Saponins and Flavonoids from Adzuki Bean (Vigna angularis L.) Ameliorate High-Fat Diet-Induced Obesity in ICR Mice.

abstract：:Drug scheduling within the international system of drug control and national legislation has been recently criticized as having insufficient footing in scientific evidence. The legal harms related to non-medical uses of certain drugs (e.g., cannabis) have arguably exceeded their physiological and social harmfulness co...

journal_title：Frontiers in pharmacology

authors： Dubljević V

更新日期：2018-08-20 00:00:00

abstract：:Neuroinflammation is regarded as one of the pathogenic factors of Alzheimer disease (AD). Previously, we showed that mice regularly injected with bacterial lipopolysaccharide (LPS) possessed the AD-like symptoms like episodic memory decline, elevated amounts of amyloid beta (Aβ) peptide (1-42), and decreased levels of...

journal_title：Frontiers in pharmacology

authors： Lykhmus O,Koval L,Voytenko L,Uspenska K,Komisarenko S,Deryabina O,Shuvalova N,Kordium V,Ustymenko A,Kyryk V,Skok M

更新日期：2019-04-17 00:00:00

abstract：:Mechanisms of pain resolution are largely unclear. Increasing evidence suggests that specialized pro-resolving mediators (SPMs), derived from fish oil docosahexaenoic acid (DHA), promote the resolution of acute inflammation and potently inhibit inflammatory and neuropathic pain. In this study, we examined the analgesi...

journal_title：Frontiers in pharmacology

authors： Zhang L,Terrando N,Xu ZZ,Bang S,Jordt SE,Maixner W,Serhan CN,Ji RR

更新日期：2018-05-01 00:00:00

abstract：:A growing set of observations points to mitochondrial dysfunction, iron accumulation, oxidative damage and chronic inflammation as common pathognomonic signs of a number of neurodegenerative diseases that includes Alzheimer's disease, Huntington disease, amyotrophic lateral sclerosis, Friedrich's ataxia and Parkinson'...

journal_title：Frontiers in pharmacology

authors： Urrutia PJ,Mena NP,Núñez MT

更新日期：2014-03-10 00:00:00

abstract：:The development of current neuroleptics was largely aiming to decrease excessive dopaminergic signaling in the striatum. However, the notion that abnormal dopamine creates psychotic symptoms by causing an aberrant assignment of salience that drives maladaptive learning chronically during disease development suggests a...

journal_title：Frontiers in pharmacology

authors： Kätzel D,Wolff AR,Bygrave AM,Bannerman DM

更新日期：2020-10-16 00:00:00

abstract：:Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum, exerts a number of pharmacological actions which are not solely limited to the central nervous system. Recently it has been demonstrated that Salvinorin A inhibits acute inflammatory response affecting leukotriene (LT) production. Since LTs are pot...

journal_title：Frontiers in pharmacology

authors： Rossi A,Caiazzo E,Bilancia R,Riemma MA,Pagano E,Cicala C,Ialenti A,Zjawiony JK,Izzo AA,Capasso R,Roviezzo F

更新日期：2017-01-13 00:00:00

abstract：:Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcriptio...

journal_title：Frontiers in pharmacology

authors： Axelsen LN,Calloe K,Holstein-Rathlou NH,Nielsen MS

更新日期：2013-10-22 00:00:00

abstract：:Neuropathic pain is still an extremely important problem in today's medicine because opioids, which are commonly used to reduce pain, have limited efficacy in this type of pathology. Therefore, complementary therapy is needed. Our experiments were performed in rats to evaluate the contribution of the purinergic system...

journal_title：Frontiers in pharmacology

authors： Jurga AM,Piotrowska A,Makuch W,Przewlocka B,Mika J

更新日期：2017-02-16 00:00:00

abstract：:We explored the therapeutic effects of Dendrobium officinale polysaccharide (DOP) on CCl4-induced liver fibrosis with respect to the intestinal hepatic axis using a rat model. Histopathological staining results showed that DOP alleviated extensive fibrous tissue proliferation in interstitium and lessened intestinal mu...

journal_title：Frontiers in pharmacology

authors： Wang K,Yang X,Wu Z,Wang H,Li Q,Mei H,You R,Zhang Y

更新日期：2020-03-12 00:00:00

abstract：:A better understanding of the negative impact of general anesthetics on gastrointestinal motility requires thorough knowledge of their molecular targets. In this respect the muscarinic cationic current (mICAT carried mainly via TRPC4 channels) that initiates cholinergic excitation-contraction coupling in the gut is of...

journal_title：Frontiers in pharmacology

authors： Melnyk MI,Dryn DO,Al Kury LT,Dziuba DO,Zholos AV

更新日期：2020-12-18 00:00:00

abstract：:Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allody...

journal_title：Frontiers in pharmacology

authors： Silva RV,Oliveira JT,Santos BLR,Dias FC,Martinez AMB,Lima CKF,Miranda ALP

更新日期：2017-10-17 00:00:00

abstract：:Osteosarcoma (OS) is a malignant primary bone tumor with high metastatic rate. C-X-C motif chemokine ligand 6 (CXCL6) and its receptor C-X-C motif chemokine receptor 1/2 (CXCR1/2) have been found to participate in the process of carcinogenesis. In this study, we evaluated the role of CXCL6/CXCR1/2 axis in proliferatio...

journal_title：Frontiers in pharmacology

authors： Liu G,An L,Zhang H,Du P,Sheng Y

更新日期：2019-03-28 00:00:00

abstract：:Objective: To evaluate the hemostasis and coagulation effect of Hemocoagulase Bothrops Atrox in benign prostatic hyperplasia (BPH) patients undergoing transurethral bipolar plasmakinetic prostatectomy (TUPKP). Methods: This study adopted a multicenter, prospective, and real world design. BPH patients undergoing TUPKP ...

journal_title：Frontiers in pharmacology

authors： Li BH,Yu ZJ,Wang CY,Zi H,Li XD,Wang XH,Ren XY,Liu TZ,Zheng H

更新日期：2019-11-27 00:00:00

abstract：:Product mislabeling and/or species fraud in Traditional Chinese Medicine (TCM) not only decrease TCM quality, but also pose a potential health issue to the end user. Up to now, methods to control TCM quality have been developed to detect specific metabolites or identify the original species. However, species quantific...

journal_title：Frontiers in pharmacology

authors： Zhao B,Xiong C,Li J,Zhang D,Shi Y,Sun W,Duan X

更新日期：2020-11-26 00:00:00

abstract：:Skeletal dysplasias represent a large and diverse group of rare conditions affecting collagen and bone. They can be clinically classified based on radiographic and physical features, and many can be further defined at a molecular level (Bonafe et al., 2015). Early diagnosis is critical to proper medical management inc...

journal_title：Frontiers in pharmacology

authors： Jelin AC,O'Hare E,Blakemore K,Jelin EB,Valle D,Hoover-Fong J

更新日期：2017-03-06 00:00:00

abstract：:Objective: To assess the validity of a treatments- and tests-based Case-Finding Algorithm for identifying patients with non-small cell lung cancer (NSCLC) from claims databases. Data sources: Primary data from the HealthCore Integrated Research Environment (HIRE)-Oncology database and the HealthCore Integrated Researc...

journal_title：Frontiers in pharmacology

authors： Turner RM,Chen YW,Fernandes AW

更新日期：2017-11-30 00:00:00

abstract：:Diabetes is affecting the social and economic developments in developing countries like Sri Lanka. Siddha Medicine (Tamil Medicine) is mostly practiced in the Eastern and Northern Provinces of Sri Lanka. Our recent review of Sri Lankan Siddha historical documents identified 171 plant species used to prepare anti-diabe...

journal_title：Frontiers in pharmacology

authors： Sathasivampillai SV,Rajamanoharan PRS,Heinrich M

更新日期：2018-10-10 00:00:00

abstract：:Cannabis extracts in oil are becoming increasingly available, and, during the last years, there has been growing public and scientific interest about therapeutic properties of these compounds for the treatment of several neurologic diseases, not just epilepsy. The discovered role of the endocannabinoid system in epile...

journal_title：Frontiers in pharmacology

authors： Raucci U,Pietrafusa N,Paolino MC,Di Nardo G,Villa MP,Pavone P,Terrin G,Specchio N,Striano P,Parisi P

更新日期：2020-09-29 00:00:00

abstract：:Background: To assess the health-related quality of life (HRQoL) of oral anticoagulant therapy users, different types of instruments are available, either general or specific tools like Duke Anticoagulation Satisfaction Scale (DASS). These tools allow the clinician to adjust the treatment regimen to focus on increasin...

journal_title：Frontiers in pharmacology

authors： AlAmmari M,Sultana K,AlHarbi SN,Marenga AS,AlTuraiki A,Althemery AU,Alfaifi AA,AlShehri A,Aqeel BF

更新日期：2020-12-17 00:00:00

abstract：:Gut microbiome maintains local gut integrity and systemic host homeostasis, where optimal control of intestinal lipopolysaccharides (LPS) activity may play an important role. LPS mainly produced from gut microbiota are a group of lipid-polysaccharide chemical complexes existing in the outer membrane of Gram-negative b...

journal_title：Frontiers in pharmacology

authors： Lin TL,Shu CC,Chen YM,Lu JJ,Wu TS,Lai WF,Tzeng CM,Lai HC,Lu CC

更新日期：2020-04-30 00:00:00

abstract：:Cissus quadrangularis (C. quadrangularis) is a plant of the Vitaceae family known for its anticonvulsant effects in traditional medicine. The objective of this study was to elucidate the anxiolytic and antiepileptic effects of aqueous extract of C. quadrangularis. The mice were divided into different groups and treate...

journal_title：Frontiers in pharmacology

authors： Moto FCO,Arsa'a A,Ngoupaye GT,Taiwe GS,Njapdounke JSK,Kandeda AK,Nkantchoua GCN,Omam Omam JP,Pale S,Kouemou NE,Ayissi Mbomo ER,Pahaye DB,Ojong L,Mairara V,Ngo Bum E

更新日期：2018-07-17 00:00:00

abstract：:The radioresistance of tumors affect the outcome of radiotherapy. Accumulating data suggest that 1α,25(OH)2D3 is a potential anti-oncogenic molecule in various cancers. In the present study, we investigated the radiosensitive effects and underlying mechanisms of 1α,25(OH)2D3in vitro and in vivo. We found that 1α,25(OH...

journal_title：Frontiers in pharmacology

authors： Ji MT,Nie J,Nie XF,Hu WT,Pei HL,Wan JM,Wang AQ,Zhou GM,Zhang ZL,Chang L,Li BY

更新日期：2020-08-07 00:00:00

abstract：:Despite an improved understanding of the genetic background and the pathomechanisms of amyotrophic lateral sclerosis (ALS) no novel disease-modifying therapies have been successfully implemented in clinical routine. Riluzole still remains the only clinically approved substance in human ALS treatment with limited effic...

journal_title：Frontiers in pharmacology

authors： Günther R,Balck A,Koch JC,Nientiedt T,Sereda M,Bähr M,Lingor P,Tönges L

更新日期：2017-01-31 00:00:00

abstract：:Uterine leiomyomas are the most common benign neoplasms in women of reproductive age. However, non-surgical treatments for uterine myomas have not been fully evaluated. In Korea and China, Gyejibongnyeong-hwan (GBH) is widely used to treat gynecological diseases. Thus, we investigated the effects of GBH in human uteri...

journal_title：Frontiers in pharmacology

authors： Lee SM,Choi ES,Ha E,Ji KY,Shin SJ,Jung J

更新日期：2019-09-25 00:00:00

abstract：:Uric acid (UA) is the end product of purine nucleotide metabolism in the human body. Hyperuricemia is an abnormally high level of UA in the blood and may result in arthritis and gout. The prevalence of hyperuricemia has been increasing globally. Epidemiological studies have shown that UA levels are positively correlat...

journal_title：Frontiers in pharmacology

authors： Yu W,Cheng JD

更新日期：2020-11-16 00:00:00

abstract：BACKGROUND:Infection with the Hepatitis C Virus (HCV) is a widespread transmittable disease with a diagnosed prevalence of 2.0%. Fortunately, it is now curable in most patients. Sales of medicines to treat HCV infection grew 2.7% per year between 2004 and 2011, enhanced by the launch of the protease inhibitors (PIs) bo...

journal_title：Frontiers in pharmacology

authors： de Bruijn W,Ibáñez C,Frisk P,Bak Pedersen H,Alkan A,Vella Bonanno P,Brkičić LS,Bucsics A,Dedet G,Eriksen J,Fadare JO,Fürst J,Gallego G,Godói IP,Guerra Júnior AA,Gürsöz H,Jan S,Jones J,Joppi R,Kerman S,Laius O,Ma

更新日期：2016-07-22 00:00:00

abstract：:Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. In Parkinson's disease patients, CBD is able to attenuate the psychotic symptoms induced by L-DOPA and to improve quality of life. Repeated administration of...

journal_title：Frontiers in pharmacology

authors： Peres FF,Levin R,Suiama MA,Diana MC,Gouvêa DA,Almeida V,Santos CM,Lungato L,Zuardi AW,Hallak JE,Crippa JA,Vânia D,Silva RH,Abílio VC

更新日期：2016-09-28 00:00:00

abstract：:The pentose phosphate pathway (PPP), which branches from glycolysis, is correlated with cancer cell proliferation, survival and senescence. In this study, differences in the metabolic profile of the PPP and the redox status of human lung carcinoma A549 cells and cisplatin-induced multidrug-resistant A549/DDP cells wer...

journal_title：Frontiers in pharmacology

authors： Hong W,Cai P,Xu C,Cao D,Yu W,Zhao Z,Huang M,Jin J

更新日期：2018-01-31 00:00:00

abstract：:Wear particles that detach from the surface of prostheses induce excessive activation of osteoclast and immoderate release of inflammatory cytokines that lead to peri-implant osteolysis and aseptic loosening. In this work, we investigated whether magnoflorine, a quaternary aporphine alkaloid extracted from the Chinese...

journal_title：Frontiers in pharmacology

authors： Sun Z,Zeng J,Wang W,Jia X,Wu Q,Yu D,Mao Y

更新日期：2020-04-02 00:00:00

abstract：:Background and Objectives: Although the relationship between the use of proton pump inhibitors (PPIs) and pulmonary tuberculosis (TB) in Taiwan published in 2014. Due to just only one article and not enough comprehensively, we explore this issue. Methods: We conducted a population-based case-control study to identify ...

journal_title：Frontiers in pharmacology

authors： Cheng KC,Liao KF,Lin CL,Lai SW

更新日期：2017-07-19 00:00:00