Abstract：
:Most surgeons, ourselves including, use retrograde cardioplegia in numerable operations in cardiac surgery. It is believed to be not only supplementary to antegrade, but also a unique alternative in special complicated cases. Regarding CABGs (coronary artery bypass grafts), many authors advocate its routine use together with antegrade, while others do not suggest it for standard practice. The existing disagreement on this special item is consequential to the different results among various protocols which have studied the effect of antegrade and retrograde perfusion. In these studies, fundamental variations in design, materials, and methods have resulted in an inability to compare results. Additionally, most of the published protocols studying cardioplegic arrest offer only a gross estimation of the microcirculatory perfusion, which is the basis of myocardial protection. Our present review is an attempt to elucidate the differences, explain the necessity of comparing retrograde cardioplegia alone with antegrade in CABGs for the reproduction of safe results, clarify the role of Thebesian veins and venovenous connections during retroperfusion, consider the critical anatomic differences between human hearts and those of animals which may result in serious study bias, and, finally, offer an explanation of what may really be going on in the microcirculation during antegrade and retrograde perfusion using a human capillary model.
journal_name
Med Sci Monitjournal_title
Medical science monitor : international medical journal of experimental and clinical researchauthors
Kouerinis IA,Manopoulos CG,Zografos GC,Apostolakis EI,Tsilimingas NB,Argiriou ME,Gorgoulis VG,Dedeilias PG,Tsoukas A,Bolos K,Tsangaris SGsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
RA265-8issue
11eissn
1234-1010issn
1643-3750pii
8935journal_volume
12pub_type
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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doi：
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更新日期：2007-08-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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更新日期：2010-06-01 00:00:00
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