Mitochondrial GSH Systems in CA1 Pyramidal Cells and Astrocytes React Differently during Oxygen-Glucose Deprivation and Reperfusion.

abstract：:Savella (milnacipran), a selective serotonin and noradrenaline reuptake inhibitor, was approved by the FDA on January 14th, 2009, for the treatment of fibromyalgia. ...

journal_title：ACS chemical neuroscience

authors： Hopkins CR

更新日期：2010-05-19 00:00:00

abstract：:Several antidepressants increase adult hippocampal neurogenesis (ahNG) in rodents, primates, and, potentially, humans. This effect may at least partially account for their therapeutic activity. The availability of antidepressants whose mechanism of action involves different neurotransmitter receptors represents an opp...

journal_title：ACS chemical neuroscience

authors： Bortolotto V,Mancini F,Mangano G,Salem R,Xia E,Del Grosso E,Bianchi M,Canonico PL,Polenzani L,Grilli M

更新日期：2017-09-20 00:00:00

abstract：:Angiotensin converting enzyme (ACE) is a dipeptidyl peptidase transmembrane bound enzyme. Generally, ACE inhibitors are used for the cardiovascular disorders. ACE inhibitors are primary agents for the management of hypertension, so these cannot be avoided for further use. The present Review focuses on the implications...

journal_title：ACS chemical neuroscience

authors： Kaur P,Muthuraman A,Kaur M

更新日期：2015-04-15 00:00:00

abstract：:Krokodil is the street name for a homemade mixture that has been used as a cheap substitute for heroin. The main active substance in krokodil is desomorphine, an opioid that is 10 times more potent than morphine. Krokodil use began in Russia and Ukraine but has spread throughout several countries in Europe and North A...

journal_title：ACS chemical neuroscience

authors： Alves EA

更新日期：2020-09-17 00:00:00

abstract：:Extensive experimental and computational studies have suggested that multiple Zn(2+) binding modes in amyloid β (Aβ) peptides could exist simultaneously. However, consistent results have not been obtained for the effects of Zn(2+) binding on Aβ structure, dynamics, and kinetics in particular. Some key questions such a...

journal_title：ACS chemical neuroscience

authors： Xu L,Wang X,Wang X

更新日期：2013-11-20 00:00:00

abstract：:We propose a tripartite biochemical mechanism for memory. Three physiologic components are involved, namely, the neuron (individual and circuit), the surrounding neural extracellular matrix, and the various trace metals distributed within the matrix. The binding of a metal cation affects a corresponding nanostructure ...

journal_title：ACS chemical neuroscience

authors： Marx G,Gilon C

更新日期：2012-08-15 00:00:00

abstract：:Single-cell mass spectrometry has become an established technique to study specific molecular properties such as the neuropeptide complement of identified neurons. Here, we describe a strategy to characterize, by MALDI-TOF mass spectrometry, neurochemical composition of neurons that were identified by their electrophy...

journal_title：ACS chemical neuroscience

authors： Neupert S,Fusca D,Kloppenburg P,Predel R

更新日期：2018-08-15 00:00:00

abstract：:The 5-HT2A receptor (5-HT2AR) and 5-HT2CR are localized to the same neurons within the medial prefrontal cortex (mPFC), which regulates executive function, decision-making, and reward-guided learning and memory processes. The 5-HT2AR and 5-HT2CR coimmunoprecipitate in the mPFC of male Sprague-Dawley rats, while in vit...

journal_title：ACS chemical neuroscience

authors： Price AE,Sholler DJ,Stutz SJ,Anastasio NC,Cunningham KA

更新日期：2019-07-17 00:00:00

abstract：:The transporters for the neurotransmitters serotonin and dopamine (SERT and DAT, respectively) are targets for drugs used in the treatment of mental disorders and widely used drugs of abuse. Studies of prokaryotic homologues have advanced our structural understanding of SERT and DAT, but it still remains enigmatic whe...

journal_title：ACS chemical neuroscience

authors： Andersen J,Ladefoged LK,Kristensen TN,Munro L,Grouleff J,Stuhr-Hansen N,Kristensen AS,Schiøtt B,Strømgaard K

更新日期：2016-10-19 00:00:00

abstract：:The nonmedical (i.e., recreational) misuse of synthetic cannabinoids (SCs) is a worldwide public health problem. When compared to cannabis, the misuse of SCs is associated with a higher incidence of serious adverse effects, suggesting the possible involvement of noncannabinoid sites of action. Here, we find that, unli...

journal_title：ACS chemical neuroscience

authors： Yano H,Adhikari P,Naing S,Hoffman AF,Baumann MH,Lupica CR,Shi L

更新日期：2020-05-20 00:00:00

abstract：:The aggregation of α-synuclein (α-Syn) has been implicated strongly in Parkinson's disease (PD). The intrinsically disordered nature of α-Syn makes this protein prone to self-association or heteroassociation with another protein or lipid. While conformational fluctuation and free radical chemistry have been shown to p...

journal_title：ACS chemical neuroscience

authors： Ghosh S,Mahapatra A,Chattopadhyay K

更新日期：2019-03-20 00:00:00

abstract：:MMP-9 plays a detrimental role in the pathology of several neurological diseases and, thus, represents an important target for intervention. The water-soluble prodrug ND-478 is hydrolyzed to the active MMP-9 inhibitor ND-322, which in turn is N-acetylated to the even more potent metabolite ND-364. We used a sensitive ...

journal_title：ACS chemical neuroscience

authors： Song W,Peng Z,Gooyit M,Suckow MA,Schroeder VA,Wolter WR,Lee M,Ikejiri M,Cui J,Gu Z,Chang M

更新日期：2013-08-21 00:00:00

abstract：:For an affliction that debilitates an estimated 50 million adults in the United States, the current chronic pain management approaches are inadequate. The Centers for Disease Control and Prevention have called for a minimization in opioid prescription and use for chronic pain conditions, and thus, it is imperative to ...

journal_title：ACS chemical neuroscience

authors： Cai S,Bellampalli SS,Yu J,Li W,Ji Y,Wijeratne EMK,Dorame A,Luo S,Shan Z,Khanna M,Moutal A,Streicher JM,Gunatilaka AAL,Khanna R

更新日期：2019-03-20 00:00:00

abstract：:High levels of histamine H3 receptors (H3Rs) are found in the globus pallidus (GP), a neuronal nucleus in the basal ganglia involved in the control of motor behavior. By using rat GP isolated nerve terminals (synaptosomes), we studied whether H3R activation modified the previously reported enhancing action of adenosin...

journal_title：ACS chemical neuroscience

authors： Morales-Figueroa GE,Márquez-Gómez R,González-Pantoja R,Escamilla-Sánchez J,Arias-Montaño JA

更新日期：2014-08-20 00:00:00

abstract：:The understanding of the interaction between the membrane of neurons and amyloid-β peptides is of crucial importance to shed light on the mechanism of toxicity in Alzheimer's disease. This paper describes how supercritical angle fluorescence spectroscopy was applied to monitor in real-time the interaction between a su...

journal_title：ACS chemical neuroscience

authors： Dubois V,Serrano D,Seeger S

更新日期：2019-12-18 00:00:00

abstract：:The discovery of haloperidol catalyzed a breakthrough in our understanding of the biochemical basis of schizophrenia, improved the treatment of psychosis, and facilitated deinstitutionalization. In doing so, it solidified the role for chemical neuroscience as a means to elucidate the molecular underpinnings of complex...

journal_title：ACS chemical neuroscience

authors： Tyler MW,Zaldivar-Diez J,Haggarty SJ

更新日期：2017-03-15 00:00:00

abstract：:Glutamate is the major excitatory transmitter in the mammalian CNS, exerting its effects through both ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors (mGlus) belong to family C of the G-protein-coupled receptors (GPCRs). The eight mGlus identified to date are classified into three...

journal_title：ACS chemical neuroscience

authors： Lindsley CW,Bates BS,Menon UN,Jadhav SB,Kane AS,Jones CK,Rodriguez AL,Conn PJ,Olsen CM,Winder DG,Emmitte KA

更新日期：2011-08-17 00:00:00

abstract：:Glycans are intimately involved in several facets of neuronal development and neuropathology. However, the metabolic labeling of surface glycans in primary neurons is a difficult task because of the neurotoxicity of unnatural monosaccharides that are used as a metabolic precursor, hindering the progress of metabolic e...

journal_title：ACS chemical neuroscience

authors： Choi JY,Park M,Cho H,Kim MH,Kang K,Choi IS

更新日期：2017-12-20 00:00:00

abstract：:Aggregation of hyperphosphorylated tau is the hallmark of several tauopathies, including Alzheimer's disease (AD). Although the mechanism underlying tau-associated neuronal damage remains unclear, it is believed that tau hyperphosphorylation is one of the key features in disease progression. A recent study demonstrate...

journal_title：ACS chemical neuroscience

authors： Tripathi T,Prakash J,Shav-Tal Y

更新日期：2019-01-16 00:00:00

abstract：:Peripheral immunity is thought to be dysregulated in Parkinson's disease (PD) and may provide an avenue for novel immunotherapeutic interventions. Gut microbiota is a potential factor for modulating immunotherapy response. Considering the possibly complex role of the gut-brain axis in PD, we used a preclinical model t...

journal_title：ACS chemical neuroscience

authors： Klann E,Tagliamonte MS,Ukhanova M,Mai V,Vedam-Mai V

更新日期：2020-10-21 00:00:00

abstract：:The glycine receptor (GlyR) is a ligand-activated chloride channel, whose mutations are the major cause of hereditary hyperekplexia. The hyperekplexia-causing R271Q mutation, which is located at the extracellular outer mouth of the channel pore, dramatically impairs the GlyR function manifesting a reduced sensitivity ...

journal_title：ACS chemical neuroscience

authors： Han L,Shan Q

更新日期：2020-10-21 00:00:00

abstract：:Online electrochemical detection techniques are the state-of-the-art for evaluating chemical communication in the brain underlying motivated behavior and decision making. In this Viewpoint, we discuss avenues for future technological development, as well as the requirement for increasingly sophisticated and interdisci...

journal_title：ACS chemical neuroscience

authors： Wassum KM,Phillips PE

更新日期：2015-01-21 00:00:00

abstract：:As the intrinsic origin of the hypothesis for β-amyloid (Aβ) from Alzheimer's disease, histidine behaviors were found to play a crucial role in Aβ aggregation. To investigate the histidine behaviors during the early stage of aggregation, Aβ40/42 pentamers with different histidine isomer states were simulated at the at...

journal_title：ACS chemical neuroscience

authors： Xing X,Zhao W,Hu D,Kang B,Shi H,Lee JY,Ai H

更新日期：2019-05-15 00:00:00

abstract：:Oligomers of amyloid-β (AβO) are deemed key in synaptotoxicity and amyloid seeding of Alzheimer's disease (AD). However, the heterogeneous and dynamic nature of AβO and inadequate markers for AβO subtypes have stymied effective AβO identification and therapeutic targeting in vivo. We identified an AβO-subclass epitope...

journal_title：ACS chemical neuroscience

authors： Silverman JM,Gibbs E,Peng X,Martens KM,Balducci C,Wang J,Yousefi M,Cowan CM,Lamour G,Louadi S,Ban Y,Robert J,Stukas S,Forloni G,Hsiung GR,Plotkin SS,Wellington CL,Cashman NR

更新日期：2018-07-18 00:00:00

abstract：:Development of pharmacological tools for the ionotropic glutamate receptors (iGluRs) is imperative for the study and understanding of the role and function of these receptors in the central nervous system. We report the synthesis of 18 analogues of (2 S,3 R)-2-carboxy-3-pyrrolidine acetic acid (3a), which explores the...

journal_title：ACS chemical neuroscience

authors： Poulie CBM,Alcaide A,Krell-Jørgensen M,Larsen Y,Astier E,Bjørn-Yoshimoto WE,Yi F,Syrenne JT,Storgaard M,Nielsen B,Frydenvang KA,Jensen AA,Hansen KB,Pickering DS,Bunch L

更新日期：2019-06-19 00:00:00

abstract：:Amyloid-β (Aβ), the main constituent in senile plaques found in the brain of patients with Alzheimer's disease (AD), is considered as a causative factor in AD pathogenesis. The clinical examination of the brains of patients with AD has demonstrated that caspase-3 colocalizes with senile plaques. Cellular studies have ...

journal_title：ACS chemical neuroscience

authors： Chang YJ,Linh NH,Shih YH,Yu HM,Li MS,Chen YR

更新日期：2016-08-17 00:00:00

abstract：:On the basis of the drug-repositioning and redeveloping strategy, first-generation dual-target inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5) have been recently reported as a potentially novel therapeutic method for the treatment of Alzheimer's disease (AD), and the lead compound 2 has proven...

journal_title：ACS chemical neuroscience

authors： Ni W,Wang H,Li X,Zheng X,Wang M,Zhang J,Gong Q,Ling D,Mao F,Zhang H,Li J

更新日期：2018-07-18 00:00:00

abstract：:Phosphodiesterase 10 (PDE10) inhibitors have received much attention as promising therapeutic agents for central nervous system (CNS) disorders such as schizophrenia and Huntington's disease. Recently, a hit compound 1 with a novel chromone scaffold has shown moderate inhibitory activity against PDE10A (IC50 = 500 nM)...

journal_title：ACS chemical neuroscience

authors： Yu YF,Zhang C,Huang YY,Zhang S,Zhou Q,Li X,Lai Z,Li Z,Gao Y,Wu Y,Guo L,Wu D,Luo HB

更新日期：2020-04-01 00:00:00

abstract：:Essential hypertension is a major risk factor for cardiovascular disease that can lead eventually to structural and functional alterations in the brain. Accumulating evidence has suggested that the increased activities in renin-angiotensin system and sympathetic nerve participated in the pathogenesis of hypertension t...

journal_title：ACS chemical neuroscience

authors： Li Y,Yu R,Zhang D,Yang W,Hou Q,Li Y,Jiang H

更新日期：2020-06-03 00:00:00

abstract：:The delivery of specific genes into neurons offers a potent approach for treatment of diseases as well as for the study of neuronal cell biology. Here we investigated the capabilities of cationic amino acid based lipid assemblies to act as nonviral gene delivery vectors in primary cultured neurons. An arginine-based l...

journal_title：ACS chemical neuroscience

authors： Aoshima Y,Hokama R,Sou K,Sarker SR,Iida K,Nakamura H,Inoue T,Takeoka S

更新日期：2013-12-18 00:00:00