Quetiapine for schizophrenia.


BACKGROUND:Quetiapine is a novel atypical antipsychotic with low propensity for movement disorder adverse effects. It is used for treatment of schizophrenia and other psychoses. OBJECTIVES:To determine the effects of quetiapine for schizophrenia in comparison to placebo, classical and other atypical antipsychotics. SEARCH STRATEGY:Electronic searches of Biological Abstracts (1982-1997), CINAHL (1982-1997), the Cochrane Library (1998, Issue 1), the Cochrane Schizophrenia Group's Register of trials (1998), EMBASE (1980-1998), MEDLINE (1966-1998), PsycLIT (1974-1997), SocioFile (1974-1997) and many conference proceedings and hand searches of specific journals were undertaken. Zeneca Pharmaceuticals was contacted for information regarding unpublished trials. SELECTION CRITERIA:All controlled trials where adults with schizophrenia or similar illnesses were randomised to quetiapine, placebo or other neuroleptic drugs and where clinically relevant outcomes were reported. DATA COLLECTION AND ANALYSIS:Citations and, where possible, abstracts were independently inspected by reviewers, papers ordered, re-inspected and quality assessed. Data were also independently extracted. For homogeneous dichotomous data the Peto odds ratio (OR), 95% confidence interval (CI) and, where appropriate, the number needed to treat (NNT) was calculated on an intention-to-treat basis. MAIN RESULTS:Seven trials of short duration are included (31 reports) and seven are excluded (15 reports). Apart from that of 'leaving the study early', all other results may be prone to bias and should be viewed with caution since dropout rates are high (48-61%) in each arm of all studies. There are data suggesting less people allocated quetiapine leave the study early (53%) than those in the placebo group (61%) (OR 0.67 CI 0.48-0. 95). Data incorporating considerable assumptions about the many people who left early suggest that global state and psychotic symptoms - both positive and negative - may be more helped by quetiapine than placebo. Although some of these data reach statistical significance their clinical importance is difficult to interpret. While the incidences of extrapyramidal side effects are not different between quetiapine and placebo, side effects such as dizziness and dry mouth are more prevalent in the quetiapine treated group. High proportions of trial participants also leave when quetiapine is compared to chlorpromazine or haloperidol (57% by six weeks). Quetiapine is as potent as chlorpromazine and haloperidol as regards global and mental state but it may cause higher incidences of dry mouth and sleepiness. Extrapyramidal side effects are the same as those of chlorpromazine but may be less than haloperidol. High dose quetiapine is better than low dose quetiapine with regard to leaving the study early, and limited data suggest that the higher dose is also better at marginally improving global state (n = 1, OR 0.70, CI 0.50-0.99, NNT 11). There are no clear differences between high and low dose groups in respect of extrapyramidal side effects. REVIEWER'S CONCLUSIONS:The high dropout rates are a large problem in interpreting any results other than 'leaving the study early' since about half the data were not available at the end of studies. Before quetiapine's use can be recommended, we need more large, well conducted trials that provide short, medium and long term outcomes relevant to carers and clinicians.


Srisurapanont M,Disayavanish C,Taimkaew K





Has Abstract


2000-01-01 00:00:00










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    abstract:BACKGROUND:Post-dural puncture headache (PDPH) is a common complication of lumbar punctures. Several theories have identified the leakage of cerebrospinal fluid (CSF) through the hole in the dura as a cause of this side effect. Therefore, it is necessary to take preventive measures to avoid this complication. Prolonged...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Arevalo-Rodriguez I,Ciapponi A,Munoz L,Roqué i Figuls M,Bonfill Cosp X

    更新日期:2013-07-12 00:00:00

  • Antibiotics for the common cold.

    abstract:BACKGROUND:The common cold is considered to be caused by viruses and it has long been believed that antibiotics have no role in treating this condition. In many countries doctors will often prescribe antibiotics for the common cold in the belief that they may prevent secondary bacterial infection and in some cases to r...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Arroll B,Kenealy T

    更新日期:2002-01-01 00:00:00

  • Oral protein calorie supplementation for children with chronic disease.

    abstract:BACKGROUND:Poor growth and nutritional status are common in children with chronic diseases. Oral protein calorie supplements are used to improve nutritional status in these children. These expensive products may be associated with some adverse effects, e.g. the development of inappropriate eating behaviour patterns. Th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Francis DK,Smith J,Saljuqi T,Watling RM

    更新日期:2015-05-27 00:00:00

  • Low level laser therapy (classes I, II and III) for the treatment of osteoarthritis.

    abstract:BACKGROUND:Osteoarthritis (OA) affects a large proportion of the population. Low Level Laser Therapy (LLLT) is a light source that generates extremely pure light, of a single wavelength. The effect is not thermal, but rather related to photochemical reactions in the cells. LLLT was introduced as an alternative non-inva...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Brosseau L,Welch V,Wells G,deBie R,Gam A,Harman K,Morin M,Shea B,Tugwell P

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  • Miniport versus standard ports for laparoscopic cholecystectomy.

    abstract:BACKGROUND:In conventional (standard) laparoscopic cholecystectomy, four abdominal ports (two of 10 mm diameter and two of 5 mm diameter) are used. Recently, use of smaller ports have been reported. OBJECTIVES:To assess the benefits and harms of miniport (defined as ports smaller than conventional ports) laparoscopic ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Gurusamy KS,Samraj K,Ramamoorthy R,Farouk M,Fusai G,Davidson BR

    更新日期:2010-03-17 00:00:00

  • Aerobic physical exercise for adult patients with haematological malignancies.

    abstract:BACKGROUND:Although people with haematological malignancies have to endure long phases of therapy and immobility, which is known to diminish their physical performance level, the advice to rest and avoid intensive exercises is still common practice. This recommendation is partly due to the severe anaemia and thrombocyt...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Knips L,Bergenthal N,Streckmann F,Monsef I,Elter T,Skoetz N

    更新日期:2019-01-31 00:00:00

  • Integration of HIV/AIDS services with maternal, neonatal and child health, nutrition, and family planning services.

    abstract:BACKGROUND:The integration of HIV/AIDS and maternal, neonatal, child health and nutrition services (MNCHN), including family planning (FP) is recognized as a key strategy to reduce maternal and child mortality and control the HIV/AIDS epidemic. However, limited evidence exists on the effectiveness of service integratio...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Lindegren ML,Kennedy CE,Bain-Brickley D,Azman H,Creanga AA,Butler LM,Spaulding AB,Horvath T,Kennedy GE

    更新日期:2012-09-12 00:00:00

  • Laparoscopic "drilling" by diathermy or laser for ovulation induction in anovulatory polycystic ovary syndrome.

    abstract:BACKGROUND:Problems in inducing ovulation in women with polycystic ovary syndrome (PCOS) and anovulation (failure to ovulate) are well recognised. Surgical ovarian wedge resection was the first established treatment for anovulatory PCOS patients but was largely abandoned because of the risk of post-surgical adhesion fo...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Farquhar C,Vandekerckhove P,Lilford R

    更新日期:2001-01-01 00:00:00

  • Psychosocial interventions for preventing and treating depression in dialysis patients.

    abstract:BACKGROUND:People with end-stage kidney disease (ESKD) treated with dialysis are frequently affected by major depression. Dialysis patients have prioritised depression as a critically important clinical outcome in nephrology trials. Psychological and social support are potential treatments for depression, although a Co...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Natale P,Palmer SC,Ruospo M,Saglimbene VM,Rabindranath KS,Strippoli GF

    更新日期:2019-12-02 00:00:00

  • Autoinflation for hearing loss associated with otitis media with effusion.

    abstract:BACKGROUND:This is an update of a Cochrane review first published in The Cochrane Library in Issue 4, 2006.Otitis media with effusion (OME) or 'glue ear' is an accumulation of fluid in the middle ear, in the absence of acute inflammation or infection. It is the commonest cause of acquired hearing loss in childhood and ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Perera R,Glasziou PP,Heneghan CJ,McLellan J,Williamson I

    更新日期:2013-05-31 00:00:00

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    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) who require urgent initiation of dialysis but without having a permanent dialysis access have traditionally commenced haemodialysis (HD) using a central venous catheter (CVC). However, several studies have reported that urgent initiation of peritoneal dialysis (PD) ...

    journal_title:The Cochrane database of systematic reviews

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    authors: Htay H,Johnson DW,Craig JC,Teixeira-Pinto A,Hawley CM,Cho Y

    更新日期:2021-01-27 00:00:00

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    abstract:BACKGROUND:Vomiting caused by acute gastroenteritis is very common in children and adolescents. Treatment of vomiting in children can be problematic and the use of antiemetics remains a controversial issue. There have been concerns expressed about apparently unacceptable levels of side effects such as sedation and extr...

    journal_title:The Cochrane database of systematic reviews

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    authors: Alhashimi D,Alhashimi H,Fedorowicz Z

    更新日期:2006-07-19 00:00:00

  • Marine-derived n-3 fatty acids therapy for stroke.

    abstract:BACKGROUND:Currently, with stroke burden increasing, there is a need to explore therapeutic options that ameliorate the acute insult. There is substantial evidence of a neuroprotective effect of marine-derived n-3 polyunsaturated fatty acids (PUFAs) in experimental stroke, leading to a better functional outcome. OBJEC...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Alvarez Campano CG,Macleod MJ,Aucott L,Thies F

    更新日期:2019-06-26 00:00:00

  • Lamotrigine for acute and chronic pain.

    abstract:BACKGROUND:This is an update of the original Cochrane review published in Issue 2, 2007. Some antiepileptic medicines have a place in the treatment of neuropathic pain (pain due to nerve damage). This updated review adds five new additional studies looking at evidence for Lamotrigine as an effective treatment for acute...

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    authors: Wiffen PJ,Derry S,Moore RA

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    abstract:BACKGROUND:Managed withdrawal is a necessary step prior to drug-free treatment or as the end point of long-term substitution treatment. OBJECTIVES:To assess the effectiveness of opioid antagonists in combination with minimal sedation to manage opioid withdrawal. SEARCH STRATEGY:We searched the Cochrane Central Regist...

    journal_title:The Cochrane database of systematic reviews

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    authors: Gowing L,Ali R,White JM

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    abstract:BACKGROUND:Fractures of the shaft of the humerus account for 1% to 3% of all fractures in adults. The management of these fractures, including surgical intervention, varies widely. OBJECTIVES:To assess and compare the effects of surgical versus non-surgical intervention for non-pathological fractures of the humeral sh...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Gosler MW,Testroote M,Morrenhof JW,Janzing HM

    更新日期:2012-01-18 00:00:00

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    abstract:BACKGROUND:Cycling is an attractive form of transport. It is beneficial to the individual as a form of physical activity that may fit more readily into an individual's daily routine, such as for cycling to work and to the shops, than other physical activities such as visiting a gym. Cycling is also beneficial to the wi...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mulvaney CA,Smith S,Watson MC,Parkin J,Coupland C,Miller P,Kendrick D,McClintock H

    更新日期:2015-12-10 00:00:00

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    abstract:BACKGROUND:Patients with early stage cervical cancer (stages IA2, IB1 or IIA) with risk factors such as lymph node metastasis, lympho vascular space invasion, depth invasion of more than 10mm, microscopic parametrial invasion, non-squamous histology and positive surgical margins have a high risk of recurrence when comp...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Rosa DD,Medeiros LR,Edelweiss MI,Bozzetti MC,Pohlmann PR,Stein AT,Dickinson HO

    更新日期:2009-07-08 00:00:00

  • Topical negative pressure for treating chronic wounds.

    abstract:BACKGROUND:Chronic wounds mainly affect the elderly and those with multiple health problems. Despite the use of modern dressings, some of these wounds take a long time to heal, fail to heal, or recur, causing significant pain and discomfort to the person and cost to health services. Topical negative pressure (TNP) is u...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Ubbink DT,Westerbos SJ,Evans D,Land L,Vermeulen H

    更新日期:2008-07-16 00:00:00

  • Potassium binders for chronic hyperkalaemia in people with chronic kidney disease.

    abstract:BACKGROUND:Hyperkalaemia is a common electrolyte abnormality caused by reduced renal potassium excretion in patients with chronic kidney diseases (CKD). Potassium binders, such as sodium polystyrene sulfonate and calcium polystyrene sulfonate, are widely used but may lead to constipation and other adverse gastrointesti...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析


    authors: Natale P,Palmer SC,Ruospo M,Saglimbene VM,Strippoli GF

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    abstract:BACKGROUND:Seasonal affective disorder (SAD) is a seasonal pattern of recurrent major depressive episodes that most commonly occurs during autumn or winter and remits in spring. The prevalence of SAD ranges from 1.5% to 9%, depending on latitude. The predictable seasonal aspect of SAD provides a promising opportunity f...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章


    authors: Nussbaumer-Streit B,Forneris CA,Morgan LC,Van Noord MG,Gaynes BN,Greenblatt A,Wipplinger J,Lux LJ,Winkler D,Gartlehner G

    更新日期:2019-03-18 00:00:00

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    abstract:BACKGROUND:Pain dysfunction syndrome (PDS) is the most common temporomandibular disorder (TMD). There are many synonyms for this condition including facial arthromylagia, TMJ dysfunction syndrome, myofacial pain dysfunction syndrome, craniomandibular dysfunction and myofacial pain dysfunction. The aetiology of PDS is m...

    journal_title:The Cochrane database of systematic reviews

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    authors: Al-Ani MZ,Davies SJ,Gray RJ,Sloan P,Glenny AM

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    abstract:BACKGROUND:Multi-strategic community wide interventions for physical activity are increasingly popular but their ability to achieve population level improvements is unknown. OBJECTIVES:To evaluate the effects of community wide, multi-strategic interventions upon population levels of physical activity. SEARCH METHODS:...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Baker PR,Francis DP,Soares J,Weightman AL,Foster C

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    abstract:BACKGROUND:Dental sealants were introduced in the 1960s to help prevent dental caries, mainly in the pits and fissures of occlusal tooth surfaces. Sealants act to prevent bacteria growth that can lead to dental decay. Evidence suggests that fissure sealants are effective in preventing caries in children and adolescents...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Ahovuo-Saloranta A,Forss H,Walsh T,Nordblad A,Mäkelä M,Worthington HV

    更新日期:2017-07-31 00:00:00

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    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Abalos E,Duley L,Steyn DW,Henderson-Smart DJ

    更新日期:2001-01-01 00:00:00

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    abstract:BACKGROUND:Recurrent chest pain in the absence of coronary artery disease is a common problem that sometimes leads to excess use of medical care. Although many studies examine the causes of pain in these patients, few clinical trails have evaluated treatment. The studies reviewed in this paper provide an insight into t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Kisely S,Campbell LA,Skerritt P

    更新日期:2005-01-25 00:00:00

  • Homocysteine lowering interventions for peripheral arterial disease and bypass grafts.

    abstract:BACKGROUND:Elevated plasma levels of the amino acid homocysteine (hyperhomocysteinaemia) are associated with narrowing or blocking of the arteries (atherosclerosis). Treatment to lower homocysteine levels has been shown to be both effective and cheap in healthy volunteers. However, the impact of reducing homocysteine l...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Andras A,Stansby G,Hansrani M

    更新日期:2013-07-19 00:00:00

  • Flupenthixol versus placebo for schizophrenia.

    abstract:BACKGROUND:Flupenthixol, first made available in the UK in 1965, has been used as a treatment for schizophrenia for decades. OBJECTIVES:To evaluate the absolute clinical effects of flupenthixol for schizophrenia in comparison with placebo. SEARCH METHODS:We searched the Cochrane Schizophrenia Group Trials Register (A...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Shen X,Xia J,Adams CE

    更新日期:2012-11-14 00:00:00

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    abstract:BACKGROUND:Epithelial ovarian cancer accounts for about 90% of all cases of ovarian cancer. Debulking surgery and six courses of platinum-based chemotherapy results in complete clinical remission (CCR) in up to 75% of cases. However, 75% of the responders will relapse within a median time of 18 to 28 months and only 20...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Mei L,Chen H,Wei DM,Fang F,Liu GJ,Xie HY,Wang X,Zou J,Han X,Feng D

    更新日期:2010-09-08 00:00:00

  • Yoga in addition to standard care for patients with haematological malignancies.

    abstract:BACKGROUND:Haematological malignancies are malignant neoplasms of the myeloid or lymphatic cell lines including leukaemia, lymphoma and myeloma. In order to manage physical and psychological aspects of the disease and its treatment, complementary therapies like yoga are coming increasingly into focus. However, the effe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审


    authors: Felbel S,Meerpohl JJ,Monsef I,Engert A,Skoetz N

    更新日期:2014-06-12 00:00:00