Calcium and neurogenesis in Alzheimer's disease.

abstract：:D-norpseudoephedrine (NPE), also known as cathine, is found naturally in the shrub Catha edulis "Khat." NPE has been widely used as an appetite suppressant for the treatment of obesity. Although it is known that NPE acts on α1-adrenergic receptors, there is little information about the role of dopamine receptors on NP...

journal_title：Frontiers in neuroscience

authors： Kalyanasundar B,Perez CI,Arroyo B,Moreno MG,Gutierrez R

更新日期：2020-10-16 00:00:00

abstract：:Homeostasis in the nervous system requires intricate regulation and is largely accomplished by the blood-brain barrier (BBB). The major gate keeper of the vertebrate BBB is vascular endothelial cells, which form tight junctions (TJs). To gain insight into the development of the BBB, we studied the carpet glia, a subpe...

journal_title：Frontiers in neuroscience

authors： Ho TY,Wu WH,Hung SJ,Liu T,Lee YM,Liu YH

更新日期：2019-03-29 00:00:00

abstract：:Recent non-invasive brain stimulation techniques in combination with motor training can enhance neuroplasticity and learning. It is reasonable to assume that such neuroplasticity-based interventions constitute a useful rehabilitative tool for patients with Parkinson's Disease (PD). Regarding motor skill training, many...

journal_title：Frontiers in neuroscience

authors： Horiba M,Ueki Y,Nojima I,Shimizu Y,Sahashi K,Itamoto S,Suzuki A,Yamada G,Matsukawa N,Wada I

更新日期：2019-06-19 00:00:00

abstract：:Neural stem cells-based therapies have shown great potential for central nervous system regeneration, with three-dimensional (3D) culture systems representing a key technique for tissue engineering applications, as well as disease modeling and drug screenings. Self-assembling peptides (SAPs), providing biomimetic synt...

journal_title：Frontiers in neuroscience

authors： Marchini A,Favoino C,Gelain F

更新日期：2020-05-05 00:00:00

abstract：:To ensure survival, animals must update the internal representations of their environment in a trial-and-error fashion. Psychological studies of associative learning and neurophysiological analyses of dopaminergic neurons have suggested that this updating process involves the temporal-difference (TD) method in the bas...

journal_title：Frontiers in neuroscience

authors： Wen C,Ogura Y,Matsushima T

更新日期：2016-11-08 00:00:00

abstract：:Manual scoring of polysomnography data is labor-intensive and time-consuming, and most existing software does not account for subjective differences and user variability. Therefore, we evaluated a supervised machine learning algorithm, SomnivoreTM, for automated wake-sleep stage classification. We designed an algorith...

journal_title：Frontiers in neuroscience

authors： Allocca G,Ma S,Martelli D,Cerri M,Del Vecchio F,Bastianini S,Zoccoli G,Amici R,Morairty SR,Aulsebrook AE,Blackburn S,Lesku JA,Rattenborg NC,Vyssotski AL,Wams E,Porcheret K,Wulff K,Foster R,Chan JKM,Nicholas CL,Fre

更新日期：2019-03-18 00:00:00

abstract：:Many complex brain disorders, such as autism spectrum disorders, exhibit a wide range of symptoms and disability. To understand how brain communication is impaired in such conditions, functional connectivity studies seek to understand individual differences in brain network structure in terms of covariates that measur...

journal_title：Frontiers in neuroscience

authors： Narayan M,Allen GI

更新日期：2016-04-12 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder causing a progressive motor weakness of all voluntary muscles, whose progression challenges communication modalities such as handwriting or speech. The current study investigated whether ALS subjects can use Eye-On-Line (EOL), a novel eye-operated com...

journal_title：Frontiers in neuroscience

authors： Lenglet T,Mirault J,Veyrat-Masson M,Funkiewiez A,Amador MDM,Bruneteau G,Le Forestier N,Pradat PF,Salachas F,Vacher Y,Lacomblez L,Lorenceau J

更新日期：2019-05-29 00:00:00

abstract：:The habenular neural circuit is attracting increasing attention from researchers in fields as diverse as neuroscience, medicine, behavior, development, and evolution. Recent studies have revealed that this part of the limbic system in the dorsal diencephalon is involved in reward, addiction, and other behaviors and it...

journal_title：Frontiers in neuroscience

authors： Beretta CA,Dross N,Guiterrez-Triana JA,Ryu S,Carl M

更新日期：2012-04-23 00:00:00

abstract：:SpiNNaker is a digital neuromorphic architecture, designed specifically for the low power simulation of large-scale spiking neural networks at speeds close to biological real-time. Unlike other neuromorphic systems, SpiNNaker allows users to develop their own neuron and synapse models as well as specify arbitrary conn...

journal_title：Frontiers in neuroscience

authors： Mikaitis M,Pineda García G,Knight JC,Furber SB

更新日期：2018-02-27 00:00:00

abstract：:Ever since the modern rediscovery of psychedelic substances by Western society, several authors have independently proposed that their effects bear a high resemblance to the dreams and dreamlike experiences occurring naturally during the sleep-wake cycle. Recent studies in humans have provided neurophysiological evide...

journal_title：Frontiers in neuroscience

authors： Sanz C,Zamberlan F,Erowid E,Erowid F,Tagliazucchi E

更新日期：2018-01-22 00:00:00

abstract：:Hardware-based spiking neural networks (SNNs) inspired by a biological nervous system are regarded as an innovative computing system with very low power consumption and massively parallel operation. To train SNNs with supervision, we propose an efficient on-chip training scheme approximating backpropagation algorithm ...

journal_title：Frontiers in neuroscience

authors： Kwon D,Lim S,Bae JH,Lee ST,Kim H,Seo YT,Oh S,Kim J,Yeom K,Park BG,Lee JH

更新日期：2020-07-07 00:00:00

abstract：:The role of Histamine H3 receptors (H3Rs) in memory, and the prospective of H3R antagonists in pharmacological control of neurodegenerative disorders, e.g., Alzheimer disease (AD) is well-accepted. For that reason, the procognitive effects of the H3R antagonist DL77 on cognitive impairments induced with MK801 were tes...

journal_title：Frontiers in neuroscience

authors： Eissa N,Khan N,Ojha SK,Łazewska D,Kieć-Kononowicz K,Sadek B

更新日期：2018-02-12 00:00:00

abstract：:The aim of this work was to test if a novel transcranial direct current stimulation (tDCS) montage boosts the accuracy of lower limb motor imagery (MI) detection by using a real-time brain-machine interface (BMI) based on electroencephalographic (EEG) signals. The tDCS montage designed was composed of two anodes and o...

journal_title：Frontiers in neuroscience

authors： Rodríguez-Ugarte M,Iáñez E,Ortiz M,Azorín JM

更新日期：2018-10-23 00:00:00

abstract：:Cochlear outer hair cells (OHC) receive direct efferent feedback from the caudal auditory brainstem via the medial olivocochlear (MOC) bundle. This circuit provides the neural substrate for the MOC reflex, which inhibits cochlear amplifier gain and is believed to play a role in listening in noise and protection from a...

journal_title：Frontiers in neuroscience

authors： Smith SB,Lichtenhan JT,Cone BK

更新日期：2017-04-04 00:00:00

abstract：:Increasing evidence suggests that noncoding RNAs play key roles in cellular processes, particularly in the brain. The present study used RNA sequencing to identify the transcriptional landscape of two human neural progenitor cell lines, SK-N-SH and ReNcell CX, as they differentiate into human cortical projection neuro...

journal_title：Frontiers in neuroscience

authors： Hecht PM,Ballesteros-Yanez I,Grepo N,Knowles JA,Campbell DB

更新日期：2015-10-23 00:00:00

abstract：:We generally experience a stable visual world in spite of regular disruptions caused by our own movements (saccades, blinks) or by the visual input itself (flashes, occlusions). In trying to understand the mechanisms responsible for this stability, saccades have been particularly well-studied, and a number of peri-sac...

journal_title：Frontiers in neuroscience

authors： Chota S,McLelland D,Lavergne L,Zimmermann E,Cavanagh P,VanRullen R

更新日期：2020-03-17 00:00:00

abstract：:Central sleep apnea is a sudden arrest of breathing during sleep caused by the central commands to the thoracoabdominal muscles. It is a widespread phenomenon in both healthy and diseased people, as well as in some animals. However, there is an ongoing debate whether it can be considered as a pathological deviation of...

journal_title：Frontiers in neuroscience

authors： Limanskaya AV,Busygina II,Levichkina EV,Pigarev IN

更新日期：2020-06-17 00:00:00

abstract：:Neudesin (neuron-derived neurotrophic factor; NENF) was identified as a neurotrophic factor that is involved in neuronal differentiation and survival. It is abundantly expressed in the central nervous system, and its neurotrophic activity is exerted via the mitogen-activated protein kinase (MAPK) and phosphatidylinosi...

journal_title：Frontiers in neuroscience

authors： Kimura I,Nakayama Y,Zhao Y,Konishi M,Itoh N

更新日期：2013-06-25 00:00:00

abstract：:Posterior parietal cortex is frequently activated during episodic memory retrieval but its role during retrieval and its interactions with the hippocampus are not yet clear. In this fMRI study, we investigated the neural bases of recognition memory when study repetitions and retrieval goals were manipulated. During en...

journal_title：Frontiers in neuroscience

authors： Ciaramelli E,Burianová H,Vallesi A,Cabeza R,Moscovitch M

更新日期：2020-11-03 00:00:00

abstract：:For safe application of exoskeletons in people with spinal cord injury at home or in the community, it is required to have completed an exoskeleton training in which users learn to perform basic and advanced skills. So far, a framework to test exoskeleton skills is lacking. The aim of this study was to develop and tes...

journal_title：Frontiers in neuroscience

authors： van Dijsseldonk RB,Rijken H,van Nes IJW,van de Meent H,Keijsers NLW

更新日期：2017-12-12 00:00:00

abstract：:Emerging neuroimaging studies emphasize the dynamic organization of spontaneous brain activity in both human and non-human primates, even under anesthesia. In a recent study, we were able to characterize the heterogeneous architecture of intrinsic functional flexibility in the awake, resting human brain using time-res...

journal_title：Frontiers in neuroscience

authors： Yin D,Zhang Z,Wang Z,Zeljic K,Lv Q,Cai D,Wang Y,Wang Z

更新日期：2019-02-28 00:00:00

abstract：:The neuropeptide oxytocin (OT) plays an important role in the regulation of social and anxiety-like behavior. Our previous studies have shown that OT neurons send projections from the hypothalamus to the dorsolateral bed nucleus of the stria terminalis (BNSTdl), a forebrain region critically involved in the modulation...

journal_title：Frontiers in neuroscience

authors： Martinon D,Dabrowska J

更新日期：2018-03-21 00:00:00

abstract：:Hormonal contraceptives are on the market for more than 50 years and used by 100 million women worldwide. However, while endogenous steroids have been convincingly associated with change in brain structure, function and cognitive performance, the effects of synthetic steroids contained in hormonal contraceptives on br...

journal_title：Frontiers in neuroscience

authors： Pletzer BA,Kerschbaum HH

更新日期：2014-08-21 00:00:00

abstract：:Background: Degenerative cervical myelopathy (DCM), also known as cervical spondylotic myelopathy is the leading cause of spinal cord compression in adults. The mainstay of treatment is surgical decompression, which leads to partial recovery of symptoms, however, long term prognosis of the condition remains poor. Desp...

journal_title：Frontiers in neuroscience

authors： Akter F,Yu X,Qin X,Yao S,Nikrouz P,Syed YA,Kotter M

更新日期：2020-04-30 00:00:00

abstract：:People are very precise in the discrimination of a line orientation relative to the cardinal (vertical and horizontal) axes, while their orientation discrimination sensitivity along the oblique axes is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the "oblique ef...

journal_title：Frontiers in neuroscience

authors： Sysoeva OV,Davletshina MA,Orekhova EV,Galuta IA,Stroganova TA

更新日期：2016-01-21 00:00:00

abstract：Objectives:Acute sleep deprivation (SD) seriously affects cognitive functions, such as attention, memory, and response inhibition. Previous neuroimaging studies have demonstrated a close relationship between the functional activities of the precuneus (PC) and the function of alert attention. However, the specific effec...

journal_title：Frontiers in neuroscience

authors： Li B,Zhang L,Zhang Y,Chen Y,Peng J,Shao Y,Zhang X

更新日期：2020-12-21 00:00:00

abstract：:Aggressive behavior is associated with dysfunctional frontolimbic emotion regulation circuits. Recent findings suggest serotonin as a primary transmitter for prefrontal amygdala control. However, the association between serotonin levels, amygdala regulation, and aggression is still a matter of debate. Neurobehavioral ...

journal_title：Frontiers in neuroscience

authors： Klasen M,Wolf D,Eisner PD,Eggermann T,Zerres K,Zepf FD,Weber R,Mathiak K

更新日期：2019-02-22 00:00:00

abstract：OBJECTIVES:The thickness of the brain's cortical gray matter (GM) and the fractional anisotropy (FA) of the cerebral white matter (WM) each follow an inverted U-shape trajectory with age. The two measures are positively correlated and may be modulated by common biological mechanisms. We employed four types of genetic a...

journal_title：Frontiers in neuroscience

authors： Kochunov P,Glahn DC,Nichols TE,Winkler AM,Hong EL,Holcomb HH,Stein JL,Thompson PM,Curran JE,Carless MA,Olvera RL,Johnson MP,Cole SA,Kochunov V,Kent J,Blangero J

更新日期：2011-10-19 00:00:00

abstract：:It is undisputed that presenting a rhythmic stimulus leads to a measurable brain response that follows the rhythmic structure of this stimulus. What is still debated, however, is the question whether this brain response exclusively reflects a regular repetition of evoked responses, or whether it also includes entraine...

journal_title：Frontiers in neuroscience

authors： Zoefel B,Ten Oever S,Sack AT

更新日期：2018-03-07 00:00:00