当前位置： SCI文献检索 > MEDICAL SCIENCE MONITOR期刊下所有文献 > Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells.

Cucurbitacin B Inhibits the Hippo-YAP Signaling Pathway and Exerts Anticancer Activity in Colorectal Cancer Cells.

Abstract：

:BACKGROUND Colorectal carcinoma (CRC) is one of the most frequently diagnosed malignancies. Cucurbitacin B (CuB) is a natural compound isolated from herbs and shows anticancer activity in several cancers. MATERIAL AND METHODS Here, we analyzed the effects of different CuB concentrations on the proliferative and invasive behaviors of CRC cells using MTT, clonogenic assay, Transwell invasion, and wound healing assays. Flow cytometry was performed to measure the apoptotic effects of CuB on CRC cells. Western blot and real-time PCR were used to investigate the expression of apoptosis and Hippo-YAP signaling pathway proteins. RESULTS CuB inhibited the proliferation and invasion of CRC cells while promoting apoptosis. In addition, the Western blot and real-time PCR results indicated that CuB suppressed YAP expression and its downstream target genes Cyr 61 and c-Myc in CRC cells. To assess the underlying mechanism, we investigated the upstream regulating factor LATS1, and the results revealed that CuB upregulated LATS1 expression in CRC cells. CONCLUSIONS In conclusion, our findings uncovered a novel therapeutic mechanism of CuB and suggest that there is therapeutic potential and feasibility in developing novel YAP inhibitors for cancer treatment.

journal_name

Med Sci Monit

journal_title

Medical science monitor : international medical journal of experimental and clinical research

authors

Chai Y,Xiang K,Wu Y,Zhang T,Liu Y,Liu X,Zhen W,Si Y

doi

10.12659/MSM.911594

subject

Has Abstract

pub_date

2018-12-19 00:00:00

pages

9251-9258

eissn

1234-1010

issn

1643-3750

pii

911594

journal_volume

24

pub_type

杂志文章

相关文献

MEDICAL SCIENCE MONITOR文献大全
  • Underlying Genes Involved in Atherosclerotic Macrophages: Insights from Microarray Data Mining.

    abstract：:BACKGROUND In an atherosclerotic artery wall, monocyte-derived macrophages are the principal mediators that respond to pathogens and inflammation. The present study aimed to investigate potential genetic changes in gene expression between normal tissue-resident macrophages and atherosclerotic macrophages in the human ...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.917068

    authors： Wang W,Zhang K,Zhang H,Li M,Zhao Y,Wang B,Xin W,Yang W,Zhang J,Yue S,Yang X

    更新日期：2019-12-25 00:00:00

  • Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases.

    abstract：:Periodontal diseases are characterized by pathological destruction of extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) are a significant part of the degradation of ECM. However, the regulation of MMPs expression level in periodontal diseases is as yet undetermined. RECK (reversion-in...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/msm.896546

    authors： Liu N,Zhou B,Zhu G

    更新日期：2016-06-07 00:00:00

  • Successful treatment of a critical burn patient with obstinate hyperglycemia and septic shock from pan-drug-resistant strains.

    abstract：BACKGROUND:The treatment of critical burn patients involves fluid resuscitation, homeostasis, prevention of infection, support and maintenance of organ functions, nutritional support, and wound repair. Correct management of these problems is a fierce challenge facing burn clinicians. This report presents a critical bur...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：

    authors： Xiao SC,Zhu SH,Xia ZF,Ma B,Cheng DS

    更新日期：2009-11-01 00:00:00

  • Minimally Invasive Unilateral vs. Bilateral Pedicle Screw Fixation and Lumbar Interbody Fusion in Treatment of Multi-Segment Lumbar Degenerative Disorders.

    abstract：:BACKGROUND The choice for instrumentation with minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in treatment of degenerative lumbar disorders (DLD) remains controversial. The goal of this study was to investigate clinical outcomes in consecutive patients with multi-segment DLD treated with unilater...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章,收录出版

    doi：10.12659/msm.894890

    authors： Liu X,Li G,Wang J,Zhang H

    更新日期：2015-11-25 00:00:00

  • Ripasudil Attenuates Lipopolysaccharide (LPS)-Mediated Apoptosis and Inflammation in Pulmonary Microvascular Endothelial Cells via ROCK2/eNOS Signaling.

    abstract：:BACKGROUND Microvascular endothelial inflammation and apoptosis are responsible for septic acute lung injury (ALI). Ripasudil is a novel Rho/Rho kinase (ROCK) inhibitor which shows therapeutic effects on several vascular diseases. The aim of this study was to investigate the protective effects and correlated molecular...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.910184

    authors： Yang J,Ruan F,Zheng Z

    更新日期：2018-05-16 00:00:00

  • Olig2 Silence Ameliorates Cuprizone-Induced Schizophrenia-Like Symptoms in Mice.

    abstract：:BACKGROUND The pathogenesis of schizophrenia is complex and oligodendrocyte abnormality is an important component of the pathogenesis found in schizophrenia. This study was designed to evaluate the function of olig2 in cuprizone-induced schizophrenia-like symptoms in a mouse model, and to assess the related mechanisms...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/msm.903842

    authors： Liu H,Zhai J,Wang B,Fang M

    更新日期：2017-10-09 00:00:00

  • Apoptosis Factors of Lens Epithelial Cells Responsible for Cataractogenesis in Vitrectomized Eyes with Silicone Oil Tamponade.

    abstract：BACKGROUND:The aim of this study was to determine the expression of apoptotic factors Bax, Bcl-2, and Caspase-3 in lens epithelial cells (LECs) from cataracts secondary to pars plana vitrectomy with silicone oil (SO) tamponade. We also investigated the impact of SO emulsification on the expression of apoptotic factors....

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/msm.897630

    authors： Zhu L,Zhao K,Lou D

    更新日期：2016-03-09 00:00:00

  • Value of Antral Nodularity for the Diagnosis of Helicobacter pylori Infection in Children.

    abstract：BACKGROUND:The aim of this study was to confirm the role of antral nodularity in the diagnosis of Helicobacter pylori (H. pylori) infection in children. MATERIAL AND METHODS:This prospective study included 107 children (58 male; 54.2%), between the ages of 3 and 18 years, infected with H. pylori, which was confirmed i...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.893467

    authors： Łazowska-Przeorek I,Kotowska M,Banasiuk M,Karolewska-Bochenek K,Banaszkiewicz A,Gawrońska A,Albrecht P

    更新日期：2015-06-24 00:00:00

  • Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway.

    abstract：:BACKGROUND Sepsis combined with myocardial injury is an important cause of septic shock and multiple organ failure. However, the molecular mechanism of sepsis-induced myocardial dysfunction has not yet been thoroughly studied. Resveratrol has been an important research topic due its organ-protection function, but the ...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.918369

    authors： Shang X,Lin K,Yu R,Zhu P,Zhang Y,Wang L,Xu J,Chen K

    更新日期：2019-12-06 00:00:00

  • Mean Platelet Volume, C-Reactive Protein, and Prognosis in Patients with Acute Ischemic Stroke Following Intravenous Thrombolytic Treatment.

    abstract：:BACKGROUND The aim of this study was to investigate the association between mean platelet volume (MPV), C-reactive protein (CRP), and prognosis in patients with acute ischemic stroke (AIS) following intravenous (IV) thrombolytic treatment. MATERIAL AND METHODS A retrospective clinical study included 129 patients withi...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.906813

    authors： İnanç Y,Giray S,İnanç Y

    更新日期：2018-06-05 00:00:00

  • Low dose morphine adjuvant therapy for enhanced efficacy of antipsychotic drug action: potential involvement of endogenous morphine in the pathophysiology of schizophrenia.

    abstract：:Major thematic threads linking extensive preclinical and clinical efforts have established a working mechanistic scheme whereby atypical antipsychotic drugs ameliorate negative DSM IV diagnostic criteria by effecting relatively potent blockade of serotonin (5-HT)(2A) receptors coupled with weaker antagonism of dopamin...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/msm.883192

    authors： Stefano GB,Králíčková M,Ptacek R,Kuzelova H,Esch T,Kream RM

    更新日期：2012-07-01 00:00:00

  • Role of Sevoflurane on Natural Killer Group 2, Member D-Mediated Immune Response in Non-Small-Cell Lung Cancer: An In Vitro Study.

    abstract：:BACKGROUND The purpose of this study was to investigate the effects of sevoflurane on cancer immunosurveillance and metastasis in non-small-cell lung cancer (NSCLC). MATERIAL AND METHODS NCI-H23 cells, a human NSCLC cell line, were incubated with or without sevoflurane at the concentrations of 0, 12.5, 25, 50, 100, an...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.926395

    authors： Jeon S,Kim HK,Kwon JY,Baek SH,Ri HS,Choi HJ,Cho HR,Lee YS,Kim JY,Kim J,Bae J,Lee HJ

    更新日期：2020-11-03 00:00:00

  • Effect of Obesity and Leptin Level on Migraineurs.

    abstract：BACKGROUND:The aim of this study was to analyze the effects of obesity and leptin levels on patients with migraine, and to observe the change of leptin levels in migraineurs. MATERIAL AND METHODS:We enrolled 52 migraine patients from the Headache Clinic in Shandong Provincial Hospital into a randomized controlled tria...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/msm.894666

    authors： Ligong Z,Jinjin Q,Chunfu C,Congcong L,Xiaojun D

    更新日期：2015-10-28 00:00:00

  • Atorvastatin Induces Hepatotoxicity in Diabetic Rats via Oxidative Stress, Inflammation, and Anti-Apoptotic Pathway.

    abstract：:BACKGROUND Patients with diabetes mellitus (DM) commonly receive statins to suppress vulnerability to adverse cardiovascular events. It has been clinically proven that hepatotoxicity is one of the most severe adverse effects of statins. MATERIAL AND METHODS We constructed diabetic rat models by feeding rats with high-...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.915790

    authors： Zeng H,Liu Z

    更新日期：2019-08-17 00:00:00

  • Risk factors for morbidity following liver surgery.

    abstract：:The aim of this study is to define risk factors for severe complications following anatomical liver resections. The study material consists of the first 50 patients (26 women, 24 men, at mean age 50.6 years) treated at 3rd Department of Surgery 2nd Faculty of Medicine, Medical University in Warsaw. The indications for...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：

    authors： Szubert A,Sarzyński J,Biejat Z,Uryzek M,Grous A,Kowalik I,Polański JA

    更新日期：2001-05-01 00:00:00

  • Effect of hydroxyethyl starch (HAES) on degree and kinetics of erythrocyte aggregation studied with dielectric spectroscopy method.

    abstract：BACKGROUND:Colloidal fluids, e.g. hydroxyethyl starch (HAES), used as blood plasma substitutes during acute controlled normovolemic hemodilution may cause erythrocyte aggregation. The aim of the presented study was to assess the degree and rate of erythrocyte aggregation in the media containing different concentrations...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：

    authors： Jaroszyński W,Keslinka E,Wujtewicz M,Suchorzewska J,Kwiatkowski B

    更新日期：2002-07-01 00:00:00

  • Repair of Concomitant Incisional and Parastomal Hernias Using a Hybrid Technique: A Series of 32 Patients.

    abstract：BACKGROUND:Concomitant incisional and parastomal hernias is a challenging condition. We used a hybrid technique of sublay and onlay to treat patients with this condition. MATERIAL AND METHODS:The clinical data of 32 consecutive patients treated from February 2008 to April 2014 for concomitant incisional and parastomal...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.893838

    authors： Zhu X,Tian W,Li J,Sun P,Pei L,Wang S

    更新日期：2015-07-17 00:00:00

  • Molecular Mechanisms of Mild and Severe Pneumonia: Insights from RNA Sequencing.

    abstract：:BACKGROUND This study aimed to uncover the molecular mechanisms underlying mild and severe pneumonia by use of mRNA sequencing (RNA-seq). MATERIAL AND METHODS RNA was extracted from the peripheral blood of patients with mild pneumonia, severe pneumonia, and healthy controls. Sequencing was performed on the HiSeq4000 p...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/msm.900782

    authors： Huang S,Feng C,Chen L,Huang Z,Zhou X,Li B,Wang LL,Chen W,Lv FQ,Li TS

    更新日期：2017-04-06 00:00:00

  • A cry for help, do not omit the signs. Dermatitis artefacta--psychiatric problems in dermatological diseases (a review of 5 cases).

    abstract：BACKGROUND:Dermatitis artefacta (DA) is a dermatologicopsychiatric illness that is a conscious self-infliction of lesions to accessible regions of the body. The lesions usually do not resemble those of any know skin disease and there are no specific diagnostic tests to recognize them. This makes dermatitis artefacta a ...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章,评审

    doi：10.12659/msm.883474

    authors： Wojewoda K,Brenner J,Kąkol M,Naesström M,Cubała WJ,Kozicka D,Nowicki R,Sokołowska-Wojdyło M,Barańska-Rybak W

    更新日期：2012-10-01 00:00:00

  • Interferon alpha for eradication of HCV and remission of chronic hepatitis in children.

    abstract：UNLABELLED:Thirty two children (8 girls and 32 boys), aged 4-14, with chronic hepatitis C were treated with interferon alpha at a dose of 3 MU or 5 MU, given times weekly for 6 months. Five children (16%) were complete responders (defined as disappearance of viremia), none of them relapsed, 6 (19%) were partial respond...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 临床试验,杂志文章

    doi：

    authors： Majda-Stanisławska E,Szaflik I,Omulecka A

    更新日期：2000-11-01 00:00:00

  • Effects of sleep deprivation on action potential and transient outward potassium current in ventricular myocytes in rats.

    abstract：BACKGROUND:Sleep deprivation contributes to the development and recurrence of ventricular arrhythmias. However, the electrophysiological changes in ventricular myocytes in sleep deprivation are still unknown. MATERIAL AND METHODS:Sleep deprivation was induced by modified multiple platform technique. Fifty rats were as...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.893414

    authors： Fang Z,Ren YP,Lu CY,Li Y,Xu Q,Peng L,Fan YY

    更新日期：2015-02-19 00:00:00

  • Effect of Intensive Blood Pressure Control on Carotid Morphology and Hemodynamics in Chinese Patients with Hyperhomocysteinemia-Type Hypertension and High Risk of Stroke.

    abstract：:BACKGROUND Different blood pressure targets should be formulated for different groups of people. This study aimed to assess the effectiveness of intensive blood control in improving the carotid morphology and hemodynamics in Chinese patients with hyperhomocysteinemia-type hypertension and high risk of stroke. MATERIAL...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.914482

    authors： Wu W,Liu J,Li A,Li J,Yang Y,Ye X,Zheng J

    更新日期：2019-08-01 00:00:00

  • High Expression of Serine Hydroxymethyltransferase 2 Indicates Poor Prognosis of Gastric Cancer Patients.

    abstract：:BACKGROUND Serine hydroxymethyltransferase (SHMT) is the enzyme that catalyzes the reversible conversion of serine to glycine and tetrahydrofolate-bound one-carbon unit. Upregulation of SHMT2 has been observed in a variety of cancers, but the expression profile and clinical value of SHMT2 in gastric cancer (GC) are st...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.917435

    authors： Shi H,Fang X,Li Y,Zhang Y

    更新日期：2019-10-03 00:00:00

  • Inhibition of microRNA-141-3p Reduces Hypoxia-Induced Apoptosis in H9c2 Rat Cardiomyocytes by Activating the RP105-Dependent PI3K/AKT Signaling Pathway.

    abstract：:BACKGROUND Oxidative stress in myocardial ischemia results in cardiomyocyte apoptosis. The expression of microRNA-141-3p (miR-141-3p) and the 105 kD toll-like receptor protein (TLR), RP105, have been identified in cardiomyocytes in vitro. This study aimed to investigate the effects of hypoxia in H9c2 rat cardiomyoblas...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.916361

    authors： Qin Q,Cui L,Zhou Z,Zhang Z,Wang Y,Zhou C

    更新日期：2019-09-18 00:00:00

  • Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.

    abstract：:BACKGROUND Emerging evidence suggests the involvement of Reelin in chemoresistance in various cancers. However, its function in cisplatin (DDP) sensitivity of non-small cell lung cancer (NSCLC) needs to be investigated. MATERIAL AND METHODS Reelin expression in cisplatin-sensitive A549 cells and cisplatin-resistant NS...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.925298

    authors： Li JM,Yang F,Li J,Yuan WQ,Wang H,Luo YQ

    更新日期：2020-08-07 00:00:00

  • Chlamydial Plasmid-Encoded Protein pGP3 Inhibits Development of Psoriasis-Like Lesions in Mice.

    abstract：:BACKGROUND The anti-microbial protein cathelicidin LL-37 plays an important role in the pathogenesis of psoriasis by inducing inflammation. Our previous study showed that the chlamydial plasmid-encoded protein pGP3 forms a stable complex with LL-37 to neutralize its pro-inflammatory activity. Here, we explored whether...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.910472

    authors： Hou S,Xu R,Zhu C,Shan S,Han L,Wang H

    更新日期：2018-07-25 00:00:00

  • Platinum - sensitive relapsed epithelial ovarian cancer: not all the patients benefit from reinduction with carboplatin and paclitaxel.

    abstract：BACKGROUND:It is widely accepted that patients with ovarian cancer relapsing 6 to 12 months after completion of a platinum-based regimen are considered to be partially platinum-sensitive. The aim of this study was to evaluate and correlate the efficacy and toxicity of reinduction with paclitaxel-carboplatin in a platin...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：

    authors： Milović-Kovačević M,Stamatovic L,Popov I,Radošević-Jelić L,Kezic I

    更新日期：2010-11-01 00:00:00

  • Nomogram for Predicting Risk of Intestinal Complications After Colorectal Cancer Surgery.

    abstract：:BACKGROUND Intestinal complications are a major cause of morbidity after colorectal cancer surgery. This study aimed to develop an effective nomogram for predicting risk of intestinal complications following colorectal cancer surgery. MATERIAL AND METHODS We retrospectively analyzed 1876 patients who underwent colorec...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/MSM.915692

    authors： Jiang HH,Dong XL,Tang X,Li AJ,Chang Y,Li HG,Chen Y,Zhang ZY,Tang EJ,Lin MB

    更新日期：2019-03-21 00:00:00

  • Changes in chemiluminescence of whole blood of COPD patients treated with Hypoxen and effects of C₆₀ fullerenes on blood chemiluminescence.

    abstract：BACKGROUND:Chronic obstructive pulmonary disease (COPD) is an inflammatory disease associated with reactive oxygen species (ROS) production. The aim of this study was to evaluate the effect of Hypoxen treatment and the effect of HyFnC₆₀ on ROS production in patients' blood. MATERIAL/METHODS:ROS production in blood was...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 临床试验,杂志文章

    doi：10.12659/msm.882460

    authors： Novikov KN,Berdnikova NG,Novikov AK,Lyusina OY,Muhitova OG,Yablonskaya OI,Minh HD,Voeikov VL

    更新日期：2012-02-01 00:00:00

  • Postoperative Adverse Cardiovascular Events Associated with Leptin and Adverse Age After Elective Major Non-Cardiac Surgery: An Asian Single-Center Study.

    abstract：:BACKGROUND The postoperative adverse cardiovascular events (PACE) after surgery can result in prolonged length of stay and poorer prognosis. The purpose of this Asian single-center study was to investigate the potential predicative role of leptin for PACE in elderly patients undergoing major non-cardiac surgery. MATER...

    journal_title：Medical science monitor : international medical journal of experimental and clinical research

    pub_type： 杂志文章

    doi：10.12659/msm.906797

    authors： Gu Z,Sun C,Xiang D

    更新日期：2018-04-09 00:00:00