Dopamine D4 receptor gene DRD4 and its association with psychiatric disorders.

Abstract:

:Dopamine receptors control neural signals that modulates behavior. Dopamine plays an important role in normal attention; that is the reason for studying the genes of the dopaminergic system, mainly in connection with disorders of attention. DRD4 influences the postsynaptic action of dopamine and is implicated in many neurological processes, exhibits polymorphism and is one of the most studied genes in connection with psychiatric disorders. Associations were found with ADHD (attention deficit hyperactivity disorder), substance dependences, several specific personality traits, and reaction to stress. These findings have implications for pharmacogenetics. This article reviews the principle published associations of DRD4 variants with psychiatric disorders.

journal_name

Med Sci Monit

authors

Ptácek R,Kuzelová H,Stefano GB

doi

10.12659/msm.881925

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

RA215-20

issue

9

eissn

1234-1010

issn

1643-3750

pii

881925

journal_volume

17

pub_type

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