Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells.

Abstract:

:We describe a cell damage-induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PGE2), and the activity of the PGE2 receptor EP4. Although largely transient, decaying to low levels in a few days to a week, this phenotype was cumulative with damage and levels of cell markers Sca-1 and ALDH1 increased with treatment dose. The Sca-1+ , metastatic phenotype was inhibited by both Cox2 inhibitors and PGE2 receptor antagonists, suggesting novel approaches to radiosensitization.

journal_name

Mol Oncol

journal_title

Molecular oncology

authors

Gong J,Lang BJ,Weng D,Eguchi T,Murshid A,Borges TJ,Doshi S,Song B,Stevenson MA,Calderwood SK

doi

10.1002/1878-0261.12321

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

1249-1263

issue

8

eissn

1574-7891

issn

1878-0261

journal_volume

12

pub_type

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