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miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33.

Abstract：

:Deregulation of microRNAs contributes to the aberrant growth of hepatocellular carcinoma (HCC). Here, we showed that miR-634 expression was frequently decreased in HCC. Low miR-634 expression was significantly associated with larger tumor size, poorer tumor differentiation, advanced TNM stage, vascular invasion, absence of tumor capsule and unfavorable overall survival. Overexpression of miR-634 markedly attenuated cell viability, colony formation, tumor growth and metastasis, whereas miR-634 inhibition resulted in the opposite phenotypes. Furthermore, re-introduction of miR-634 induced cell apoptosis in vitro and in vivo. Mechanistically, miR-634 inhibited the expression of Rab1A and DHX33 via directly binding to the 3'-UTR of both genes. In clinical samples, the expression of Rab1A or DHX33 was reversely correlated with miR-634. Re-expression of Rab1A or DHX33 abrogated the miR-634-mediated inhibition of cell proliferation and migration. Collectively, our data suggest a tumor suppressor role of miR-634 in HCC. The newly identified miR-634/Rab1A or miR-634/DHX33 axis serves as a potential therapeutic target for the clinical management.

journal_name

Mol Oncol

journal_title

Molecular oncology

authors

Zhang CZ,Cao Y,Fu J,Yun JP,Zhang MF

doi

10.1016/j.molonc.2016.09.001

subject

Has Abstract

pub_date

2016-12-01 00:00:00

pages

1532-1541

issue

10

eissn

1574-7891

issn

1878-0261

pii

S1574-7891(16)30099-0

journal_volume

10

pub_type

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