Exosomes in Parkinson's Disease: Current Perspectives and Future Challenges.


:Exosomes, which are lipid bilayer membrane vesicles, have been implicated as carriers of biological macromolecules. In recent years, the functions of exosomes in the spreading of pathological conversion of proteins among neurons have drawn particular attention in Parkinson's disease research. Extracellular α-synuclein is proven to be associated with exosomes in vivo and in vitro. The contents of these exosomes may be altered during the pathological and clinical processes, serving as a potential target for biomarker development in Parkinson's disease. This Review highlights the current understanding of biogenesis and pathophysiological roles of exosomes. Meanwhile, exosomes are promising delivery vehicles. Artificial exosomes can be loaded with defined therapeutically active molecules, such as drugs, small interfering RNAs, long noncoding RNAs, and proteins to the brain, ensuring the site-specific targeting strategy to the recipient cells. Therefore, we will also discuss the potential applications of exosomes in developing modified exosome-based drug carrier systems to halt the pathologic propagation of Parkinson's disease.


ACS Chem Neurosci


Yuan L,Li JY




Has Abstract


2019-02-20 00:00:00










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    abstract::Lithium has been used for the treatment of mood disorders for decades though the molecular mechanism of its therapeutic action and intracellular targets remain furtive. We report that neurotropic agent Li+ binds to the neuronal calcium sensor, Downstream Regulatory Element Antagonist Modulator (DREAM), with an equilib...

    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


    authors: Azam S,Bhattarai N,Riveron A,Rodriguez S,Chapagain PP,Miksovska J

    更新日期:2020-09-02 00:00:00

  • Iron Dysregulation in Parkinson's Disease: Focused on the Autophagy-Lysosome Pathway.

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章,评审


    authors: Chen LL,Huang YJ,Cui JT,Song N,Xie J

    更新日期:2019-02-20 00:00:00

  • Promotion of Neuronal Guidance Growth by Aminated Graphene Oxide via Netrin-1/Deleted in Colorectal Cancer Signaling.

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


    authors: Liu M,Huang C,Jia Z,Zhao Z,Xiao X,Wang A,Li P,Guan X,Zhou G,Fan Y

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 历史文章,杂志文章,评审


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    更新日期:2019-05-15 00:00:00

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章,评审


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    更新日期:2018-05-16 00:00:00

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    更新日期:2015-06-17 00:00:00

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    abstract::The nicotinic acetylcholine receptor (nAChR) family, the archetype member of the pentameric ligand-gated ion channels, is ubiquitously distributed in the central and peripheral nervous systems, and its members are the targets for both genetic and acquired forms of neurological disorders. In the central nervous system,...

    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章,评审


    authors: Paz ML,Barrantes FJ

    更新日期:2019-05-15 00:00:00

  • A Rational Structured Epitope Defines a Distinct Subclass of Toxic Amyloid-beta Oligomers.

    abstract::Oligomers of amyloid-β (AβO) are deemed key in synaptotoxicity and amyloid seeding of Alzheimer's disease (AD). However, the heterogeneous and dynamic nature of AβO and inadequate markers for AβO subtypes have stymied effective AβO identification and therapeutic targeting in vivo. We identified an AβO-subclass epitope...

    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    更新日期:2018-07-18 00:00:00

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    更新日期:2014-08-20 00:00:00

  • Involvement of protein kinase C in morphine tolerance at spinal levels of rats.

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


    authors: Jin WY,Yu LC

    更新日期:2010-02-17 00:00:00

  • Increased Brain Exposure of an Alpha-Synuclein Fibrillization Modulator by Utilization of an Activated Ester Prodrug Strategy.

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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  • Direct Reprogramming of Glioblastoma Cells into Neurons Using Small Molecules.

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


    authors: Lee C,Robinson M,Willerth SM

    更新日期:2018-12-19 00:00:00

  • Maternal Exposure to Di-(2-ethylhexyl) Phthalate Impairs Hippocampal Synaptic Plasticity in Male Offspring: Involvement of Damage to Dendritic Spine Development.

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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    更新日期:2021-01-20 00:00:00

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    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


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  • Development of Clickable Photoaffinity Ligands for Metabotropic Glutamate Receptor 2 Based on Two Positive Allosteric Modulator Chemotypes.

    abstract::The metabotropic glutamate receptor 2 (mGlu2) is a transmembrane-spanning class C G protein-coupled receptor that is an attractive therapeutic target for multiple psychiatric and neurological disorders. A key challenge has been deciphering the contribution of mGlu2 relative to other closely related mGlu receptors in m...

    journal_title:ACS chemical neuroscience

    pub_type: 杂志文章


    authors: Hellyer SD,Aggarwal S,Chen ANY,Leach K,Lapinsky DJ,Gregory KJ

    更新日期:2020-06-03 00:00:00