At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression.


:Endocytosis is an important regulator of cell-cell signaling and endocytic trafficking has been increasingly implicated in control of tumor suppression. Recent insights from Drosophila indicate that impairment of multiple trafficking steps which lead to receptor degradation can cause tumor formation in epithelial organs. These tumors are characterized by sustained activation of a number of mitogenic signaling pathways, and by subversion of epithelial polarity and the apoptotic response. Cooperation between such alterations, as well as tumor-host interactions, is also observed. The recapitulation of several hallmarks of human cancers in fly tumors provides a framework to understand the role of defective endocytosis in cancer.


Mol Oncol


Molecular oncology


Vaccari T,Bilder D




Has Abstract


2009-08-01 00:00:00














  • Glycan gene expression signatures in normal and malignant breast tissue; possible role in diagnosis and progression.

    abstract::Glycosylation is the stepwise procedure of covalent attachment of oligosaccharide chains to proteins or lipids, and alterations in this process have been associated with malignant transformation. Simultaneous analysis of the expression of all glycan-related genes clearly gives the advantage of enabling a comprehensive...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Potapenko IO,Haakensen VD,Lüders T,Helland A,Bukholm I,Sørlie T,Kristensen VN,Lingjaerde OC,Børresen-Dale AL

    更新日期:2010-04-01 00:00:00

  • Near infrared photoimmunotherapy of B-cell lymphoma.

    abstract::Near infrared photoimmunotherapy (NIR-PIT) is a new, highly-selective cancer theranostics that employs an antibody-photo absorber conjugate (APC). NIR-PIT has successfully treated preclinical tumor models with APCs and is now in the first-in-human phase 1 clinical trial for head and neck cancer patients against EGFR. ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Nagaya T,Nakamura Y,Sato K,Harada T,Choyke PL,Kobayashi H

    更新日期:2016-11-01 00:00:00

  • Methylation profiling with a panel of cancer related genes: association with estrogen receptor, TP53 mutation status and expression subtypes in sporadic breast cancer.

    abstract::Breast cancer is a heterogeneous disease that can be divided in subtypes based on histology, gene expression profiles as well as differences in genomic aberrations. Distinct global DNA methylation profiles have been reported in normal breast epithelial cells as well as in breast tumors. However, the influence of the t...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Rønneberg JA,Fleischer T,Solvang HK,Nordgard SH,Edvardsen H,Potapenko I,Nebdal D,Daviaud C,Gut I,Bukholm I,Naume B,Børresen-Dale AL,Tost J,Kristensen V

    更新日期:2011-02-01 00:00:00

  • Post-transcriptional regulation of PIAS3 expression by miR-18a in malignant mesothelioma.

    abstract::Protein inhibitor of activated STAT3 (PIAS3) is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. We previous...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: He T,McColl K,Sakre N,Chen Y,Wildey G,Dowlati A

    更新日期:2018-12-01 00:00:00

  • Glycan-related gene expression signatures in breast cancer subtypes; relation to survival.

    abstract::Alterations in glycan structures are early signs of malignancy and have recently been proposed to be in part a driving force behind malignant transformation. Here, we explore whether differences in expression of genes related to the process of glycosylation exist between breast carcinoma subtypes - and look for their ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Potapenko IO,Lüders T,Russnes HG,Helland Å,Sørlie T,Kristensen VN,Nord S,Lingjærde OC,Børresen-Dale AL,Haakensen VD

    更新日期:2015-04-01 00:00:00

  • Screening and identification of small molecule inhibitors of ErbB2-induced invasion.

    abstract::ERBB2 amplification and overexpression are strongly associated with invasive cancer with high recurrence and poor prognosis. Enhanced ErbB2 signaling induces cysteine cathepsin B and L expression leading to their higher proteolytic activity (zFRase activity), which is crucial for the invasion of ErbB2-positive breast ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Brix DM,Rafn B,Bundgaard Clemmensen K,Andersen SH,Ambartsumian N,Jäättelä M,Kallunki T

    更新日期:2014-12-01 00:00:00

  • Theranostic applications of antibodies in oncology.

    abstract::Targeted therapies, including antibodies, are becoming increasingly important in cancer therapy. Important limitations, however, are that not every patient benefits from a specific antibody therapy and that responses could be short-lived due to acquired resistance. In addition, targeted therapies are quite expensive a...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Fleuren ED,Versleijen-Jonkers YM,Heskamp S,van Herpen CM,Oyen WJ,van der Graaf WT,Boerman OC

    更新日期:2014-06-01 00:00:00

  • Honokiol confers immunogenicity by dictating calreticulin exposure, activating ER stress and inhibiting epithelial-to-mesenchymal transition.

    abstract::Peritoneal dissemination is a major clinical obstacle in gastrointestinal cancer therapy, and it accounts for the majority of cancer-related mortality. Calreticulin (CRT) is over-expressed in gastric tumors and has been linked to poor prognosis. In this study, immunohistochemistry studies revealed that the up-regulati...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Liu SH,Lee WJ,Lai DW,Wu SM,Liu CY,Tien HR,Chiu CS,Peng YC,Jan YJ,Chao TH,Pan HC,Sheu ML

    更新日期:2015-04-01 00:00:00

  • Autophagy in tumour suppression and promotion.

    abstract::Autophagy, a well-described cellular mechanism for lysosomal degradation of cytoplasmic content, has emerged as a tumour suppression pathway. Recent evidence indicates that the tumour suppressor function of autophagy is mediated by scavenging of damaged oxidative organelles, thereby preventing accumulation of toxic ox...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Brech A,Ahlquist T,Lothe RA,Stenmark H

    更新日期:2009-08-01 00:00:00

  • Inhibition of doxorubicin-induced HER3-PI3K-AKT signalling enhances apoptosis of ovarian cancer cells.

    abstract::Resistance to chemotherapy is a serious problem for the successful treatment of ovarian cancer patients but signalling pathways that contribute to this chemoinsensitivity are largely unknown. We demonstrate that the chemotherapeutic drug doxorubicin induces activation of the HER3-PI3K-AKT signalling cascade in ovarian...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Bezler M,Hengstler JG,Ullrich A

    更新日期:2012-10-01 00:00:00

  • APE1/Ref-1 knockdown in pancreatic ductal adenocarcinoma - characterizing gene expression changes and identifying novel pathways using single-cell RNA sequencing.

    abstract::Apurinic/apyrimidinic endonuclease 1/redox factor-1 (APE1/Ref-1 or APE1) is a multifunctional protein that regulates numerous transcription factors associated with cancer-related pathways. Because APE1 is essential for cell viability, generation of APE1-knockout cell lines and determining a comprehensive list of genes...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Shah F,Goossens E,Atallah NM,Grimard M,Kelley MR,Fishel ML

    更新日期:2017-12-01 00:00:00

  • Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors.

    abstract::Targeted therapy for patients with HER2-positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor (ER) and HER2 expression has been proposed to play a key role in treatment failure, but little work...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Rye IH,Trinh A,Saetersdal AB,Nebdal D,Lingjaerde OC,Almendro V,Polyak K,Børresen-Dale AL,Helland Å,Markowetz F,Russnes HG

    更新日期:2018-11-01 00:00:00

  • FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome.

    abstract::Estrogen receptor-alpha (ERα)-positive breast cancer is often treated with antihormonal regimens. However, resistance to treatment is common, leading to metastatic disease. ERα activity requires the functional involvement of pioneer factors FOXA1 and GATA3, which enable ERα-chromatin binding and are crucial for ERα-dr...

    journal_title:Molecular oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Schrijver W,Schuurman K,van Rossum A,Droog M,Jeronimo C,Salta S,Henrique R,Wesseling J,Moelans C,Linn SC,van den Heuvel M,van Diest P,Zwart W

    更新日期:2018-11-01 00:00:00

  • Development of a circulating miRNA assay to monitor tumor burden: From mouse to man.

    abstract::Circulating miRNA stability suggests potential utility of miRNA based biomarkers to monitor tumor burden and/or progression, particularly in cancer types where serial biopsy is impractical. Assessment of miRNA specificity and sensitivity is challenging within the clinical setting. To address this, circulating miRNAs w...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Greystoke A,Ayub M,Rothwell DG,Morris D,Burt D,Hodgkinson CL,Morrow CJ,Smith N,Aung K,Valle J,Carter L,Blackhall F,Dive C,Brady G

    更新日期:2016-02-01 00:00:00

  • Prioritization of candidate cancer drugs based on a drug functional similarity network constructed by integrating pathway activities and drug activities.

    abstract::Due to the speed, efficiency, relative risk, and lower costs compared to traditional drug discovery, the prioritization of candidate drugs for repurposing against cancers of interest has attracted the attention of experts in recent years. Herein, we present a powerful computational approach, termed prioritization of c...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Di J,Zheng B,Kong Q,Jiang Y,Liu S,Yang Y,Han X,Sheng Y,Zhang Y,Cheng L,Han J

    更新日期:2019-10-01 00:00:00

  • Dual Constant Domain-Fab: A novel strategy to improve half-life and potency of a Met therapeutic antibody.

    abstract::The kinase receptor encoded by the Met oncogene is a sensible target for cancer therapy. The chimeric monovalent Fab fragment of the DN30 monoclonal antibody (MvDN30) has an odd mechanism of action, based on cell surface removal of Met via activation of specific plasma membrane proteases. However, the short half-life ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Cignetto S,Modica C,Chiriaco C,Fontani L,Milla P,Michieli P,Comoglio PM,Vigna E

    更新日期:2016-06-01 00:00:00

  • Comparative analysis of TTF-1 binding DNA regions in small-cell lung cancer and non-small-cell lung cancer.

    abstract::Thyroid transcription factor-1 (TTF-1, encoded by the NKX2-1 gene) is highly expressed in small-cell lung carcinoma (SCLC) and lung adenocarcinoma (LADC), but how its functional roles differ between SCLC and LADC remains to be elucidated. Here, we compared the genome-wide distributions of TTF-1 binding regions and the...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Hokari S,Tamura Y,Kaneda A,Katsura A,Morikawa M,Murai F,Ehata S,Tsutsumi S,Ishikawa Y,Aburatani H,Kikuchi T,Miyazono K,Koinuma D

    更新日期:2020-02-01 00:00:00

  • Heterogeneity of fatty acid metabolism in breast cancer cells underlies differential sensitivity to palmitate-induced apoptosis.

    abstract::Breast cancer (BrCa) metabolism is geared toward biomass synthesis and maintenance of reductive capacity. Changes in glucose and glutamine metabolism in BrCa have been widely reported, yet the contribution of fatty acids (FAs) in BrCa biology remains to be determined. We recently reported that adipocyte coculture alte...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Balaban S,Lee LS,Varney B,Aishah A,Gao Q,Shearer RF,Saunders DN,Grewal T,Hoy AJ

    更新日期:2018-09-01 00:00:00

  • Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491.

    abstract::The pivotal role of LYRIC/AEG-1 in malignant transformation, tumourigenesis and chemo-resistance has previously been demonstrated in different cell types and sub-cellular compartments. The localisation of LYRIC/AEG-1 appears crucial to its function and is regulated by three lysine-rich nuclear localisation signal regi...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Luxton HJ,Barnouin K,Kelly G,Hanrahan S,Totty N,Neal DE,Whitaker HC

    更新日期:2014-05-01 00:00:00

  • Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer.

    abstract::Infiltration of the tumor microenvironment by nerve fibers is an understudied aspect of breast carcinogenesis. In this study, the presence of nerve fibers was investigated in a cohort of 369 primary breast cancers (ductal carcinomas in situ, invasive ductal and lobular carcinomas) by immunohistochemistry for the neuro...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Pundavela J,Roselli S,Faulkner S,Attia J,Scott RJ,Thorne RF,Forbes JF,Bradshaw RA,Walker MM,Jobling P,Hondermarck H

    更新日期:2015-10-01 00:00:00

  • The interaction of PKN3 with RhoC promotes malignant growth.

    abstract::PKN3 is an AGC-family protein kinase implicated in growth of metastatic prostate cancer cells with phosphoinositide 3-kinase pathway deregulation. The molecular mechanism, however, by which PKN3 contributes to malignant growth and tumorigenesis is not well understood. Using orthotopic mouse tumor models, we now show t...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Unsal-Kacmaz K,Ragunathan S,Rosfjord E,Dann S,Upeslacis E,Grillo M,Hernandez R,Mack F,Klippel A

    更新日期:2012-06-01 00:00:00

  • Dying tumor cells stimulate proliferation of living tumor cells via caspase-dependent protein kinase Cδ activation in pancreatic ductal adenocarcinoma.

    abstract::Pancreatic cancer is one of the most lethal human cancers, and radiotherapy is often implemented for locally advanced pancreatic ductal adenocarcinoma. Tumor cell repopulation is a major challenge in treating cancers after radiotherapy. In order to address the problem of tumor repopulation, our previous studies have d...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Cheng J,Tian L,Ma J,Gong Y,Zhang Z,Chen Z,Xu B,Xiong H,Li C,Huang Q

    更新日期:2015-01-01 00:00:00

  • The epigenetics of breast cancer.

    abstract::Epigenetic changes can be defined as stable molecular alterations of a cellular phenotype such as the gene expression profile of a cell that are heritable during somatic cell divisions (and sometimes germ line transmissions) but do not involve changes of the DNA sequence itself. Epigenetic phenomena are mediated by se...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Jovanovic J,Rønneberg JA,Tost J,Kristensen V

    更新日期:2010-06-01 00:00:00

  • Heat-shock protein 27 (HSP27, HSPB1) is synthetic lethal to cells with oncogenic activation of MET, EGFR and BRAF.

    abstract::The small heat-shock protein of 27 kDa (HSP27) is highly expressed in many cancers and is associated with aggressive tumour behaviour, metastasis, poor prognosis and resistance to chemotherapy. We aimed at assessing the role of HSP27 in modulating responses to target therapies. We selected several oncogene-addicted ca...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Konda JD,Olivero M,Musiani D,Lamba S,Di Renzo MF

    更新日期:2017-06-01 00:00:00

  • Stromal SPOCK1 supports invasive pancreatic cancer growth.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is marked by an abundant stromal deposition. This stroma is suspected to harbor both tumor-promoting and tumor-suppressing properties. This is underscored by the disappointing results of stroma targeting in clinical studies. Given the complexity of tumor-stroma interaction in PD...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Veenstra VL,Damhofer H,Waasdorp C,Steins A,Kocher HM,Medema JP,van Laarhoven HW,Bijlsma MF

    更新日期:2017-08-01 00:00:00

  • Short telomere length in peripheral blood leukocyte predicts poor prognosis and indicates an immunosuppressive phenotype in gastric cancer patients.

    abstract::Compelling evidences indicate that relative telomere length (RTL) in peripheral blood leukocytes (PBLs) can predict the clinical outcome of several cancers. However, to date, the prognostic value of leukocyte RTL in gastric cancer (GC) patients has not been explored. In this study, relative telomere length (RTL) in pe...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Qu F,Li R,He X,Li Q,Xie S,Gong L,Ji G,Lu J,Bao G

    更新日期:2015-03-01 00:00:00

  • Recurrence-associated gene signature optimizes recurrence-free survival prediction of colorectal cancer.

    abstract::High throughput gene expression profiling has showed great promise in providing insight into molecular mechanisms. Metastasis-related mRNAs may potentially enrich genes with the ability to predict cancer recurrence, therefore we attempted to build a recurrence-associated gene signature to improve prognostic prediction...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Tian X,Zhu X,Yan T,Yu C,Shen C,Hu Y,Hong J,Chen H,Fang JY

    更新日期:2017-11-01 00:00:00

  • Circulating tumor cell detection and single-cell analysis using an integrated workflow based on ChimeraX® -i120 Platform: A prospective study.

    abstract::Circulating tumor cell (CTC) analysis holds great potential to be a noninvasive solution for clinical cancer management. A complete workflow that combined CTC detection and single-cell molecular analysis is required. We developed the ChimeraX® -i120 platform to facilitate negative enrichment, immunofluorescent labelin...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Wang PX,Sun YF,Jin WX,Cheng JW,Peng HX,Xu Y,Zhou KQ,Chen LM,Huang K,Wu SY,Hu B,Zhang ZF,Guo W,Cao Y,Zhou J,Fan J,Yang XR

    更新日期:2020-12-10 00:00:00

  • Genotoxic stress modulates CDC25C phosphatase alternative splicing in human breast cancer cell lines.

    abstract::CDC25 (cell division cycle 25) phosphatases are essential for cell cycle control under normal conditions and in response to DNA damage. They are represented by three isoforms, CDC25A, B and C, each of them being submitted to an alternative splicing mechanism. Alternative splicing of many genes is affected in response ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Albert H,Battaglia E,Monteiro C,Bagrel D

    更新日期:2012-10-01 00:00:00

  • The brain acid-soluble protein 1 (BASP1) interferes with the oncogenic capacity of MYC and its binding to calmodulin.

    abstract::The MYC protein is a transcription factor with oncogenic potential controlling fundamental cellular processes such as cell proliferation, metabolism, differentiation, and apoptosis. The MYC gene is a major cancer driver, and elevated MYC protein levels are a hallmark of most human cancers. We have previously shown tha...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Hartl M,Puglisi K,Nist A,Raffeiner P,Bister K

    更新日期:2020-03-01 00:00:00