Neuromicrobiology: How Microbes Influence the Brain.

abstract：:On the basis of the drug-repositioning and redeveloping strategy, first-generation dual-target inhibitors of acetylcholinesterase (AChE) and phosphodiesterase 5 (PDE5) have been recently reported as a potentially novel therapeutic method for the treatment of Alzheimer's disease (AD), and the lead compound 2 has proven...

journal_title：ACS chemical neuroscience

authors： Ni W,Wang H,Li X,Zheng X,Wang M,Zhang J,Gong Q,Ling D,Mao F,Zhang H,Li J

更新日期：2018-07-18 00:00:00

abstract：:Previous work has established that D-serine (D-Ser) plays important roles in certain neurological processes. Study on its uptake/storage and release by neuronal cells is highly significant for elucidating relevant mechanisms. In this work, PC-12 cells were incubated with racemic Ser (100 μM each enantiomer). After inc...

journal_title：ACS chemical neuroscience

authors： Li X,McCullum C,Zhao S,Hu H,Liu YM

更新日期：2015-04-15 00:00:00

abstract：:Manganese (Mn) may foster aggregation of alpha-synuclein (αSyn) contributing to the pathogenesis of PD. Here, we examined the influence of αSyn overexpression on distribution and oxidation states of Mn in frozen-hydrated primary midbrain neurons (PMNs) by synchrotron-based X-ray fluorescence (XRF) and X-ray absorption...

journal_title：ACS chemical neuroscience

authors： Dučić T,Carboni E,Lai B,Chen S,Michalke B,Lázaro DF,Outeiro TF,Bähr M,Barski E,Lingor P

更新日期：2015-10-21 00:00:00

abstract：:γ-Secretase is a multiprotein complex that catalyzes intramembrane proteolysis associated with Alzheimer's disease and cancer. Here, we have developed potent sulfonamide clickable photoaffinity probes that target γ-secretase in vitro and in cells by incorporating various photoreactive groups and walking the clickable ...

journal_title：ACS chemical neuroscience

authors： Crump CJ,Murrey HE,Ballard TE,Am Ende CW,Wu X,Gertsik N,Johnson DS,Li YM

更新日期：2016-08-17 00:00:00

abstract：:Opium is the latex from the opium poppy Papaver somniferum L., which humankind has utilized since ancient Mesopotamia all the way to modern times. Opium used to be surrounded in divine mystery or magic-like abilities and was given to cure a wide variety of diseases until its analgesic, antitussive, and antidiarrheal p...

journal_title：ACS chemical neuroscience

authors： Presley CC,Lindsley CW

更新日期：2018-10-17 00:00:00

abstract：:Recent clinical approvals of brain imaging radiotracers targeting amyloid-β provided clinicians the tools to detect and confirm Alzheimer's disease pathology without autopsy or biopsy. While current imaging agents are effective in postsymptomatic Alzheimer's patients, there is much room for improvement in earlier diag...

journal_title：ACS chemical neuroscience

authors： Neo Shin N,Jeon H,Jung Y,Baek S,Lee S,Yoo HC,Bae GH,Park K,Yang SH,Han JM,Kim I,Kim Y

更新日期：2019-06-19 00:00:00

abstract：:Neuroinflammatory processes promote a constellation of neurochemical and hormonal changes resulting in profound effects on motivational states (anhedonia), mood (depression and anxiety disorders), and cognitive function (decrements in learning and memory). The enhancement of immunoregulatory processes, such as increas...

journal_title：ACS chemical neuroscience

authors： Frank MG,Fonken LK,Watkins LR,Maier SF,Lowry CA

更新日期：2019-01-16 00:00:00

abstract：:The 5-HT2C receptor has emerged as a promising target in the treatment of a variety of central nervous system disorders. We have first identified aporphines as a new class of 5-HT2C receptor agonists. Structure-activity relationship results indicate that the aporphine core may be required for 5-HT2C receptor activity,...

journal_title：ACS chemical neuroscience

authors： Mao Q,Zhang B,Li W,Tian S,Shui W,Ye N

更新日期：2020-02-19 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are the most abundant components of glial scar formed after severe traumatic brain injury as well as spinal cord injury and play a crucial inhibitory role in axonal regeneration by selective contraction of filopodia of the growth cone of sprouting neurites. Healing of central ...

journal_title：ACS chemical neuroscience

authors： Mukherjee N,Nandi S,Garg S,Ghosh S,Ghosh S,Samat R,Ghosh S

更新日期：2020-02-05 00:00:00

abstract：:Carboranes have been extensively investigated as potential drugs for the treatment of malignant human brain tumors by boron neutron capture therapy (BNCT). This noninvasive treatment modality utilizes compounds containing the nonradioactive isotope 10B which has a high propensity to capture slow neutrons. In response,...

journal_title：ACS chemical neuroscience

authors： He T,Chittur SV,Musah RA

更新日期：2019-03-20 00:00:00

abstract：:Altered intestinal permeability has been correlated with Parkinson's pathophysiology in the enteric nervous system, before manifestations in the central nervous system (CNS). The inflammatory endotoxin or lipopolysaccharide (LPS) released by gut bacteria is known to modulate α-synuclein amyloidogenesis through the for...

journal_title：ACS chemical neuroscience

authors： Bhattacharyya D,Mohite GM,Krishnamoorthy J,Gayen N,Mehra S,Navalkar A,Kotler SA,Ratha BN,Ghosh A,Kumar R,Garai K,Mandal AK,Maji SK,Bhunia A

更新日期：2019-05-15 00:00:00

abstract：:Abnormally aggregated tau is the hallmark pathology of tauopathy neurodegenerative disorders and is a target for development of both diagnostic tools and therapeutic strategies across the tauopathy disease spectrum. Development of carbon-11- or fluorine-18-labeled radiotracers with appropriate affinity and specificity...

journal_title：ACS chemical neuroscience

authors： Fawaz MV,Brooks AF,Rodnick ME,Carpenter GM,Shao X,Desmond TJ,Sherman P,Quesada CA,Hockley BG,Kilbourn MR,Albin RL,Frey KA,Scott PJ

更新日期：2014-08-20 00:00:00

abstract：:Neurotensin (NT) exerts its analgesic effects through activation of the G protein-coupled receptors NTS1 and NTS2. This opioid-independent antinociception represents a potential alternative for pain management. While activation of NTS1 also induces a drop in blood pressure and body temperature, NTS2 appears to be an a...

journal_title：ACS chemical neuroscience

authors： Eiselt E,Gonzalez S,Martin C,Chartier M,Betti C,Longpré JM,Cavelier F,Tourwé D,Gendron L,Ballet S,Sarret P

更新日期：2019-11-20 00:00:00

abstract：:Glioblastoma (GBM) is characterized by a poor response to conventional chemotherapeutic agents, attributed to the insurgence of drug resistance mechanisms and to the presence of a subpopulation of glioma stem cells (GSCs). GBM cells and GSCs present, among others, an overexpression of antiapoptotic proteins and an inh...

journal_title：ACS chemical neuroscience

authors： Daniele S,Pietrobono D,Costa B,Giustiniano M,La Pietra V,Giacomelli C,La Regina G,Silvestri R,Taliani S,Trincavelli ML,Da Settimo F,Novellino E,Martini C,Marinelli L

更新日期：2018-01-17 00:00:00

abstract：:Promotion of neurite outgrowth and synapse formation is a key step for nervous tissue regeneration. It is important for finding a new biomaterial to guide neuron growth to target neurons. Aminated graphene oxide (NH2-GO) displays electrical properties and dispersibility, which may change the surface charge of neurons ...

journal_title：ACS chemical neuroscience

authors： Liu M,Huang C,Jia Z,Zhao Z,Xiao X,Wang A,Li P,Guan X,Zhou G,Fan Y

更新日期：2020-02-19 00:00:00

abstract：:The Chinese mitten crab (Eriocheir sinensis) is a commercially important crab in China and is usually managed at high stocking densities. Agonistic behavior directly impacts crab integrity, survival, and growth and results in economic losses. In the present study, we evaluated the modulatory effects of serotonin (5-HT...

journal_title：ACS chemical neuroscience

authors： Pang YY,Song YM,Zhang L,Song XZ,Zhang C,Lv JH,He L,Cheng YX,Yang XZ

更新日期：2019-11-20 00:00:00

abstract：:Glycans are intimately involved in several facets of neuronal development and neuropathology. However, the metabolic labeling of surface glycans in primary neurons is a difficult task because of the neurotoxicity of unnatural monosaccharides that are used as a metabolic precursor, hindering the progress of metabolic e...

journal_title：ACS chemical neuroscience

authors： Choi JY,Park M,Cho H,Kim MH,Kang K,Choi IS

更新日期：2017-12-20 00:00:00

abstract：:Currently, anti-AD drug discovery using target-based approaches is extremely challenging due to unclear etiology of AD and absence of validated therapeutic protein targets. Neuronal death, regardless of causes, plays a key role in AD progression, and it is directly linked to neuroinflammation. Meanwhile, phenotypic sc...

journal_title：ACS chemical neuroscience

authors： Zhou W,Zhong G,Fu S,Xie H,Chi T,Li L,Rao X,Zeng S,Xu D,Wang H,Sheng G,Ji X,Liu X,Ji X,Wu D,Zou L,Tortorella M,Zhang K,Hu W

更新日期：2016-11-16 00:00:00

abstract：:The glycine receptor (GlyR) is a ligand-activated chloride channel, whose mutations are the major cause of hereditary hyperekplexia. The hyperekplexia-causing R271Q mutation, which is located at the extracellular outer mouth of the channel pore, dramatically impairs the GlyR function manifesting a reduced sensitivity ...

journal_title：ACS chemical neuroscience

authors： Han L,Shan Q

更新日期：2020-10-21 00:00:00

abstract：:Exposure to di-(2-ethylhexyl) phthalate (DEHP), a widely used kind of plasticizer, can result in neurodevelopment impairments and learning and memory disorders. We studied the effects and possible mechanisms of maternal DEHP treatment on hippocampal synaptic plasticity in offspring. Pregnant Wistar rats were randomly ...

journal_title：ACS chemical neuroscience

authors： Dong J,Fu H,Fu Y,You M,Li X,Wang C,Leng K,Wang Y,Chen J

更新日期：2021-01-20 00:00:00

abstract：:An intracerebral hemorrhage (ICH) is a devastating stroke that results in high mortality and significant disability in survivors. Unfortunately, the underlying mechanisms of this injury are not yet fully understood. After the primary (mechanical) trauma, secondary degenerative events contribute to ongoing cell death i...

journal_title：ACS chemical neuroscience

authors： Hackett MJ,DeSouza M,Caine S,Bewer B,Nichol H,Paterson PG,Colbourne F

更新日期：2015-05-20 00:00:00

abstract：:The molecular pathogenesis of Alzheimer's disease (AD) is complex and sparsely understood. The relationship between AD's amyloid β (Aβ) peptides and neuronal membranes is central to Aβ's cytotoxicity and is directly modulated by the composition of the lipid headgroups. Molecular studies of the insertion of model Aβ40 ...

journal_title：ACS chemical neuroscience

authors： Tofoleanu F,Brooks BR,Buchete NV

更新日期：2015-03-18 00:00:00

abstract：:Amyloid β (Abeta) peptides in their oligomeric form have been proposed as major toxic species in Alzheimer's disease (AD). There are a limited number of anti-Abeta antibodies specific to oligomeric forms of Abeta compared to the monomeric form, and accurate measurement of oligomeric forms in biological samples, cerebr...

journal_title：ACS chemical neuroscience

authors： Matveeva EG,Rudolph A,Moll JR,Thompson RB

更新日期：2012-11-21 00:00:00

abstract：:The light emission chemistry of firefly luciferase can be harnessed to reveal otherwise invisible biological processes occurring in the brains of live animals. Though powerful, the need for the luciferase substrate D-luciferin to traverse the blood-brain barrier poses limitations on the sensitivity and interpretation ...

journal_title：ACS chemical neuroscience

authors： Mofford DM,Miller SC

更新日期：2015-08-19 00:00:00

abstract：:Stereotypy (e.g., repetitive hand waving) is a key phenotype of autism spectrum disorder, Fragile X and Rett syndromes, and other neuropsychiatric disorders, and its severity correlates with cognitive and attention deficits. There are no effective treatments, however, for stereotypy. Perturbation of serotonin (5-HT) n...

journal_title：ACS chemical neuroscience

authors： Canal CE,Felsing DE,Liu Y,Zhu W,Wood JT,Perry CK,Vemula R,Booth RG

更新日期：2015-07-15 00:00:00

abstract：:The present study was performed to investigate the possible role of protein kinase C (PKC) in morphine tolerance at spinal levels of rats. Intrathecal injection of 10 μg of morphine induced increases in the hindpaw withdrawal latency (HWL) to noxious thermal and mechanical stimulation in rats. After intrathecal inject...

journal_title：ACS chemical neuroscience

authors： Jin WY,Yu LC

更新日期：2010-02-17 00:00:00

abstract：:We recently found that tamoxifen suppresses l-glutamate transport activity of cultured astrocytes. Here, in an attempt to separate the l-glutamate transporter-inhibitory activity from the estrogen receptor-mediated genomic effects, we synthesized several compounds structurally related to tamoxifen. Among them, we iden...

journal_title：ACS chemical neuroscience

authors： Sato K,Kuriwaki J,Takahashi K,Saito Y,Oka J,Otani Y,Sha Y,Nakazawa K,Sekino Y,Ohwada T

更新日期：2012-02-15 00:00:00

abstract：:As the first drug to see widespread use for the treatment of attention deficit hyperactivity disorder (ADHD), methylphenidate was the forerunner and catalyst to the modern era of rapidly increasing diagnosis, treatment, and medication development for this condition. During its often controversial history, it has vario...

journal_title：ACS chemical neuroscience

authors： Wenthur CJ

更新日期：2016-08-17 00:00:00

abstract：:Alzheimer's disease (AD) is a significant health crisis, and current treatments provide only limited benefits to cognition at the cost of serious side effects. Recently, virtual screening techniques such as ligand-based virtual screening (LBVS) and structure-based virtual screening (SBVS) have emerged as powerful drug...

journal_title：ACS chemical neuroscience

authors： Miles JA,Ross BP

更新日期：2021-01-06 00:00:00

abstract：:Proton magnetic spectroscopy (1H-MRS) is a noninvasive imaging technique that allows for the quantification of neurometabolic compounds at millimolar concentrations in the living human brain. This technique has been most often used to assess long-term changes in human brain metabolism in psychiatric disorders, pharmac...

journal_title：ACS chemical neuroscience

authors： White TL,Gonsalves MA

更新日期：2020-09-02 00:00:00