Genotoxic stress induces Sca-1-expressing metastatic mammary cancer cells.


:We describe a cell damage-induced phenotype in mammary carcinoma cells involving acquisition of enhanced migratory and metastatic properties. Induction of this state by radiation required increased activity of the Ptgs2 gene product cyclooxygenase 2 (Cox2), secretion of its bioactive lipid product prostaglandin E2 (PGE2), and the activity of the PGE2 receptor EP4. Although largely transient, decaying to low levels in a few days to a week, this phenotype was cumulative with damage and levels of cell markers Sca-1 and ALDH1 increased with treatment dose. The Sca-1+ , metastatic phenotype was inhibited by both Cox2 inhibitors and PGE2 receptor antagonists, suggesting novel approaches to radiosensitization.


Mol Oncol


Molecular oncology


Gong J,Lang BJ,Weng D,Eguchi T,Murshid A,Borges TJ,Doshi S,Song B,Stevenson MA,Calderwood SK




Has Abstract


2018-08-01 00:00:00












  • Pharmacologic inhibition of Akt in combination with chemotherapeutic agents effectively induces apoptosis in ovarian and endometrial cancer cell lines.

    abstract::The PI3K/Akt signaling pathway, the most frequently altered signaling system in human cancer, is a crucial inducer of dysregulated proliferation and neoplastic processes; however, few therapeutic strategies using PI3K/Akt inhibitors singly have been shown to be effective. The purpose of this paper was to underline the...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Fabi F,Adam P,Parent S,Tardif L,Cadrin M,Asselin E

    更新日期:2020-12-18 00:00:00

  • Quality-assured research environments for translational cancer research.

    abstract::In order to secure high-quality cancer care for increasing numbers of cancer patients in the upcoming decades, the complete continuum of cancer research and cancer care needs a thorough overhaul, with more emphasis on prevention and early detection, and a greater focus on the development of innovative treatments that ...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Berns A

    更新日期:2019-03-01 00:00:00

  • Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle.

    abstract::Germ cell cancers (GCC) are the most frequent malignancy in young Caucasian males. GCC can consist of seminomas (SE) and non-seminomas (malignant NS: embryonal carcinoma (EC), yolk sac tumor (YS), choriocarcinoma (CH) and teratoma (TE)). Current serum-markers used for diagnosis and follow-up (AFP, hCG) are predominant...

    journal_title:Molecular oncology

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Gillis AJ,Rijlaarsdam MA,Eini R,Dorssers LC,Biermann K,Murray MJ,Nicholson JC,Coleman N,Dieckmann KP,Belge G,Bullerdiek J,Xu T,Bernard N,Looijenga LH

    更新日期:2013-12-01 00:00:00

  • Prioritization of candidate cancer drugs based on a drug functional similarity network constructed by integrating pathway activities and drug activities.

    abstract::Due to the speed, efficiency, relative risk, and lower costs compared to traditional drug discovery, the prioritization of candidate drugs for repurposing against cancers of interest has attracted the attention of experts in recent years. Herein, we present a powerful computational approach, termed prioritization of c...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Di J,Zheng B,Kong Q,Jiang Y,Liu S,Yang Y,Han X,Sheng Y,Zhang Y,Cheng L,Han J

    更新日期:2019-10-01 00:00:00

  • Intratumor heterogeneity defines treatment-resistant HER2+ breast tumors.

    abstract::Targeted therapy for patients with HER2-positive (HER2+) breast cancer has improved overall survival, but many patients still suffer relapse and death from the disease. Intratumor heterogeneity of both estrogen receptor (ER) and HER2 expression has been proposed to play a key role in treatment failure, but little work...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Rye IH,Trinh A,Saetersdal AB,Nebdal D,Lingjaerde OC,Almendro V,Polyak K,Børresen-Dale AL,Helland Å,Markowetz F,Russnes HG

    更新日期:2018-11-01 00:00:00

  • Translational cancer research - a coherent cancer research continuum.

    abstract::The main components of the cancer research continuum are basic/preclinical research, early and late clinical research and, after the adoption of an innovation by the healthcare or health organisations, outcomes research. Translational cancer research, defined as a coherent cancer research continuum, is mandatory to ad...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Ringborg U

    更新日期:2019-03-01 00:00:00

  • Next-generation clinical trials: Novel strategies to address the challenge of tumor molecular heterogeneity.

    abstract::The promise of 'personalized cancer care' with therapies toward specific molecular aberrations has potential to improve outcomes. However, there is recognized heterogeneity within any given tumor-type from patient to patient (inter-patient heterogeneity), and within an individual (intra-patient heterogeneity) as demon...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Catenacci DV

    更新日期:2015-05-01 00:00:00

  • Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.

    abstract::A significant proportion of estrogen receptor-positive (ER+) breast cancer (BC) initially responds to endocrine therapy but eventually evolves into therapy-resistant BC. Transcription factor AP-2 gamma (TFAP2C) is a known regulator of ER activity, and high expression of TFAP2C is associated with a decreased response t...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Liu J,Liu Z,Li M,Tang W,Pratap UP,Luo Y,Altwegg KA,Li X,Zou Y,Zhu H,Sareddy GR,Viswanadhapalli S,Vadlamudi RK

    更新日期:2020-12-02 00:00:00

  • Tackling the cancer burden: the economic impact of primary prevention policies.

    abstract::Cancer is a noncommunicable disease (NCD) with increasing incidence and therefore constitutes a major public health issue. To reduce the health and economic burden of cancer, policy-makers across the world have implemented a range of preventative interventions targeting risk factors with a known link to the disease. I...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Cheatley J,Aldea A,Lerouge A,Devaux M,Vuik S,Cecchini M

    更新日期:2020-10-05 00:00:00

  • Identification of lncRNAs associated with early-stage breast cancer and their prognostic implications.

    abstract::Breast cancer is the most common malignancy among women, with the highest incidence rate worldwide. Dysregulation of long noncoding RNAs during the preliminary stages of breast carcinogenesis is poorly understood. In this study, we performed RNA sequencing to identify long noncoding RNA expression profiles associated ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Deva Magendhra Rao AK,Patel K,Korivi Jyothiraj S,Meenakumari B,Sundersingh S,Sridevi V,Rajkumar T,Pandey A,Chatterjee A,Gowda H,Mani S

    更新日期:2019-06-01 00:00:00

  • Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-XL -BAX interaction.

    abstract::Tumor cells undergo senescence in response to both conventional and targeted cancer therapies. The induction of senescence in response to cancer therapy can contribute to unfavorable patient outcomes, potentially including disease relapse. This possibiliy is supported by our findings that tumor cells induced into sene...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Saleh T,Carpenter VJ,Tyutyunyk-Massey L,Murray G,Leverson JD,Souers AJ,Alotaibi MR,Faber AC,Reed J,Harada H,Gewirtz DA

    更新日期:2020-10-01 00:00:00

  • Pathway-based personalized analysis of breast cancer expression data.

    abstract:INTRODUCTION:Most analyses of high throughput cancer data represent tumors by "atomistic" single-gene properties. Pathifier, a recently introduced method, characterizes a tumor in terms of "coarse grained" pathway-based variables. METHODS:We applied Pathifier to study a very large dataset of 2000 breast cancer samples...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Livshits A,Git A,Fuks G,Caldas C,Domany E

    更新日期:2015-08-01 00:00:00

  • Cell-to-cell communication: microRNAs as hormones.

    abstract::Mammalian cells can release different types of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies. Accumulating evidence suggests that EVs play a role in cell-to-cell communication within the tumor microenvironment. EVs' components, such as proteins, noncoding RNAs [microRNAs (miRNAs...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Bayraktar R,Van Roosbroeck K,Calin GA

    更新日期:2017-12-01 00:00:00

  • Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy.

    abstract::Our limited understanding of the biological impact of the whole spectrum of early breast lesions together with a lack of accurate molecular-based risk criteria for the diagnosis and assignment of prognostic significance to biopsy findings presents an important problem in the clinical management of patients harboring p...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Moreira JM,Cabezón T,Gromova I,Gromov P,Timmermans-Wielenga V,Machado I,Llombart-Bosch A,Kroman N,Rank F,Celis JE

    更新日期:2010-12-01 00:00:00

  • Radioresistance of glioma stem cells: intrinsic characteristic or property of the 'microenvironment-stem cell unit'?

    abstract::There is increasing evidence that glioblastoma possess 'stem-like' cells, low concentrations of which can initiate a tumour. It has been proposed that these cells are radioresistant, and that this property contributes to the poor treatment outcomes of these tumours. In this paper we propose that radioresistance is not...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Mannino M,Chalmers AJ

    更新日期:2011-08-01 00:00:00

  • Cigarette smoke enhances oncogene addiction to c-MET and desensitizes EGFR-expressing non-small cell lung cancer to EGFR TKIs.

    abstract::Cigarette smoking is one of the leading risks for lung cancer and is associated with the insensitivity of non-small cell lung cancer (NSCLC) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, it remains undetermined whether and how cigarette smoke affects the therapeutic efficacy of...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Tu CY,Cheng FJ,Chen CM,Wang SL,Hsiao YC,Chen CH,Hsia TC,He YH,Wang BW,Hsieh IS,Yeh YL,Tang CH,Chen YJ,Huang WC

    更新日期:2018-05-01 00:00:00

  • HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.

    abstract::Resistance to HER2-targeted therapies remains a major obstacle in the treatment of HER2-overexpressing breast cancer. Understanding the molecular pathways that contribute to the development of drug resistance is needed to improve the clinical utility of novel agents, and to predict the success of targeted personalized...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Boulbes DR,Arold ST,Chauhan GB,Blachno KV,Deng N,Chang WC,Jin Q,Huang TH,Hsu JM,Brady SW,Bartholomeusz C,Ladbury JE,Stone S,Yu D,Hung MC,Esteva FJ

    更新日期:2015-03-01 00:00:00

  • TRPM4 is highly expressed in human colorectal tumor buds and contributes to proliferation, cell cycle, and invasion of colorectal cancer cells.

    abstract::Transient receptor potential melastatin-4 channel (TRPM4) dysregulation contributes to heart conditions, immune diseases, and cervical and prostate cancer. Up to now, the involvement of TRPM4 in colorectal cancer (CRC) pathophysiology remains unknown. Here, we investigated tumor tissue microarrays from 379 CRC patient...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Kappel S,Stokłosa P,Hauert B,Ross-Kaschitza D,Borgström A,Baur R,Galván JA,Zlobec I,Peinelt C

    更新日期:2019-11-01 00:00:00

  • Development of a circulating miRNA assay to monitor tumor burden: From mouse to man.

    abstract::Circulating miRNA stability suggests potential utility of miRNA based biomarkers to monitor tumor burden and/or progression, particularly in cancer types where serial biopsy is impractical. Assessment of miRNA specificity and sensitivity is challenging within the clinical setting. To address this, circulating miRNAs w...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Greystoke A,Ayub M,Rothwell DG,Morris D,Burt D,Hodgkinson CL,Morrow CJ,Smith N,Aung K,Valle J,Carter L,Blackhall F,Dive C,Brady G

    更新日期:2016-02-01 00:00:00

  • A 17 gene panel for non-small-cell lung cancer prognosis identified through integrative epigenomic-transcriptomic analyses of hypoxia-induced epithelial-mesenchymal transition.

    abstract::As a critical feature of the tumor microenvironment, hypoxia is known to be a potent inducer of tumor metastasis, and it has been proposed that the initial steps in metastasis involve epithelial-mesenchymal transition (EMT). The strong correlation among hypoxia, EMT, and metastasis suggests that integrative assessment...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Chen YL,Zhang Y,Wang J,Chen N,Fang W,Zhong J,Liu Y,Qin R,Yu X,Sun Z,Gao F

    更新日期:2019-07-01 00:00:00

  • A report from a conference jointly organised by the European Academy of Cancer Sciences and the Pontifical Academy of Sciences, The Vatican, November 16-17, 2018.

    abstract::Cancer is a massive challenge with a significant impact on society, healthcare systems, the economy and an increasing number of patients and their families. To help meet this societal challenge, the European Commission has recently proposed a mission-oriented approach to cancer in Horizon Europe, and about 60 particip...

    journal_title:Molecular oncology



    authors: European Academy of Cancer Sciences.

    更新日期:2019-03-01 00:00:00

  • PDGFRβ and FGFR2 mediate endothelial cell differentiation capability of triple negative breast carcinoma cells.

    abstract::Triple negative breast cancer (TNBC) is a very aggressive subgroup of breast carcinoma, still lacking specific markers for an effective targeted therapy and with a poorer prognosis compared to other breast cancer subtypes. In this study we investigated the possibility that TNBC cells contribute to the establishment of...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Plantamura I,Casalini P,Dugnani E,Sasso M,D'Ippolito E,Tortoreto M,Cacciatore M,Guarnotta C,Ghirelli C,Barajon I,Bianchi F,Triulzi T,Agresti R,Balsari A,Campiglio M,Tripodo C,Iorio MV,Tagliabue E

    更新日期:2014-07-01 00:00:00

  • The metastasis-associated molecule C4.4A promotes tissue invasion and anchorage independence by associating with the alpha6beta4 integrin.

    abstract::C4.4A is a metastasis-associated molecule that functions appear to rely on associated alph6beta4 integrin. To corroborate the impact of the C4.4A-alpha6beta4 integrin association on metastasis formation, C4.4A was knocked-down in a highly metastatic rat pancreatic adenocarcinoma (ASML, ASML-C4.4Akd). Metastasis format...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Thuma F,Ngora H,Zöller M

    更新日期:2013-10-01 00:00:00

  • Expression patterns of bone morphogenetic protein antagonists in colorectal cancer desmoplastic invasion fronts.

    abstract::Bone morphogenetic proteins (BMPs) are a group of growth factors with dual functions in cancer development and progression. Recently, certain tumor-promoting roles have been identified for selected antagonists/inhibitors (BMPIs) of this developmental pathway. A recent focus on the implication of BMP in colorectal canc...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Karagiannis GS,Treacy A,Messenger D,Grin A,Kirsch R,Riddell RH,Diamandis EP

    更新日期:2014-10-01 00:00:00

  • Genetic susceptibility to breast cancer.

    abstract::Genetic and lifestyle/environmental factors are implicated in the aetiology of breast cancer. This review summarizes the current state of knowledge on rare high penetrance mutations, as well as moderate and low-penetrance genetic variants implicated in breast cancer aetiology. We summarize recent discoveries from larg...

    journal_title:Molecular oncology

    pub_type: 杂志文章,评审


    authors: Mavaddat N,Antoniou AC,Easton DF,Garcia-Closas M

    更新日期:2010-06-01 00:00:00

  • Genetic factors associated with cancer racial disparity - an integrative study across twenty-one cancer types.

    abstract::It is well known that different racial groups have significantly different incidence and mortality rates for certain cancers. It has been suggested that biological factors play a major role in these cancer racial disparities. Previous studies on the biological factors contributing to cancer racial disparity have gener...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Li Y,Pang X,Cui Z,Zhou Y,Mao F,Lin Y,Zhang X,Shen S,Zhu P,Zhao T,Sun Q,Zhang J

    更新日期:2020-09-13 00:00:00

  • DNA polymerase β deficiency is linked to aggressive breast cancer: a comprehensive analysis of gene copy number, mRNA and protein expression in multiple cohorts.

    abstract::Short arm of chromosome 8 is a hot spot for chromosomal breaks, losses and amplifications in breast cancer. Although such genetic changes may have phenotypic consequences, the identity of candidate gene(s) remains to be clearly defined. Pol β gene is localized to chromosome 8p12-p11 and encodes a key DNA base excision...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Abdel-Fatah TM,Russell R,Agarwal D,Moseley P,Abayomi MA,Perry C,Albarakati N,Ball G,Chan S,Caldas C,Ellis IO,Madhusudan S

    更新日期:2014-05-01 00:00:00

  • Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion.

    abstract:PURPOSE:Lobular carcinoma in situ (LCIS) is both a risk indicator and non-obligate precursor of invasive lobular carcinoma (ILC). We sought to characterize the transcriptomic features of LCIS and ILC, with a focus on the identification of intrinsic molecular subtypes of LCIS and the changes involved in the progression ...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Andrade VP,Morrogh M,Qin LX,Olvera N,Giri D,Muhsen S,Sakr RA,Schizas M,Ng CK,Arroyo CD,Brogi E,Viale A,Morrow M,Reis-Filho JS,King TA

    更新日期:2015-04-01 00:00:00

  • The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.

    abstract::As treatment options for patients with incurable metastatic castration-resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase implicated in the DNA damage response (DDR) pathway that prevents the accumu...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Drápela S,Khirsariya P,van Weerden WM,Fedr R,Suchánková T,Búzová D,Červený J,Hampl A,Puhr M,Watson WR,Culig Z,Krejčí L,Paruch K,Souček K

    更新日期:2020-10-01 00:00:00

  • Acquired small cell lung cancer resistance to Chk1 inhibitors involves Wee1 up-regulation.

    abstract::Platinum-based chemotherapy has been the cornerstone treatment for small cell lung cancer (SCLC) for decades, but no major progress has been made in the past 20 years with regard to overcoming chemoresistance. As the cell cycle checkpoint kinase 1 (Chk1) plays a key role in DNA damage response to chemotherapeutic drug...

    journal_title:Molecular oncology

    pub_type: 杂志文章


    authors: Zhao X,Kim IK,Kallakury B,Chahine JJ,Iwama E,Pierobon M,Petricoin E,McCutcheon JN,Zhang YW,Umemura S,Chen V,Wang C,Giaccone G

    更新日期:2020-12-15 00:00:00