Reelin Promotes Cisplatin Resistance by Induction of Epithelial-Mesenchymal Transition via p38/GSK3β/Snail Signaling in Non-Small Cell Lung Cancer.

abstract：BACKGROUND:With a prevalence of about 1:500 to 1:1,000, autosomal dominant polycystic kidney disease (ADPKD) often causes renal failure, with many serious complications. However, there is no Food and Drug Administration (FDA) approved therapy available. MATERIAL/METHODS:MiR-199a-5p level in ADPKD patient samples, rat ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Sun L,Zhu J,Wu M,Sun H,Zhou C,Fu L,Xu C,Mei C

更新日期：2015-01-15 00:00:00

abstract：:BACKGROUND Laryngeal cancer is one of the most common malignant tumors of the head and neck. Natural compounds in traditional Chinese medicine provide many valuable potential compounds for tumor chemotherapy. Esculetin, a coumarin derivative from several herbs, inhibits proliferation of many types of cancer cells, but...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang G,Xu Y,Zhou HF

更新日期：2019-10-20 00:00:00

abstract：:BACKGROUND Hypertension and diabetes mellitus (DM) are both the risk factors for cancer. This study aimed to explore the prognostic value of fasting blood glucose (FBG) and hypertension in type 2 DM (T2DM) patients with advanced non-small cell lung cancer (NSCLC) who had received chemotherapy treatment. MATERIAL AND M...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zeng X,Zeng D,Cheng J,Xu C,Sun C,Long H,Zhu B

更新日期：2020-04-19 00:00:00

abstract：:Copper (Cu) is an essential trace element for cell metabolism as a cofactor to many key metabolic enzymes. Numerous physiological processes rely on the adequate and timely transport of copper ions mediated by copper-transporting ATPases (Cu-ATPases), which are essential for human cell growth and development. Inherited...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang Y,Li M,Yao Q,Chen C

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:It has been suggested that adherence to a Mediterranean diet reduces all causes of mortality, especially death rates due to coronary heart disease. In this review we summarize the findings of observational studies that evaluated the effect of the Mediterranean dietary pattern in the primary and secondary pre...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Panagiotakos DB,Pitsavos C,Polychronopoulos E,Chrysohoou C,Zampelas A,Trichopoulou A

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:The pathogenesis of chronic hepatitis induced by virus C as well as the mechanisms responsible for the elimination of this infection are still not fully understood. The course of HCV infection depends on the extent to which both specific and non-specific response is induced. One of the treatment methods appl...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Woźniakowska-Gesicka T,Wiśniewska-Ligier M,Kupś J

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Changing a central venous catheter occlusive dressing on a twice-weekly basis is usually recommended in hemato-oncological patients. A longer interval is believed to give rise to infections. However, frequent dressing changes might cause local cutaneous damage. MATERIAL/METHODS:Local cutaneous damage and in...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Vokurka S,Bystricka E,Visokaiova M,Scudlova J

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Our study is aimed to 1) clarify the vitamin D status in Uygur and Kazak ethnic populations and 2) elucidate the relationship between 14 SNPs (in 5 vitamin D-related genes) and vitamin D deficiency in these 2 ethnic populations. MATERIAL AND METHODS:A multistage-cluster sampling survey was carried out for r...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu X,Mao J,Zhang M,Liu H,Li H,Lei H,Han L,Gao M

更新日期：2015-07-07 00:00:00

abstract：:BACKGROUND Protein kinase C zeta (PKC ζ) plays an important role in insulin induced glycometabolism and insulin receptor (IR) associated signaling pathways. The full activation of PKC ζ depends on its translocation from cytosol to membrane and phosphorylation at Thr410. However, the mechanism of PKC ζ activation remai...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yingying X,Caijuan W,Yenan Y,Yuqin T,Xueqin C,Zhongming W

更新日期：2017-07-28 00:00:00

abstract：BACKGROUND:The aim of this study was to confirm the role of antral nodularity in the diagnosis of Helicobacter pylori (H. pylori) infection in children. MATERIAL AND METHODS:This prospective study included 107 children (58 male; 54.2%), between the ages of 3 and 18 years, infected with H. pylori, which was confirmed i...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Łazowska-Przeorek I,Kotowska M,Banasiuk M,Karolewska-Bochenek K,Banaszkiewicz A,Gawrońska A,Albrecht P

更新日期：2015-06-24 00:00:00

abstract：BACKGROUND:All Staphylococcus aureus isolated during 2003-2006 at a university hospital in Thessalia, central Greece, from ulcerative upper-extremity infections were tested for the presence of PVL gene and for possible clonal relationship to validate the role of PVL toxin in the clinical features of these infections an...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Dailiana ZH,Rigopoulos N,Varitimidis SE,Poultsides L,Petinaki E,Malizos KN

更新日期：2008-10-01 00:00:00

abstract：:BACKGROUND Catheter radiofrequency ablation for typical atrial flutter is considered to be safe and effective. However, atrial fibrillation (AF) following cavotricuspid isthmus ablation for atrial flutter has been reported in patients without a previous history of AF, which has implications for the decision to use ora...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Warchoł I,Bińkowski BJ,Kucejko T,Sobiczewska J,Lubiński A

更新日期：2019-05-05 00:00:00

abstract：BACKGROUND:Advances in perinatal medicine have required an extensive knowledge of fetal aorto-iliac measurements. The present study was performed to compile reference data for dimensions of the abdominal aorta at varying gestational ages. MATERIAL/METHODS:Using the methods of anatomical dissection, digital-image analy...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Szpinda M,Szpinda A,Woźniak A,Mila-Kierzenkowska C,Kosiński A,Grzybiak M

更新日期：2012-10-01 00:00:00

abstract：:BACKGROUND The factors associated with osteoporosis are poorly understood in the Chinese population. This study aimed to examine the factors associated with osteoporosis and with fractures in a Chinese elderly population. MATERIAL AND METHODS This was a cross-sectional study of elderly people living in Tianjin between...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang Y,Ding H,Wang X,Wei Z,Feng S

更新日期：2019-07-27 00:00:00

abstract：BACKGROUND:Risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), may be increased in liver cirrhosis. We conducted a single-center study to explore the epidemiology, risk factors, and in-hospital mortality of VTE in Chinese patients with liver cirrhosis. MATERIAL/METHO...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang X,Qi X,De Stefano V,Hou F,Ning Z,Zhao J,Peng Y,Li J,Deng H,Li H,Guo X

更新日期：2016-03-24 00:00:00

abstract：BACKGROUND:Psychological disturbances are frequent in Crohn's disease (CD) patients. However, epidemiological studies of non-western CD populations are limited and may be confounded by genetic and disease-related influences. The aim of this study was to assess the prevalence and risk factors for depression and symptoms...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Brandi MT,Ribeiro MS,Chebli LA,Franco MB,Pinto AL,Gaburri PD,Zanini A,Chebli JM

更新日期：2009-08-01 00:00:00

abstract：BACKGROUND:The aim was to reveal the mechanism of hemolysis-induced acute pancreatitis and to evaluate the role of heme and heme oxygenase activity in inducing pancreatic inflammation in an experimental hemolysis model. MATERIAL/METHODS:Hemolytic anemia was induced in rats by intraperitoneal injection of 60 mg/kg acet...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Saruç M,Yuceyar H,Turkel N,Ozutemiz O,Tuzcuoglu I,Ayhan S,Yuce G,Coker I,Huseyino A

更新日期：2007-03-01 00:00:00

abstract：:BACKGROUND Lung cancer is among the most common causes of cancer-related deaths worldwide, but its tumorigenic mechanisms are largely unknown. Long non-coding RNAs (LncRNAs) have been shown to have significant roles in multiple cancers. Herein, we aimed to elucidate the detailed effects of a newly-discovered LncRNA, t...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Su P,Wang F,Qi B,Wang T,Zhang S

更新日期：2017-04-11 00:00:00

abstract：BACKGROUND:High-frequency oscillations (ripples) are proposed to be involved in memory consolidation. Ripple oscillations persist in the absence of chemical synaptic transmission and inhibitors of gapjunctions were shown to block high-frequency oscillations in hippocampal slices. In this study we investigated the effec...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Hosseinzadeh H,Asl MN,Parvardeh S,Tagi Mansouri SM

更新日期：2005-03-01 00:00:00

abstract：:BACKGROUND The World Health Organization (WHO) histological classification for gastric cancer is widely accepted and used. However, its impact on predicting lymph node metastasis and recurrence in early gastric cancer (EGC) is not well studied. MATERIAL AND METHODS From 1987 to 2005, 2873 EGC patients with known WHO h...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Lai JF,Xu WN,Noh SH,Lu WQ

更新日期：2016-09-05 00:00:00

abstract：:BACKGROUND Sepsis causes the highest mortality in non-cardiovascular intensive care units worldwide. Recent research has demonstrated that the late phase of sepsis, characterized as septic immunosuppression, is the central pathophysiological mechanism of immune dysfunction. Investigating the suppressive mechanism of i...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhou Y,Xia Q,Wang X,Fu S

更新日期：2018-07-11 00:00:00

abstract：INTRODUCTION:Tumors arising in the lungs are in over 90% bronchogenic carcinomas that have been attributed predominantly to tobacco smoking, asbestos or air pollution but little is known about endogenous factors that could facilitate their development and invasiveness. The lungs originate embryologically from the same ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gocyk W,Nikliński T,Olechnowicz H,Duda A,Bielański W,Konturek PC,Konturek SJ

更新日期：2000-11-01 00:00:00

abstract：:BACKGROUND Therapeutic evaluation of 3-dimensional conformal radiotherapy (3DCRT) is rarely reported for non-resectable hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). The aim of this study was to determine the value of contrast-enhanced ultrasound (CEUS) in evaluating the therapeutic response o...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li H,Liu J,Chen M,Li H,Long L

更新日期：2018-11-14 00:00:00

abstract：:Most surgeons, ourselves including, use retrograde cardioplegia in numerable operations in cardiac surgery. It is believed to be not only supplementary to antegrade, but also a unique alternative in special complicated cases. Regarding CABGs (coronary artery bypass grafts), many authors advocate its routine use togeth...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kouerinis IA,Manopoulos CG,Zografos GC,Apostolakis EI,Tsilimingas NB,Argiriou ME,Gorgoulis VG,Dedeilias PG,Tsoukas A,Bolos K,Tsangaris SG

更新日期：2006-11-01 00:00:00

abstract：:BACKGROUND Ethnic background may affect the prevalence of nasal bone absence and the length of the nasal bone. This study aimed to elucidate the significance of absent or hypoplastic fetal nasal bone in the Chinese Han population and to formulate an optimal management plan for patients age 35 or older in cases of isol...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen Y,Lv M,Dong T,Chen Q,Qian Y,Zhao B,Luo Q

更新日期：2020-07-26 00:00:00

abstract：:BACKGROUND Phenylketonuria (PKU) is an inborn error of metabolism caused by mutations in the phenylalanine hydroxylase (PAH) gene. When untreated, PKU leads to a significant intellectual deficiency. Although early initiation of dietary therapy allows normal cognitive development, low adherence to treatment may result ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Vieira Neto E,Maia Filho HS,Monteiro CB,Carvalho LM,da Cruz TS,de Barros BV,Ribeiro MG

更新日期：2018-10-30 00:00:00

abstract：:BACKGROUND To explore the effect of hypoxic preconditioning on the JAK/STAT3 signaling pathway and its effect on trophoblast cell viability and angiogenesis in preeclampsia (PE). MATERIAL AND METHODS Placental tissues from normal pregnant women and PE patients were collected to detect the expression levels of JAK and ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu C,Li X,Guo P,Wang J

更新日期：2017-10-14 00:00:00

abstract：:We report the case of a 70-year-old woman with ST-segment elevation myocardial infarction of the anterior wall, complicated by ventricular septal rupture (two septal defects--VSDs) with symptoms of cardiogenic shock. After 6 weeks of conservative treatment with inotropes and intra-aortic balloon support, the patient u...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Stępień-Wojno M,Konopka A,Marona M,Greszata L,Dyk W,Stępińska J

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Several studies have reported the association of PTPN2 gene with type 1 diabetes mellitus (T1DM) in many populations but not in the Chinese Han population. Therefore, the goal of our study was to replicate the reported association between 2 single-nucleotide polymorphisms (SNPs; rs478582 and rs2542151) in th...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Peng H,Li J,Chen X,Zhou X,Zhu W,Li F

更新日期：2015-09-07 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate susceptibility-weighted imaging (SWI) signal changes in different brain regions in a rabbit model of acute hemorrhagic anemia. MATERIAL/METHODS:Ten New Zealand white rabbits were used for construction of the model of acute hemorrhagic anemia. Signal intensities of SW...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xia J,Xie N,Feng Y,Yin A,Liu P,Zhou R,Lin F,Teng G,Lei Y

更新日期：2014-07-25 00:00:00