Brain Map of Intrinsic Functional Flexibility in Anesthetized Monkeys and Awake Humans.

Abstract:

:Emerging neuroimaging studies emphasize the dynamic organization of spontaneous brain activity in both human and non-human primates, even under anesthesia. In a recent study, we were able to characterize the heterogeneous architecture of intrinsic functional flexibility in the awake, resting human brain using time-resolved analysis and a probabilistic model. However, it is unknown whether this organizational principle is preserved in the anesthetized monkey brain, and how anesthesia affects dynamic and static measurements of spontaneous brain activity. To investigate these issues, we collected resting-state functional magnetic resonance imaging (fMRI) datasets from 178 awake humans and 11 anesthetized monkeys (all healthy). Our recently established method, a complexity measurement (i.e., Shannon entropy) of dynamic functional connectivity patterns of each brain region, was used to map the intrinsic functional flexibility across the cerebral cortex. To further explore the potential effects of anesthesia, we performed time series analysis and correlation analysis between dynamic and static measurements within awake human and anesthetized monkey brains, respectively. We observed a heterogeneous profile of intrinsic functional flexibility in the anesthetized monkey brain, which showed some similarities to that of awake humans (r = 0.30, p = 0.007). However, we found that brain activity in anesthetized monkeys generally shifted toward random fluctuations. Moreover, there is a negative correlation between nodal entropy for the distribution of dynamic functional connectivity patterns and static functional connectivity strength in anesthetized monkeys, but not in awake humans. Our findings indicate that the heterogeneous architecture of intrinsic functional flexibility across cortex probably reflects an evolutionarily conserved aspect of functional brain organization, which persists across levels of cognitive processing (states of consciousness). The coupling between nodal entropy for the distribution of dynamic functional connectivity patterns and static functional connectivity strength may serve as a potential signature of anesthesia. This study not only offers fresh insight into the evolution of brain functional architecture, but also advances our understanding of the dynamics of spontaneous brain activity.

journal_name

Front Neurosci

authors

Yin D,Zhang Z,Wang Z,Zeljic K,Lv Q,Cai D,Wang Y,Wang Z

doi

10.3389/fnins.2019.00174

subject

Has Abstract

pub_date

2019-02-28 00:00:00

pages

174

eissn

1662-4548

issn

1662-453X

journal_volume

13

pub_type

杂志文章
  • Investigation of Deep-Learning-Driven Identification of Multiple Sclerosis Patients Based on Susceptibility-Weighted Images Using Relevance Analysis.

    abstract::The diagnosis of multiple sclerosis (MS) is usually based on clinical symptoms and signs of damage to the central nervous system, which is assessed using magnetic resonance imaging. The correct interpretation of these data requires excellent clinical expertise and experience. Deep neural networks aim to assist clinici...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.609468

    authors: Lopatina A,Ropele S,Sibgatulin R,Reichenbach JR,Güllmar D

    更新日期:2020-12-18 00:00:00

  • Inference of human affective states from psychophysiological measurements extracted under ecologically valid conditions.

    abstract::Compared to standard laboratory protocols, the measurement of psychophysiological signals in real world experiments poses technical and methodological challenges due to external factors that cannot be directly controlled. To address this problem, we propose a hybrid approach based on an immersive and human accessible ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2014.00286

    authors: Betella A,Zucca R,Cetnarski R,Greco A,Lanatà A,Mazzei D,Tognetti A,Arsiwalla XD,Omedas P,De Rossi D,Verschure PF

    更新日期:2014-09-24 00:00:00

  • Virtual Balancing for Studying and Training Postural Control.

    abstract::Postural control during free stance has been frequently interpreted in terms of balancing an inverted pendulum. This even holds, if subjects do not balance their own, but an external body weight. We introduce here a virtual balancing apparatus, which produces torque in the ankle joint as a function of ankle angle rese...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00531

    authors: Buettner D,Dalin D,Wiesmeier IK,Maurer C

    更新日期:2017-09-26 00:00:00

  • GPUs Outperform Current HPC and Neuromorphic Solutions in Terms of Speed and Energy When Simulating a Highly-Connected Cortical Model.

    abstract::While neuromorphic systems may be the ultimate platform for deploying spiking neural networks (SNNs), their distributed nature and optimization for specific types of models makes them unwieldy tools for developing them. Instead, SNN models tend to be developed and simulated on computers or clusters of computers with s...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00941

    authors: Knight JC,Nowotny T

    更新日期:2018-12-12 00:00:00

  • Chronic Timed Sleep Restriction Attenuates LepRb-Mediated Signaling Pathways and Circadian Clock Gene Expression in the Rat Hypothalamus.

    abstract::The sleep duration of adolescents has continued to decline over the past 20 years. Sleep insufficiency is one of the most important risk factors for obesity, but the mechanisms underlying the association are unclear. Therefore, the hypothalamic-regulated mechanisms of appetite and the circadian clock gene expression w...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00909

    authors: Sun Q,Liu Y,Wei W,Wu D,Lin R,Wen D,Jia L

    更新日期:2020-09-08 00:00:00

  • Mechanisms Linking Olfactory Impairment and Risk of Mortality.

    abstract::Olfaction is a sense involved in a complex set of tasks, influencing eating behavior, increasing awareness of environmental hazards and affecting social communication. Surprisingly, smell disorders are very frequent, especially in the elderly population. Several recent studies conducted mostly in older subjects have d...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00140

    authors: Van Regemorter V,Hummel T,Rosenzweig F,Mouraux A,Rombaux P,Huart C

    更新日期:2020-02-21 00:00:00

  • Calcium and neurogenesis in Alzheimer's disease.

    abstract::It was evidenced that impairment of calcium homeostasis is a potential mechanism in the development of Alzheimer's disease (AD). It remains, however, unclear how the calcium signaling are associated with in AD progression. Here we review recent studies to discuss the relationship among the signaling of intracellular c...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2010.00194

    authors: Wang JM,Sun C

    更新日期:2010-12-02 00:00:00

  • Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson's Disease and Related Diseases.

    abstract::Available evidence suggests that diabetes mellitus (DM) is a non-genetic risk factor for Parkinson's disease (PD). PD and DM have shared similarities in pathogenetic mechanisms, including age, environmental factors, inflammatory reaction, and protein aggregation, etc. α-Synuclein is the primary protein component in th...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00063

    authors: Sun Y,Guo C,Yuan L,Li W,Wang ZY,Yue F,Li JY

    更新日期:2020-02-07 00:00:00

  • Pathophysiological Changes of Physical Barriers of Peripheral Nerves After Injury.

    abstract::Peripheral nerves are composed of complex layered anatomical structures, including epineurium, perineurium, and endoneurium. Perineurium and endoneurium contain many physical barriers, including the blood-nerve barrier at endoneurial vessels and the perineurial barrier. These physical barriers help to eliminate flux p...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2018.00597

    authors: Liu Q,Wang X,Yi S

    更新日期:2018-08-23 00:00:00

  • Systemic Low-Frequency Oscillations in BOLD Signal Vary with Tissue Type.

    abstract::Blood-oxygen-level dependent (BOLD) signals are widely used in functional magnetic resonance imaging (fMRI) as a proxy measure of brain activation. However, because these signals are blood-related, they are also influenced by other physiological processes. This is especially true in resting state fMRI, during which no...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00313

    authors: Tong Y,Hocke LM,Lindsey KP,Erdoğan SB,Vitaliano G,Caine CE,Frederick Bd

    更新日期:2016-06-30 00:00:00

  • Neurodegenerative Susceptibility During Maternal Nutritional Programing: Are Central and Peripheral Innate Immune Training Relevant?

    abstract::Maternal overnutrition modulates body weight, development of metabolic failure and, potentially, neurodegenerative susceptibility in the offspring. Overnutrition sets a chronic pro-inflammatory profile that integrates peripheral and central immune activation nodes, damaging neuronal physiology and survival. Innate imm...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnins.2020.00013

    authors: Cárdenas-Tueme M,Montalvo-Martínez L,Maldonado-Ruiz R,Camacho-Morales A,Reséndez-Pérez D

    更新日期:2020-02-04 00:00:00

  • Peak Width of Skeletonized Mean Diffusivity as a Marker of Diffuse Cerebrovascular Damage.

    abstract:Background:The peak width of skeletonized mean diffusivity (PSMD) has been proposed as a fully automated imaging marker of relevance to cerebral small vessel disease (SVD). We assessed PSMD in relation to conventional SVD markers, global measures of neurodegeneration, and cognition. Methods:145 participants underwent ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00238

    authors: Low A,Mak E,Stefaniak JD,Malpetti M,Nicastro N,Savulich G,Chouliaras L,Markus HS,Rowe JB,O'Brien JT

    更新日期:2020-03-19 00:00:00

  • Left Shifting of Language Related Activity Induced by Bihemispheric tDCS in Postacute Aphasia Following Stroke.

    abstract::Both anodal transcranial direct current stimulation (tDCS) of the left IFG and cathodal stimulation of the right IFG were shown to improve rehabilitation of stroke patients with Broca's aphasia. The study aimed at assessing the impact of a bihemispheric IFG stimulation compared to sham on postacute non-fluent aphasia....

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00295

    authors: Feil S,Eisenhut P,Strakeljahn F,Müller S,Nauer C,Bansi J,Weber S,Liebs A,Lefaucheur JP,Kesselring J,Gonzenbach R,Mylius V

    更新日期:2019-04-26 00:00:00

  • Combined Behavioral and Mismatch Negativity Evidence for the Effects of Long-Lasting High-Definition tDCS in Disorders of Consciousness: A Pilot Study.

    abstract:Objective:To evaluate the effects of long-term High-definition transcranial direct current stimulation (HD-tDCS) over precuneus on the level of consciousness (LOC) and the relationship between Mismatch negativity (MMN) and the LOC over the therapy period in patients with Disorders of consciousness (DOCs). Methods:We e...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00381

    authors: Wang X,Guo Y,Zhang Y,Li J,Gao Z,Li Y,Zhou T,Zhang H,He J,Cong F

    更新日期:2020-04-28 00:00:00

  • Stress-Induced Microstructural Alterations Correlate With the Cognitive Performance of Rats: A Longitudinal in vivo Diffusion Tensor Imaging Study.

    abstract::Background: Stress-induced cellular changes in limbic brain structures contribute to the development of various psychopathologies. In vivo detection of these microstructural changes may help us to develop objective biomarkers for psychiatric disorders. Diffusion tensor imaging (DTI) is an advanced neuroimaging techniq...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00474

    authors: Nagy SA,Vranesics A,Varga Z,Csabai D,Bruszt N,Bali ZK,Perlaki G,Hernádi I,Berente Z,Miseta A,Dóczi T,Czéh B

    更新日期:2020-06-03 00:00:00

  • Event-Related Potential Responses to Task Switching Are Sensitive to Choice of Spatial Filter.

    abstract::Event-related potential (ERP) studies using the task-switching paradigm show that multiple ERP components are modulated by activation of proactive control processes involved in preparing to repeat or switch task and reactive control processes involved in implementation of the current or new task. Our understanding of ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2018.00143

    authors: Wong ASW,Cooper PS,Conley AC,McKewen M,Fulham WR,Michie PT,Karayanidis F

    更新日期:2018-03-08 00:00:00

  • MSA Mimic? Rare Occurrence of Anti-Hu Autonomic Failure and Thymoma in a Patient with Parkinsonism: Case Report and Literature Review.

    abstract::Thymoma is a tumor originating from thymic gland, frequently manifesting with paraneoplastic neurological disorders. Its association with paraneoplastic dysautonomia is relatively uncommon. Here, we describe the challenging case of a 71 year-old female who developed subacute autonomic failure with digestive pseudo-obs...

    journal_title:Frontiers in neuroscience

    pub_type:

    doi:10.3389/fnins.2018.00017

    authors: Ricigliano VAG,Fossati B,Saraceno L,Cavalli M,Bazzigaluppi E,Meola G

    更新日期:2018-01-24 00:00:00

  • Reduced Oblique Effect in Children with Autism Spectrum Disorders (ASD).

    abstract::People are very precise in the discrimination of a line orientation relative to the cardinal (vertical and horizontal) axes, while their orientation discrimination sensitivity along the oblique axes is less refined. This difference in discrimination sensitivity along cardinal and oblique axes is called the "oblique ef...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2015.00512

    authors: Sysoeva OV,Davletshina MA,Orekhova EV,Galuta IA,Stroganova TA

    更新日期:2016-01-21 00:00:00

  • The Effect of Music Intervention on Attention in Children: Experimental Evidence.

    abstract::Although music has been utilized as a therapeutic tool for children with cognitive impairments, how it improves children's cognitive function remains poorly understood. As a first step toward understanding music's effectiveness and as a means of assessing cognitive function improvement, we focused on attention, which ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00757

    authors: Kasuya-Ueba Y,Zhao S,Toichi M

    更新日期:2020-07-24 00:00:00

  • Corrigendum: Increased Activation of Default Mode Network in Early Parkinson's With Excessive Daytime Sleepiness.

    abstract::[This corrects the article DOI: 10.3389/fnins.2019.01334.]. ...

    journal_title:Frontiers in neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnins.2020.00426

    authors: Ooi LQR,Wen MC,Ng SY,Chia NS,Chew IHM,Lee W,Xu Z,Hartono S,Tan EK,Chan LL,Tan LC

    更新日期:2020-05-12 00:00:00

  • Development of Performance and ERPs in a Flanker Task in Children and Adolescents with Tourette Syndrome-A Follow-Up Study.

    abstract::Background: Tourette Syndrome (TS) is a neurodevelopmental disorder with childhood-onset, with a typical decline in tic severity, as well as an increasing ability to suppress tics in late childhood and adolescence. These processes develop in parallel with general improvement of self-regulatory abilities, and performan...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00305

    authors: Eichele H,Eichele T,Marquardt L,Adolfsdottir S,Hugdahl K,Sørensen L,Plessen KJ

    更新日期:2017-06-12 00:00:00

  • STDP and STDP variations with memristors for spiking neuromorphic learning systems.

    abstract::In this paper we review several ways of realizing asynchronous Spike-Timing-Dependent-Plasticity (STDP) using memristors as synapses. Our focus is on how to use individual memristors to implement synaptic weight multiplications, in a way such that it is not necessary to (a) introduce global synchronization and (b) to ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2013.00002

    authors: Serrano-Gotarredona T,Masquelier T,Prodromakis T,Indiveri G,Linares-Barranco B

    更新日期:2013-02-18 00:00:00

  • Robust Candidates for Language Development and Evolution Are Significantly Dysregulated in the Blood of People With Williams Syndrome.

    abstract::Williams syndrome (WS) is a clinical condition, involving cognitive deficits and an uneven language profile, which has been the object of intense inquiry over the last decades. Although WS results from the hemideletion of around two dozen genes in chromosome 7, no gene has yet been probed to account for, or contribute...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00258

    authors: Benítez-Burraco A,Kimura R

    更新日期:2019-03-26 00:00:00

  • Analysis of Interrelationships among Voluntary and Prosthetic Leg Joint Parameters Using Cyclograms.

    abstract::The walking mechanism of a prosthetic leg user is a tightly coordinated movement of several joints and limb segments. The interaction among the voluntary and mechanical joints and segments requires particular biomechanical insight. This study aims to analyze the inter-relationship between amputees' voluntary and mecha...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2017.00230

    authors: Jasni F,Hamzaid NA,Mohd Syah NE,Chung TY,Abu Osman NA

    更新日期:2017-04-25 00:00:00

  • Chronic Tinnitus Exhibits Bidirectional Functional Dysconnectivity in Frontostriatal Circuit.

    abstract:Purpose:The phantom sound of tinnitus is considered to be associated with abnormal functional coupling between the nucleus accumbens (NAc) and the prefrontal cortex, which may form a frontostriatal top-down gating system to evaluate and modulate sensory signals. Resting-state functional magnetic resonance imaging (fMRI...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01299

    authors: Xu JJ,Cui J,Feng Y,Yong W,Chen H,Chen YC,Yin X,Wu Y

    更新日期:2019-12-06 00:00:00

  • A Comparative Study of Different EEG Reference Choices for Event-Related Potentials Extracted by Independent Component Analysis.

    abstract::In the event-related potential (ERP) of scalp electroencephalography (EEG) studies, the vertex reference (Cz), linked mastoids or ears (LM), and average reference (AVG) are popular reference methods, and the reference electrode standardization technique (REST) is increasingly applied. Because scalp EEG recordings are ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.01068

    authors: Dong L,Liu X,Zhao L,Lai Y,Gong D,Liu T,Yao D

    更新日期:2019-10-11 00:00:00

  • Targeted Re-Sequencing Approach of Candidate Genes Implicates Rare Potentially Functional Variants in Tourette Syndrome Etiology.

    abstract::Although the genetic basis of Tourette Syndrome (TS) remains unclear, several candidate genes have been implicated. Using a set of 382 TS individuals of European ancestry we investigated four candidate genes for TS (HDC, SLITRK1, BTBD9, and SLC6A4) in an effort to identify possibly causal variants using a targeted re-...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2016.00428

    authors: Alexander J,Potamianou H,Xing J,Deng L,Karagiannidis I,Tsetsos F,Drineas P,Tarnok Z,Rizzo R,Wolanczyk T,Farkas L,Nagy P,Szymanska U,Androutsos C,Tsironi V,Koumoula A,Barta C,TSGeneSEE.,Sandor P,Barr CL,Tischfield

    更新日期:2016-09-21 00:00:00

  • Pumilio Regulates Sleep Homeostasis in Response to Chronic Sleep Deprivation in Drosophila melanogaster.

    abstract::Recent studies have identified the Drosophila brain circuits involved in the sleep/wake switch and have pointed to the modulation of neuronal excitability as one of the underlying mechanisms triggering sleep need. In this study we aimed to explore the link between the homeostatic regulation of neuronal excitability an...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00319

    authors: De Jesús-Olmo LA,Rodríguez N,Francia M,Alemán-Rios J,Pacheco-Agosto CJ,Ortega-Torres J,Nieves R,Fuenzalida-Uribe N,Ghezzi A,Agosto JL

    更新日期:2020-04-17 00:00:00

  • Expressional Profiling of Carpet Glia in the Developing Drosophila Eye Reveals Its Molecular Signature of Morphology Regulators.

    abstract::Homeostasis in the nervous system requires intricate regulation and is largely accomplished by the blood-brain barrier (BBB). The major gate keeper of the vertebrate BBB is vascular endothelial cells, which form tight junctions (TJs). To gain insight into the development of the BBB, we studied the carpet glia, a subpe...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2019.00244

    authors: Ho TY,Wu WH,Hung SJ,Liu T,Lee YM,Liu YH

    更新日期:2019-03-29 00:00:00

  • MiR224-5p Inhibitor Restrains Neuronal Apoptosis by Targeting NR4A1 in the Oxygen-Glucose Deprivation (OGD) Model.

    abstract::This study was designed to investigate the molecular mechanism of stroke and to explore the effect of miR-224-5p in hypoxic cortical neurons. Firstly, we established a middle cerebral artery occlusion (MCAO) model with Sprague-Dawley rats. Triphenyltetrazolium chloride (TTC) staining showed the brain infarction of an ...

    journal_title:Frontiers in neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnins.2020.00613

    authors: Liu LL,Qiao S,Wang ML,Wu HK,Su YX,Wang KM,Liu XW

    更新日期:2020-06-25 00:00:00