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Recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as CNS therapeutics.

Abstract：

:This Review describes recent activity in the advancement of ligands for the metabotropic glutamate 4 receptor subtype and their potential utility as central nervous system (CNS) therapeutics. Until recently, there was a paucity of compounds with suitable selectivity and druglike properties to elucidate the value of this target. The search for selective entities has led several groups to the investigation of allosteric modulators as a path to optimization of potential ligands. Recent efforts, discussed here, have afforded a variety of derivatives with improvements in potency, solubility, and pharmacokinetic properties that garner support for continued investigation and optimization.

journal_name

ACS Chem Neurosci

journal_title

ACS chemical neuroscience

authors

Robichaud AJ,Engers DW,Lindsley CW,Hopkins CR

doi

10.1021/cn200043e

subject

Has Abstract

pub_date

2011-08-17 00:00:00

pages

433-49

issue

8

issn

1948-7193

journal_volume

2

pub_type

杂志文章,评审

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