Resveratrol Induces Endothelial Progenitor Cells Angiogenesis via MiR-542-3p by Targeting Angiopoietin-2 and Involves in Recanalization of Venous Thrombosis.

Abstract:

:BACKGROUND Endothelial progenitor cells (EPCs) play an important role in therapeutic angiogenesis. Besides, resveratrol (RSV) exerts many pharmacological functions in regulation of cell function. Furthermore, microRNAs (miRNAs) have been considered to be of great significance in biological process. In this study, we aimed to investigate the effect of RSV on EPCs and its potential mechanism that involved in recanalization of venous thrombosis. MATERIAL AND METHODS EPCs were treated with RSV, and angiogenic functions was evaluated by tube formation and migration assays. miR-542-3p expression level in EPCs was assessed and exogenously modified. Bioinformatic analysis was applied to detect the potential target of miR-542-3p. Effects of RSV treatment in vivo venous thrombosis rat model were evaluated. RESULTS RSV enhanced angiogenic function of EPCs and decreased expression of miR-542-3p. Dual luciferase reporter gene and western blot results confirmed angiopoietin-2 (ANGPT2) was a direct target of miR-542-3p. It was found that inhibition of miR-542-3p contributed to angiogenesis of EPCs and elevated ANGPT2 protein level. Finally, in a rat model of venous thrombosis, RSV-treated EPCs promoted recanalization of thrombi. CONCLUSIONS We demonstrated that RSV can contribute to progenitor cells angiogenesis via miR-542-3p by targeting ANGPT2, subsequently enhanced recanalization of thrombi.

journal_name

Med Sci Monit

authors

Lu Z,Wang S,Zhu X,Yuan X,Zhan Y,Li Y,Wang W

doi

10.12659/MSM.917013

subject

Has Abstract

pub_date

2019-10-13 00:00:00

pages

7675-7683

eissn

1234-1010

issn

1643-3750

pii

917013

journal_volume

25

pub_type

杂志文章
  • Lysophosphatidic Acid Promotes Expression and Activation of Matrix Metalloproteinase 9 (MMP9) in THP-1 Cells via Toll-Like Receptor 4/Nuclear Factor-κB (TLR4/NF-κB) Signaling Pathway.

    abstract::BACKGROUND Lysophosphatidic acid (LPA) is an active compound of oxidized low-density lipoprotein that serves as an endogenous TLR4 ligand. Ligand activation of TLR4 activates nuclear factor-kappaB (NF-κB) and the transcription of NF-κB-regulated inflammatory cytokines, which are involved in the development of atherosc...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.906450

    authors: Zhou ZB,Yang B,Li X,Liu H,Lei G

    更新日期:2018-07-13 00:00:00

  • Delays in Motor Development in Children with Down Syndrome.

    abstract:BACKGROUND:Children with Down syndrome (DS) present with delays in motor development. The reduced size of the cerebrum, brain maturation disorders, and pathophysiological processes lead to motor development delay. The aim of this study was to examine the gross motor function and estimate what motor abilities are signif...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.893377

    authors: Malak R,Kostiukow A,Krawczyk-Wasielewska A,Mojs E,Samborski W

    更新日期:2015-07-01 00:00:00

  • Evaluation of Risk Factors for Falls in Patients with Rheumatoid Arthritis.

    abstract::BACKGROUND The aim of our study was to investigate the risk factors for falls in the rheumatoid arthritis (RA) patient population in Poland. This would be a major step towards the development of new fall prevention programs. MATERIAL AND METHODS There were 450 RA patients who met the criteria of the American College o...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.921862

    authors: Mikos M,Kucharska E,Lulek AM,Kłosiński M,Batko B

    更新日期:2020-04-15 00:00:00

  • Association Between Alcohol Consumption and Metabolic Syndrome in a Community-Based Cohort of Korean Adults.

    abstract::BACKGROUND The relationship between alcohol consumption and metabolic syndrome (MetS) remains controversial. This study investigated the relationship between alcohol consumption and MetS components and prevalence. MATERIAL AND METHODS We analyzed 10 037 subjects (3076 MetS and 6961 non-MetS) in a community-based cohor...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.901309

    authors: Kim SK,Hong SH,Chung JH,Cho KB

    更新日期:2017-05-03 00:00:00

  • Hypertonic Saline Alleviates Brain Edema After Traumatic Brain Injury via Downregulation of Aquaporin 4 in Rats.

    abstract::BACKGROUND Hypertonic saline (HS) has been successfully used for treatment of various forms of brain edema. Decreased expression of aquaporin (AQP)4 and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-a and interleukin (IL)-1b have been linked to edema pathogenesis. This study examined the effect of 3% ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.907212

    authors: Yin J,Zhang H,Chen H,Lv Q,Jin X

    更新日期:2018-03-30 00:00:00

  • Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.

    abstract::BACKGROUND The aim of this study was to discuss the possible roles and clinical value of 2 circRNAs (hsa_circ_0049224 and has_circ_0049220) in SLE patients. MATERIAL AND METHODS Reverse-transcription real-time polymerase chain reaction (RT-PCR) was conducted to detect the expressions of hsa_circ_0049224, has_circ_0049...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.906507

    authors: Zhang C,Huang J,Chen Y,Shi W

    更新日期:2018-04-02 00:00:00

  • Diurnal profile of melatonin secretion in the acute phase of major depression and in remission.

    abstract:BACKGROUND:The aim of this study was to determine whether there are differences in the 24-hour melatonin secretion profile between patients with major depression (MD) before and after clomipramine treatment, and a control group, and also whether or not there exist statistically significant differences in the melatonin ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Rabe-Jabłońska J,Szymańska A

    更新日期:2001-09-01 00:00:00

  • Insulin Resistance Is Associated with Interleukin 1β (IL-1β) in Non-Diabetic Hemodialysis Patients.

    abstract::BACKGROUND Insulin resistance (IR) and inflammation are associated with increased risk of complications in chronic kidney disease (CKD) patients. However, the relationship between IR and the important proinflammatory interleukin-1β (IL-1β) is unclear in CKD patients. MATERIAL AND METHODS We conducted a cross-sectional...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.906269

    authors: Bi X,Ai H,Wu Q,Fan Q,Ding F,Hu C,Ding W

    更新日期:2018-02-13 00:00:00

  • Clinical onset of the Crohn's disease after eradication therapy of Helicobacter pylori infection. Does Helicobacter pylori infection interact with natural history of inflammatory bowel diseases?

    abstract:BACKGROUND:There are conflicting reports concerning the prevalence of Helicobacter pylori infection in patients with inflammatory bowel diseases: some studies connected Sulphasalazine therapy and lower incidence of Helicobacter pylori infection, but others showed lower prevalence of Helicobacter pylori infection in inf...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Jovanovic IR,Milosavjevic TN,Jankovic GP,Micev MM,Dugalic PD,Saranovic D,Ugljesic MM,Popovic DV,Bulajic MM

    更新日期:2001-01-01 00:00:00

  • Transcription factors having impact on vascular endothelial growth factor (VEGF) gene expression in angiogenesis.

    abstract::This article discusses the role of transcription factors in vascular endothelial growth factor (VEGF) gene expression. Angiogenesis is a complex and multilevel process of new capillary formation on the basis of already existing blood vessels. Physiologically, it is a very strictly regulated process, which results in a...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,评审

    doi:

    authors: Jośko J,Mazurek M

    更新日期:2004-04-01 00:00:00

  • Long Non-Coding RNA Cancer Susceptibility Candidate 2a (CASC2a) Is a Marker of Early Recurrence After Radical Cystectomy in Patients with Urothelial Carcinoma of the Bladder.

    abstract::BACKGROUND The aim of this study was to investigate the expression of long non-coding RNAs (lncRNA) cancer susceptibility candidate 2a (CASC2a) in patients with urothelial carcinoma of the bladder (UCB) and its predictive value in the recurrence of UCB after radical cystectomy (RC). MATERIAL AND METHODS Tumor and pair...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.905393

    authors: Li Z,Wang KE,Zhou XL,Zhou J,Ye CH

    更新日期:2018-01-23 00:00:00

  • Tirilazad mesylate improve water immersion stress induced decrease in erythrocyte deformability in the rats.

    abstract:BACKGROUND:Water immersion stress (WIS) in rats causes decrease in deformability of red blood cells (RBC). We hypothesize that this phenomenon is mediated by reactive oxygen species. Since tirilazad mesylate (U74006F) is a potent scavenger of free oxygen radicals, the aim of this study was to investigate possible influ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Chmiel B,Grabowska-Bochenek R,Piskorska D

    更新日期:2001-01-01 00:00:00

  • Association between reversal in the expression of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel and age-related atrial fibrillation.

    abstract:BACKGROUND:We compared cardiac electrophysiological indicators and regional expression levels of cardiac hyperpolarization-activated cyclic nucleotide-gated (HCN) channels between adult and aged dogs to identify possible mechanisms of age-related atrial fibrillation. MATERIAL/METHODS:Corrected sinus node recovery time...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.892505

    authors: Li YD,Hong YF,Zhang Y,Zhou XH,Ji YT,Li HL,Hu GJ,Li JX,Sun L,Zhang JH,Xin Q,Yusufuaji Y,Xiong J,Tang BP

    更新日期:2014-11-14 00:00:00

  • Treatment of Adenomyosis with Subcutaneous Etonogestrel Implants: A Clinical Observational Study in 17 Patients.

    abstract::BACKGROUND Adenomyosis is a cause of chronic pelvic pain in women of reproductive age. The aim of this study was to investigate the effects of subcutaneous etonogestrel implantation on adenomyosis. MATERIAL AND METHODS A clinical observational study included 17 women with adenomyosis who were treated with subcutaneous...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.908979

    authors: Wu J,Huang Y,Chen L,Hu J,Zou Y

    更新日期:2018-09-01 00:00:00

  • A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders.

    abstract:BACKGROUND:L-carnitine was proposed as a potential treatment for patients diagnosed with an autism spectrum disorder to improve mitochondrial dysfunction, but no prior randomized controlled trials have been conducted. MATERIAL/METHODS:Thirty subjects diagnosed with an ASD were randomly assigned to receive a standardiz...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,随机对照试验

    doi:10.12659/msm.881792

    authors: Geier DA,Kern JK,Davis G,King PG,Adams JB,Young JL,Geier MR

    更新日期:2011-06-01 00:00:00

  • Electrocardiographic changes in hospitalized patients with leptospirosis over a 10-year period.

    abstract:BACKGROUND:The aim of this study was to investigate the incidence and type of ECG changes in patients with leptospirosis regardless of clinical evidence of cardiac involvement. MATERIAL/METHODS:A total of 97 patients with serologically confirmed leptospirosis treated at the University Hospital for Infectious Diseases ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.881847

    authors: Škerk V,Markotić A,Puljiz I,Kuzman I,Čeljuska Tošev E,Habuš J,Turk N,Begovac J

    更新日期:2011-07-01 00:00:00

  • Robot-Assisted Radical Prostatectomy Is More Beneficial for Prostate Cancer Patients: A System Review and Meta-Analysis.

    abstract::BACKGROUND Robot-assisted radical prostatectomy (RARP) is increasingly used worldwide, but comparisons of perioperative, functional, and oncologic outcomes among RARP, laparoscopic radical prostatectomy (LRP), and open radical prostatectomy (ORP) remain inconsistent. MATERIAL AND METHODS Systematic literature searches...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,meta分析,评审

    doi:10.12659/msm.907092

    authors: Du Y,Long Q,Guan B,Mu L,Tian J,Jiang Y,Bai X,Wu D

    更新日期:2018-01-14 00:00:00

  • Higher Concentration of Hypertonic Saline Shows Better Recovery Effects on Rabbits with Uncontrolled Hemorrhagic Shock.

    abstract::BACKGROUND Our previous study found a novel fluid combination with better resuscitation effects under hypotensive condition at the early stage of uncontrolled hemorrhagic shock (UHS). However, the optimal recovery concentration of hypertonic saline in this fluid combination remains unknown. This experiment aimed to ex...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.916937

    authors: Xu L,Kang F,Hu W,Liu X

    更新日期:2019-10-30 00:00:00

  • The association of ventricular tachycardia and endothelial dysfunction in the setting of acute myocardial infarction with ST elevation.

    abstract:BACKGROUND:Ventricular tachycardia (VT) is frequently seen in ischemic settings like acute myocardial infarction with ST segment elevation (STEMI). Endothelial dysfunction (ED) represents inflammation and the loss of all protective features of the endothelium. We aimed to examine the association between VT and ED in pa...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/msm.884026

    authors: Škerk V,Markotić A,Delić Brkljačić D,Manola S,Krčmar T,Gabrić ID,Stajminger G,Pintarić H

    更新日期:2013-11-20 00:00:00

  • Specific Inhibition of β-Catenin in Jeko-1 Mantle Cell Lymphoma Cell Line Decreases Proliferation and Induces Apoptosis.

    abstract:BACKGROUND:The canonical Wnt signaling pathway has been considered as a potent oncogenic signaling in the initiation and progression of hematological malignancies. As a key regulator of the Wnt signaling pathway, the role of β-catenin in mantle cell lymphoma (MCL) pathogenesis and progression was investigated in this s...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.893514

    authors: He J,Huang Y,Weng J,Xiao L,Weng K,Ma X

    更新日期:2015-07-31 00:00:00

  • miR-26a-5p Regulates Synovial Fibroblast Invasion in Patients with Rheumatoid Arthritis by Targeting Smad 1.

    abstract::BACKGROUND We studied the expression and effect of miR-26a-5p in synovial fibroblast in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS The synovial tissues of 55 RA patients with total knee arthroplasty performed from January 2016 to December 2016 were collected as the RA group, and 62 patients without ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,收录出版

    doi:10.12659/MSM.907816

    authors: Zhang W,Chen L,Jiang Y,Shen Y

    更新日期:2018-07-26 00:00:00

  • Protective effects of aqueous fruit extract from Sea Buckthorn (Hippophae rhamnoides L. Spp. Turkestanica) on haloperidol-induced orofacial dyskinesia and neuronal alterations in the striatum.

    abstract:BACKGROUND:Long-term treatment of haloperidol, a neuroleptic, induces neurodegeneration specifically in the striatum (caudate and putamen), which plays an important role in the development of orofacial dyskinesia, a putative model of tardive dyskinesia (TD). This study investigated the protective effects of a concomita...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Batool F,Shah AH,Ahmed SD,Saify ZS,Haleem DJ

    更新日期:2010-08-01 00:00:00

  • Correlation of APOBEC3G Polymorphism with Human Papillomavirus (HPV) Persistent Infection and Progression of Cervical Lesions.

    abstract::BACKGROUND We studied the effect of APOBEC3G on persistent human papillomavirus (HPV) infection and the correlation between APOBEC3G polymorphism and HPV persistent infection and cervical disease progression in Uygur women in China. MATERIAL AND METHODS From January 2015 to December 2017, we enrolled 529 Uygur ethnic ...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.916142

    authors: Sui S,Chen H,Han L,Wang L,Niyazi M,Zhu K

    更新日期:2019-09-17 00:00:00

  • A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis.

    abstract:BACKGROUND:To examine the effect of probiotics as adjunctive therapy for the treatment of rheumatoid arthritis (RA). A sample size of 30 subjects was calculated to determine a moderate effect. MATERIAL/METHODS:A three month double-blind, placebo-controlled study was performed using probiotic Lactobacillus rhamnosus GR...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章,随机对照试验

    doi:10.12659/msm.881808

    authors: Pineda Mde L,Thompson SF,Summers K,de Leon F,Pope J,Reid G

    更新日期:2011-06-01 00:00:00

  • Blood serum and neutrophil L-arginine concentrations and nitric oxide release by neutrophils in chronic uremic patients and healthy persons.

    abstract:BACKGROUND:Plasma levels of L-arginine have previously been evaluated in several studies to reveal either down- or up-regulation of the L-arginine/NO pathway in chronic uremia. MATERIAL/METHODS:We studied L-arginine plasma levels along with intracellular neutrophil concentration and NO release by peripheral blood neut...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:

    authors: Rysz J,Guga P,Grycewicz T,Mudyna J,Luciak M

    更新日期:2003-07-01 00:00:00

  • Fasting Serum Low-Density Lipoprotein (LDL) Before Liver Transplantation Predicts Post-Transplant Survival.

    abstract::BACKGROUND The disordered metabolism of liver function in liver cancer patients can affect postoperative survival after liver transplantation. We assessed whether the levels of various chemicals in liver metabolism prior to receiving a liver transplant were prognostic factors and metabolism markers in predicting survi...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.913700

    authors: Li X,Gong J,Zhou W,Zhang H,Zheng J,Liang J,Hu B

    更新日期:2019-04-01 00:00:00

  • Role of Sevoflurane on Natural Killer Group 2, Member D-Mediated Immune Response in Non-Small-Cell Lung Cancer: An In Vitro Study.

    abstract::BACKGROUND The purpose of this study was to investigate the effects of sevoflurane on cancer immunosurveillance and metastasis in non-small-cell lung cancer (NSCLC). MATERIAL AND METHODS NCI-H23 cells, a human NSCLC cell line, were incubated with or without sevoflurane at the concentrations of 0, 12.5, 25, 50, 100, an...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.926395

    authors: Jeon S,Kim HK,Kwon JY,Baek SH,Ri HS,Choi HJ,Cho HR,Lee YS,Kim JY,Kim J,Bae J,Lee HJ

    更新日期:2020-11-03 00:00:00

  • Inhibitory Effect of Sirtuin6 (SIRT6) on Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells.

    abstract::BACKGROUND The imbalance between bone resorption and formation is the basic mechanism underlying osteoporosis in the elderly. Osteogenesis is the differentiation of human mesenchymal stem cells (hMSCs) into osteoblasts. Sirtuin6 (SIRT6) regulates various biological functions, including differentiation. Transient recep...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.917118

    authors: Xiao F,Zhou Y,Liu Y,Xie M,Guo G

    更新日期:2019-11-08 00:00:00

  • Predictive Value of A2HD Scoring for Transient Symptoms Associated with Infarction.

    abstract::BACKGROUND Effective early management of cerebral infarction patients with transient ischemic attack (TIA) is undermined by an inability to predict who is at highest risk of stroke. MATERIAL AND METHODS A total of 577 TIA patients with symptoms lasting no more than 1 hour were prospectively investigated and divided in...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.911941

    authors: Lu Y,Yu J,Hu J,Tan Y,Wu J,Zhao Y,Liu X

    更新日期:2019-01-02 00:00:00

  • Applicability of standard parameters in diagnostics of primary open-angle glaucoma.

    abstract:BACKGROUND:The aim of this study was to evaluate the sensitivity, specificity, and likelihood ratio of standard diagnostic parameters C/D, NFI, and MD and their applicability in diagnostics of primary open-angle glaucoma. MATERIAL AND METHODS:This study included 194 subjects (371 eyes), ages 30 to 65 years old, who un...

    journal_title:Medical science monitor : international medical journal of experimental and clinical research

    pub_type: 杂志文章

    doi:10.12659/MSM.883994

    authors: Polaczek-Krupa B,Grabska-Liberek I

    更新日期:2013-08-09 00:00:00