Abstract：
BACKGROUND:Focal adhesion kinase (FAK) is an enzyme of the tyrosine kinase group linked to signaling pathways between cells and the extracellular matrix. In tumor cells in vitro, FAK expression correlated with their ability for invasion and metastasis. Additionally, in vivo FAK has been implicated in malignant transformation and disease progression. The aim of the present study was to evaluate the clinical significance of FAK expression in breast ductal invasive carcinoma (DIC). MATERIAL/METHODS:Immunocytochemical techniques were used to assess FAK expression on cytological material obtained from 73 patients with breast DIC. FAK expression status (positivity, overexpression, and intensity of immunostaining) was compared with clinicopathological parameters and the tumor cells' proliferative capacity. RESULTS:Sixty-four of the 73 DIC cases (88%) were FAK positive and FAK protein overexpression was noted in 15 of the 73 (21%). In the DIC cases examined, FAK positivity correlated with tumor size (p=0.016) and FAK protein overexpression with tumor histological grade (p=0.034) and the tumor cells' proliferative capacity (p=0.003). The intensity of FAK protein staining did not significantly correlate with any of the examined clinicopathological parameters. CONCLUSIONS:In breast DIC it becomes evident that FAK protein positivity and overexpression correlate with important clinicopathological parameters. Further molecular and clinical studies are required to delineate the significance of FAK as a factor for better prognosis and management of breast cancer patients.
journal_name
Med Sci Monitjournal_title
Medical science monitor : international medical journal of experimental and clinical researchauthors
Theocharis SE,Klijanienko JT,Padoy E,Athanassiou S,Sastre-Garau XXsubject
Has Abstractpub_date
2009-08-01 00:00:00pages
BR221-6issue
8eissn
1234-1010issn
1643-3750pii
878132journal_volume
15pub_type
杂志文章abstract：BACKGROUND:Intraoperative bacterial contamination is a major risk factor for postoperative wound infections. This study investigated the influence of type of ventilation system on intraoperative airborne bacterial burden before and after installation of unidirectional displacement air flow systems. MATERIAL AND METHOD...
journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：10.12659/MSM.894251
更新日期：2015-08-13 00:00:00
abstract：BACKGROUND:The purpose of our research was to determine diagnosis and outcomes for non-contact lens related Acanthamoeba keratitis in south India. MATERIAL/METHODS:A retrospective review of the medical and microbiology records of culture-positive Acanthamoeba cases presenting between 1987 and 2001 to a tertiary eye ca...
journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：
更新日期：2003-04-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：10.12659/MSM.918782
更新日期：2019-08-08 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：
更新日期：2002-11-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：10.12659/MSM.914868
更新日期：2019-04-25 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：10.12659/MSM.890265
更新日期：2014-03-14 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
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更新日期：2018-07-15 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章,评审
doi：
更新日期：2005-07-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research pub_type： 杂志文章 doi：10.12659/MSM.918597 更新日期：2019-12-25 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章,撤回出版物
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更新日期：2020-04-09 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：
更新日期：2006-04-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章,评审
doi：
更新日期：2009-01-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 临床试验,杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：
更新日期：2007-06-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
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更新日期：2019-12-22 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：
更新日期：2008-05-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：10.12659/MSM.920320
更新日期：2020-07-17 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：10.12659/MSM.908589
更新日期：2018-06-20 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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更新日期：2007-04-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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更新日期：2016-06-07 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
doi：
更新日期：2006-08-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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更新日期：2015-05-20 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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更新日期：2015-03-16 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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更新日期：2008-12-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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更新日期：2001-01-01 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
pub_type： 杂志文章
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更新日期：2014-07-25 00:00:00
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journal_title：Medical science monitor : international medical journal of experimental and clinical research
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