当前位置： SCI文献检索 > ACS Chemical Neuroscience期刊下所有文献 > Serotonin: A New Hope in Alzheimer's Disease?

Serotonin: A New Hope in Alzheimer's Disease?

Abstract：

:Alzheimer's disease (AD) is the most common form of dementia affecting 35 million individuals worldwide. Current AD treatments provide only brief symptomatic relief. It is therefore urgent to replace this symptomatic approach with a curative one. Increasing serotonin signaling as well as developing molecules that enhance serotonin concentration in the synaptic cleft have been debated as possible therapeutic strategies to slow the progression of AD. In this Viewpoint, we discuss exciting new insights regarding the modulation of serotonin signaling for AD prevention and therapy.

journal_name

ACS Chem Neurosci

journal_title

ACS chemical neuroscience

authors

Claeysen S,Bockaert J,Giannoni P

doi

10.1021/acschemneuro.5b00135

subject

Has Abstract

pub_date

2015-07-15 00:00:00

pages

940-3

issue

7

issn

1948-7193

journal_volume

6

pub_type

杂志文章

相关文献

ACS Chemical Neuroscience文献大全
  • Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice.

    abstract：:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by multiple hallmarks including extracellular amyloid (Aβ) plaques, neurofibrillary tangles, dysfunctional blood-brain barrier (BBB), neuroinflammation, and impaired autophagy. Thus, novel strategies that target multiple disease pathways wo...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.9b00175

    authors： Al Rihani SB,Darakjian LI,Kaddoumi A

    更新日期：2019-08-21 00:00:00

  • Reversal of Peripheral Neuropathic Pain by the Small-Molecule Natural Product Physalin F via Block of CaV2.3 (R-Type) and CaV2.2 (N-Type) Voltage-Gated Calcium Channels.

    abstract：:No universally efficacious therapy exists for chronic pain, a disease affecting one-fifth of the global population. An overreliance on the prescription of opioids for chronic pain despite their poor ability to improve function has led to a national opioid crisis. In 2018, the NIH launched a Helping to End Addiction Lo...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.9b00166

    authors： Shan Z,Cai S,Yu J,Zhang Z,Vallecillo TGM,Serafini MJ,Thomas AM,Pham NYN,Bellampalli SS,Moutal A,Zhou Y,Xu GB,Xu YM,Luo S,Patek M,Streicher JM,Gunatilaka AAL,Khanna R

    更新日期：2019-06-19 00:00:00

  • Synthesis, biophysical, and pharmacological evaluation of the melanocortin agonist AST3-88: modifications of peptide backbone at Trp 7 position lead to a potent, selective, and stable ligand of the melanocortin 4 receptor (MC4R).

    abstract：:The melanocortin-3 (MC3R) and melanocortin-4 (MC4R) receptors are expressed in the brain and are implicated in the regulation of food intake and energy homeostasis. The endogenous agonist ligands for these receptors (α-, β-, γ-MSH and ACTH) are linear peptides with limited receptor subtype selectivity and metabolic st...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/cn5000953

    authors： Singh A,Dirain ML,Wilczynski A,Chen C,Gosnell BA,Levine AS,Edison AS,Haskell-Luevano C

    更新日期：2014-10-15 00:00:00

  • Hydrogels in spinal cord injury repair strategies.

    abstract：:Nowadays there are at present no efficient therapies for spinal cord injury (SCI), and new approaches have to be proposed. Recently, a new regenerative medicine strategy has been suggested using smart biomaterials able to carry and deliver cells and/or drugs in the damaged spinal cord. Among the wide field of emerging...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章,评审

    doi：10.1021/cn200030w

    authors： Perale G,Rossi F,Sundstrom E,Bacchiega S,Masi M,Forloni G,Veglianese P

    更新日期：2011-07-20 00:00:00

  • Comparison of the binding and functional properties of two structurally different D2 dopamine receptor subtype selective compounds.

    abstract：:We previously reported on the synthesis of substituted phenyl-4-hydroxy-1-piperidyl indole analogues with nanomolar affinity at D2 dopamine receptors, ranging from 10- to 100-fold selective for D2 compared to the D3 dopamine receptor subtype. More recently, we evaluated a panel of aripiprazole analogues, identifying s...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/cn300142q

    authors： Luedtke RR,Mishra Y,Wang Q,Griffin SA,Bell-Horner C,Taylor M,Vangveravong S,Dillon GH,Huang RQ,Reichert DE,Mach RH

    更新日期：2012-12-19 00:00:00

  • A Difluoroboron β-Diketonate Probe Shows "Turn-on" Near-Infrared Fluorescence Specific for Tau Fibrils.

    abstract：:Tau aggregation in neuronal cells has recently received significant attention as a robust predictor of the progression of Alzheimer's disease (AD) because of its proven correlation with the degree of cognitive impairment in AD patients. Accordingly, noninvasive imaging of tau aggregates has been highlighted as a promi...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.7b00224

    authors： Park KS,Kim MK,Seo Y,Ha T,Yoo K,Hyeon SJ,Hwang YJ,Lee J,Ryu H,Choo H,Chong Y

    更新日期：2017-10-18 00:00:00

  • DARK Classics in Chemical Neuroscience: Opium, a Historical Perspective.

    abstract：:Opium is the latex from the opium poppy Papaver somniferum L., which humankind has utilized since ancient Mesopotamia all the way to modern times. Opium used to be surrounded in divine mystery or magic-like abilities and was given to cure a wide variety of diseases until its analgesic, antitussive, and antidiarrheal p...

    journal_title：ACS chemical neuroscience

    pub_type： 历史文章,杂志文章,评审

    doi：10.1021/acschemneuro.8b00459

    authors： Presley CC,Lindsley CW

    更新日期：2018-10-17 00:00:00

  • Ethylatropine Bromide as a Peripherally Restricted Muscarinic Antagonist.

    abstract：:Quaternary ammonium analogues of atropine that are unable to cross the blood-brain barrier are used to alleviate peripheral muscarinic toxicity in animal models of epilepsy produced by systemic administration of pilocarpine or diisopropylfluorophosphate (DFP). Currently, methylatropine is the most popular and potent o...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.6b00334

    authors： Rojas A,Ganesh T,Walker A,Dingledine R

    更新日期：2017-04-19 00:00:00

  • Discovery of Melanocortin Ligands via a Double Simultaneous Substitution Strategy Based on the Ac-His-dPhe-Arg-Trp-NH2 Template.

    abstract：:The melanocortin system regulates an array of diverse physiological functions including pigmentation, feeding behavior, energy homeostasis, cardiovascular regulation, sexual function, and steroidogenesis. Endogenous melanocortin agonist ligands all possess the minimal messaging tetrapeptide sequence His-Phe-Arg-Trp. B...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.8b00181

    authors： Todorovic A,Lensing CJ,Holder JR,Scott JW,Sorensen NB,Haskell-Luevano C

    更新日期：2018-11-21 00:00:00

  • Eckmaxol, a Phlorotannin Extracted from Ecklonia maxima, Produces Anti-β-amyloid Oligomer Neuroprotective Effects Possibly via Directly Acting on Glycogen Synthase Kinase 3β.

    abstract：:Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid oligomer, which can induce neurotoxicity, is generally regarded as the main neurotoxin in Alzheimer's disease. Here we report that eckmaxol, a phlorotannin extracted from the brown alga Ecklonia maxima, c...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.7b00527

    authors： Wang J,Zheng J,Huang C,Zhao J,Lin J,Zhou X,Naman CB,Wang N,Gerwick WH,Wang Q,Yan X,Cui W,He S

    更新日期：2018-06-20 00:00:00

  • Interrogating the Molecular Basis for Substrate Recognition in Serotonin and Dopamine Transporters with High-Affinity Substrate-Based Bivalent Ligands.

    abstract：:The transporters for the neurotransmitters serotonin and dopamine (SERT and DAT, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. Studies of prokaryotic homologues have advanced our structural understanding of SERT and DAT, but it still remains enigmatic whe...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.6b00164

    authors： Andersen J,Ladefoged LK,Kristensen TN,Munro L,Grouleff J,Stuhr-Hansen N,Kristensen AS,Schiøtt B,Strømgaard K

    更新日期：2016-10-19 00:00:00

  • Do Toxic Synthetic Cannabinoid Receptor Agonists Have Signature in Vitro Activity Profiles? A Case Study of AMB-FUBINACA.

    abstract：:Recreational consumption of synthetic cannabinoid receptor agonists (SCRAs) is a growing crisis in public health in many parts of the world. AMB-FUBINACA is a member of this class of drugs and is responsible for a large proportion of SCRA-related toxicity both in New Zealand and internationally. Strikingly, little is ...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.9b00429

    authors： Finlay DB,Manning JJ,Ibsen MS,Macdonald CE,Patel M,Javitch JA,Banister SD,Glass M

    更新日期：2019-10-16 00:00:00

  • Involvement of protein kinase C in morphine tolerance at spinal levels of rats.

    abstract：:The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats. Intrathecal injection of 10 μg of morphine induced increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. After intrathecal inject...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/cn900005d

    authors： Jin WY,Yu LC

    更新日期：2010-02-17 00:00:00

  • Different Inhibitors of Aβ42-Induced Toxicity Have Distinct Metal-Ion Dependency.

    abstract：:Oligomers of amyloid β-protein (Aβ) are thought to be the proximal toxic agents initiating the neuropathologic process in Alzheimer's disease (AD). Therefore, targeting the self-assembly and oligomerization of Aβ has been an important strategy for designing AD therapeutics. In parallel, research into the metallobiolog...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.0c00192

    authors： Mason AJ,Hurst I,Malik R,Siddique I,Solomonov I,Sagi I,Klärner FG,Schrader T,Bitan G

    更新日期：2020-08-05 00:00:00

  • Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities.

    abstract：:The finding that acetylcholinesterase (AChE) colocalizes with β-amyloid (Aβ) and promotes and accelerates Aβ aggregation has renewed an intense interest in developing new multifunctional AChE inhibitors as potential disease-modifying drugs for Alzheimer's therapy. To this end, we have developed a new class of selectiv...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/cn100069c

    authors： Zheng H,Youdim MB,Fridkin M

    更新日期：2010-11-17 00:00:00

  • Brain glucose-6-phosphate dehydrogenase protects against endogenous oxidative DNA damage and neurodegeneration in aged mice.

    abstract：:Glucose-6-phosphate dehydrogenase (G6PD) protects the embryo from endogenous and xenobiotic-enhanced oxidative DNA damage and embryopathies. Here we show in aged mice that G6PD similarly protects against endogenous reactive oxygen species (ROS)-mediated neurodegeneration. In G6PD-normal (G6PD(+/+)) and heterozygous (G...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/cn400079y

    authors： Jeng W,Loniewska MM,Wells PG

    更新日期：2013-07-17 00:00:00

  • Analysis and synthesis in olfaction.

    abstract：:Natural environments contain numerous volatile compounds emanating from a large number of sources, and the survival of many animals depends on their ability to segregate odors of interest within complex odorous scenes. In a recent paper, we described how the ability of mice to detect odors within mixtures depends on t...

    journal_title：ACS chemical neuroscience

    pub_type： 评论,杂志文章

    doi：10.1021/cn500199n

    authors： Rokni D,Murthy VN

    更新日期：2014-10-15 00:00:00

  • Predicting Multi-Interfacial Binding Mechanisms of NLRP3 and ASC Pyrin Domains in Inflammasome Activation.

    abstract：:NLRP3-PYD inflammasome activates an inflammatory pathway in response to a wide variety of cell damage or infections. Dysregulated NLRP3 inflammatory signaling has many chronic inflammatory and autoimmune disorders. NLRP3 and ASC have a PYD, a superfamily member of the Death Domain, which plays a key role in inflammato...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.0c00519

    authors： Riaz M,Rehman AU,Shah SA,Rafiq H,Lu S,Qiu Y,Wadood A

    更新日期：2021-01-27 00:00:00

  • Protective Effect of a Mitochondria-Targeted Peptide against the Development of Chemotherapy-Induced Peripheral Neuropathy in Mice.

    abstract：:Several chemotherapeutic agents used for cancer treatment induce dose-limiting peripheral neuropathy that compromises patients' quality of life and limits cancer treatment. Recently, mitochondrial dysfunction has been shown to be involved in the mechanism of chemotherapy-induced peripheral neuropathy. SS-20 is a mitoc...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.8b00013

    authors： Toyama S,Shimoyama N,Szeto HH,Schiller PW,Shimoyama M

    更新日期：2018-07-18 00:00:00

  • Investigation of a calcium-responsive contrast agent in cellular model systems: feasibility for use as a smart molecular probe in functional MRI.

    abstract：:Responsive or smart contrast agents (SCAs) represent a promising direction for development of novel functional MRI (fMRI) methods for the eventual noninvasive assessment of brain function. In particular, SCAs that respond to Ca(2+) may allow tracking neuronal activity independent of brain vasculature, thus avoiding th...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/cn500049n

    authors： Angelovski G,Gottschalk S,Milošević M,Engelmann J,Hagberg GE,Kadjane P,Andjus P,Logothetis NK

    更新日期：2014-05-21 00:00:00

  • Analysis of Single Neurons by Perforated Patch Clamp Recordings and MALDI-TOF Mass Spectrometry.

    abstract：:Single-cell mass spectrometry has become an established technique to study specific molecular properties such as the neuropeptide complement of identified neurons. Here, we describe a strategy to characterize, by MALDI-TOF mass spectrometry, neurochemical composition of neurons that were identified by their electrophy...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.8b00163

    authors： Neupert S,Fusca D,Kloppenburg P,Predel R

    更新日期：2018-08-15 00:00:00

  • ACS chemical neuroscience molecule spotlight on savella.

    abstract：:Savella (milnacipran), a selective serotonin and noradrenaline reuptake inhibitor, was approved by the FDA on January 14th, 2009, for the treatment of fibromyalgia. ...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章,评审

    doi：10.1021/cn1000233

    authors： Hopkins CR

    更新日期：2010-05-19 00:00:00

  • Endogenous Serotonin 5-HT2A and 5-HT2C Receptors Associate in the Medial Prefrontal Cortex.

    abstract：:The 5-HT2A receptor (5-HT2AR) and 5-HT2CR are localized to the same neurons within the medial prefrontal cortex (mPFC), which regulates executive function, decision-making, and reward-guided learning and memory processes. The 5-HT2AR and 5-HT2CR coimmunoprecipitate in the mPFC of male Sprague-Dawley rats, while in vit...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.8b00669

    authors： Price AE,Sholler DJ,Stutz SJ,Anastasio NC,Cunningham KA

    更新日期：2019-07-17 00:00:00

  • Mitochondrial GSH Systems in CA1 Pyramidal Cells and Astrocytes React Differently during Oxygen-Glucose Deprivation and Reperfusion.

    abstract：:Pyramidal cells and astrocytes have differential susceptibility to oxygen-glucose deprivation and reperfusion (OGD-RP). It is known that excessive reactive oxygen species (ROS) in mitochondria initiates cell death, while glutathione (GSH) is one of the major defenses against ROS. Although it is known that astrocytes c...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.7b00369

    authors： Yin B,Barrionuevo G,Weber SG

    更新日期：2018-04-18 00:00:00

  • Alzheimer's Disease, the "One-Molecule, One-Target" Paradigm, and the Multitarget Directed Ligand Approach.

    abstract：:No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-directed ligands since the beginning of modern medicinal chemistry, without knowing it, most possibly. The challenge to discover the efficient Multi-Target Small Molecules (MTSMs) for Alzheimer's disease (AD) therapy implies...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章,评审

    doi：10.1021/acschemneuro.8b00069

    authors： Oset-Gasque MJ,Marco-Contelles J

    更新日期：2018-03-21 00:00:00

  • Exosomes in Parkinson's Disease: Current Perspectives and Future Challenges.

    abstract：:Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章,评审

    doi：10.1021/acschemneuro.8b00469

    authors： Yuan L,Li JY

    更新日期：2019-02-20 00:00:00

  • The molecular basis of memory.

    abstract：:We propose a tripartite biochemical mechanism for memory. Three physiologic components are involved, namely, the neuron (individual and circuit), the surrounding neural extracellular matrix, and the various trace metals distributed within the matrix. The binding of a metal cation affects a corresponding nanostructure ...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/cn300097b

    authors： Marx G,Gilon C

    更新日期：2012-08-15 00:00:00

  • Delivery of Dual Drug Loaded Lipid Based Nanoparticles across the Blood-Brain Barrier Impart Enhanced Neuroprotection in a Rotenone Induced Mouse Model of Parkinson's Disease.

    abstract：:Parkinson's disease (PD) is the most widespread form of dementia where there is an age related degeneration of dopaminergic neurons in the substantia nigra region of the brain. Accumulation of α-synuclein (αS) protein aggregate, mitochondrial dysfunction, oxidative stress, and neuronal cell death are the pathological ...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.6b00207

    authors： Kundu P,Das M,Tripathy K,Sahoo SK

    更新日期：2016-12-21 00:00:00

  • Pharmacology of Valinate and tert-Leucinate Synthetic Cannabinoids 5F-AMBICA, 5F-AMB, 5F-ADB, AMB-FUBINACA, MDMB-FUBINACA, MDMB-CHMICA, and Their Analogues.

    abstract：:Indole and indazole synthetic cannabinoids (SCs) featuring l-valinate or l-tert-leucinate pendant group have recently emerged as prevalent recreational drugs, and their use has been associated with serious adverse health effects. Due to the limited pharmacological data available for these compounds, 5F-AMBICA, 5F-AMB,...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.6b00137

    authors： Banister SD,Longworth M,Kevin R,Sachdev S,Santiago M,Stuart J,Mack JB,Glass M,McGregor IS,Connor M,Kassiou M

    更新日期：2016-09-21 00:00:00

  • Discovery and Optimization of Triazine Nitrile Inhibitors of Toxoplasma gondii Cathepsin L for the Potential Treatment of Chronic Toxoplasmosis in the CNS.

    abstract：:With roughly 2 billion people infected, the neurotropic protozoan Toxoplasma gondii remains one of the most pervasive and infectious parasites. Toxoplasma infection is the second leading cause of death due to foodborne illness in the United States, causes severe disease in immunocompromised patients, and is correlated...

    journal_title：ACS chemical neuroscience

    pub_type： 杂志文章

    doi：10.1021/acschemneuro.9b00674

    authors： Zwicker JD,Smith D,Guerra AJ,Hitchens JR,Haug N,Vander Roest S,Lee P,Wen B,Sun D,Wang L,Keep RF,Xiang J,Carruthers VB,Larsen SD

    更新日期：2020-08-19 00:00:00