The epigenetics of breast cancer.

abstract：:Resistance to chemotherapy is a serious problem for the successful treatment of ovarian cancer patients but signalling pathways that contribute to this chemoinsensitivity are largely unknown. We demonstrate that the chemotherapeutic drug doxorubicin induces activation of the HER3-PI3K-AKT signalling cascade in ovarian...

journal_title：Molecular oncology

authors： Bezler M,Hengstler JG,Ullrich A

更新日期：2012-10-01 00:00:00

abstract：:Epigenetic silencing of miRNA is a primary mechanism of aberrant miRNA expression in cancer, and hypermethylation of miRNA promoters has been reported to contribute to prostate cancer initiation and progression. Recent data have shown that the miR-193b promoter is hypermethylated in prostate cancer compared with norma...

journal_title：Molecular oncology

authors： Mazzu YZ,Yoshikawa Y,Nandakumar S,Chakraborty G,Armenia J,Jehane LE,Lee GM,Kantoff PW

更新日期：2019-09-01 00:00:00

abstract：:Recently, RNAs interacting with proteins have been implicated in playing an important role in the occurrence and progression of oesophageal squamous cell carcinoma (ESCC). In this study, we found that NELFA mRNA interacts with Rad17 through a novel noncoding mode in the nucleus and that the aberrant expression of USF2...

journal_title：Molecular oncology

authors： Xu J,Wang G,Gong W,Guo S,Li D,Zhan Q

更新日期：2020-03-01 00:00:00

abstract：:Tripartite motif containing 27 (TRIM27) is highly expressed in lung cancer, including non-small-cell lung cancer (NSCLC). Here, we profiled DNA methylation of lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) tumours from 613 early-stage NSCLC patients and evaluated associations between CpG methylatio...

journal_title：Molecular oncology

authors： Ji X,Lin L,Shen S,Dong X,Chen C,Li Y,Zhu Y,Huang H,Chen J,Chen X,Wei L,He J,Duan W,Su L,Jiang Y,Fan J,Guan J,You D,Shafer A,Bjaanæs MM,Karlsson A,Planck M,Staaf J,Helland Å,Esteller M,Wei Y,Zhang R,C

更新日期：2020-11-01 00:00:00

abstract：:Protein inhibitor of activated STAT3 (PIAS3) is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. We previous...

journal_title：Molecular oncology

authors： He T,McColl K,Sakre N,Chen Y,Wildey G,Dowlati A

更新日期：2018-12-01 00:00:00

abstract：PURPOSE:To compare the distribution and prognostic effect of the breast cancer molecular subtypes in young and elderly breast cancer patients. PATIENTS AND METHODS:Our study population (n = 822) consisted of all early breast cancer patients primarily treated with surgery in our center between 1985 and 1996. A total of...

journal_title：Molecular oncology

authors： de Kruijf EM,Bastiaannet E,Rubertá F,de Craen AJ,Kuppen PJ,Smit VT,van de Velde CJ,Liefers GJ

更新日期：2014-07-01 00:00:00

abstract：:Nucleophosmin-anaplastic lymphoma kinase-expressing (NPM-ALK+ ) T-cell lymphoma is an aggressive neoplasm that is more commonly seen in children and young adults. The pathogenesis of NPM-ALK+ T-cell lymphoma is not completely understood. Wild-type ALK is a receptor tyrosine kinase that is physiologically expressed in ...

journal_title：Molecular oncology

authors： Shi W,George SK,George B,Curry CV,Murzabdillaeva A,Alkan S,Amin HM

更新日期：2017-09-01 00:00:00

abstract：:Cancer cells undergo epithelial-to-mesenchymal transition (EMT) in response to hypoxia. Exosomes produced in tumor microenvironments carry microRNAs (miRNAs) that affect proliferation, metastasis, and EMT. Hypoxic regulation of EMT is associated with telomerase content and stability, but the underlying mechanisms rema...

journal_title：Molecular oncology

authors： Zhang X,Bai J,Yin H,Long L,Zheng Z,Wang Q,Chen F,Yu X,Zhou Y

更新日期：2020-10-01 00:00:00

abstract：:Genetic alterations responsible for the initiation of cancer may serve as immediate biomarkers for early diagnosis. Plasma levels of cell-free DNA (cfDNA) in patients with cancer are higher than those in healthy individuals; however, the major technical challenge for the widespread implementation of cfDNA genotyping a...

journal_title：Molecular oncology

authors： Ono Y,Sugitani A,Karasaki H,Ogata M,Nozaki R,Sasajima J,Yokochi T,Asahara S,Koizumi K,Ando K,Hironaka K,Daito T,Mizukami Y

更新日期：2017-10-01 00:00:00

abstract：:SMURF2 is a member of the HECT family of E3 ubiquitin ligases that have important roles as a negative regulator of transforming growth factor-β (TGF-β) signaling through ubiquitin-mediated degradation of TGF-β receptor I. However, the regulatory mechanism of SMURF2 is largely unknown. In this study, we identified that...

journal_title：Molecular oncology

authors： Chae DK,Park J,Cho M,Ban E,Jang M,Yoo YS,Kim EE,Baik JH,Song EJ

更新日期：2019-12-01 00:00:00

abstract：:Near infrared photoimmunotherapy (NIR-PIT) is a new, highly-selective cancer theranostics that employs an antibody-photo absorber conjugate (APC). NIR-PIT has successfully treated preclinical tumor models with APCs and is now in the first-in-human phase 1 clinical trial for head and neck cancer patients against EGFR. ...

journal_title：Molecular oncology

authors： Nagaya T,Nakamura Y,Sato K,Harada T,Choyke PL,Kobayashi H

更新日期：2016-11-01 00:00:00

abstract：:The ability to predict responsiveness to drugs in individual patients is limited. We hypothesized that integrating molecular information from databases would yield predictions that could be experimentally tested to develop transcriptomic signatures for specific drugs. We analyzed lung adenocarcinoma patient data from ...

journal_title：Molecular oncology

authors： Tavassoly I,Hu Y,Zhao S,Mariottini C,Boran A,Chen Y,Li L,Tolentino RE,Jayaraman G,Goldfarb J,Gallo J,Iyengar R

更新日期：2019-08-01 00:00:00

abstract：:Infiltration of the tumor microenvironment by nerve fibers is an understudied aspect of breast carcinogenesis. In this study, the presence of nerve fibers was investigated in a cohort of 369 primary breast cancers (ductal carcinomas in situ, invasive ductal and lobular carcinomas) by immunohistochemistry for the neuro...

journal_title：Molecular oncology

authors： Pundavela J,Roselli S,Faulkner S,Attia J,Scott RJ,Thorne RF,Forbes JF,Bradshaw RA,Walker MM,Jobling P,Hondermarck H

更新日期：2015-10-01 00:00:00

abstract：:Triple-negative breast cancer (TNBC) liver metastasis is associated with poor prognosis and low patient survival. It occurs when tumor cells disseminate from primary tumors, circulate in blood/lymph [circulating tumor cells (CTCs)], and acquire distinct characteristics during disease progression toward the metastatic ...

journal_title：Molecular oncology

authors： Vishnoi M,Liu NH,Yin W,Boral D,Scamardo A,Hong D,Marchetti D

更新日期：2019-09-01 00:00:00

abstract：:Breast cancers with BRCA1 germline mutation have a characteristic DNA copy number (CN) pattern. We developed a test that assigns CN profiles to be 'BRCA1-like' or 'non-BRCA1-like', which refers to resembling a BRCA1-mutated tumor or resembling a tumor without a BRCA1 mutation, respectively. Approximately one third of ...

journal_title：Molecular oncology

authors： Schouten PC,Grigoriadis A,Kuilman T,Mirza H,Watkins JA,Cooke SA,van Dyk E,Severson TM,Rueda OM,Hoogstraat M,Verhagen CV,Natrajan R,Chin SF,Lips EH,Kruizinga J,Velds A,Nieuwland M,Kerkhoven RM,Krijgsman O,Vens C,Pe

更新日期：2015-08-01 00:00:00

abstract：:Peritoneal dissemination is a major clinical obstacle in gastrointestinal cancer therapy, and it accounts for the majority of cancer-related mortality. Calreticulin (CRT) is over-expressed in gastric tumors and has been linked to poor prognosis. In this study, immunohistochemistry studies revealed that the up-regulati...

journal_title：Molecular oncology

authors： Liu SH,Lee WJ,Lai DW,Wu SM,Liu CY,Tien HR,Chiu CS,Peng YC,Jan YJ,Chao TH,Pan HC,Sheu ML

更新日期：2015-04-01 00:00:00

abstract：:Breast cancer tissue overexpresses fucosylated glycans, such as sialyl-Lewis X/A (sLeX/A ), and α-1,3/4-fucosyltransferases (FUTs) in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E-selectin, initiating tumor extravasation. However, their...

journal_title：Molecular oncology

authors： Carrascal MA,Silva M,Ramalho JS,Pen C,Martins M,Pascoal C,Amaral C,Serrano I,Oliveira MJ,Sackstein R,Videira PA

更新日期：2018-05-01 00:00:00

abstract：:It has been hypothesized based on accumulated data that a class of small noncoding RNAs, termed microRNAs, are key factors in intercellular communication. Here, microRNAs present in interstitial breast tumor fluids have been analyzed to identify relevant markers for a diagnosis of breast cancer and to elucidate the cr...

journal_title：Molecular oncology

authors： Halvorsen AR,Helland Å,Gromov P,Wielenga VT,Talman MM,Brunner N,Sandhu V,Børresen-Dale AL,Gromova I,Haakensen VD

更新日期：2017-02-01 00:00:00

abstract：:Most solid tumors, including colorectal cancers, shed cell-free DNA (ctDNA) in the blood. ctDNA can be analyzed to generate molecular profiles which capture the heterogeneity of the disease more comprehensively then tumor tissue biopsies. This approach commonly called 'liquid biopsy' can be applied to monitor response...

journal_title：Molecular oncology

authors： Siravegna G,Bardelli A

更新日期：2016-03-01 00:00:00

abstract：:Gene and protein expression of programmed death-ligand 1 (PD-L1) are prognostic in early breast cancer (BC), but their prognostic information is inconsistent at least in some biological subgroups. The validated prognostic gene signatures (GS) in BC are mainly based on proliferation and estrogen receptor (ER)-related g...

journal_title：Molecular oncology

authors： Zerdes I,Sifakis EG,Matikas A,Chrétien S,Tobin NP,Hartman J,Rassidakis GZ,Bergh J,Foukakis T

更新日期：2020-05-01 00:00:00

abstract：:Poly-ADP-ribose-polymerase inhibitors (PARPi) are considered to be optimal tools for specifically enhancing radiosensitivity. This effect has been shown to be replication-dependent and more profound in HR-deficient tumors. Here, we present a new mode of PARPi-mediated radiosensitization which was observed in four out ...

journal_title：Molecular oncology

authors： Kötter A,Cornils K,Borgmann K,Dahm-Daphi J,Petersen C,Dikomey E,Mansour WY

更新日期：2014-12-01 00:00:00

abstract：:DNA ploidy analysis is useful for prognostication in cancer patients, but the genomic details underlying ploidy changes are not fully understood. To improve this understanding, we compared DNA ploidy status with karyotypic and comparative genomic hybridization data on 51 endometrial adenocarcinomas. Out of 34 DNA dipl...

journal_title：Molecular oncology

authors： Kildal W,Micci F,Risberg B,Abeler VM,Kristensen GB,Heim S,Danielsen HE

更新日期：2012-02-01 00:00:00

abstract：:A significant proportion of estrogen receptor-positive (ER+) breast cancer (BC) initially responds to endocrine therapy but eventually evolves into therapy-resistant BC. Transcription factor AP-2 gamma (TFAP2C) is a known regulator of ER activity, and high expression of TFAP2C is associated with a decreased response t...

journal_title：Molecular oncology

authors： Liu J,Liu Z,Li M,Tang W,Pratap UP,Luo Y,Altwegg KA,Li X,Zou Y,Zhu H,Sareddy GR,Viswanadhapalli S,Vadlamudi RK

更新日期：2020-12-02 00:00:00

abstract：:Around 50% of all human microRNAs reside within introns of coding genes and are usually co-transcribed. Gene expression datasets, therefore, should contain a wealth of miRNA-relevant latent information, exploitable for many basic and translational research aims. The present study was undertaken to investigate this pos...

journal_title：Molecular oncology

authors： Monterisi S,D'Ario G,Dama E,Rotmensz N,Confalonieri S,Tordonato C,Troglio F,Bertalot G,Maisonneuve P,Viale G,Nicassio F,Vecchi M,Di Fiore PP,Bianchi F

更新日期：2015-02-01 00:00:00

abstract：:Germ cell cancers (GCC) are the most frequent malignancy in young Caucasian males. GCC can consist of seminomas (SE) and non-seminomas (malignant NS: embryonal carcinoma (EC), yolk sac tumor (YS), choriocarcinoma (CH) and teratoma (TE)). Current serum-markers used for diagnosis and follow-up (AFP, hCG) are predominant...

journal_title：Molecular oncology

authors： Gillis AJ,Rijlaarsdam MA,Eini R,Dorssers LC,Biermann K,Murray MJ,Nicholson JC,Coleman N,Dieckmann KP,Belge G,Bullerdiek J,Xu T,Bernard N,Looijenga LH

更新日期：2013-12-01 00:00:00

abstract：:Central nervous system (CNS) metastasis is one of the serious complications of epidermal growth factor receptor (EGFR)-mutant lung cancer, which arises due to poor penetration of the brain-blood barrier by EGFR-tyrosine kinase inhibitors (EGFR-TKIs). Although osimertinib, a third-generation EGFR-TKI, has efficacy agai...

journal_title：Molecular oncology

authors： Kim DH,Choi YJ,Sung KJ,Yoo SA,Sung YH,Kim JK,Choi CM,Yun M,Lee EY,Jin YS,Cook S,Rho JK,Lee JC

更新日期：2018-12-01 00:00:00

abstract：:Natural products remain a significant source of anticancer chemotherapeutics. The search for targeted drugs for cancer treatment includes consideration of natural products, which may provide new opportunities for antitumor cytotoxicity as single agents or in combination therapy. We examined the association of molecula...

journal_title：Molecular oncology

authors： Krushkal J,Negi S,Yee LM,Evans JR,Grkovic T,Palmisano A,Fang J,Sankaran H,McShane LM,Zhao Y,O'Keefe BR

更新日期：2020-11-09 00:00:00

abstract：BACKGROUND:The association between nuclear factor I/B (NFIB) gene and triple negative breast cancer has been previously suggested. METHODS:We investigated the relationship between NFIB mRNA and protein expression and molecular subtypes of breast cancer as well as the effect of NFIB silencing on the proliferation and a...

journal_title：Molecular oncology

authors： Moon HG,Hwang KT,Kim JA,Kim HS,Lee MJ,Jung EM,Ko E,Han W,Noh DY

更新日期：2011-12-01 00:00:00

abstract：:PKN3 is an AGC-family protein kinase implicated in growth of metastatic prostate cancer cells with phosphoinositide 3-kinase pathway deregulation. The molecular mechanism, however, by which PKN3 contributes to malignant growth and tumorigenesis is not well understood. Using orthotopic mouse tumor models, we now show t...

journal_title：Molecular oncology

authors： Unsal-Kacmaz K,Ragunathan S,Rosfjord E,Dann S,Upeslacis E,Grillo M,Hernandez R,Mack F,Klippel A

更新日期：2012-06-01 00:00:00

abstract：:Amplification of 3q26.2, found in many cancer lineages, is a frequent and early event in ovarian cancer. We previously defined the most frequent region of copy number increase at 3q26.2 to EVI1 (ecotropic viral integration site-1) and MDS1 (myelodysplastic syndrome 1) (aka MECOM), an observation recently confirmed by ...

journal_title：Molecular oncology

authors： Dutta P,Bui T,Bauckman KA,Keyomarsi K,Mills GB,Nanjundan M

更新日期：2013-06-01 00:00:00