ACS chemical neuroscience molecule spotlight on savella.

abstract：:Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder, with a 10% genetic linkage, of which 20% of these cases may be attributed to mutations in superoxide dismutase (SOD1). Specific mutations in SOD1 have been associated with disease duration, which can be highly variable ranging from a life...

journal_title：ACS chemical neuroscience

authors： Abu-Hamad S,Kahn J,Leyton-Jaimes MF,Rosenblatt J,Israelson A

更新日期：2017-10-18 00:00:00

abstract：:Amyloid-β (Aβ) is a peptide fragment that is prone to aggregate into large fibrils under physiological conditions. Many techniques have been developed to quickly monitor the transition from a primarily monomeric peptide into fibrils. Here we propose a novel method for both incubating and monitoring changes in Aβ aggre...

journal_title：ACS chemical neuroscience

authors： Cook NP,Martí AA

更新日期：2012-11-21 00:00:00

abstract：:The nitrocatechol derivatives tolcapone (1) and entacapone (2), used as adjunctive therapy in the treatment of Parkinson's disease, were investigated for their potential to inhibit the tau-derived-hexapeptide 306VQIVYK311. They were compared to small molecules that contain similar pharmacophores including the catechol...

journal_title：ACS chemical neuroscience

authors： Mohamed T,Hoang T,Jelokhani-Niaraki M,Rao PP

更新日期：2013-12-18 00:00:00

abstract：:Stereotypy (e.g., repetitive hand waving) is a key phenotype of autism spectrum disorder, Fragile X and Rett syndromes, and other neuropsychiatric disorders, and its severity correlates with cognitive and attention deficits. There are no effective treatments, however, for stereotypy. Perturbation of serotonin (5-HT) n...

journal_title：ACS chemical neuroscience

authors： Canal CE,Felsing DE,Liu Y,Zhu W,Wood JT,Perry CK,Vemula R,Booth RG

更新日期：2015-07-15 00:00:00

abstract：:While fibrillar deposits of hyperphosphorylated protein tau are a key hallmark of several neurodegenerative diseases such as Alzheimer's disease, small oligomers have been speculated to be the key toxic aggregate species. Trivalent metal ions were shown to promote tau oligomer formation in vitro. However, little is kn...

journal_title：ACS chemical neuroscience

authors： Nuebling GS,Plesch E,Ruf VC,Högen T,Lorenzl S,Kamp F,Giese A,Levin J

更新日期：2020-03-18 00:00:00

abstract：:Several lines of evidence suggest the presence of severe acute respiratory coronavirus-2 (SARS-CoV-2) in wastewater. The use of sewage water for irrigation is common in many developing countries, and it is only partially treated in the majority of countries with less than 10% of collected wastewater receiving any form...

journal_title：ACS chemical neuroscience

authors： Siddiqui R,Khamis M,Ibrahim T,Khan NA

更新日期：2020-10-07 00:00:00

abstract：:Neuroinflammatory processes promote a constellation of neurochemical and hormonal changes resulting in profound effects on motivational states (anhedonia), mood (depression and anxiety disorders), and cognitive function (decrements in learning and memory). The enhancement of immunoregulatory processes, such as increas...

journal_title：ACS chemical neuroscience

authors： Frank MG,Fonken LK,Watkins LR,Maier SF,Lowry CA

更新日期：2019-01-16 00:00:00

abstract：:A major challenge in neuroscience is to decipher the logic of neural circuitry and to link it to learning, memory, and behavior. Synaptic transmission is a critical event underlying information processing within neural circuitry. In the extracellular space, the concentrations and distributions of excitatory, inhibitor...

journal_title：ACS chemical neuroscience

authors： Liang R,Broussard GJ,Tian L

更新日期：2015-01-21 00:00:00

abstract：:As the major psychoactive agent in opium and direct precursor for heroin, morphine is a historically critical molecule in chemical neuroscience. A structurally complex phenanthrene alkaloid produced by Papaver somniferum, morphine has fascinated chemists seeking to disentangle pharmacologically beneficial analgesic ef...

journal_title：ACS chemical neuroscience

authors： Devereaux AL,Mercer SL,Cunningham CW

更新日期：2018-10-17 00:00:00

abstract：:Alzheimer's disease is a progressive neurodegenerative disorder that mainly affects the elderly. Soluble β-amyloid oligomer, which can induce neurotoxicity, is generally regarded as the main neurotoxin in Alzheimer's disease. Here we report that eckmaxol, a phlorotannin extracted from the brown alga Ecklonia maxima, c...

journal_title：ACS chemical neuroscience

authors： Wang J,Zheng J,Huang C,Zhao J,Lin J,Zhou X,Naman CB,Wang N,Gerwick WH,Wang Q,Yan X,Cui W,He S

更新日期：2018-06-20 00:00:00

abstract：:Relapse to cocaine dependence, even after extended abstinence, involves a number of liability factors including impulsivity (predisposition toward rapid, unplanned reactions to stimuli without regard to negative consequences) and cue reactivity (sensitivity to cues associated with cocaine-taking which can promote coca...

journal_title：ACS chemical neuroscience

authors： Cunningham KA,Anastasio NC,Fox RG,Stutz SJ,Bubar MJ,Swinford SE,Watson CS,Gilbertson SR,Rice KC,Rosenzweig-Lipson S,Moeller FG

更新日期：2013-01-16 00:00:00

abstract：:Cognitive dysfunctions, including impaired attention, learning, memory, and problem solving, occur in psychiatric diseases, such as depression, and are a hallmark of aging. Altered GABAergic signaling is similarly reported across these conditions, but therapeutic approaches are limited by pan-receptor activities of be...

journal_title：ACS chemical neuroscience

authors： Prevot TD,Li G,Cook JM,Sibille E

更新日期：2019-05-15 00:00:00

abstract：:An intracerebral hemorrhage (ICH) is a devastating stroke that results in high mortality and significant disability in survivors. Unfortunately, the underlying mechanisms of this injury are not yet fully understood. After the primary (mechanical) trauma, secondary degenerative events contribute to ongoing cell death i...

journal_title：ACS chemical neuroscience

authors： Hackett MJ,DeSouza M,Caine S,Bewer B,Nichol H,Paterson PG,Colbourne F

更新日期：2015-05-20 00:00:00

abstract：:The neurotransmitter dopamine is heavily implicated in intracranial self-stimulation (ICSS). Many drugs of abuse that affect ICSS behavior target the dopaminergic system, and optogenetic activation of dopamine neurons is sufficient to support self-stimulation. However, the patterns of phasic dopamine release during IC...

journal_title：ACS chemical neuroscience

authors： Rodeberg NT,Johnson JA,Bucher ES,Wightman RM

更新日期：2016-11-16 00:00:00

abstract：:Recent clinical approvals of brain imaging radiotracers targeting amyloid-β provided clinicians the tools to detect and confirm Alzheimer's disease pathology without autopsy or biopsy. While current imaging agents are effective in postsymptomatic Alzheimer's patients, there is much room for improvement in earlier diag...

journal_title：ACS chemical neuroscience

authors： Neo Shin N,Jeon H,Jung Y,Baek S,Lee S,Yoo HC,Bae GH,Park K,Yang SH,Han JM,Kim I,Kim Y

更新日期：2019-06-19 00:00:00

abstract：:α-Synuclein (α-syn) is a 140-amino acid protein that plays a central role in the pathogenesis of Parkinson's disease (PD) and other synucleinopathies. However, the molecular determinants that are responsible for triggering and/or propagating α-syn aggregation and toxicity remain poorly understood. Several studies have...

journal_title：ACS chemical neuroscience

authors： Lu Y,Prudent M,Fauvet B,Lashuel HA,Girault HH

更新日期：2011-11-16 00:00:00

abstract：:Central norepinephrine (NE) and dopamine (DA) are involved in a variety of physiological functions and behaviors. Accumulating evidence suggests that NE neurons originating from the locus coeruleus (LC) innervate DA neurons of the ventral tegmental area (VTA) and influence VTA-DA neural activity. However, the underlyi...

journal_title：ACS chemical neuroscience

authors： Park JW,Bhimani RV,Park J

更新日期：2017-09-20 00:00:00

abstract：:We report the results of computational modeling of a three-dimensional all-atom structure of the membrane-associated protein encoded by the NAT8L gene, aspartate N-acetyltransferase, which is essential for brain synthesis of N-acetyl-l-aspartate (NAA). The lack of experimentally derived three-dimensional structures of...

journal_title：ACS chemical neuroscience

authors： Polyakov IV,Kniga AE,Grigorenko BL,Nemukhin AV

更新日期：2020-08-05 00:00:00

abstract：:A series of bimodal metabotropic glutamate-receptor targeted MRI contrast agents has been developed and evaluated, based on established competitive metabotropic Glu receptor subtype 5 (mGluR5) antagonists. In order to directly visualize mGluR5 binding of these agents on the surface of live astrocytes, variations in th...

journal_title：ACS chemical neuroscience

authors： Mishra A,Mishra R,Gottschalk S,Pal R,Sim N,Engelmann J,Goldberg M,Parker D

更新日期：2014-02-19 00:00:00

abstract：:The permeation of the potassium ion (K+) through the selectivity filter (SF) of the large conductance Ca2+-activated potassium (Slo1) channel remains an interesting question to study. Although the mode of K+ entering and leaving the SF has been revealed, the mechanism of K+ passing through the SF is still not clear. I...

journal_title：ACS chemical neuroscience

authors： Guo J,Tan Z,Ji Y

更新日期：2019-08-21 00:00:00

abstract：:The finding that acetylcholinesterase (AChE) colocalizes with β-amyloid (Aβ) and promotes and accelerates Aβ aggregation has renewed an intense interest in developing new multifunctional AChE inhibitors as potential disease-modifying drugs for Alzheimer's therapy. To this end, we have developed a new class of selectiv...

journal_title：ACS chemical neuroscience

authors： Zheng H,Youdim MB,Fridkin M

更新日期：2010-11-17 00:00:00

abstract：:A new generation of ligands designed to interact with the α-helix/β-strand discordant region of the amyloid-β peptide (Aβ) and to counteract its oligomerization is presented. These ligands are designed to interact with and stabilize the Aβ central helix (residues 13-26) in an α-helical conformation with increased inte...

journal_title：ACS chemical neuroscience

authors： Honcharenko D,Juneja A,Roshan F,Maity J,Galán-Acosta L,Biverstål H,Hjorth E,Johansson J,Fisahn A,Nilsson L,Strömberg R

更新日期：2019-03-20 00:00:00

abstract：:Extensive experimental and computational studies have suggested that multiple Zn(2+) binding modes in amyloid β (Aβ) peptides could exist simultaneously. However, consistent results have not been obtained for the effects of Zn(2+) binding on Aβ structure, dynamics, and kinetics in particular. Some key questions such a...

journal_title：ACS chemical neuroscience

authors： Xu L,Wang X,Wang X

更新日期：2013-11-20 00:00:00

abstract：:The effect of the bis-sulfonated iron(III) corrole (1-Fe), a potent decomposition catalyst of reactive oxygen species, on rescuing SN4741 cells that were damaged by 6-hydroxydopamine (6-OHDA) was investigated as an in vitro model system for studying cell death of dopaminergic neurons in the substantia nigra. Important...

journal_title：ACS chemical neuroscience

authors： Soll M,Bar Am O,Mahammed A,Saltsman I,Mandel S,Youdim MB,Gross Z

更新日期：2016-10-19 00:00:00

abstract：:Bipolar disorder is a complex neuropsychiatric disorder, characterized by intermittent episodes of mania and depression. Recent studies have indicated argyrophilic grains, composed of hyperphosphorylated tau, are observable in postmortem brains of bipolar patients. It remains uncertain how tau hyperphosphorylation res...

journal_title：ACS chemical neuroscience

authors： Naserkhaki R,Zamanzadeh S,Baharvand H,Nabavi SM,Pakdaman H,Shahbazi S,Vosough M,Ghaedi G,Barzegar A,Mirtorabi D,Hedayatshodeh M,Ehsani E,Falahati M,Hajipour MJ,Shahpasand K

更新日期：2019-03-20 00:00:00

abstract：:No selective drugs exist, and we have been designing, synthesizing, and evaluating multitarget-directed ligands since the beginning of modern medicinal chemistry, without knowing it, most possibly. The challenge to discover the efficient Multi-Target Small Molecules (MTSMs) for Alzheimer's disease (AD) therapy implies...

journal_title：ACS chemical neuroscience

authors： Oset-Gasque MJ,Marco-Contelles J

更新日期：2018-03-21 00:00:00

abstract：:Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by multiple hallmarks including extracellular amyloid (Aβ) plaques, neurofibrillary tangles, dysfunctional blood-brain barrier (BBB), neuroinflammation, and impaired autophagy. Thus, novel strategies that target multiple disease pathways wo...

journal_title：ACS chemical neuroscience

authors： Al Rihani SB,Darakjian LI,Kaddoumi A

更新日期：2019-08-21 00:00:00

abstract：:Proton magnetic spectroscopy (1H-MRS) is a noninvasive imaging technique that allows for the quantification of neurometabolic compounds at millimolar concentrations in the living human brain. This technique has been most often used to assess long-term changes in human brain metabolism in psychiatric disorders, pharmac...

journal_title：ACS chemical neuroscience

authors： White TL,Gonsalves MA

更新日期：2020-09-02 00:00:00

abstract：:Protein function depends on both protein structure and amino acid (aa) sequence. Here we show that modular features of both structure and function can be quantified economically from the aa sequences alone for the small (40,42 aa) plaque-forming (aggregative) amyloid beta fragments. Some edge and center features of th...

journal_title：ACS chemical neuroscience

authors： Phillips JC

更新日期：2015-05-20 00:00:00

abstract：:The development of a noninvasive method for the detection of Alzheimer's disease is of high current interest, which can be critical in early diagnosis and in guiding treatment of the disease. The aggregates of β-amyloid are a pathological hallmark of Alzheimer's disease. Carbohydrates such as gangliosides have been sh...

journal_title：ACS chemical neuroscience

authors： Kouyoumdjian H,Zhu DC,El-Dakdouki MH,Lorenz K,Chen J,Li W,Huang X

更新日期：2013-04-17 00:00:00