Primary Leptomeningeal Oligodendroglioma, IDH-Mutant, 1p/19q-Codeleted.

Abstract:

:We present a case of a 43-year-old woman with a history of headaches and blurry vision. Ophthalmologic examination identified papilledema. MR imaging demonstrated a right parietal region mass with patchy areas of contrast enhancement and focal calcifications. Intraoperative examination and exploration revealed an extra-axial mass with no apparent parenchymal involvement. Microscopic examination revealed solid sheets of tumor cells with clear cell cytologic features and no discernable intra-parenchymal tumor component. Molecular studies demonstrated the presence of IDH1 IDH1 c.395G>A p.R132H and CIC c.601C>T p.R281W mutations and 1p/19q codeletion. The radiographic features, gross appearance, and microscopic and molecular characteristics of the mass support the diagnosis of primary leptomeningeal oligodendroglioma, IDH-mutant, 1p/19-codeleted. This case represents one of a very few reported instances of molecularly-defined solitary, primary, intracranial oligodendroglioma, without definitive involvement of the brain parenchyma.

journal_name

Front Neurol

journal_title

Frontiers in neurology

authors

Ballester LY,Dunbar E,Guha-Thakurta N,Henson JW,Chandler H,Watkins J,Fuller GN

doi

10.3389/fneur.2018.00700

subject

Has Abstract

pub_date

2018-08-27 00:00:00

pages

700

issn

1664-2295

journal_volume

9

pub_type

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