The Sineoculis Homeobox Homolog 1 (SIX1) Gene Regulates Paclitaxel Resistance by Affecting Reactive Oxygen Species and Autophagy in Human Hepatocellular Carcinoma Cell Line HepG2.

abstract：:BACKGROUND Gemcitabine plus cisplatin (GP) is a novel regimen of induction chemotherapy (IC) for treating locoregional advanced nasopharyngeal cancer (NPC). This retrospective study aimed to compare the efficacy of GP and TP (paclitaxel plus cisplatin) regimens in tumor volume reduction after IC. MATERIAL AND METHODS ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zheng L,Liao W,Xu P,Li B,Wen H,Zhang S

更新日期：2018-11-08 00:00:00

abstract：:BACKGROUND Hypertonic saline (HS) has been successfully used for treatment of various forms of brain edema. Decreased expression of aquaporin (AQP)4 and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-a and interleukin (IL)-1b have been linked to edema pathogenesis. This study examined the effect of 3% ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yin J,Zhang H,Chen H,Lv Q,Jin X

更新日期：2018-03-30 00:00:00

abstract：:BACKGROUND Liver cancer is one of the most common malignancies around the world and one of the major causes of cancer related mortality. The objective of this study was to evaluate the anticancer effect of the natural compound psilostachyin-A on 5-fluorouracil-resistant human liver carcinoma cells and its effects on a...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Liu J,Liu Y,Liu Y,Huang L,Wang G,Wang J,Xu X,Shi C,Huang J

更新日期：2019-09-07 00:00:00

abstract：:BACKGROUND Fucoxanthin is a carotenoid present in the chloroplasts of brown seaweeds. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a cytokine that selectively induces apoptosis in many tumor cells and is an attractive candidate for antitumor therapies. MATERIAL AND METHODS After human cervical ca...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jin Y,Qiu S,Shao N,Zheng J

更新日期：2018-01-01 00:00:00

abstract：:BACKGROUND The aim of this study was to investigate the role of deubiquitinase [ovarian tumor domain-containing protein 5 (OTUD5)] in regulating Akt ubiquitination and its effect on the radiosensitivity of cervical cancer. MATERIAL AND METHODS Cervical cancer C33A cells were cultured, and then 2 groups of cells (overe...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yin F,He H,Zhang B,Zheng J,Wang M,Zhang M,Cui H

更新日期：2019-05-10 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the protective effects of L-glutamine (GLN) against liver and kidney injury caused by acute toxicity of deltamethrin (DLM). MATERIAL AND METHODS:Thirty-two rats were indiscriminately separated into 4 groups with 8 rats each: control group (distilled water; 10 ml/kg, ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gündüz E,Ülger BV,İbiloğlu İ,Ekinci A,Dursun R,Zengin Y,İçer M,Uslukaya Ö,Ekinci C,Güloğlu C

更新日期：2015-04-19 00:00:00

abstract：:BACKGROUND The objective of the present study was to identify the association between miR-15a-5p and CDKN2B, and their roles in regulating the development of abdominal aortic aneurysm (AAA). MATERIAL AND METHODS We searched the miRNA database online (www.mirdb.org) and used a luciferase reporter assay system to study ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gao P,Si J,Yang B,Yu J

更新日期：2017-02-18 00:00:00

abstract：BACKGROUND:The aim was to assess the effect of trimetazidine (TMZ) on mitochondrial alterations induced in a canine model of brief, repeated episodes of ischemia. MATERIAL/METHODS:Twelve crossbred dogs were analyzed, after double-blind randomization, to a 7-day treatment with either TMZ or placebo. Twenty brief, compl...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Morillas Blasco PJ,Hernándiz Martinez A,Azorín Villena I,Portolés Sanz M,Pallarés Carratala V,Martinez VB,Capdevilla Carbonell C,Aguilar Llopis A,Cosín Aguilar J

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:Bone marrow transplantation (BMT) is one of the most efficient methods for the treatment of hematological neoplasms. Its successful application requires previous complete remission (CR) and exclusion of residual disease. MATERIAL/METHODS:This 31P MRS study reports data collected during several years of obse...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kuliszkiewicz-Janus M,Baczyński S,Jurczyk A

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:The Wada test is usually used for pre-surgical assessment of language lateralization. Considering its invasiveness and risk of complications, alternative methods have been proposed but they are not always applicable to non-cooperative patients. In this study we explored the possibility of using optical topog...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Bembich S,Demarini S,Clarici A,Massaccesi S,Grasso DL

更新日期：2011-12-01 00:00:00

abstract：:BACKGROUND In existing research on the importance of student breakfast, few studies have focused on the impact of breakfast on student cognitive development. Further, empirical research in this field is mostly based correlation analysis, in which it is difficult to control the influence of selection bias on the analys...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yao J,Liu Y,Zhou S

更新日期：2019-11-22 00:00:00

abstract：BACKGROUND:The problem of the potential impact of personal music players on the auditory system remains an open question. The purpose of the present study was to investigate, by means of otoacoustic emissions (OAEs), whether listening to music on a personal player affected auditory function. MATERIAL/METHODS:A group o...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Trzaskowski B,Jędrzejczak WW,Piłka E,Cieślicka M,Skarżyński H

更新日期：2014-08-13 00:00:00

abstract：BACKGROUND:Invasive fungal infections due to Candida species constitute an increasing clinical problem. There are no guidelines for the management of candidemia in children undergoing surgical procedures for congenital heart defects (CHD). The aim of the study was to draw attention to the problem of candidemia in child...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jaworski R,Irga N,Haponiuk I,Chojnicki M,Arlukowicz E,Steffek M,Sroka M,Gierat-Haponiuk K,Juscinski J,Palkowska L,Sendrowska A,Kosiak W

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Activation of endothelial K+ channels and the subsequent increase in intracellular Ca2+, may be an important step in the release of relaxant factors in response to endothelium-dependent vasodilator agents. However, the type of K+ channel involved in hyperpolarization of the endothelium and the subsequent rel...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Qiu Y,Quilley J

更新日期：2001-11-01 00:00:00

abstract：:BACKGROUND Effects of liver dysfunction on target-controlled infusion (TCI) with Marsh parameters of propofol remain poorly documented. The purpose of this study was to evaluate the performance of propofol TCI in a cohort of Chinese patients with severe hepatic insufficiency. MATERIAL AND METHODS We assigned 32 patien...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chi X,Pan J,Cai J,Luo G,Li S,Yuan D,Rui J,Chen W,Hei Z

更新日期：2018-09-30 00:00:00

abstract：BACKGROUND:High-frequency oscillations (ripples) are proposed to be involved in memory consolidation. Ripple oscillations persist in the absence of chemical synaptic transmission and inhibitors of gapjunctions were shown to block high-frequency oscillations in hippocampal slices. In this study we investigated the effec...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Hosseinzadeh H,Asl MN,Parvardeh S,Tagi Mansouri SM

更新日期：2005-03-01 00:00:00

abstract：:BACKGROUND Chronic obstructive pulmonary disease (COPD) is a commonly diagnosed condition in people older than 50 years of age. In advanced stage of this disease, integrated care (IC) is recommended as an optimal approach. IC allows for holistic and patient-focused care carried out at the patient's home. The aim of th...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Bandurska E,Damps-Konstańska I,Popowski P,Jędrzejczyk T,Janowiak P,Świętnicka K,Zarzeczna-Baran M,Jassem E

更新日期：2017-06-12 00:00:00

abstract：BACKGROUND:Peroxidases are widely distributed and have been isolated from many higher-order plants, animal tissues, yeast and microorganisms. During measurements of peroxidase activities in samples of human plasma, we noticed the presence of a compound in the plasma which was interfering with the peroxidase assay. In t...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Padiglia A,Medda R,Longu S,Pedersen JZ,Floris G

更新日期：2002-11-01 00:00:00

abstract：:Dopamine receptors control neural signals that modulates behavior. Dopamine plays an important role in normal attention; that is the reason for studying the genes of the dopaminergic system, mainly in connection with disorders of attention. DRD4 influences the postsynaptic action of dopamine and is implicated in many ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ptácek R,Kuzelová H,Stefano GB

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:The aim of this study was to investigate the prevalence of glaucoma in obstructive sleep apnea syndrome (OSAS) and to determine the efficacy of the equipment used in the treatment of this disease. MATERIAL AND METHODS:In this cross-sectional study, 38 patients with OSAS used the continuous positive airway p...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ulusoy S,Erden M,Dinc ME,Yavuz N,Caglar E,Dalgic A,Erdogan C

更新日期：2015-11-08 00:00:00

abstract：BACKGROUND:Vibrio vulnificus (V. vulnificus) is a seafood-borne infectious pathogen that can be lethal to humans. The infection has been correlated with pre-existing liver disease, particularly liver cirrhosis. Awareness of V. vulnificus infection among Japanese citizens is low, despite the increasing number of patient...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Nagao Y,Matsuoka H,Seike M,Yamasaki K,Kato J,Nakajima T,Miyazaki Y,Ohno T,Inuzuka S,Ohira H,Yokosuka O,Yatsuhashi H,Mori T,Honda K,Kawaguchi T,Ide T,Sata M

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Macrolide antibiotics are highly active in vitro against B.burgdorferi, but have limited efficacy in the treatment of patients with Lyme Disease. As macrolides are less active at a low pH, their poor clinical activity might be due to localization of borrelia to an acidic endosome, and their activity improved...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Donta ST

更新日期：2003-11-01 00:00:00

abstract：:BACKGROUND Colon adenocarcinoma (COAD) is one of the most common malignant tumors and has high incidence and mortality rates. The interferon regulatory factor (IRF) family is known as a key transcription factor in the IFN signaling pathway and cellular immunity. This research explored the relationship between the IRF ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yuemaier M,Zhou Z,Zhou Y,Wu C,Li F,Liang X,Kang H,Shen D,Gao F,Lin J

更新日期：2020-11-08 00:00:00

abstract：:BACKGROUND This study investigated the effect of occupational stress and circadian clock gene polymorphism on sleep disorder of oil workers in Xinjiang, China. MATERIAL AND METHODS We enrolled 2300 Xinjiang oil workers who had been working for at least 1 year. The Chinese revised version of the Occupational Stress Que...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Ning L,Shi L,Tao N,Li R,Jiang T,Liu J

更新日期：2020-08-01 00:00:00

abstract：:BACKGROUND The habit of khat (Catha Edulis Forskal) chewing is widely practiced in the southern regions of Saudi Arabia, Yemen, and East Africa. This social habit has tremendous effects on oral and general health of khat chewers. Khat may affect bacterial species in plaque biofilms on oral rehabilitation materials. Th...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Al Moaleem MM,Porwal A,Al Ahmari NM,Shariff M,Homeida H,Khalid A

更新日期：2020-01-20 00:00:00

abstract：BACKGROUND:Dihydrolipoamide dehydrogenase (DLD) deficiency is a rare cause of primary lactic acidosis in infancy. MATERIAL AND METHODS:This article presents the results of biochemical and molecular analyses and metabolic response to treatment procedures in a 10-week old boy presenting with vomiting, progressive hypoto...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Cerna L,Wenchich L,Hansiková H,Kmoch S,Peskova K,Chrastina P,Brynda J,Zeman J

更新日期：2001-11-01 00:00:00

abstract：:BACKGROUND The objective of the current study was to guide the early clinical treatment strategies by assessing the recovery of abnormal coagulation in acute promyelocytic leukemia (APL) patients during induction therapy. MATERIAL AND METHODS Retrospective analysis was performed in 112 newly-diagnosed patients with AP...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Song YH,Qiao C,Xiao LC,Zhang R,Lu H-

更新日期：2018-05-17 00:00:00

abstract：:BACKGROUND The aim of this study was to analyze the differences in vaginal microecological factors and genital tract infections among pregnant women of different ages. MATERIAL AND METHODS This study included 751 pregnant women from West China Second University Hospital, Sichuan University, China, from January 2015 to...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yu F,Tang YT,Hu ZQ,Lin XN

更新日期：2018-08-01 00:00:00

abstract：:BACKGROUND Splenic injury is the leading cause of major bleeding after blunt abdominal trauma. We examined the clinical and radiological presentations, management, and outcome of blunt splenic injuries (BSI) in our institution. MATERIAL AND METHODS A retrospective study of BSI patients between 2011 and 2014 was conduc...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jabbour G,Al-Hassani A,El-Menyar A,Abdelrahman H,Peralta R,Ellabib M,Al-Jogol H,Asim M,Al-Thani H

更新日期：2017-07-12 00:00:00

abstract：BACKGROUND:Our objective was to determine whether adenosine-induced ischemia exerts a delayed cardiac protective effect in patients with stable effort angina ischemic heart disease. MATERIAL/METHODS:The study group was comprised of 32 patients (men) with symptoms of stable effort angina, aged 38-65 years (Group 1), an...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gawor Z,Granosik A,Grabowicz W,Piotrowski G,Grycewicz T,Goch A,Markuszewski L,Goch JH

更新日期：2003-05-01 00:00:00