Distinct Analgesic Actions of DHA and DHA-Derived Specialized Pro-Resolving Mediators on Post-operative Pain After Bone Fracture in Mice.

abstract：:A Chinese herbal decoction, Zishen Jiangtang Pill (ZJP), has been clinically prescribed to diabetic patients to prevent excessive blood sugar levels for decades. However, the potential mechanisms of this action have not been well investigated. The purpose of this study was to explore the metabolic variations in respon...

journal_title：Frontiers in pharmacology

authors： Chen J,Zheng L,Hu Z,Wang F,Huang S,Li Z,Zheng P,Zhang S,Yi T,Li H

更新日期：2019-03-19 00:00:00

abstract：Objective:Drawing a growth curve of multidrug-resistant Pseudomonas aeruginosa (MDR-PA) provides a foundation for susceptibility testing. By observing in vitro antibacterial activity and ultrastructure cthanges on MDR-PA of the effective components in the drug-containing serum of rats after the administration of Fuzhen...

journal_title：Frontiers in pharmacology

authors： Xu H,Liu C,Li M,Wang C,Liu G,Wang H,Ma J,Li L,Chen M,Cheng M,Yao X,Lin Y,Zhao S,Wang Y,Wang M

更新日期：2020-02-12 00:00:00

abstract：:Increasing evidence has demonstrated that neuroinflammation contributes to the development of depressive-like behaviors, in both animal models and human patients; however, the brain areas and signaling pathways involved are still elusive. Recent studies have suggested novel roles of the habenula in the onset of depres...

journal_title：Frontiers in pharmacology

authors： Zhao YW,Pan YQ,Tang MM,Lin WJ

更新日期：2018-05-15 00:00:00

abstract：:Lung cancer is one of main causes of cancer mortality and 83% of lung cancer cases are classified as non-small cell lung cancer (NSCLC). Patients with NSCLC usually have a poor prognosis and one of the leading causes is drug resistance. With the progress of drug therapy, the emergence and development of drug resistanc...

journal_title：Frontiers in pharmacology

authors： Sun R,Wang R,Chang S,Li K,Sun R,Wang M,Li Z

更新日期：2019-12-18 00:00:00

abstract：:Tacrolimus (Tac) is a profoundly effective immunosuppressant that reduces the risk of rejection after solid organ transplantation. However, its use is hampered by its narrow therapeutic window along with its highly variable pharmacological (pharmacokinetic [PK] and pharmacodynamic [PD]) profile. Part of this variabili...

journal_title：Frontiers in pharmacology

authors： Woillard JB,Mourad M,Neely M,Capron A,van Schaik RH,van Gelder T,Lloberas N,Hesselink DA,Marquet P,Haufroid V,Elens L

更新日期：2017-06-08 00:00:00

abstract：:Rheumatoid arthritis is an autoimmune disease characterized by synovial hyperplasia and progressive joint destruction. As reported previously, recombinant human endostatin (rhEndostatin) is associated with inhibition of joint bone destruction present in rat adjuvant-induced arthritis; however, the effect of rhEndostat...

journal_title：Frontiers in pharmacology

authors： Chen N,Gao RF,Yuan FL,Zhao MD

更新日期：2016-06-01 00:00:00

abstract：:Drug-induced liver injury (DILI) is a major clinical problem where natural compounds hold promise for its abrogation. Khaya grandifoliola (Meliaceae) is used in Cameroonian traditional medicine for the treatment of liver related diseases and has been studied for its hepatoprotective properties. Till date, reports show...

journal_title：Frontiers in pharmacology

authors： Kouam AF,Yuan F,Njayou FN,He H,Tsayem RF,Oladejo BO,Song F,Moundipa PF,Gao GF

更新日期：2017-09-19 00:00:00

abstract：:Melanoma immunotherapy, specifically the autotransplant of dendritic cells charged with tumors antigens, has shown promising results in clinical trials. The positive clinical effects of this therapy have been associated to increased Th17 response and delayed-type hypersensitivity (DTH) against to tumor antigens. Some ...

journal_title：Frontiers in pharmacology

authors： Robles-Planells C,Michelson SA,Mena J,Escrig D,Rojas JL,Sanchez-Guerrero G,Hernández R,Barrera-Avalos C,Rojo LE,Sauma D,Kalergis AM,Imarai M,Fernández R,Robles CA,Leiva-Salcedo E,Santander R,Escobar A,Acuña-Castillo C

更新日期：2019-10-22 00:00:00

abstract：:More than a century has passed since the first surgical mesh for hernia repair was developed, and, to date, this is still the most widely used method despite the great number of complications it poses. The purpose of this study was to combine stem cell therapy and laparoscopy for the treatment of congenital hernia in ...

journal_title：Frontiers in pharmacology

authors： Marinaro F,Casado JG,Blázquez R,Brun MV,Marcos R,Santos M,Duque FJ,López E,Álvarez V,Usón A,Sánchez-Margallo FM

更新日期：2020-09-25 00:00:00

abstract：:Background and Objectives: Limited research focuses on the risk of ischemic cerebrovascular disease associated with use of dipeptidyl peptidase-4 inhibitors (DPP-4 inhibitors) in patients with type 2 diabetes mellitus in Taiwan. This study aimed to investigate the association between DPP-4 inhibitors use and the first...

journal_title：Frontiers in pharmacology

authors： Lai SW,Liao KF,Lin CL,Lin HF

更新日期：2017-11-22 00:00:00

abstract：:Imatinib (IM), as first inhibitor of the oncogenic tyrosine kinase BCR-ABL, has been widely used to treat chronic myeloid leukemia (CML) for decades in clinic. However, resistance to IM usually occurs in CML patients. The bone marrow (BM), as the predominant microenvironment of CML, secretes an abundant amount of cyto...

journal_title：Frontiers in pharmacology

authors： Zhang X,Liu Y,Lu L,Huang S,Ding Y,Zhang Y,Guo Q,Li Z,Zhao L

更新日期：2017-08-11 00:00:00

abstract：:Dysregulation of the complement system is central to age-related macular degeneration (AMD), the leading cause of blindness in the developed world. Most of the genetic variation associated with AMD resides in complement genes, with the greatest risk associated with polymorphisms in the complement factor H (CFH) gene; ...

journal_title：Frontiers in pharmacology

authors： Stravalaci M,Davi F,Parente R,Gobbi M,Bottazzi B,Mantovani A,Day AJ,Clark SJ,Romano MR,Inforzato A

更新日期：2020-11-26 00:00:00

abstract：:Background and Objective: Idiopathic central precocious puberty (ICPP) is characterized by early pubertal changes, the acceleration of growth velocity, and rapid bone maturation that often results in reduced adult height. Gonadotrophin-releasing hormone agonist (GnRHa) is currently considered to be an effective therap...

journal_title：Frontiers in pharmacology

authors： Yu HK,Liu X,Chen JK,Wang S,Quan XY

更新日期：2019-02-11 00:00:00

abstract：:The pathophysiology of inflammation and oxidative stress generated during different types of cancers and anticancer treatments is well documented. Traditionally, grape pomace is used for animal feed, organic fertilizers, ethanol production or is disposed as waste. Because grape pomace is a rich source of antioxidant c...

journal_title：Frontiers in pharmacology

authors： Balea ŞS,Pârvu AE,Pârvu M,Vlase L,Dehelean CA,Pop TI

更新日期：2020-07-03 00:00:00

abstract：:Wnt/β-catenin signaling is involved in various biological processes, including the development of the central nervous system. The dysfunction of mitochondria has been shown to participate in the progress of subarachnoid hemorrhage (SAH). Traumatic subarachnoid hemorrhage (tSAH) is a serious complication in acute crani...

journal_title：Frontiers in pharmacology

authors： Li Y,Wang J,Li Z,Cheng H,Zhang Z,Luo T,Zhang X,Gao G,Lu H,Li L

更新日期：2020-01-30 00:00:00

abstract：:The exponential growth of the Internet of Things and the global popularity and remarkable decline in cost of the mobile phone is driving the digital transformation of medical practice. The rapidly maturing digital, non-medical world of mobile (wireless) devices, cloud computing and social networking is coalescing with...

journal_title：Frontiers in pharmacology

authors： Loizou GD

更新日期：2016-07-21 00:00:00

abstract：:The present paper continues a more complex research related to the increased synergism in terms of both anti-inflammatory and analgesic effect obtained by the addition of chlorpheniramine (CLF) to the common acetylsalicylic acid (ASA), acetaminophen (PAR), and caffeine (CAF) combination. This synergistic effect was pr...

journal_title：Frontiers in pharmacology

authors： Voicu VA,Mircioiu C,Plesa C,Jinga M,Balaban V,Sandulovici R,Costache AM,Anuta V,Mircioiu I

更新日期：2019-06-20 00:00:00

abstract：:Tumor-targeting nanomaterial-based chemotherapeutic drug delivery systems have been shown to represent an efficacious approach for the treatment of cancer because of their stability in blood circulation and predictable delivery patterns, enhanced tumor-selective drug accumulation, and decreased toxicity to normal tiss...

journal_title：Frontiers in pharmacology

authors： Yu T,Li Y,Gu X,Li Q

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Abiraterone Acetate (AA) is approved for the treatment of mCRPC after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated and for treatment of mCRPC progressed during or after docetaxel-based chemotherapy regimen. The aim of this study is to evaluate the role of early...

journal_title：Frontiers in pharmacology

authors： Facchini G,Caffo O,Ortega C,D'Aniello C,Di Napoli M,Cecere SC,Della Pepa C,Crispo A,Maines F,Ruatta F,Iovane G,Pisconti S,Montella M,Berretta M,Pignata S,Cavaliere C

更新日期：2016-05-18 00:00:00

abstract：:Xueshuantong Lyophilized Powder (XST), consisting of a series of saponins extracted from Panax notoginseng, is widely applied to treat acute cerebral infarction, stroke, and coronary heart disease in China. However, most adverse drug reactions (ADR) in clinic are caused by quality problems of XST. In this study, six b...

journal_title：Frontiers in pharmacology

authors： Yang ZR,Wang ZH,Tang JF,Yan Y,Yue SJ,Feng WW,Shi ZY,Meng XT,Peng C,Wang CY,Meng DL,Yan D

更新日期：2018-06-15 00:00:00

abstract：:Hachimijiogan (HJG) is a traditional herbal medicine that improves anxiety disorders in patients with dementia. In this study, we tested the hypothesis that HJG exerts neurotrophic factor-like effects to ameliorate memory impairment in Alzheimer disease (AD) model rats. First, we describe that HJG acts to induce neuri...

journal_title：Frontiers in pharmacology

authors： Kubota K,Fukue H,Sato H,Hashimoto K,Fujikane A,Moriyama H,Watanabe T,Katsurabayashi S,Kainuma M,Iwasaki K

更新日期：2017-11-21 00:00:00

abstract：:Salvinorin A, a neoclerodane diterpene isolated from Salvia divinorum, exerts a number of pharmacological actions which are not solely limited to the central nervous system. Recently it has been demonstrated that Salvinorin A inhibits acute inflammatory response affecting leukotriene (LT) production. Since LTs are pot...

journal_title：Frontiers in pharmacology

authors： Rossi A,Caiazzo E,Bilancia R,Riemma MA,Pagano E,Cicala C,Ialenti A,Zjawiony JK,Izzo AA,Capasso R,Roviezzo F

更新日期：2017-01-13 00:00:00

abstract：:There are currently a number of imaging techniques available for evaluating the morphology of liposomes and other nanoparticles, with each having its own advantages and disadvantages that should be considered when interpreting data. Controlling and validating the morphology of nanoparticles is of key importance for th...

journal_title：Frontiers in pharmacology

authors： Robson AL,Dastoor PC,Flynn J,Palmer W,Martin A,Smith DW,Woldu A,Hua S

更新日期：2018-02-06 00:00:00

abstract：:In this paper we discuss the consensus view on the use of qualifying biomarkers in drug safety, raised within the frame of the XXIV meeting of the Spanish Society of Clinical Pharmacology held in Málaga (Spain) in October, 2011. The widespread use of biomarkers as surrogate endpoints is a goal that scientists have lon...

journal_title：Frontiers in pharmacology

authors： Agúndez JA,Del Barrio J,Padró T,Stephens C,Farré M,Andrade RJ,Badimon L,García-Martín E,Vilahur G,Lucena MI

更新日期：2012-01-19 00:00:00

abstract：:The radioresistance of tumors affect the outcome of radiotherapy. Accumulating data suggest that 1α,25(OH)2D3 is a potential anti-oncogenic molecule in various cancers. In the present study, we investigated the radiosensitive effects and underlying mechanisms of 1α,25(OH)2D3in vitro and in vivo. We found that 1α,25(OH...

journal_title：Frontiers in pharmacology

authors： Ji MT,Nie J,Nie XF,Hu WT,Pei HL,Wan JM,Wang AQ,Zhou GM,Zhang ZL,Chang L,Li BY

更新日期：2020-08-07 00:00:00

abstract：:Localized neuropathic pain can be relieved following the topical application of high-concentration capsaicin. This clinical effect is thought to be related to the temporary desensitization of capsaicin- and heat-sensitive epidermal nociceptors. The objective of the present study was to examine whether the changes in t...

journal_title：Frontiers in pharmacology

authors： van Neerven SGA,Mouraux A

更新日期：2020-05-19 00:00:00

abstract：Objective:Current prevention and/or treatment options for respiratory syncytial virus (RSV) infections are limited as no vaccine is available. Prophylaxis with palivizumab is very expensive and requires multiple intramuscular injections over the RSV season. Here we present proof-of-concept data using nebulized palivizu...

journal_title：Frontiers in pharmacology

authors： Rajapaksa AE,Do LAH,Suryawijaya Ong D,Sourial M,Veysey D,Beare R,Hughes W,Yang W,Bischof RJ,McDonnell A,Eu P,Yeo LY,Licciardi PV,Mulholland EK

更新日期：2020-08-19 00:00:00

abstract：:Animal poisons and venoms are comprised of different classes of molecules displaying wide-ranging pharmacological activities. This review aims to provide an in-depth view of toxin-based compounds from terrestrial and marine organisms used as diagnostic tools, experimental molecules to validate postulated therapeutic t...

journal_title：Frontiers in pharmacology

authors： Bordon KCF,Cologna CT,Fornari-Baldo EC,Pinheiro-Júnior EL,Cerni FA,Amorim FG,Anjolette FAP,Cordeiro FA,Wiezel GA,Cardoso IA,Ferreira IG,de Oliveira IS,Boldrini-França J,Pucca MB,Baldo MA,Arantes EC

更新日期：2020-07-24 00:00:00

abstract：:Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its cont...

journal_title：Frontiers in pharmacology

authors： Guo Y,Sun L,Xiao L,Gou R,Fang Y,Liang Y,Wang R,Li N,Liu F,Tang L

更新日期：2017-10-30 00:00:00

abstract：:Fibrosis is a major player in cardiovascular disease, both as a contributor to the development of disease, as well as a post-injury response that drives progression. Despite the identification of many mechanisms responsible for cardiovascular fibrosis, to date no treatments have emerged that have effectively reduced t...

journal_title：Frontiers in pharmacology

authors： McVicker BL,Bennett RG

更新日期：2017-05-31 00:00:00