Does neuroinflammation turn on the flame in Alzheimer's disease? Focus on astrocytes.

abstract：:Traumatic brain injury (TBI) is a major public health concern that affects 69 million individuals each year worldwide. Neuropsychologists report that up to 40% of individuals undergoing evaluations for TBI may be malingering neurocognitive deficits for a compensatory reward. The memory recognition test of malingering ...

journal_title：Frontiers in neuroscience

authors： Neal J,Strothkamp S,Bedingar E,Cordero P,Wagner B,Vagnini V,Jiang Y

更新日期：2019-09-25 00:00:00

abstract：:Glutamate-induced excitotoxicity is one of the main causes of neuronal cell death in stroke. Compound 22a has been previously reported as a promising neuroprotective compound derived from tetramethylpyrazine, which is a widely used active ingredient of traditional Chinese medicine Chuanxiong (Ligusticum wallichii Fran...

journal_title：Frontiers in neuroscience

authors： Chen H,Cao J,Zhu Z,Zhang G,Shan L,Yu P,Wang Y,Sun Y,Zhang Z

更新日期：2018-08-15 00:00:00

abstract：:Animal functional magnetic resonance imaging (fMRI) has provided key insights into the physiological mechanisms underlying healthy and diseased brain states. In non-human primates, resting-state fMRI studies are commonly conducted under isoflurane anesthesia, where anesthetic concentration is used to roughly infer ane...

journal_title：Frontiers in neuroscience

authors： Zhang Z,Cai DC,Wang Z,Zeljic K,Wang Z,Wang Y

更新日期：2019-04-11 00:00:00

abstract：:Advanced algorithms are required to reveal the complex relations between neural and behavioral data. In this study, forelimb electromyography (EMG) signals were reconstructed from multi-unit neural signals recorded with multiple electrode arrays (MEAs) from the corticospinal tract (CST) in rats. A six-layer convolutio...

journal_title：Frontiers in neuroscience

authors： Guo Y,Gok S,Sahin M

更新日期：2018-10-17 00:00:00

abstract：:Brain-behavior correlations are commonly used to explore the associations between the brain and human behavior in cognitive neuroscience studies. There are many critics of the correlation approach, however. Most problems associated with correlation approaches originate in the weak statistical power of traditional corr...

journal_title：Frontiers in neuroscience

authors： Zhou X,Li M,Zhou H,Li L,Cui J

更新日期：2018-11-06 00:00:00

abstract：:Graph neural networks (GNN) rely on graph operations that include neural network training for various graph related tasks. Recently, several attempts have been made to apply the GNNs to functional magnetic resonance image (fMRI) data. Despite recent progresses, a common limitation is its difficulty to explain the clas...

journal_title：Frontiers in neuroscience

authors： Kim BH,Ye JC

更新日期：2020-06-30 00:00:00

abstract：:Numerous observational studies have shown that depressive symptoms are common in individuals with mild cognitive impairment (MCI) who have a higher rate of progress to dementia. However, it is still uncertain whether there are any differences between MCI patients with and without depression symptom in their brain func...

journal_title：Frontiers in neuroscience

authors： Yu Y,Li Z,Lin Y,Yu J,Peng G,Zhang K,Jia X,Luo B

更新日期：2019-12-17 00:00:00

abstract：:Manual scoring of polysomnography data is labor-intensive and time-consuming, and most existing software does not account for subjective differences and user variability. Therefore, we evaluated a supervised machine learning algorithm, SomnivoreTM, for automated wake-sleep stage classification. We designed an algorith...

journal_title：Frontiers in neuroscience

authors： Allocca G,Ma S,Martelli D,Cerri M,Del Vecchio F,Bastianini S,Zoccoli G,Amici R,Morairty SR,Aulsebrook AE,Blackburn S,Lesku JA,Rattenborg NC,Vyssotski AL,Wams E,Porcheret K,Wulff K,Foster R,Chan JKM,Nicholas CL,Fre

更新日期：2019-03-18 00:00:00

abstract：:Transsynaptic connections enabling cell-cell adhesion and cellular communication are a vital part of synapse formation, maintenance and function. A recently discovered interaction between the Adhesion GPCRs Latrophilins and the type II single transmembrane proteins Teneurins at mammalian synapses is vital for synapse ...

journal_title：Frontiers in neuroscience

authors： Schöneberg T,Prömel S

更新日期：2019-03-12 00:00:00

abstract：:We present a spiking neural network model of the thalamic Lateral Geniculate Nucleus (LGN) developed on SpiNNaker, which is a state-of-the-art digital neuromorphic hardware built with very-low-power ARM processors. The parallel, event-based data processing in SpiNNaker makes it viable for building massively parallel n...

journal_title：Frontiers in neuroscience

authors： Sen-Bhattacharya B,Serrano-Gotarredona T,Balassa L,Bhattacharya A,Stokes AB,Rowley A,Sugiarto I,Furber S

更新日期：2017-08-09 00:00:00

abstract：:The functional characterization of crustacean neuropeptides and their cognate receptors has not kept pace with the recent advances in sequence determination and, therefore, our understanding of the physiological roles of neuropeptides in this important arthropod sub-phylum is rather limited. We identified a candidate ...

journal_title：Frontiers in neuroscience

authors： Alexander J,Oliphant A,Wilcockson DC,Webster SG

更新日期：2018-07-04 00:00:00

abstract：:Spinocerebellar ataxia (SCA) is a part of the cerebellar neurodegenerative disease group that is diverse in genetics and phenotypes. It usually shows autosomal dominant inheritance. SCAs, always together with the cerebellar degeneration, may exhibit clinical deficits in brainstem or eye, especially retina or optic ner...

journal_title：Frontiers in neuroscience

authors： Park JY,Joo K,Woo SJ

更新日期：2020-08-21 00:00:00

abstract：:Emerging evidence suggest an impaired endocannabinoid activity in the pathophysiology of binge eating disorder (BED). Herein, we investigated whether endocannabinoid tone could be modified as a consequence of dietary-induced binge eating in female rats. For this purpose, brain levels of the endocannabinoids anandamide...

journal_title：Frontiers in neuroscience

authors： Satta V,Scherma M,Piscitelli F,Usai P,Castelli MP,Bisogno T,Fratta W,Fadda P

更新日期：2018-02-02 00:00:00

abstract：Background:Emerging evidence demonstrates that diet-induced obesity disrupts corticolimbic circuits underlying emotional regulation. Studies directed at understanding how obesity alters brain and behavior are easily confounded by a myriad of complications related to obesity. This study investigated the early neurobiolo...

journal_title：Frontiers in neuroscience

authors： Vega-Torres JD,Azadian M,Rios-Orsini RA,Reyes-Rivera AL,Ontiveros-Angel P,Figueroa JD

更新日期：2020-06-30 00:00:00

abstract：:Wireless electroencephalography (EEG) of small animal subjects typically utilizes miniaturized EEG devices which require a robust recording and electrode assembly that remains in place while also being well-tolerated by the animal so as not to impair the ability of the animal to perform normal living activities or exp...

journal_title：Frontiers in neuroscience

authors： Vogler EC,Flynn DT,Busciglio F,Bohannan RC,Tran A,Mahavongtrakul M,Busciglio JA

更新日期：2017-11-14 00:00:00

abstract：:The human cerebellum has recently been discovered to contribute to cognition and emotion beyond the planning and execution of movement, suggesting its functional heterogeneity. We aimed to identify the functional parcellation of the cerebellum using information from resting-state functional magnetic resonance imaging ...

journal_title：Frontiers in neuroscience

authors： Wang C,Kipping J,Bao C,Ji H,Qiu A

更新日期：2016-05-02 00:00:00

abstract：Purpose:Brain iron accumulation has been suggested as a pathomechanism in patients with type 2 diabetes mellitus (T2DM) with cognitive impairment. This research aims to examine the total-brain pattern of iron accumulation in relation to executive function decline in patients with T2DM by voxel-based quantitative suscep...

journal_title：Frontiers in neuroscience

authors： Li J,Zhang Q,Zhang N,Guo L

更新日期：2021-01-15 00:00:00

abstract：:Antipsychotic drugs (APDs) are widely prescribed to control various mental disorders. As mental disorders are chronic diseases, these drugs are often used over a life-time. However, APDs can cause serious glucometabolic side-effects including type 2 diabetes and hyperglycaemic emergency, leading to medication non-comp...

journal_title：Frontiers in neuroscience

authors： Chen J,Huang XF,Shao R,Chen C,Deng C

更新日期：2017-11-21 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fnins.2019.00117.]. ...

journal_title：Frontiers in neuroscience

authors： Zuo XN,Biswal BB,Poldrack RA

更新日期：2019-04-16 00:00:00

abstract：:Throughout development, neural stem cells (NSCs) give rise to differentiated neurons, astrocytes, and oligodendrocytes which together modulate perception, memory, and behavior in the adult nervous system. To understand how NSCs contribute to postnatal/adult brain remodeling and repair after injury, the lateral ventric...

journal_title：Frontiers in neuroscience

authors： Adlaf EW,Mitchell-Dick A,Kuo CT

更新日期：2016-03-24 00:00:00

abstract：:The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly complex polarized morphology. The motor protein complex cytoplasmic dynein has an important role ...

journal_title：Frontiers in neuroscience

authors： Jaarsma D,Hoogenraad CC

更新日期：2015-10-26 00:00:00

abstract：:A coordinate transformation framework for understanding how neurons compute sensorimotor behaviors has generated significant advances toward our understanding of basic brain function. This influential scaffold focuses on neuronal encoding of spatial information represented in different coordinate systems (e.g., eye-ce...

journal_title：Frontiers in neuroscience

authors： Chang SW

更新日期：2013-08-21 00:00:00

abstract：:We review the role of oscillations in the brain and in the auditory system showing that the ability of humans to distinguish changes in pitch can be explained as a precise analysis of temporal information in auditory signals by neural oscillations. The connections between auditory brain stem chopper neurons construct ...

journal_title：Frontiers in neuroscience

authors： Bahmer A,Gupta DS

更新日期：2018-10-31 00:00:00

abstract：:The ability to delegate control over repetitive tasks from higher to lower neural centers may be a fundamental innovation in human cognition. Plausibly, the massive neurocomputational challenges associated with the mastery of balance during the evolution of bipedality in proto-humans provided a strong selective advant...

journal_title：Frontiers in neuroscience

authors： Shine JM,Shine R

更新日期：2014-04-29 00:00:00

abstract：:Introduction: Spasticity is a typical motor disorder in patients affected by stroke. Typically post-stroke rehabilitation consists of repetition of mobilization exercises on impaired limbs, aimed to reduce muscle hypertonia and mitigate spastic reflexes. It is currently strongly debated if the treatment's effectivenes...

journal_title：Frontiers in neuroscience

authors： Crea S,Cempini M,Mazzoleni S,Carrozza MC,Posteraro F,Vitiello N

更新日期：2017-05-12 00:00:00

abstract：:The ternary complex factor (TCF) Elk-1 is a transcription factor that regulates immediate early gene (IEG) expression via the serum response element (SRE) DNA consensus site. Elk-1 is associated with a dimer of serum response factor (SRF) at the SRE site, and its phosphorylation occurs at specific residues in response...

journal_title：Frontiers in neuroscience

authors： Besnard A,Galan-Rodriguez B,Vanhoutte P,Caboche J

更新日期：2011-03-16 00:00:00

abstract：:In a previous study using transcranial alternating current stimulation (tACS), we found preliminary evidence that phase coherence in the alpha band (8-12 Hz) within the fronto-parietal network may critically support top-down control of spatial attention (van Schouwenburg et al., 2017). Specifically, synchronous alpha-...

journal_title：Frontiers in neuroscience

authors： van Schouwenburg MR,Sörensen LKA,de Klerk R,Reteig LC,Slagter HA

更新日期：2018-07-03 00:00:00

abstract：:Spinal cord injury (SCI), one of the most severe types of neurological damage, results in persistent motor and sensory dysfunction and involves complex gene alterations. Circular RNAs (circRNAs) are a recently discovered class of regulatory molecules, and their roles in SCI still need to be addressed. This study compr...

journal_title：Frontiers in neuroscience

authors： Wu R,Mao S,Wang Y,Zhou S,Liu Y,Liu M,Gu X,Yu B

更新日期：2019-12-10 00:00:00

abstract：:Although the palatability of sucrose is the primary reason for why it is over consumed, it is not well understood how it is encoded in the nucleus accumbens shell (NAcSh), a brain region involved in reward, feeding, and sensory/motor transformations. Similarly, untouched are issues regarding how an external auditory s...

journal_title：Frontiers in neuroscience

authors： Villavicencio M,Moreno MG,Simon SA,Gutierrez R

更新日期：2018-05-04 00:00:00

abstract：:Donepezil is a potent acetylcholinesterase inhibitor, largely used worldwide to alleviate cognitive symptoms in Alzheimer's disease (AD). Beyond the widely described neuronal impact of donepezil, it was recently shown that targeting connexins, the proteins involved in astrocyte network organization, potentiates donepe...

journal_title：Frontiers in neuroscience

authors： Vidal B,Droguerre M,Valdebenito M,Zimmer L,Hamon M,Mouthon F,Charvériat M

更新日期：2020-08-12 00:00:00