Role of Osterix and MicroRNAs in Bone Formation and Tooth Development.

Abstract:

:Osterix (Osx) is an osteoblast-specific transcription factor that is essential for bone formation. MicroRNAs (miRNAs) are ~22-nucleotide-long noncoding RNAs that play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. They can also control osteoblast-mediated bone formation and osteoclast-related bone remodeling. The vital roles of Osx and miRNAs during bone formation have been well studied, but very few studies have discussed their co-functions and the relationships between them. In this review, we outline the significant functions of Osx and miRNAs on certain cell types during osteogenesis and illustrate their roles during tooth development. More importantly, we discuss the relationship between Osx and miRNAs, which we believe could lead to a new treatment for skeletal and periodontal diseases.

journal_name

Med Sci Monit

authors

Wang C,Liao H,Cao Z

doi

10.12659/msm.896742

subject

Has Abstract

pub_date

2016-08-20 00:00:00

pages

2934-42

eissn

1234-1010

issn

1643-3750

pii

896742

journal_volume

22

pub_type

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