当前位置： SCI文献检索 > Journal of Neuroinflammation期刊下所有文献 > Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury.

Delayed mGluR5 activation limits neuroinflammation and neurodegeneration after traumatic brain injury.

Abstract：

BACKGROUND:Traumatic brain injury initiates biochemical processes that lead to secondary neurodegeneration. Imaging studies suggest that tissue loss may continue for months or years after traumatic brain injury in association with chronic microglial activation. Recently we found that metabotropic glutamate receptor 5 (mGluR5) activation by (RS)-2-chloro-5-hydroxyphenylglycine (CHPG) decreases microglial activation and release of associated pro-inflammatory factors in vitro, which is mediated in part through inhibition of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. Here we examined whether delayed CHPG administration reduces chronic neuroinflammation and associated neurodegeneration after experimental traumatic brain injury in mice. METHODS:One month after controlled cortical impact traumatic brain injury, C57Bl/6 mice were randomly assigned to treatment with single dose intracerebroventricular CHPG, vehicle or CHPG plus a selective mGluR5 antagonist, 3-((2-Methyl-4-thiazolyl)ethynyl)pyridine. Lesion volume, white matter tract integrity and neurological recovery were assessed over the following three months. RESULTS:Traumatic brain injury resulted in mGluR5 expression in reactive microglia of the cortex and hippocampus at one month post-injury. Delayed CHPG treatment reduced expression of reactive microglia expressing NADPH oxidase subunits; decreased hippocampal neuronal loss; limited lesion progression, as measured by repeated T2-weighted magnetic resonance imaging (at one, two and three months) and white matter loss, as measured by high field ex vivo diffusion tensor imaging at four months; and significantly improved motor and cognitive recovery in comparison to the other treatment groups. CONCLUSION:Markedly delayed, single dose treatment with CHPG significantly improves functional recovery and limits lesion progression after experimental traumatic brain injury, likely in part through actions at mGluR5 receptors that modulate neuroinflammation.

journal_name

J Neuroinflammation

journal_title

Journal of neuroinflammation

authors

Byrnes KR,Loane DJ,Stoica BA,Zhang J,Faden AI

doi

10.1186/1742-2094-9-43

subject

Has Abstract

pub_date

2012-02-28 00:00:00

pages

43

issn

1742-2094

pii

1742-2094-9-43

journal_volume

9

pub_type

杂志文章

相关文献

Journal of Neuroinflammation文献大全
  • DHCR24 exerts neuroprotection upon inflammation-induced neuronal death.

    abstract：BACKGROUND:DHCR24, involved in the de novo synthesis of cholesterol and protection of neuronal cells against different stress conditions, has been shown to be selectively downregulated in neurons of the affected brain areas in Alzheimer's disease. METHODS:Here, we investigated whether the overexpression of DHCR24 prot...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0991-6

    authors： Martiskainen H,Paldanius KMA,Natunen T,Takalo M,Marttinen M,Leskelä S,Huber N,Mäkinen P,Bertling E,Dhungana H,Huuskonen M,Honkakoski P,Hotulainen P,Rilla K,Koistinaho J,Soininen H,Malm T,Haapasalo A,Hiltunen M

    更新日期：2017-11-07 00:00:00

  • Ibrutinib suppresses LPS-induced neuroinflammatory responses in BV2 microglial cells and wild-type mice.

    abstract：BACKGROUND:The FDA-approved small-molecule drug ibrutinib is an effective targeted therapy for patients with chronic lymphocytic leukemia (CLL). Ibrutinib inhibits Bruton's tyrosine kinase (BTK), a kinase involved in B cell receptor signaling. However, the potential regulation of neuroinflammatory responses in the brai...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1308-0

    authors： Nam HY,Nam JH,Yoon G,Lee JY,Nam Y,Kang HJ,Cho HJ,Kim J,Hoe HS

    更新日期：2018-09-19 00:00:00

  • Mesenchymal stem cells exert anti-proliferative effect on lipopolysaccharide-stimulated BV2 microglia by reducing tumour necrosis factor-α levels.

    abstract：BACKGROUND:Progression of neurodegenerative diseases occurs when microglia, upon persistent activation, perpetuate a cycle of damage in the central nervous system. Use of mesenchymal stem cells (MSC) has been suggested as an approach to manage microglia activation based on their immunomodulatory functions. In the prese...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-014-0149-8

    authors： Jose S,Tan SW,Ooi YY,Ramasamy R,Vidyadaran S

    更新日期：2014-09-03 00:00:00

  • Intermittent fasting attenuates lipopolysaccharide-induced neuroinflammation and memory impairment.

    abstract：BACKGROUND:Systemic bacterial infections often result in enduring cognitive impairment and are a risk factor for dementia. There are currently no effective treatments for infection-induced cognitive impairment. Previous studies have shown that intermittent fasting (IF) can increase the resistance of neurons to injury a...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-85

    authors： Vasconcelos AR,Yshii LM,Viel TA,Buck HS,Mattson MP,Scavone C,Kawamoto EM

    更新日期：2014-05-06 00:00:00

  • Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury.

    abstract：BACKGROUND:Traumatic brain injury (TBI) initiates a neuroinflammatory cascade that contributes to substantial neuronal damage and behavioral impairment, and Toll-like receptor 4 (TLR4) is an important mediator of thiscascade. In the current study, we tested the hypothesis that curcumin, a phytochemical compound with po...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-59

    authors： Zhu HT,Bian C,Yuan JC,Chu WH,Xiang X,Chen F,Wang CS,Feng H,Lin JK

    更新日期：2014-03-27 00:00:00

  • High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects.

    abstract：BACKGROUND:Transforming growth factor β (TGF-β) is a cytokine having multiple functions in the central nervous system such as promoting repair mechanisms in degenerative diseases and stroke. To date, however, its neuroprotective effects in non-disease conditions have not been studied METHODS:With the aim of exploring ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-9-42

    authors： Piras F,Salani F,Bossù P,Caltagirone C,Spalletta G

    更新日期：2012-02-28 00:00:00

  • Sphingosine-1-phosphate receptor subtype 1 activation in the central nervous system contributes to morphine withdrawal in rodents.

    abstract：:Opioid therapies for chronic pain are undermined by many adverse side effects that reduce their efficacy and lead to dependence, abuse, reduced quality of life, and even death. We have recently reported that sphingosine-1-phosphate (S1P) 1 receptor (S1PR1) antagonists block the development of morphine-induced hyperalg...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-01975-2

    authors： Doyle TM,Hutchinson MR,Braden K,Janes K,Staikopoulos V,Chen Z,Neumann WL,Spiegel S,Salvemini D

    更新日期：2020-10-22 00:00:00

  • [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis.

    abstract：BACKGROUND:The cystine/glutamate antiporter (xc-) has been implicated in several neurological disorders and, specifically, in multiple sclerosis (MS) as a mediator of glutamate excitotoxicity and proinflammatory immune responses. We aimed to evaluate an xc-specific positron emission tomography (PET) radiotracer, (4S)-4...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-018-1080-1

    authors： Hoehne A,James ML,Alam IS,Ronald JA,Schneider B,D'Souza A,Witney TH,Andrews LE,Cropper HC,Behera D,Gowrishankar G,Ding Z,Wyss-Coray T,Chin FT,Biswal S,Gambhir SS

    更新日期：2018-02-22 00:00:00

  • Mesenchymal stem cells inhibit lipopolysaccharide-induced inflammatory responses of BV2 microglial cells through TSG-6.

    abstract：:Microglia are the primary immunocompetent cells in brain tissue and microglia-mediated inflammation is associated with the pathogenesis of various neuronal disorders. Recently, many studies have shown that mesenchymal stem cells (MSCs) display a remarkable ability to modulate inflammatory and immune responses through ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-11-135

    authors： Liu Y,Zhang R,Yan K,Chen F,Huang W,Lv B,Sun C,Xu L,Li F,Jiang X

    更新日期：2014-08-04 00:00:00

  • Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP).

    abstract：BACKGROUND:Adult human mesenchymal stem/stromal cells (hMSCs) from bone marrow have been reported to exhibit beneficial effects on spinal cord injury (SCI). A neuropeptide, pituitary adenylate cyclase-activating polypeptide (PACAP) is known to decrease neuronal cell death and inflammatory response after ischemia, SCI, ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0252-5

    authors： Tsumuraya T,Ohtaki H,Song D,Sato A,Watanabe J,Hiraizumi Y,Nakamachi T,Xu Z,Dohi K,Hashimoto H,Atsumi T,Shioda S

    更新日期：2015-02-22 00:00:00

  • Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures.

    abstract：OBJECTIVE:Febrile seizures are the most common form of childhood seizures. Fever is induced by pro-inflammatory cytokines during infection, and pro-inflammatory cytokines may trigger the development of febrile seizures. In order to determine whether active inflammation, including high mobility group box-1 (HMGB1) and p...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-8-135

    authors： Choi J,Min HJ,Shin JS

    更新日期：2011-10-11 00:00:00

  • The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome.

    abstract：:Obstructive sleep apnea syndrome (OSAS), a state of sleep disorder, is characterized by repetitive apnea, chronic hypoxia, oxygen desaturation, and hypercapnia. Previous studies have revealed that intermittent hypoxia (IH) conditions in OSAS patients elicited neuron injury (especially in the hippocampus and cortex), l...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章,评审

    doi：10.1186/s12974-020-01905-2

    authors： Liu X,Ma Y,Ouyang R,Zeng Z,Zhan Z,Lu H,Cui Y,Dai Z,Luo L,He C,Li H,Zong D,Chen Y

    更新日期：2020-08-01 00:00:00

  • Secretory PLA2-IIA: a new inflammatory factor for Alzheimer's disease.

    abstract：:Secretory phospholipase A2-IIA (sPLA2-IIA) is an inflammatory protein known to play a role in the pathogenesis of many inflammatory diseases. Although this enzyme has also been implicated in the pathogenesis of neurodegenerative diseases, there has not been a direct demonstration of its expression in diseased human br...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-3-28

    authors： Moses GS,Jensen MD,Lue LF,Walker DG,Sun AY,Simonyi A,Sun GY

    更新日期：2006-10-07 00:00:00

  • Antidiabetic drug glyburide modulates depressive-like behavior comorbid with insulin resistance.

    abstract：BACKGROUND:Abundant reports indicated that depression was often comorbid with type 2 diabetes and even metabolic syndrome. Considering they might share common biological origins, it was tentatively attributed to the chronic cytokine-mediated inflammatory response which was induced by dysregulation of HPA axis and overa...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0985-4

    authors： Su WJ,Peng W,Gong H,Liu YZ,Zhang Y,Lian YJ,Cao ZY,Wu R,Liu LL,Wang B,Wang YX,Jiang CL

    更新日期：2017-10-30 00:00:00

  • HIV-1 Tat-shortened neurite outgrowth through regulation of microRNA-132 and its target gene expression.

    abstract：BACKGROUND:Synaptodendritic damage is a pathological hallmark of HIV-associated neurocognitive disorders, and HIV-1 Tat protein is known to cause such injury in the central nervous system. In this study, we aimed to determine the molecular mechanisms of Tat-induced neurite shortening, specifically the roles of miR-132,...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0716-2

    authors： Rahimian P,He JJ

    更新日期：2016-09-15 00:00:00

  • Prevention of methamphetamine-induced microglial cell death by TNF-α and IL-6 through activation of the JAK-STAT pathway.

    abstract：BACKGROUND:It is well known that methamphetamine (METH) is neurotoxic and recent studies have suggested the involvement of neuroinflammatory processes in brain dysfunction induced by misuse of this drug. Indeed, glial cells seem to be activated in response to METH, but its effects on microglial cells are not fully unde...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-9-103

    authors： Coelho-Santos V,Gonçalves J,Fontes-Ribeiro C,Silva AP

    更新日期：2012-07-06 00:00:00

  • LPS-induced systemic inflammation reveals an immunomodulatory role for the prion protein at the blood-brain interface.

    abstract：BACKGROUND:The cellular prion protein (PrPC) is an evolutionary conserved protein abundantly expressed not only in the central nervous system but also peripherally including the immune system. A line of Norwegian dairy goats naturally devoid of PrPC (PRNP Ter/Ter) provides a novel model for studying PrPC physiology. M...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0879-5

    authors： Salvesen Ø,Reiten MR,Espenes A,Bakkebø MK,Tranulis MA,Ersdal C

    更新日期：2017-05-22 00:00:00

  • The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis.

    abstract：:Multiple sclerosis (MS) is thought to be a CD4+ T cell mediated autoimmune demyelinating disease of the central nervous system (CNS) that is rarely diagnosed during infancy. Cellular and molecular mechanisms that confer disease resistance in this age group are unknown. We tested the hypothesis that a differential comp...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-10-67

    authors： Cravens PD,Kieseier BC,Hussain R,Herndon E,Arellano B,Ben LH,Timmons BC,Castro-Rojas C,Hartung HP,Hemmer B,Weber MS,Zamvil SS,Stüve O

    更新日期：2013-05-24 00:00:00

  • The antidepressant-like effects of pioglitazone in a chronic mild stress mouse model are associated with PPARγ-mediated alteration of microglial activation phenotypes.

    abstract：BACKGROUND:Discoveries that microglia-mediated neuroinflammation is involved in the pathological process of depression provided a new strategy for novel antidepressant therapy. Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating inflammation and microglial polarization and, therefore, ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-016-0728-y

    authors： Zhao Q,Wu X,Yan S,Xie X,Fan Y,Zhang J,Peng C,You Z

    更新日期：2016-10-04 00:00:00

  • Activation of the nuclear receptor PPARδ is neuroprotective in a transgenic mouse model of Alzheimer's disease through inhibition of inflammation.

    abstract：BACKGROUND:Alzheimer's disease (AD) is a multifactorial disorder associated with the accumulation of soluble forms of beta-amyloid (Aβ) and its subsequent deposition into plaques. One of the major contributors to neuronal death is chronic and uncontrolled inflammatory activation of microglial cells around the plaques a...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-014-0229-9

    authors： Malm T,Mariani M,Donovan LJ,Neilson L,Landreth GE

    更新日期：2015-01-16 00:00:00

  • Increased frequency of IL-6-producing non-classical monocytes in neuromyelitis optica spectrum disorder.

    abstract：BACKGROUND:Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease of the central nervous system that preferentially affects the optic nerves, spinal cord, and area postrema. A series of evidence suggested that B cells play a fundamental role in the pathogenesis of NMOSD. However, there are...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0961-z

    authors： Kong BS,Kim Y,Kim GY,Hyun JW,Kim SH,Jeong A,Kim HJ

    更新日期：2017-09-25 00:00:00

  • Lack of neuroinflammation in the HIV-1 transgenic rat: an [(18)F]-DPA714 PET imaging study.

    abstract：BACKGROUND:HIV-associated neuroinflammation is believed to be a major contributing factor in the development of HIV-associated neurocognitive disorders (HAND). In this study, we used micropositron emission tomography (PET) imaging to quantify neuroinflammation in HIV-1 transgenic rat (Tg), a small animal model of HIV, ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0390-9

    authors： Lee DE,Yue X,Ibrahim WG,Lentz MR,Peterson KL,Jagoda EM,Kassiou M,Maric D,Reid WC,Hammoud DA

    更新日期：2015-09-17 00:00:00

  • Osteopetrotic (op/op) mice have reduced microglia, no Abeta deposition, and no changes in dopaminergic neurons.

    abstract：BACKGROUND:Activation of microglia is a part of the inflammatory response in neurodegenerative diseases but its role in the pathophysiology of these diseases is still unclear. The osteopetrotic (op/op) mouse lacks colony-stimulating factor-1 (CSF-1) and thus has a deficiency in microglia and macrophages. Prior reports ...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-4-31

    authors： Kondo Y,Lemere CA,Seabrook TJ

    更新日期：2007-12-20 00:00:00

  • Increased CCL2, CCL3, CCL5, and IL-1β cytokine concentration in piriform cortex, hippocampus, and neocortex after pilocarpine-induced seizures.

    abstract：BACKGROUND:Cytokines and chemokines play an important role in the neuroinflammatory response to an initial precipitating injury such as status epilepticus (SE). These signaling molecules participate in recruitment of immune cells, including brain macrophages (microglia), as well as neuroplastic changes, deterioration o...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-015-0347-z

    authors： Arisi GM,Foresti ML,Katki K,Shapiro LA

    更新日期：2015-07-02 00:00:00

  • Activation of toll like receptor 4 attenuates GABA synthesis and postsynaptic GABA receptor activities in the spinal dorsal horn via releasing interleukin-1 beta.

    abstract：:Toll like receptor 4 (TLR4) is an innate immune pattern recognition receptor, expressed predominantly on microglia in the CNS. Activation of spinal TLR4 plays a critical role in the genesis of pathological pain induced by nerve injury, bone cancer, and tissue inflammation. Currently, it remains unknown how synaptic ac...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-014-0222-3

    authors： Yan X,Jiang E,Weng HR

    更新日期：2015-01-09 00:00:00

  • Scolopendra subspinipes mutilans attenuates neuroinflammation in symptomatic hSOD1(G93A) mice.

    abstract：BACKGROUND:Amyotrophic lateral sclerosis (ALS) is a progressive, adult-onset neurodegenerative disorder characterized by selective motor neuron death in the spinal cord, brainstem, and motor cortex. Neuroinflammation is one of several pathological causes of degenerating motor neurons and is induced by activated microgl...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-10-131

    authors： Cai M,Choi SM,Song BK,Son I,Kim S,Yang EJ

    更新日期：2013-10-29 00:00:00

  • Discovery of novel L-type voltage-gated calcium channel blockers and application for the prevention of inflammation and angiogenesis.

    abstract：BACKGROUND:The ways in which microglia activate and promote neovascularization (NV) are not fully understood. Recent in vivo evidence supports the theory that calcium is required for the transition of microglia from a surveillance state to an active one. The objectives of this study were to discover novel L-type voltag...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-020-01801-9

    authors： Saddala MS,Lennikov A,Mukwaya A,Yang Y,Hill MA,Lagali N,Huang H

    更新日期：2020-04-25 00:00:00

  • Neutrophil contribution to spinal cord injury and repair.

    abstract：:Spinal cord injuries remain a critical issue in experimental and clinical research nowadays, and it is now well accepted that the immune response and subsequent inflammatory reactions are of significant importance in regulating the damage/repair balance after injury. The role of macrophages in such nervous system lesi...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章,评审

    doi：10.1186/s12974-014-0150-2

    authors： Neirinckx V,Coste C,Franzen R,Gothot A,Rogister B,Wislet S

    更新日期：2014-08-28 00:00:00

  • α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation.

    abstract：BACKGROUND:Although evidence suggests that the prevalence of Parkinson's disease (PD) is lower in smokers than in non-smokers, the mechanisms of nicotine-induced neuroprotection remain unclear. Stimulation of the α7 nicotinic acetylcholine receptor (α7-nAChR) seems to be a crucial mechanism underlying the anti-inflamma...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/1742-2094-9-98

    authors： Liu Y,Hu J,Wu J,Zhu C,Hui Y,Han Y,Huang Z,Ellsworth K,Fan W

    更新日期：2012-05-24 00:00:00

  • Differential expression of Cathepsin E in transthyretin amyloidosis: from neuropathology to the immune system.

    abstract：BACKGROUND:Increasing evidence supports a key role for inflammation in the neurodegenerative process of familial amyloidotic polyneuropathy (FAP). While there seems to be an overactivation of the neuronal interleukin-1 signaling pathway, the immune response is apparently compromised in FAP. Accordingly, little immune c...

    journal_title：Journal of neuroinflammation

    pub_type： 杂志文章

    doi：10.1186/s12974-017-0891-9

    authors： Gonçalves NP,Moreira J,Martins D,Vieira P,Obici L,Merlini G,Saraiva M,Saraiva MJ

    更新日期：2017-06-06 00:00:00