更新日期：2017-11-01 00:00:00