Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration.

abstract：:The absence of biomarkers to accurately predict anticancer therapy response remains a major obstacle in clinical oncology. We applied a genome-wide loss-of-function screening approach in human haploid cells to characterize genetic vulnerabilities to classical microtubule-targeting agents. Using docetaxel and vinorelbi...

journal_title：Molecular oncology

authors： Gerhards NM,Blomen VA,Mutlu M,Nieuwenhuis J,Howald D,Guyader C,Jonkers J,Brummelkamp TR,Rottenberg S

更新日期：2018-06-01 00:00:00

abstract：:Breast cancer is the most common malignancy among women, with the highest incidence rate worldwide. Dysregulation of long noncoding RNAs during the preliminary stages of breast carcinogenesis is poorly understood. In this study, we performed RNA sequencing to identify long noncoding RNA expression profiles associated ...

journal_title：Molecular oncology

authors： Deva Magendhra Rao AK,Patel K,Korivi Jyothiraj S,Meenakumari B,Sundersingh S,Sridevi V,Rajkumar T,Pandey A,Chatterjee A,Gowda H,Mani S

更新日期：2019-06-01 00:00:00

abstract：:The PI3K/Akt signaling pathway, the most frequently altered signaling system in human cancer, is a crucial inducer of dysregulated proliferation and neoplastic processes; however, few therapeutic strategies using PI3K/Akt inhibitors singly have been shown to be effective. The purpose of this paper was to underline the...

journal_title：Molecular oncology

authors： Fabi F,Adam P,Parent S,Tardif L,Cadrin M,Asselin E

更新日期：2020-12-18 00:00:00

abstract：PURPOSE:To compare the distribution and prognostic effect of the breast cancer molecular subtypes in young and elderly breast cancer patients. PATIENTS AND METHODS:Our study population (n = 822) consisted of all early breast cancer patients primarily treated with surgery in our center between 1985 and 1996. A total of...

journal_title：Molecular oncology

authors： de Kruijf EM,Bastiaannet E,Rubertá F,de Craen AJ,Kuppen PJ,Smit VT,van de Velde CJ,Liefers GJ

更新日期：2014-07-01 00:00:00

abstract：:The above article, published online on 28 February 2020 in Wiley Online Library (wileyonlinelibrary.com) as an Accepted Article (https://doi.org/10.1002/1878-0261.12656), has been withdrawn at the authors' request, and in agreement between the authors, the journal Editors in Chief J. E. Celis and K. Ryan, and John Wil...

journal_title：Molecular oncology

authors：

更新日期：2020-12-01 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1 or APE1) is a multifunctional protein that regulates numerous transcription factors associated with cancer-related pathways. Because APE1 is essential for cell viability, generation of APE1-knockout cell lines and determining a comprehensive list of genes...

journal_title：Molecular oncology

authors： Shah F,Goossens E,Atallah NM,Grimard M,Kelley MR,Fishel ML

更新日期：2017-12-01 00:00:00

abstract：:Ovarian cancer is the most lethal gynecologic malignancy. About 75% of ovarian cancer patients relapse and/or develop chemo-resistant disease after initial response to standard-of-care treatment with platinum-based therapies. HER2 amplifications and overexpression in ovarian cancer are reported to vary, and responses ...

journal_title：Molecular oncology

authors： Harris FR,Zhang P,Yang L,Hou X,Leventakos K,Weroha SJ,Vasmatzis G,Kovtun IV

更新日期：2019-02-01 00:00:00

abstract：:Medullary thyroid cancer (MTC) is a tumor highly resistant to chemo- and radiotherapy. Drug resistance can be induced by epigenetic changes such as aberrant DNA methylation. To overcome drug resistance, we explored a promising approach based on the use of 5-aza-2'-deoxycytidine (AZA), a demethylating agent, in combina...

journal_title：Molecular oncology

authors： Vitale G,Dicitore A,Pepe D,Gentilini D,Grassi ES,Borghi MO,Gelmini G,Cantone MC,Gaudenzi G,Misso G,Di Blasio AM,Hofland LJ,Caraglia M,Persani L

更新日期：2017-08-01 00:00:00

abstract：:Comprehensive Cancer Centres (CCCs) serve as critical drivers for improving cancer survival. In Europe, we have developed an Excellence Designation System (EDS) consisting of criteria to assess "excellence" of CCCs in translational research (bench to bedside and back), with the expectation that many European CCCs will...

journal_title：Molecular oncology

authors： Rajan A,Berns A,Ringborg U,Celis J,Ponder B,Caldas C,Livingston D,Bristow RG,Hecht TT,Tursz T,van Luenen H,Bono P,Helander T,Seamon K,Smyth JF,Louvard D,Eggermont A,van Harten WH

更新日期：2016-05-01 00:00:00

abstract：:As treatment options for patients with incurable metastatic castration-resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase implicated in the DNA damage response (DDR) pathway that prevents the accumu...

journal_title：Molecular oncology

authors： Drápela S,Khirsariya P,van Weerden WM,Fedr R,Suchánková T,Búzová D,Červený J,Hampl A,Puhr M,Watson WR,Culig Z,Krejčí L,Paruch K,Souček K

更新日期：2020-10-01 00:00:00

abstract：:Hydrophobic neoantigens are more immunogenic because they are better presented by the major histocompatibility complex and better recognized by T cells. Tumor cells can evade the immune response by expressing checkpoints such as programmed death ligand 1. Checkpoint blockade reactivates immune recognition and can be e...

journal_title：Molecular oncology

authors： Pham TV,Boichard A,Goodman A,Riviere P,Yeerna H,Tamayo P,Kurzrock R

更新日期：2020-08-01 00:00:00

abstract：:There is increasing evidence that glioblastoma possess 'stem-like' cells, low concentrations of which can initiate a tumour. It has been proposed that these cells are radioresistant, and that this property contributes to the poor treatment outcomes of these tumours. In this paper we propose that radioresistance is not...

journal_title：Molecular oncology

authors： Mannino M,Chalmers AJ

更新日期：2011-08-01 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1, encoded by the NKX2-1 gene) is highly expressed in small-cell lung carcinoma (SCLC) and lung adenocarcinoma (LADC), but how its functional roles differ between SCLC and LADC remains to be elucidated. Here, we compared the genome-wide distributions of TTF-1 binding regions and the...

journal_title：Molecular oncology

authors： Hokari S,Tamura Y,Kaneda A,Katsura A,Morikawa M,Murai F,Ehata S,Tsutsumi S,Ishikawa Y,Aburatani H,Kikuchi T,Miyazono K,Koinuma D

更新日期：2020-02-01 00:00:00

abstract：:Hypoxia is a feature of the microenvironment of many cancers and can trigger epithelial-mesenchymal transition (EMT), a process by which cells acquire a more invasive phenotype with enriched survival. A remodeling of adenosine 5'-triphosphate (ATP)-induced Ca(2+) signaling via purinergic receptors is associated with e...

journal_title：Molecular oncology

authors： Azimi I,Beilby H,Davis FM,Marcial DL,Kenny PA,Thompson EW,Roberts-Thomson SJ,Monteith GR

更新日期：2016-01-01 00:00:00

abstract：:The GILUPI CellCollector (CC) is a novel in vivo circulating tumor cell (CTC) detection device reported to overcome the limitations of small blood sample volumes. The aim of this prospective, blinded study was to evaluate the clinical application of the CC and to compare its performance to the CellSearch (CS) system i...

journal_title：Molecular oncology

authors： Dizdar L,Fluegen G,van Dalum G,Honisch E,Neves RP,Niederacher D,Neubauer H,Fehm T,Rehders A,Krieg A,Knoefel WT,Stoecklein NH

更新日期：2019-07-01 00:00:00

abstract：:The diversity of breast cancers reflects variations in underlying biology and affects the clinical implications for patients. Gene expression studies have identified five major subtypes- Luminal A, Luminal B, basal-like, ErbB2+ and Normal-Like. We set out to determine the role of DNA methylation in subtypes by perform...

journal_title：Molecular oncology

authors： Kamalakaran S,Varadan V,Giercksky Russnes HE,Levy D,Kendall J,Janevski A,Riggs M,Banerjee N,Synnestvedt M,Schlichting E,Kåresen R,Shama Prasada K,Rotti H,Rao R,Rao L,Eric Tang MH,Satyamoorthy K,Lucito R,Wigler M,Dim

更新日期：2011-02-01 00:00:00

abstract：:Tumour suppressor p53, a master transcriptional regulator determines cell fate through preferential activation/repression of a myriad of genes during stress. Till date, activation and preferential binding of p53 on different promoters was reported to be influenced by the nature, strength and duration of stress which m...

journal_title：Molecular oncology

authors： Thakur B,Ray P

更新日期：2016-10-01 00:00:00

abstract：:We have recently gained a remarkable understanding of the mutational landscape of head and neck squamous cell carcinoma (HNSCC). However, the nature of the dysregulated signaling networks contributing to HNSCC progression is still poorly defined. Here, we have focused on the role of the family of mitogen activated kin...

journal_title：Molecular oncology

authors： Leelahavanichkul K,Amornphimoltham P,Molinolo AA,Basile JR,Koontongkaew S,Gutkind JS

更新日期：2014-02-01 00:00:00

abstract：PURPOSE:DNA analysis by NGS has become important to direct the clinical care of cancer patients. However, NGS is not successful in all cases, and the factors responsible for test failures have not been systematically evaluated. MATERIALS AND METHODS:A series of 1528 solid and hematolymphoid tumor specimens was tested ...

journal_title：Molecular oncology

authors： Al-Kateb H,Nguyen TT,Steger-May K,Pfeifer JD

更新日期：2015-11-01 00:00:00

abstract：:miRNAs in circulating extracellular vesicles (EVs) are promising biomarkers for cancer. However, their diagnostic ability for early-stage non-small-cell lung cancer (NSCLC) is not well known. In this study, the circulating EV miRNAs profiling was initially performed in 36 untreated NSCLC patients and 36 healthy contro...

journal_title：Molecular oncology

authors： Zhong Y,Ding X,Bian Y,Wang J,Zhou W,Wang X,Li P,Shen Y,Wang JJ,Li J,Zhang C,Wang C

更新日期：2020-12-19 00:00:00

abstract：:Circulating tumor cell (CTC) analysis holds great potential to be a noninvasive solution for clinical cancer management. A complete workflow that combined CTC detection and single-cell molecular analysis is required. We developed the ChimeraX® -i120 platform to facilitate negative enrichment, immunofluorescent labelin...

journal_title：Molecular oncology

authors： Wang PX,Sun YF,Jin WX,Cheng JW,Peng HX,Xu Y,Zhou KQ,Chen LM,Huang K,Wu SY,Hu B,Zhang ZF,Guo W,Cao Y,Zhou J,Fan J,Yang XR

更新日期：2020-12-10 00:00:00

abstract：:Cullin 4B, a member of the Cullins, which serve as scaffolds to facilitate the assembly of E3 ligase complexes, is aberrantly expressed in many cancers, including osteosarcoma. Recently, we observed that CUL4B forms the CRL4BDCAF11 E3 ligase, which specifically ubiquitinates and degrades the cyclin-dependent kinase (C...

journal_title：Molecular oncology

authors： Zhang C,Chen B,Jiang K,Lao L,Shen H,Chen Z

更新日期：2018-04-01 00:00:00

abstract：:The pivotal role of LYRIC/AEG-1 in malignant transformation, tumourigenesis and chemo-resistance has previously been demonstrated in different cell types and sub-cellular compartments. The localisation of LYRIC/AEG-1 appears crucial to its function and is regulated by three lysine-rich nuclear localisation signal regi...

journal_title：Molecular oncology

authors： Luxton HJ,Barnouin K,Kelly G,Hanrahan S,Totty N,Neal DE,Whitaker HC

更新日期：2014-05-01 00:00:00

abstract：:Mouse models of human cancers may provide a valuable resource for the discovery of cancer biomarkers. We have developed a practical strategy for profiling specific proteins in mouse plasma using low-volume sandwich-immunoassays. We used this method to profile the levels of 14 different cytokines, acute-phase reactants...

journal_title：Molecular oncology

authors： Forrester S,Hung KE,Kuick R,Kucherlapati R,Haab BB

更新日期：2007-09-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease that can be divided in subtypes based on histology, gene expression profiles as well as differences in genomic aberrations. Distinct global DNA methylation profiles have been reported in normal breast epithelial cells as well as in breast tumors. However, the influence of the t...

journal_title：Molecular oncology

authors： Rønneberg JA,Fleischer T,Solvang HK,Nordgard SH,Edvardsen H,Potapenko I,Nebdal D,Daviaud C,Gut I,Bukholm I,Naume B,Børresen-Dale AL,Tost J,Kristensen V

更新日期：2011-02-01 00:00:00

abstract：:Tumor growth, especially in the late stage, requires adequate nutrients and rich vasculature, in which PKM2 plays a convergent role. It has been reported that PKM2, together with FOXM1D, is upregulated in late stage colorectal cancer and associated with metastasis; however, their underlying mechanism for promoting tum...

journal_title：Molecular oncology

authors： Zhang W,Zhang X,Huang S,Chen J,Ding P,Wang Q,Li L,Lv X,Li L,Zhang P,Zhou D,Wen W,Wang Y,Lei QY,Wu J,Hu W

更新日期：2020-12-13 00:00:00

abstract：:GPNMB is a melanoma-associated glycoprotein that is targeted by the CR011-vcMMAE antibody-drug conjugate (ADC). Previous studies have shown that CR011-vcMMAE induces the apoptosis of GPNMB-expressing tumor cells in vitro and tumor regression in xenograft models. This ADC is currently in clinical trials for melanoma. I...

journal_title：Molecular oncology

authors： Qian X,Mills E,Torgov M,LaRochelle WJ,Jeffers M

更新日期：2008-06-01 00:00:00

abstract：:Estrogen receptor-alpha (ERα)-positive breast cancer is often treated with antihormonal regimens. However, resistance to treatment is common, leading to metastatic disease. ERα activity requires the functional involvement of pioneer factors FOXA1 and GATA3, which enable ERα-chromatin binding and are crucial for ERα-dr...

journal_title：Molecular oncology

authors： Schrijver W,Schuurman K,van Rossum A,Droog M,Jeronimo C,Salta S,Henrique R,Wesseling J,Moelans C,Linn SC,van den Heuvel M,van Diest P,Zwart W

更新日期：2018-11-01 00:00:00

abstract：:DNA ploidy analysis is useful for prognostication in cancer patients, but the genomic details underlying ploidy changes are not fully understood. To improve this understanding, we compared DNA ploidy status with karyotypic and comparative genomic hybridization data on 51 endometrial adenocarcinomas. Out of 34 DNA dipl...

journal_title：Molecular oncology

authors： Kildal W,Micci F,Risberg B,Abeler VM,Kristensen GB,Heim S,Danielsen HE

更新日期：2012-02-01 00:00:00

abstract：:Alterations in glycan structures are early signs of malignancy and have recently been proposed to be in part a driving force behind malignant transformation. Here, we explore whether differences in expression of genes related to the process of glycosylation exist between breast carcinoma subtypes - and look for their ...

journal_title：Molecular oncology

authors： Potapenko IO,Lüders T,Russnes HG,Helland Å,Sørlie T,Kristensen VN,Nord S,Lingjærde OC,Børresen-Dale AL,Haakensen VD

更新日期：2015-04-01 00:00:00