Epigenetic-smoking interaction reveals histologically heterogeneous effects of TRIM27 DNA methylation on overall survival among early-stage NSCLC patients.

abstract：:CDC25 (cell division cycle 25) phosphatases are essential for cell cycle control under normal conditions and in response to DNA damage. They are represented by three isoforms, CDC25A, B and C, each of them being submitted to an alternative splicing mechanism. Alternative splicing of many genes is affected in response ...

journal_title：Molecular oncology

authors： Albert H,Battaglia E,Monteiro C,Bagrel D

更新日期：2012-10-01 00:00:00

abstract：:Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype such as the gene expression profile of a cell that are heritable during somatic cell divisions (and sometimes germ line transmissions) but do not involve changes of the DNA sequence itself. Epigenetic phenomena are mediated by se...

journal_title：Molecular oncology

authors： Jovanovic J,Rønneberg JA,Tost J,Kristensen V

更新日期：2010-06-01 00:00:00

abstract：:Poly-ADP-ribose-polymerase inhibitors (PARPi) are considered to be optimal tools for specifically enhancing radiosensitivity. This effect has been shown to be replication-dependent and more profound in HR-deficient tumors. Here, we present a new mode of PARPi-mediated radiosensitization which was observed in four out ...

journal_title：Molecular oncology

authors： Kötter A,Cornils K,Borgmann K,Dahm-Daphi J,Petersen C,Dikomey E,Mansour WY

更新日期：2014-12-01 00:00:00

abstract：:PKN3 is an AGC-family protein kinase implicated in growth of metastatic prostate cancer cells with phosphoinositide 3-kinase pathway deregulation. The molecular mechanism, however, by which PKN3 contributes to malignant growth and tumorigenesis is not well understood. Using orthotopic mouse tumor models, we now show t...

journal_title：Molecular oncology

authors： Unsal-Kacmaz K,Ragunathan S,Rosfjord E,Dann S,Upeslacis E,Grillo M,Hernandez R,Mack F,Klippel A

更新日期：2012-06-01 00:00:00

abstract：:Cancer cells undergo epithelial-to-mesenchymal transition (EMT) in response to hypoxia. Exosomes produced in tumor microenvironments carry microRNAs (miRNAs) that affect proliferation, metastasis, and EMT. Hypoxic regulation of EMT is associated with telomerase content and stability, but the underlying mechanisms rema...

journal_title：Molecular oncology

authors： Zhang X,Bai J,Yin H,Long L,Zheng Z,Wang Q,Chen F,Yu X,Zhou Y

更新日期：2020-10-01 00:00:00

abstract：:Recently, RNAs interacting with proteins have been implicated in playing an important role in the occurrence and progression of oesophageal squamous cell carcinoma (ESCC). In this study, we found that NELFA mRNA interacts with Rad17 through a novel noncoding mode in the nucleus and that the aberrant expression of USF2...

journal_title：Molecular oncology

authors： Xu J,Wang G,Gong W,Guo S,Li D,Zhan Q

更新日期：2020-03-01 00:00:00

abstract：:A significant proportion of estrogen receptor-positive (ER+) breast cancer (BC) initially responds to endocrine therapy but eventually evolves into therapy-resistant BC. Transcription factor AP-2 gamma (TFAP2C) is a known regulator of ER activity, and high expression of TFAP2C is associated with a decreased response t...

journal_title：Molecular oncology

authors： Liu J,Liu Z,Li M,Tang W,Pratap UP,Luo Y,Altwegg KA,Li X,Zou Y,Zhu H,Sareddy GR,Viswanadhapalli S,Vadlamudi RK

更新日期：2020-12-02 00:00:00

abstract：:Tumors can be depicted as wounds that never heal, and are infiltrated by a large array of inflammatory and immune cells. Tumor-associated chronic inflammation is a hallmark of cancer that fosters progression to a metastatic stage, as has been extensively reviewed lately. Indeed, inflammatory cells persisting in the tu...

journal_title：Molecular oncology

authors： Suarez-Carmona M,Lesage J,Cataldo D,Gilles C

更新日期：2017-07-01 00:00:00

abstract：:JS-2 is a novel gene located at 5p15.2 and originally detected in primary oesophageal cancer. There is no study on the role of JS-2 in colorectal cancer. The aim of this study is to determine the gene copy number and expression of JS-2 in a large cohort of patients with colorectal tumours and correlate these to the cl...

journal_title：Molecular oncology

authors： Lam AK,Gopalan V,Nassiri MR,Kasim K,Dissanayake J,Tang JC,Smith RA

更新日期：2011-10-01 00:00:00

abstract：:Transient receptor potential melastatin-4 channel (TRPM4) dysregulation contributes to heart conditions, immune diseases, and cervical and prostate cancer. Up to now, the involvement of TRPM4 in colorectal cancer (CRC) pathophysiology remains unknown. Here, we investigated tumor tissue microarrays from 379 CRC patient...

journal_title：Molecular oncology

authors： Kappel S,Stokłosa P,Hauert B,Ross-Kaschitza D,Borgström A,Baur R,Galván JA,Zlobec I,Peinelt C

更新日期：2019-11-01 00:00:00

abstract：:Targeted toxin-based therapeutics are hindered by poor intracellular uptake, limited stability and non-specific immune stimulation. To address these problems, ligand-targeted toxins in combination with low dose saponin mixtures have been adapted and tested in vivo in the past, however, undefined saponin raw mixtures a...

journal_title：Molecular oncology

authors： Thakur M,Mergel K,Weng A,von Mallinckrodt B,Gilabert-Oriol R,Dürkop H,Melzig MF,Fuchs H

更新日期：2013-06-01 00:00:00

abstract：:In our previous study, we identified 1241 loci with somatic copy number alterations in human hepatocellular carcinoma (HCC) using Affymetrix SNP 6.0 arrays, and a putative cancer gene SERPINA5 was uncovered in a novel chromosomal region with recurrent copy number loss at 14q31.1-32.13. The SERPINA5 was reported to be ...

journal_title：Molecular oncology

authors： Jing Y,Jia D,Wong CM,Oi-Lin Ng I,Zhang Z,Liu L,Wang Q,Zhao F,Li J,Yao M,Wu X,He X

更新日期：2014-03-01 00:00:00

abstract：INTRODUCTION:Most analyses of high throughput cancer data represent tumors by "atomistic" single-gene properties. Pathifier, a recently introduced method, characterizes a tumor in terms of "coarse grained" pathway-based variables. METHODS:We applied Pathifier to study a very large dataset of 2000 breast cancer samples...

journal_title：Molecular oncology

authors： Livshits A,Git A,Fuks G,Caldas C,Domany E

更新日期：2015-08-01 00:00:00

abstract：:Angiogenin (ANG), a 14-kDa pro-angiogenic secreted protein, has been shown to play a role in cell migration and tumor invasion, which involve proteolytic cleavage of plasminogen to generate plasmin. However, the mechanism by which ANG regulates plasmin formation and cell migration was not known. Our studies here detec...

journal_title：Molecular oncology

authors： Dutta S,Bandyopadhyay C,Bottero V,Veettil MV,Wilson L,Pins MR,Johnson KE,Warshall C,Chandran B

更新日期：2014-05-01 00:00:00

abstract：:Glioblastoma (GBM) is an incurable brain tumor for which new treatment strategies are urgently needed. Next-generation sequencing of GBM has most often been performed retrospectively and on archival tissue from both diagnostic and relapse surgeries with limited knowledge of clinical information, including treatment gi...

journal_title：Molecular oncology

authors： Nørøxe DS,Yde CW,Østrup O,Michaelsen SR,Schmidt AY,Kinalis S,Torp MH,Skjøth-Rasmussen J,Brennum J,Hamerlik P,Poulsen HS,Nielsen FC,Lassen U

更新日期：2020-09-04 00:00:00

abstract：:Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can contribute to unfavorable patient outcomes, potentially including disease relapse. This possibiliy is supported by our findings that tumor cells induced into sene...

journal_title：Molecular oncology

authors： Saleh T,Carpenter VJ,Tyutyunyk-Massey L,Murray G,Leverson JD,Souers AJ,Alotaibi MR,Faber AC,Reed J,Harada H,Gewirtz DA

更新日期：2020-10-01 00:00:00

abstract：:Amplification of 3q26.2, found in many cancer lineages, is a frequent and early event in ovarian cancer. We previously defined the most frequent region of copy number increase at 3q26.2 to EVI1 (ecotropic viral integration site-1) and MDS1 (myelodysplastic syndrome 1) (aka MECOM), an observation recently confirmed by ...

journal_title：Molecular oncology

authors： Dutta P,Bui T,Bauckman KA,Keyomarsi K,Mills GB,Nanjundan M

更新日期：2013-06-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored a promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), a demethylating agent, in combina...

journal_title：Molecular oncology

authors： Vitale G,Dicitore A,Pepe D,Gentilini D,Grassi ES,Borghi MO,Gelmini G,Cantone MC,Gaudenzi G,Misso G,Di Blasio AM,Hofland LJ,Caraglia M,Persani L

更新日期：2017-08-01 00:00:00

abstract：:Resistance to chemotherapy is a serious problem for the successful treatment of ovarian cancer patients but signalling pathways that contribute to this chemoinsensitivity are largely unknown. We demonstrate that the chemotherapeutic drug doxorubicin induces activation of the HER3-PI3K-AKT signalling cascade in ovarian...

journal_title：Molecular oncology

authors： Bezler M,Hengstler JG,Ullrich A

更新日期：2012-10-01 00:00:00

abstract：:Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11 E3 ligase, which specifically ubiquitinates and degrades the cyclin-dependent kinase (C...

journal_title：Molecular oncology

authors： Zhang C,Chen B,Jiang K,Lao L,Shen H,Chen Z

更新日期：2018-04-01 00:00:00

abstract：:The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample volumes. The aim of this prospective, blinded study was to evaluate the clinical application of the CC and to compare its performance to the CellSearch (CS) system i...

journal_title：Molecular oncology

authors： Dizdar L,Fluegen G,van Dalum G,Honisch E,Neves RP,Niederacher D,Neubauer H,Fehm T,Rehders A,Krieg A,Knoefel WT,Stoecklein NH

更新日期：2019-07-01 00:00:00

abstract：:Circulating miRNA stability suggests potential utility of miRNA based biomarkers to monitor tumor burden and/or progression, particularly in cancer types where serial biopsy is impractical. Assessment of miRNA specificity and sensitivity is challenging within the clinical setting. To address this, circulating miRNAs w...

journal_title：Molecular oncology

authors： Greystoke A,Ayub M,Rothwell DG,Morris D,Burt D,Hodgkinson CL,Morrow CJ,Smith N,Aung K,Valle J,Carter L,Blackhall F,Dive C,Brady G

更新日期：2016-02-01 00:00:00

abstract：:Cancer is a noncommunicable disease (NCD) with increasing incidence and therefore constitutes a major public health issue. To reduce the health and economic burden of cancer, policy-makers across the world have implemented a range of preventative interventions targeting risk factors with a known link to the disease. I...

journal_title：Molecular oncology

authors： Cheatley J,Aldea A,Lerouge A,Devaux M,Vuik S,Cecchini M

更新日期：2020-10-05 00:00:00

abstract：:There is increasing evidence that glioblastoma possess 'stem-like' cells, low concentrations of which can initiate a tumour. It has been proposed that these cells are radioresistant, and that this property contributes to the poor treatment outcomes of these tumours. In this paper we propose that radioresistance is not...

journal_title：Molecular oncology

authors： Mannino M,Chalmers AJ

更新日期：2011-08-01 00:00:00

abstract：:Comprehensive Cancer Centres (CCCs) serve as critical drivers for improving cancer survival. In Europe, we have developed an Excellence Designation System (EDS) consisting of criteria to assess "excellence" of CCCs in translational research (bench to bedside and back), with the expectation that many European CCCs will...

journal_title：Molecular oncology

authors： Rajan A,Berns A,Ringborg U,Celis J,Ponder B,Caldas C,Livingston D,Bristow RG,Hecht TT,Tursz T,van Luenen H,Bono P,Helander T,Seamon K,Smyth JF,Louvard D,Eggermont A,van Harten WH

更新日期：2016-05-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1 or APE1) is a multifunctional protein that regulates numerous transcription factors associated with cancer-related pathways. Because APE1 is essential for cell viability, generation of APE1-knockout cell lines and determining a comprehensive list of genes...

journal_title：Molecular oncology

authors： Shah F,Goossens E,Atallah NM,Grimard M,Kelley MR,Fishel ML

更新日期：2017-12-01 00:00:00

abstract：PURPOSE:Lobular carcinoma in situ (LCIS) is both a risk indicator and non-obligate precursor of invasive lobular carcinoma (ILC). We sought to characterize the transcriptomic features of LCIS and ILC, with a focus on the identification of intrinsic molecular subtypes of LCIS and the changes involved in the progression ...

journal_title：Molecular oncology

authors： Andrade VP,Morrogh M,Qin LX,Olvera N,Giri D,Muhsen S,Sakr RA,Schizas M,Ng CK,Arroyo CD,Brogi E,Viale A,Morrow M,Reis-Filho JS,King TA

更新日期：2015-04-01 00:00:00

abstract：:The concept of polypharmacology involves the interaction of drug molecules with multiple molecular targets. It provides a unique opportunity for the repurposing of already-approved drugs to target key factors involved in human diseases. Herein, we used an in silico target prediction algorithm to investigate the mechan...

journal_title：Molecular oncology

authors： Ariey-Bonnet J,Carrasco K,Le Grand M,Hoffer L,Betzi S,Feracci M,Tsvetkov P,Devred F,Collette Y,Morelli X,Ballester P,Pasquier E

更新日期：2020-12-01 00:00:00

abstract：:Glycosylation is the stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process have been associated with malignant transformation. Simultaneous analysis of the expression of all glycan-related genes clearly gives the advantage of enabling a comprehensive...

journal_title：Molecular oncology

authors： Potapenko IO,Haakensen VD,Lüders T,Helland A,Bukholm I,Sørlie T,Kristensen VN,Lingjaerde OC,Børresen-Dale AL

更新日期：2010-04-01 00:00:00

abstract：:miRNAs in circulating extracellular vesicles (EVs) are promising biomarkers for cancer. However, their diagnostic ability for early-stage non-small-cell lung cancer (NSCLC) is not well known. In this study, the circulating EV miRNAs profiling was initially performed in 36 untreated NSCLC patients and 36 healthy contro...

journal_title：Molecular oncology

authors： Zhong Y,Ding X,Bian Y,Wang J,Zhou W,Wang X,Li P,Shen Y,Wang JJ,Li J,Zhang C,Wang C

更新日期：2020-12-19 00:00:00