Resveratrol Protects the Myocardium in Sepsis by Activating the Phosphatidylinositol 3-Kinases (PI3K)/AKT/Mammalian Target of Rapamycin (mTOR) Pathway and Inhibiting the Nuclear Factor-κB (NF-κB) Signaling Pathway.

Abstract:

:BACKGROUND Sepsis combined with myocardial injury is an important cause of septic shock and multiple organ failure. However, the molecular mechanism of sepsis-induced myocardial dysfunction has not yet been thoroughly studied. Resveratrol has been an important research topic due its organ-protection function, but the specific mechanism is unclear. The purpose of this study was to explore the mechanism of organ injury in sepsis and to investigate the molecular mechanism of resveratrol in myocardial protection in sepsis. MATERIAL AND METHODS A classical Sprague-Dawley rat model of sepsis peritonitis was constructed for further experiments. The PI3K inhibitor LY294002 and resveratrol were used to intervene in a rat model of cardiomyopathy. HE staining was used to observe pathological changes. Cardiomyocyte apoptosis was detected by TUNEL assay. Western blot analysis was used to detect the level of maker proteins. RESULTS The PI3K inhibitors could promote cardiac abnormalities and apoptosis, but resveratrol showed the opposite effect. The upregulation function of the PI3K inhibitor on the expression of NF-kappaB, IL-6, IL-1ß, and TLR4 in LPS rats was not obvious, but the expression of TNF-a in LPS+LY294002 rats was increased by 22.85% compared with that in LPS rats (P<0.05). Compared with the LPS group, the expression of NF-kappaB, TNF-alpha, IL-6, IL-1ß, and TLR4 in the LPS+resveratrol group was decreased. The expression of p-PI3K, p-AKT, and p-mTOR in LPS+LY294002 was reduced. The expression p-PI3K, p-AKT, and p-mTOR in the myocardium of the LPS+resveratrol group was increased. CONCLUSIONS Resveratrol can protect the myocardium in sepsis by activating the PI3K/AKT/mTOR signaling pathway and inhibiting the NF-kappaB signaling pathway and related inflammatory factors.

journal_name

Med Sci Monit

authors

Shang X,Lin K,Yu R,Zhu P,Zhang Y,Wang L,Xu J,Chen K

doi

10.12659/MSM.918369

subject

Has Abstract

pub_date

2019-12-06 00:00:00

pages

9290-9298

eissn

1234-1010

issn

1643-3750

pii

918369

journal_volume

25

pub_type

杂志文章
  • High Human Cytomegalovirus IgG Level is Associated with Increased Incidence of Diabetic Atherosclerosis in Type 2 Diabetes Mellitus Patients.

    abstract::BACKGROUND At present, whether human cytomegalovirus (HCMV) infection is associated with type 2 diabetes mellitus (T2DM) is debatable. The effect of active HCMV infection on glucose regulation has been poorly studied. Although HCMV infection is correlated with atherosclerosis in cardiovascular disease, the role of HCM...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896071

    authors: Zhang J,Liu YY,Sun HL,Li S,Xiong HR,Yang ZQ,Xiang GD,Jiang XJ

    更新日期:2015-12-30 00:00:00

  • Total intravenous anaesthesia with methohexitone or propofol for knee arthroscopy in day-case surgery.

    abstract::The aim of the study was to assess the usefulness of methohexitone and propofol in total intravenous anaesthesia applied during planned knee joint arthroscopy in day-case surgery. Studies comprised 186 patients divided into 2 groups depending on the anaesthetic used (methohexitone n = 112 or propofol n = 74). ECG, hea...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Piotrowski D,Gaszyński W,Ulbrich K,Kaszyński Z

    更新日期:2000-01-01 00:00:00

  • Effect and Mechanism of QiShenYiQi Pill on Experimental Autoimmune Myocarditis Rats.

    abstract:BACKGROUND:To observe the effect of QiShenYiQi pill (QSYQ) on experimental autoimmune myocarditis rats, and to explore its mechanism of action. MATERIAL/METHODS:Lewis rats underwent the injection of myocardial myosin mixed with Freund's complete adjuvant were randomized into 3 groups: model, valsartan, and QSYQ groups...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.895655

    authors: Lv S,Wu M,Li M,Wang Q,Xu L,Wang X,Zhang J

    更新日期:2016-03-06 00:00:00

  • Prognostic value of duration of untreated psychosis in long-term outcome of schizophrenia.

    abstract:BACKGROUND:The goal of this prognostic study was to investigate whether the duration of untreated psychosis (DUP) may have a prognostic value with regard to the further course of the illness. MATERIAL/METHODS:Fifty-eight patients (77% of the original study group) diagnosed with DSM III schizophrenia and later re-diagn...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.881768

    authors: Cechnicki A,Hanuszkiewicz I,Polczyk R,Bielańska A

    更新日期:2011-05-01 00:00:00

  • In utero surgery - current state of the art: part I.

    abstract:BACKGROUND:Fetal surgery, also referred to as in utero, prenatal or intrauterine surgery, consists of treatment of congenital malformations during fetal period. The idea of treating malformations diagnosed in the course of intrauterine life dates back to 1963, when Lilly performed first blood transfusion in the fetus. ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 历史文章,杂志文章,评审

    doi:

    authors: Wójcicki P,Drozdowski P

    更新日期:2010-11-01 00:00:00

  • The in vivo binding site for oncoprotein c-Myc in the promoter for Epstein-Barr virus (EBV) encoding RNA (EBER) 1 suggests a specific role for EBV in lymphomagenesis.

    abstract:BACKGROUND:Epstein-Barr virus (EBV) was isolated in the 1960s from the African childhood tumor, Burkitt's Lymphoma (BL), characterized by the translocation of the c-myc gene into one of the immunoglobulin loci. Due to the extreme discrepancy between the widespread dissemination of EBV infection and the overall rarity o...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Niller HH,Salamon D,Ilg K,Koroknai A,Banati F,Bauml G,Rucker O,Schwarzmann F,Wolf H,Minarovits J

    更新日期:2003-01-01 00:00:00

  • miR-200bc/429 Inhibits Osteosarcoma Cell Proliferation and Invasion by Targeting PMP22.

    abstract::BACKGROUND MicroRNAs (miRNAs) are small non-coding RNAs which play a crucial role in diverse biological processes and could contribute to cancer development and progression. MiR-200bc/429 have been found to be aberrantly expressed in osteosarcoma (OS). However, the features of miR-200bc/429 in the tumorigenesis and pr...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.900084

    authors: Li X,Jiang H,Xiao L,Wang S,Zheng J

    更新日期:2017-02-24 00:00:00

  • Ultrasound investigation of the glenohumeral joint by anterior access in patients with rheumatoid arthritis and healthy controls.

    abstract:BACKGROUND:The aim of this study was to measure glenohumeral joint (GHJ) parameters via the anterior access through ultrasound and to compare to data from posterior and inferior accesses. MATERIAL AND METHODS:Twenty healthy controls (M: F=15: 5, aged 45.1±11.2 years) and 16 patients (M: F=5: 11, aged 54.6±14.7 years) ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.892520

    authors: Rozin AP,Toledano K,Dagan A,Balbir-Gurman A

    更新日期:2015-02-18 00:00:00

  • Oxidized Low Density Lipoprotein-Induced Atherogenic Response of Human Umbilical Vascular Endothelial Cells (HUVECs) was Protected by Atorvastatin by Regulating miR-26a-5p/Phosphatase and Tensin Homolog (PTEN).

    abstract::BACKGROUND Atherosclerosis is a chronic and multifactorial disease, and it is the main reason of coronary heart disease, cerebral infarction, and peripheral vascular disease, which leads to the formation of lesions in arterial blood vessels. Our study aimed to explore the protective effect and its underlying mechanism...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.918405

    authors: Jia Z,An L,Lu Y,Xu C,Wang S,Wang J,Teng X

    更新日期:2019-12-22 00:00:00

  • Retrograde cardioplegia in CABG: is it really useful? The microcirculation and a capillary unit model.

    abstract::Most surgeons, ourselves including, use retrograde cardioplegia in numerable operations in cardiac surgery. It is believed to be not only supplementary to antegrade, but also a unique alternative in special complicated cases. Regarding CABGs (coronary artery bypass grafts), many authors advocate its routine use togeth...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,评审

    doi:

    authors: Kouerinis IA,Manopoulos CG,Zografos GC,Apostolakis EI,Tsilimingas NB,Argiriou ME,Gorgoulis VG,Dedeilias PG,Tsoukas A,Bolos K,Tsangaris SG

    更新日期:2006-11-01 00:00:00

  • Diffusion Tensor Imaging in Diagnosis of Post-Traumatic Syringomyelia in Spinal Cord Injury in Rats.

    abstract::BACKGROUND Post-traumatic syringomyelia (PTS) is a common disease after spinal cord injury (SCI). The present study was performed to evaluate the advantages of diffusion tensor imaging (DTI) in estimating SCI and prognosing PTS in SCI rats. MATERIAL AND METHODS Forty rats were divided into 3 groups based on the extent...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.907955

    authors: Zhang C,Chen K,Han X,Fu J,Douglas P,Morozova AY,Abakumov MA,Gubsky IL,Li D,Guo J,Zhang X,Wang G,Chekhonin VP

    更新日期:2018-01-09 00:00:00

  • Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics.

    abstract::BACKGROUND Endometriosis is a common gynecologic disorder with enigmatic etiopathogenesis and is characterized by tumor-like biological behaviors. Recently, circular RNAs (circRNAs) have attracted considerable attention because they exert very important functions in the progression of human cancers. However, little is...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.913885

    authors: Zhang M,Ren C,Xiao Y,Xia X,Fang X

    更新日期:2018-12-19 00:00:00

  • Effects on the ipsilateral testis during progression of experimental varicocele in rat.

    abstract:BACKGROUND:We used an animal model of experimental varicocele to investigate the effects on the ipsilateral testis during the progression of experimental varicocele in rat. MATERIAL/METHODS:Experimental varicocele was induced by partial ligation of the left renal vein in rats. Rats in each control group were subjected...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Zheng Y,Zhang X,Zhou J,Cheng F,Zhou B

    更新日期:2008-06-01 00:00:00

  • 1,25(OH)2D3 Protects Liver Fibrosis Through Decreasing the Generation of TH17 Cells.

    abstract::BACKGROUND The aim of this study was to study the effects of 1-alpha,25-dihydroxy-cholecalcifero (1,25(OH)2D3) on liver fibrosis and the generation of Th17 cells in vivo and in vitro. MATERIAL AND METHODS Thirty C57 mice were randomly divided into control, model, and treatment groups. Hepatic fibrosis was induced by s...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.904271

    authors: Gu L,Xu Q,Cao H

    更新日期:2017-04-29 00:00:00

  • Triptolide Inhibits Invasion and Tumorigenesis of Hepatocellular Carcinoma MHCC-97H Cells Through NF-κB Signaling.

    abstract::BACKGROUND We investigated whether the plant-derived agent triptolide (TPL) could effectively inhibit the growth and invasion of human hepatocellular carcinoma (HCC) cells. MATERIAL AND METHODS MHCC-97H cells were treated with various concentration of TPL for various times. To detect the effect of NF-κB on TPL-induced...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.898801

    authors: Wang H,Ma D,Wang C,Zhao S,Liu C

    更新日期:2016-05-30 00:00:00

  • Proximal femoral nail vs. dynamic hip screw in treatment of intertrochanteric fractures: a meta-analysis.

    abstract:BACKGROUND:The aim of this meta-analysis was to compare the outcomes of proximal femoral nail (PFN) and dynamic hip screw (DHS) in treatment of intertrochanteric fractures. MATERIAL AND METHODS:Relevant randomized or quasi-randomized controlled studies comparing the effects of PFN and DHS were searched for following t...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,meta分析

    doi:10.12659/MSM.890962

    authors: Zhang K,Zhang S,Yang J,Dong W,Wang S,Cheng Y,Al-Qwbani M,Wang Q,Yu B

    更新日期:2014-09-12 00:00:00

  • Effects of Different Training Loads on Emotional State and mRNA and Protein Expressions of N-Methyl-D-Aspartate Receptor Subunits, Postsynaptic Density 95, and Kinesin Family Member 17 in Hippocampus of Rats.

    abstract::BACKGROUND Emotional state can be affected by different training loads. The aim of this study was to explore the changes of rat emotional state, as well as the mRNA and protein expressions of N-methyl-D-aspartate receptors (NMDARs), postsynaptic density 95 (PSD-95), and kinesin family member 17 (KIF-17) in the hippoca...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.906781

    authors: Ren H,Yu X,Yu L,Zhang Y,Xie H,Shi N,Chen L

    更新日期:2017-10-17 00:00:00

  • Lack of nephrotoxicity of gadopentetate dimeglumine-enhanced non-vascular MRI and MRI without contrast agent in patients at high-risk for acute kidney injury.

    abstract:BACKGROUND:Gadolinium chelates (GCs) have been traditionally considered as non-nephrotoxic magnetic resonance imaging (MRI) contrast materials. However, it has been suggested in some recent articles that GCs may have a nephrotoxic potential, but most of these reports are retrospective. However, the evaluated contrast a...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 临床试验,杂志文章

    doi:10.12659/MSM.889579

    authors: Gok Oguz E,Kiykim A,Turgutalp K,Olmaz R,Ozhan O,Muslu N,Horoz M,Bardak S,Sungur MA

    更新日期:2013-11-06 00:00:00

  • Correlation of Brain Perfusion with White Matter Hyperintensity, Brain Atrophy, and Cognition in Patients with Posterior Cerebral Artery Stenosis and Subjective Cognitive Decline.

    abstract::BACKGROUND This study aimed to investigate the correlation of brain perfusion with white matter hyperintensity (WMH), brain atrophy, and cognition in patients with moderate to severe posterior cerebral artery stenosis (PCAS). MATERIAL AND METHODS 65 patients with memory decline as the main complaint and no history of ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.909188

    authors: Liu M,Nie ZY,Li RR,Zhang W,Wang H,He YS,Zhao LJ,Li YX

    更新日期:2018-08-17 00:00:00

  • Gemcitabine Conjugated Chitosan and Double Antibodies (Abc-GC-Gemcitabine Nanoparticles) Enhanced Cytoplasmic Uptake of Gemcitabine and Inhibit Proliferation and Metastasis In Human SW1990 Pancreatic Cancer Cells.

    abstract::BACKGROUND Pancreatic cancer is considered a chemoresistant neoplasm with extremely dismal prognosis and gemcitabine treatment is associated with many side effects and poor overall survival. The study aimed at developing a new nanobioconjugate, which specifically delivered gemcitabine and anti-EGFR antibody into pancr...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.901292

    authors: Xiao J,Yu H

    更新日期:2017-04-03 00:00:00

  • Minimally Invasive Unilateral vs. Bilateral Pedicle Screw Fixation and Lumbar Interbody Fusion in Treatment of Multi-Segment Lumbar Degenerative Disorders.

    abstract::BACKGROUND The choice for instrumentation with minimally invasive transforaminal lumbar interbody fusion (MIS-TLIF) in treatment of degenerative lumbar disorders (DLD) remains controversial. The goal of this study was to investigate clinical outcomes in consecutive patients with multi-segment DLD treated with unilater...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,收录出版

    doi:10.12659/msm.894890

    authors: Liu X,Li G,Wang J,Zhang H

    更新日期:2015-11-25 00:00:00

  • Composition of phospholipid fatty acids in erythrocyte membranes of children with chronic juvenile arthritis: clinical and biochemical correlations.

    abstract::Systemic diseases of connective tissue, including chronic juvenile arthritis are associated with a number of metabolic disorders such as e.g. lipid disturbances. The purpose of the present work was to analyse the composition of fatty acids in erythrocyte phospholipids of children with juvenile chronic arthritis and to...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Górska A,Nawrocki A,Urban M,Florys B

    更新日期:2000-01-01 00:00:00

  • Fighting AIDS in Sub-Saharan Africa: is a public- private partnership a viable paradigm?

    abstract:UNLABELLED:In their most recent study, the United Nations AIDS Program estimates that about 22 million people around the world have died from AIDS, and about 40 million more are currently infected with the HIV virus. About 83% of AIDS deaths and 71% of HIV infections have occurred in war-ravaged, poverty-stricken Sub-S...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Clark PA,O'Brien K

    更新日期:2003-09-01 00:00:00

  • Genetic Variants of PTPN2 Gene in Chinese Children with Type 1 Diabetes Mellitus.

    abstract:BACKGROUND:Several studies have reported the association of PTPN2 gene with type 1 diabetes mellitus (T1DM) in many populations but not in the Chinese Han population. Therefore, the goal of our study was to replicate the reported association between 2 single-nucleotide polymorphisms (SNPs; rs478582 and rs2542151) in th...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.893607

    authors: Peng H,Li J,Chen X,Zhou X,Zhu W,Li F

    更新日期:2015-09-07 00:00:00

  • Nimotuzumab Combined with Chemotherapy is a Promising Treatment for Locally Advanced and Metastatic Esophageal Cancer.

    abstract::BACKGROUND Nimotuzumab is an anti-EGFR monoclonal antibody which has been widely used in cancer treatment. However, the safety and efficacy of nimotuzumab combined with chemotherapy in locally advanced or metastatic esophageal cancer patients remain unclear. MATERIAL AND METHODS To address this open question, we colle...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,随机对照试验

    doi:10.12659/msm.902645

    authors: Han X,Lu N,Pan Y,Xu J

    更新日期:2017-01-24 00:00:00

  • Telomere Length Assessment for Prediction of Organ Transplantation Outcome. Future or Failure: A Review of the Literature.

    abstract::Telomeres are located at each end of eukaryotic chromosomes. Their functional role is genomic stability maintenance. The protective role of telomeres depends on various factors, including number of nucleotides repeats, telomere-binding proteins, and telomerase activity. Organ transplantation is the preferred replaceme...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,评审

    doi:10.12659/msm.899490

    authors: Kłoda K,Domański L,Mierzecki A

    更新日期:2017-01-11 00:00:00

  • Hypoxia-Responsive Mir-301a and Mir-301b Promote Radioresistance of Prostate Cancer Cells via Downregulating NDRG2.

    abstract::BACKGROUND MiR-301a and miR-301b are 2 oncomiRs involved in multiple types of cancer. In this study, we explored the expression change of miR-301a and miR-301b in prostate cancer cells in hypoxia and studied their regulation of autophagy and radiosensitivity of prostate cancer cells. MATERIAL AND METHODS QRT-PCR was p...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.896832

    authors: Wang W,Liu M,Guan Y,Wu Q

    更新日期:2016-06-21 00:00:00

  • Cyclic fatigue resistance of Mtwo NiTi rotary instruments used by experienced and novice operators--an in vivo and in vitro study.

    abstract:BACKGROUND:The aim of the present study was to evaluate the cyclic fatigue resistance of Mtwo NiTi rotary instruments after clinical use by 1 experienced and 1 novice operator. MATERIAL/METHODS:Cyclic fatigue testing of instruments was performed on tapered artificial canals with a 5 mm radius of curvature and 60° angle...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.882887

    authors: Plotino G,Al-Sudani D,Pulino S,Grande NM,Marcoli PA,Pizzi S,Testarelli L,Gambarini G

    更新日期:2012-06-01 00:00:00

  • Impact of Integrated Care Model (ICM) on Direct Medical Costs in Management of Advanced Chronic Obstructive Pulmonary Disease (COPD).

    abstract::BACKGROUND Chronic obstructive pulmonary disease (COPD) is a commonly diagnosed condition in people older than 50 years of age. In advanced stage of this disease, integrated care (IC) is recommended as an optimal approach. IC allows for holistic and patient-focused care carried out at the patient's home. The aim of th...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.901982

    authors: Bandurska E,Damps-Konstańska I,Popowski P,Jędrzejczyk T,Janowiak P,Świętnicka K,Zarzeczna-Baran M,Jassem E

    更新日期:2017-06-12 00:00:00

  • Differences in Cpg Island Distribution Between Subgenotypes of the Hepatitis B Virus Genotype.

    abstract::BACKGROUND Hepatitis B virus (HBV) genotypes show genomic variations, resulting in different CpG islands in each HBV genotypes or subgenotype. This study aimed to establish reference sequences for each HBV subgenotype of A-H genotypes and to analyze the characteristics of the CpG islands. MATERIAL AND METHODS There we...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.910049

    authors: Chen L,Shi Y,Yang W,Zhang Y,Xie Q,Li Y,Li X,Li J,Zhang Z

    更新日期:2018-09-25 00:00:00