Recent advances in the involvement of long non-coding RNAs in neural stem cell biology and brain pathophysiology.

abstract：:Accurate evaluation of the appearance of QTc sex differences during childhood and adolescence is intricate. Inter-subject differences of individual QT/RR patterns make generic heart rate corrections inaccurate because of fast resting heart rates in children. The study investigated 527 healthy children and adolescents ...

journal_title：Frontiers in physiology

authors： Andršová I,Hnatkova K,Helánová K,Šišáková M,Novotný T,Kala P,Malik M

更新日期：2019-08-02 00:00:00

abstract：:We recorded via telemetry the arterial blood pressure (BP) and heart rate (HR) response to classical conditioning following the spontaneous onset of autoimmune diabetes in BBDP/Wor rats vs. age-matched, diabetes-resistant control (BBDR/Wor) rats. Our purpose was to evaluate the autonomic regulatory responses to an acu...

journal_title：Frontiers in physiology

authors： Randall DC,Speakman RO,Silcox DL,Brown LV,Brown DR,Gong MC,Patwardhan A,Reynolds LR,Karounos DG,Burgess DE,Anigbogu CN

更新日期：2011-08-27 00:00:00

abstract：:Atherosclerosis is considered as a chronic disease of arterial wall, with a strong contribution of inflammation. Dendritic cells (DCs) play a crucial role in the initiation of proatherogenic inflammatory response. Mature DCs present self-antigens thereby supporting differentiation of naïve T cells to effector cells th...

journal_title：Frontiers in physiology

authors： Chistiakov DA,Sobenin IA,Orekhov AN,Bobryshev YV

更新日期：2014-05-27 00:00:00

abstract：:There are animal species that have adapted to life at high altitude and hypobaric hypoxia conditions in the Andean highlands. One such species is the llama (Lama glama), which seem to have developed efficient protective mechanisms to avoid maladaptation resulting from chronic hypoxia, such as a resistance to the devel...

journal_title：Frontiers in physiology

authors： López V,Moraga FA,Llanos AJ,Ebensperger G,Taborda MI,Uribe E

更新日期：2018-05-29 00:00:00

abstract：:Characterization of flow properties in cerebral arteries with 1.5 and 3 Tesla MRI is usually limited to large cerebral arteries and difficult to evaluate in the small perforating arteries due to insufficient spatial resolution. In this study, we assessed the feasibility to measure blood flow waveforms in the small len...

journal_title：Frontiers in physiology

authors： Schnerr RS,Jansen JFA,Uludag K,Hofman PAM,Wildberger JE,van Oostenbrugge RJ,Backes WH

更新日期：2017-11-24 00:00:00

abstract：:Mucolipins (TRPML) are endosome/lysosome Ca2+ permeable channels belonging to the family of transient receptor potential channels. In mammals, there are three TRPML proteins, TRPML1, 2, and 3, encoded by MCOLN1-3 genes. Among these channels, TRPML1 is a reactive oxygen species sensor localized on the lysosomal membran...

journal_title：Frontiers in physiology

authors： Santoni G,Maggi F,Amantini C,Marinelli O,Nabissi M,Morelli MB

更新日期：2020-03-24 00:00:00

abstract：BACKGROUND:In patients with arterial hypertension, increased blood pressure (BP) variability contributes to end organ damage independently from mean levels of arterial BP. Increased BP variability has been linked to alterations in autonomic function including sympathetic overdrive. We hypothesized that catheter-based r...

journal_title：Frontiers in physiology

authors： Zuern CS,Rizas KD,Eick C,Stoleriu C,Bunk L,Barthel P,Balletshofer B,Gawaz M,Bauer A

更新日期：2012-05-10 00:00:00

abstract：:In insects, locomotion is the result of rhythm generating thoracic circuits and their modulation by sensory reflexes and by inputs from the two head ganglia, the cerebral and the gnathal ganglia (GNG), which act as higher order neuronal centers playing different functions in the initiation, goal-direction, and mainten...

journal_title：Frontiers in physiology

authors： Emanuel S,Kaiser M,Pflueger HJ,Libersat F

更新日期：2020-02-21 00:00:00

abstract：:Objective: Despite the improvement in ventricular assist device (VAD) therapy in adults and in adolescents, in infant population only Berlin Heart EXCOR (BHE) is licensed as long term VAD to bridge children to Heart Transplantation (HTx). Particularly demanding in terms of morbidity and mortality are smallest patients...

journal_title：Frontiers in physiology

authors： Di Molfetta A,Gandolfo F,Filippelli S,Perri G,Di Chiara L,Iacobelli R,Adorisio R,Favia I,Rizza A,Testa G,Di Nardo M,Amodeo A

更新日期：2016-12-06 00:00:00

abstract：:Patients undergoing the complex treatment for hematological malignancies are exposed to a high physiological and psychological distress inducing fatigue and physical inactivity. In line with cancer-related metabolic changes patients are predisposed for skeletal muscle mass loss that leads to a functional decline, affe...

journal_title：Frontiers in physiology

authors： Schink K,Reljic D,Herrmann HJ,Meyer J,Mackensen A,Neurath MF,Zopf Y

更新日期：2018-12-18 00:00:00

abstract：:Background: Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) is highly effective in alleviating motor symptoms of Parkinson's disease (PD) which are not optimally controlled by dopamine replacement therapy. Clinical studies and reports suggest that STN-DBS may result in increased impulsivity and de novo impulse co...

journal_title：Frontiers in physiology

authors： Mandali A,Chakravarthy VS,Rajan R,Sarma S,Kishore A

更新日期：2016-11-29 00:00:00

abstract：:Singlet oxygen generated in a type II photodynamic action, due to its limited lifetime (1 μs) and reactive distance (<10 nm), could regulate live cell function nanoscopically. The genetically-encoded protein photosensitizers (engineered fluorescent proteins such as KillerRed, TagRFP, and flavin-binding proteins such a...

journal_title：Frontiers in physiology

authors： Jiang HN,Li Y,Cui ZJ

更新日期：2017-04-04 00:00:00

abstract：Introduction:Hypothermia has notable effects on platelets, platelet function, fibrinogen, and coagulation factors. Common laboratory techniques cannot identify those effects, because blood samples are usually warmed to 37°C before analysis and do not fully reflect the in vivo situation. Multiple aspects of the pathophy...

journal_title：Frontiers in physiology

authors： Wallner B,Schenk B,Hermann M,Paal P,Falk M,Strapazzon G,Martini WZ,Brugger H,Fries D

更新日期：2020-07-14 00:00:00

abstract：:Glucose metabolism is a biologically important metabolic process. Glycogen synthase kinase (GSK-3) is a key enzyme located in the middle of the sugar metabolism pathway that can regulate the energy metabolism process in the body through insulin signaling. This paper mainly explores the regulatory effect of glycogen sy...

journal_title：Frontiers in physiology

authors： Ding YJ,Li GY,Xu CD,Wu Y,Zhou ZS,Wang SG,Li C

更新日期：2020-11-25 00:00:00

abstract：AIM:The signaling pathways involved in the regulation of cardiac GLUT4 translocation/glucose uptake and CD36 translocation/long-chain fatty acid uptake are not fully understood. We compared in heart/muscle-specific PKC-λ knockout mice the roles of atypical PKCs (PKC-ζ and PKC-λ) in regulating cardiac glucose and fatty ...

journal_title：Frontiers in physiology

authors： Habets DD,Luiken JJ,Ouwens M,Coumans WA,Vergouwe M,Maarbjerg SJ,Leitges M,Bonen A,Richter EA,Glatz JF

更新日期：2012-09-11 00:00:00

abstract：:Troponin I (TnI) is a major regulator of cardiac muscle contraction and relaxation. During physiological and pathological stress, TnI is differentially phosphorylated at multiple residues through different signaling pathways to match cardiac function to demand. The combination of these TnI phosphorylations can exhibit...

journal_title：Frontiers in physiology

authors： Salhi HE,Hassel NC,Siddiqui JK,Brundage EA,Ziolo MT,Janssen PM,Davis JP,Biesiadecki BJ

更新日期：2016-12-15 00:00:00

abstract：:Background: Although endothelial cell protein C receptor (EPCR) gene Ser219Gly polymorphism has been associated with venous thromboembolism (VTE) susceptibility, no clear consensus has yet been reached. Objective and methods: A meta-analysis of 9,494 subjects from 13 individual studies was conducted to better elucidat...

journal_title：Frontiers in physiology

authors： Li YY,Wu JJ,Yang XX,Geng HY,Gong G,Kim HJ

更新日期：2017-05-26 00:00:00

abstract：:Introduction: Although short-term (approximately 10-min) fatiguing DP has been reported not to alter the joint kinematics or displacement of the centre of mass (COM) of high-level skiers, we hypothesize that prolonged DP does change these kinematics, since muscular strength is impaired following endurance events lasti...

journal_title：Frontiers in physiology

authors： Zoppirolli C,Bortolan L,Stella F,Boccia G,Holmberg HC,Schena F,Pellegrini B

更新日期：2018-07-25 00:00:00

abstract：:For many hereditary disorders, although the underlying genetic mutation may be known, the molecular mechanism leading to hemolytic anemia is still unclear and needs further investigation. Previous studies revealed an increased intracellular Ca2+ in red blood cells (RBCs) from patients with sickle cell disease, thalass...

journal_title：Frontiers in physiology

authors： Hertz L,Huisjes R,Llaudet-Planas E,Petkova-Kirova P,Makhro A,Danielczok JG,Egee S,Del Mar Mañú-Pereira M,van Wijk R,Vives Corrons JL,Bogdanova A,Kaestner L

更新日期：2017-09-06 00:00:00

abstract：:A moderate hypoxic stimulus is considered a promising therapeutic modality for several pathological states including obesity. There is scientific evidence suggesting that when hypoxia and physical activity are combined, they could provide benefits for the obese population. The aim of the present study was to investiga...

journal_title：Frontiers in physiology

authors： Camacho-Cardenosa A,Camacho-Cardenosa M,Burtscher M,Martínez-Guardado I,Timon R,Brazo-Sayavera J,Olcina G

更新日期：2018-02-07 00:00:00

abstract：:The goal here is to describe our current understanding of heme metabolism and the deleterious effects of "free" heme on immunological processes, endothelial function, systemic inflammation, and various end-organ tissues (e.g., kidney, lung, liver, etc.), with particular attention paid to the role of hemopexin (HPX). B...

journal_title：Frontiers in physiology

authors： Smith A,McCulloh RJ

更新日期：2015-06-30 00:00:00

abstract：:Circulating microRNAs have proven to be reliable biomarkers, due to their high stability, both in vivo in the circulation, and ex vivo during sample preparation and storage. Small nucleolar RNAs (snoRNAs) are a different type of small non-coding RNAs that can also be reliably measured in plasma, but have only been stu...

journal_title：Frontiers in physiology

authors： Håkansson KEJ,Sollie O,Simons KH,Quax PHA,Jensen J,Nossent AY

更新日期：2018-08-22 00:00:00

abstract：:Progressive aging induces several structural and functional alterations in the cardiovascular system, among whom particularly important are a reduced number of myocardial cells and increased interstitial collagen fibers, which result in impaired left ventricular diastolic function. Even in the absence of cardiovascula...

journal_title：Frontiers in physiology

authors： Vigorito C,Giallauria F

更新日期：2014-02-20 00:00:00

abstract：:The generation of neural network dynamics relies on the interactions between the intrinsic and synaptic properties of their neural components. Moreover, neuromodulators allow networks to change these properties and adjust their activity to specific challenges. Endogenous continuous ("tonic") neuromodulation can regula...

journal_title：Frontiers in physiology

authors： Peña-Ortega F

更新日期：2012-07-20 00:00:00

abstract：AIMS:It has been previously shown that the probiotic kefir (a symbiotic matrix containing acid bacteria and yeasts) attenuated the hypertension and the endothelial dysfunction in spontaneously hypertensive rats (SHR). In the present study, the effect of chronic administration of kefir on the cardiac autonomic control o...

journal_title：Frontiers in physiology

authors： Klippel BF,Duemke LB,Leal MA,Friques AG,Dantas EM,Dalvi RF,Gava AL,Pereira TM,Andrade TU,Meyrelles SS,Campagnaro BP,Vasquez EC

更新日期：2016-06-07 00:00:00

abstract：:We present a novel approach to quantify heart rate variability (HRV) and the results of applying this approach to synthetic and original data sets. Our approach evaluates the periodicity of heart rate by calculating the transform of Relative Shannon Entropy, the maximum value of the RR interval periodogram, and the ma...

journal_title：Frontiers in physiology

authors： Thungtong A,Knoch MF,Jacono FJ,Dick TE,Loparo KA

更新日期：2018-06-19 00:00:00

abstract：:Regular physical exercise provides many health benefits, protecting against the development of chronic diseases, and improving quality of life. Some of the mechanisms by which exercise provides these effects are the promotion of an anti-inflammatory state, reinforcement of the neuromuscular function, and activation of...

journal_title：Frontiers in physiology

authors： Cerdá B,Pérez M,Pérez-Santiago JD,Tornero-Aguilera JF,González-Soltero R,Larrosa M

更新日期：2016-02-18 00:00:00

abstract：:[This corrects the article DOI: 10.3389/fphys.2019.00815.]. ...

journal_title：Frontiers in physiology

authors： Chonat S,Risinger M,Sakthivel H,Niss O,Rothman JA,Hsieh L,Chou ST,Kwiatkowski JL,Khandros E,Gorman MF,Wells DT,Maghathe T,Dagaonkar N,Seu KG,Zhang K,Zhang W,Kalfa TA

更新日期：2019-10-18 00:00:00

abstract：:Overconsumption of fructose leads to metabolic syndrome as a result of hypertension, insulin resistance, and hyperlipidemia. In this study, the renal function of animals submitted to high fructose intake was analyzed from weaning to adulthood using in vivo and ex vivo methods, being compared with a normal control grou...

journal_title：Frontiers in physiology

authors： Yokota R,Ronchi FA,Fernandes FB,Jara ZP,Rosa RM,Leite APO,Fiorino P,Farah V,do Nascimento NRF,Fonteles MC,Casarini DE

更新日期：2018-10-10 00:00:00

abstract：:The main purpose was to analyze quantitatively the the average surface EMGs of the muscles that function around the elbow and shoulder joints of both arms in bimanual "rowing" movements, which were produced under identical elastic loads applied to the levers ("oars"). The muscles of PM group ("pulling" muscles: elbow ...

journal_title：Frontiers in physiology

authors： Tomiak T,Gorkovenko AV,Tal'nov AN,Abramovych TI,Mishchenko VS,Vereshchaka IV,Kostyukov AI

更新日期：2015-11-27 00:00:00