Co-targeting HER2/ErbB2 and insulin-like growth factor-1 receptors causes synergistic inhibition of growth in HER2-overexpressing breast cancer cells.

abstract：BACKGROUND:The aim of the present study was to evaluate the cyclic fatigue resistance of Mtwo NiTi rotary instruments after clinical use by 1 experienced and 1 novice operator. MATERIAL/METHODS:Cyclic fatigue testing of instruments was performed on tapered artificial canals with a 5 mm radius of curvature and 60° angle...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Plotino G,Al-Sudani D,Pulino S,Grande NM,Marcoli PA,Pizzi S,Testarelli L,Gambarini G

更新日期：2012-06-01 00:00:00

abstract：:BACKGROUND MiR-301a and miR-301b are 2 oncomiRs involved in multiple types of cancer. In this study, we explored the expression change of miR-301a and miR-301b in prostate cancer cells in hypoxia and studied their regulation of autophagy and radiosensitivity of prostate cancer cells. MATERIAL AND METHODS QRT-PCR was p...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wang W,Liu M,Guan Y,Wu Q

更新日期：2016-06-21 00:00:00

abstract：BACKGROUND:Dermatitis artefacta (DA) is a dermatologicopsychiatric illness that is a conscious self-infliction of lesions to accessible regions of the body. The lesions usually do not resemble those of any know skin disease and there are no specific diagnostic tests to recognize them. This makes dermatitis artefacta a ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Wojewoda K,Brenner J,Kąkol M,Naesström M,Cubała WJ,Kozicka D,Nowicki R,Sokołowska-Wojdyło M,Barańska-Rybak W

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Children with hydrocephalus and increased intracranial pressure are treated with ventricular shunts. Multiple head CT is used to assess shunt malfunction and changes in ventricular size (volume). Because of the naturally high contrast of the head structures in CT imaging, a low-dose protocol for hydrocephali...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Rybka K,Staniszewska AM,Biegański T

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Because of numerous abnormalities of craniovertebraljunction development observed in the prenatal period, the region has been studied thoroughly in order to elucidate the mechanism of axial differentiation, dependence of vertebral morphology on the development of ossification centers and the mechanisms regul...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kedzia A,Czyz M,Nowakowska-Kotas M,Adamek A

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Many investigations have focused on optimal doses/schedules since regulatory agency approval of paclitaxel (Taxol). Paclitaxel is generally administered at doses of 175-225 mg/m2 over 3 hours or 135-175 mg/m2 over 24 hours, every 3 weeks. The purpose of this study was to simplify administration and render it...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Kosmas C,Tsavaris N

更新日期：2006-11-01 00:00:00

abstract：:The prevalence of hepatitis B infection in population in Poland is low and averages 1-1.5%. However, it means that about 380,000 Poles constantly or temporarily replicate HBV. Chronic HBV infection is associated with increased risk of serious liver diseases and it is estimated that 25-40% of patients with chronic hepa...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Simon K,Rotter K,Zalewska M,Gładysz A

更新日期：2000-09-01 00:00:00

abstract：:BACKGROUND The aim of this study was to investigate the clinical significance of NLRP3 and HMGB1 in patients with active ulcerative colitis. MATERIAL AND METHODS This was a prospective observational study which included a total of 62 cases with active ulcerative colitis during January 2017 to December 2018. The patien...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen Y,Wu D,Sun L

更新日期：2020-01-05 00:00:00

abstract：:BACKGROUND This study aimed to establish an easy, safe, and cost-saving intestinal anastomotic method. MATERIAL AND METHODS Between January 2014 and February 2016, a total of 150 patients with gastric cancer who underwent surgery in the Department of General Surgery of Xuzhou Medical University Affiliated Hospital wer...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yao L,Li C,Zhu X,Shao Y,Meng S,Shi L,Wang H

更新日期：2016-11-26 00:00:00

abstract：BACKGROUND:Human saliva, a complex secretion that contains a mixture of inorganic and organic molecules, plays an essential role in the maintenance of oral health. Mucins are the major macromolecular component of the secretion and are considered the first line of defense for epithelial tissues. The aim of this study wa...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Gabryel-Porowska H,Gornowicz A,Bielawska A,Wójcicka A,Maciorkowska E,Grabowska SZ,Bielawski K

更新日期：2014-01-18 00:00:00

abstract：:BACKGROUND Nimotuzumab is an anti-EGFR monoclonal antibody which has been widely used in cancer treatment. However, the safety and efficacy of nimotuzumab combined with chemotherapy in locally advanced or metastatic esophageal cancer patients remain unclear. MATERIAL AND METHODS To address this open question, we colle...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Han X,Lu N,Pan Y,Xu J

更新日期：2017-01-24 00:00:00

abstract：:BACKGROUND The relationship between thyroid hormones and body anthropometric measures in type 2 diabetes mellitus (T2DM) patients with normal thyroid function is unclear. The purpose of this study was to evaluate the association between thyroid hormones and body composition in euthyroid T2DM patients in men and women....

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Chen L,Zhang M,Xiang S,Jiang X,Gu H,Sha Q,Qu M,Xu T

更新日期：2021-01-02 00:00:00

abstract：:BACKGROUND We explored the intervention effect of a smartphone medical app on complications and quality of life of patients with nasopharyngeal carcinoma who underwent radiotherapy and chemotherapy. MATERIAL AND METHODS We divided 132 patients with nasopharyngeal carcinoma who received radiotherapy and chemotherapy fo...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Di R,Li G

更新日期：2018-09-04 00:00:00

abstract：:BACKGROUND Although tendinopathy is common, its underlying pathogenesis is poorly understood. This study aimed to investigate the possible pathogenesis of tendinopathy. MATERIAL AND METHODS In this study, a total of 24 rats were randomly and evenly divided into a control (CON) group and a strenuous treadmill running (...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu SY,Li SF,Ni GX

更新日期：2016-10-15 00:00:00

abstract：BACKGROUND:The elderly population is growing in Turkey, as it is worldwide. The average age of residents in rural areas of Turkey is relatively high and is gradually increasing. The purpose of this study is to summarize the fitness and frailty of elderly adults living in a rural area of Turkey characterized by a relati...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Çakmur H

更新日期：2015-04-30 00:00:00

abstract：:BACKGROUND We aimed to investigate the functions of long non-coding RNA (lncRNA) non-coding RNA activated by DNA damage (NORAD) in glioma and identify the potential mechanisms. MATERIAL AND METHODS The expression of NORAD and AKR1B1 in human glioma cell lines were examined using reverse transcription-quantitative poly...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Luo L,Chen C,He H,Cai M,Ling C

更新日期：2020-07-21 00:00:00

abstract：BACKGROUND:The canonical Wnt signaling pathway has been considered as a potent oncogenic signaling in the initiation and progression of hematological malignancies. As a key regulator of the Wnt signaling pathway, the role of β-catenin in mantle cell lymphoma (MCL) pathogenesis and progression was investigated in this s...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： He J,Huang Y,Weng J,Xiao L,Weng K,Ma X

更新日期：2015-07-31 00:00:00

abstract：:BACKGROUND The disordered metabolism of liver function in liver cancer patients can affect postoperative survival after liver transplantation. We assessed whether the levels of various chemicals in liver metabolism prior to receiving a liver transplant were prognostic factors and metabolism markers in predicting survi...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li X,Gong J,Zhou W,Zhang H,Zheng J,Liang J,Hu B

更新日期：2019-04-01 00:00:00

abstract：:Subclavian 'steal' phenomenon is a function of the proximal subclavian artery (SA) steno-occlusive disease, with subsequent retrograde blood flow in the ipsilateral vertebral artery (VA). The symptoms from the compromised vertebrobasilar and brachial blood flows constitute the subclavian steal syndrome (SSS), and incl...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Osiro S,Zurada A,Gielecki J,Shoja MM,Tubbs RS,Loukas M

更新日期：2012-05-01 00:00:00

abstract：:BACKGROUND The C677T polymorphism of the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism has been associated with hypertension and coronary heart disease, but its relationship with carotid artery remains unknown. This study aimed to investigate the association between the C677T polymorphism of the M...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li A,Huang W,Yang Q,Peng L,Liu Q

更新日期：2020-07-17 00:00:00

abstract：BACKGROUND:The changes and correlations of TRAIL (TNF-related apoptosis-inducing-ligand) and CXCL8 (IL8) prior to treatment and three months following therapy as well as the corresponding Positron emission tomography (PET/CT) (SUV(max): standardized uptake maximum values) results were evaluated. MATERIAL AND METHODS:T...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Celik B,Yalcin AD,Bisgin A,Dimitrakopoulou-Strauss A,Kargi A,Strauss LG

更新日期：2013-10-21 00:00:00

abstract：:BACKGROUND Functional dyspepsia (FD) refers to a group of upper gastrointestinal syndromes, subdivided into two types: postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS). The etiology of FD remains unclear; however, unhealthy dietary habit is one potential underlying cause. We aim to explore the a...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Xu JH,Lai Y,Zhuang LP,Huang CZ,Li CQ,Chen QK,Yu T

更新日期：2017-08-15 00:00:00

abstract：BACKGROUND:ED overcrowding is fast becoming a national crisis although no definition exists. The purpose of this study is to develop and pilot a sampling form that accurately reflects the concept of ED Overcrowding. MATERIAL/METHODS:A 26-question site-sampling form was designed based on input from academic physicians ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Weiss SJ,Arndahl J,Ernst AA,Derlet R,Richards J,Nick TG

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Haemorrhagic hypotension is accompanied by an increase in endogenous opioid system activity, however, its significance is not fully recognised. Therefore, the role of endogenous opioid peptides in the central cardiovascular regulation in haemorrhagic shock was reviewed. CONCLUSIONS:Complex central opioid me...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Jochem J,Jośko J,Gwóźdź B

更新日期：2001-05-01 00:00:00

abstract：:BACKGROUND Rheumatoid arthritis (RA) is an inflammatory disorder that is present in approximately 1% of the world's population. This study was aimed to investigate the effect of retinoic acid-platinum (II) complex [RT-Pt(II)] on rheumatoid arthritis (RA) and to explore the mechanism involved. MATERIAL AND METHODS MH7A...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Cui Z,Lin Y,Liu Y,Cao L,Cui L

更新日期：2020-08-03 00:00:00

abstract：:BACKGROUND Calcium overload, inflammation, and apoptosis play important roles in myocardial ischemia-reperfusion injury (MIRI). Gastrodin pretreatment can alleviate MIRI. This study observed sarcoplasmic reticulum calcium transport ATPase (Ca2+-ATPase, SERCA) and calcium phosphate (PLB) protein expression in the ventr...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Li Y,Wang X,Lou C

更新日期：2016-09-19 00:00:00

abstract：:BACKGROUND Lung cancer and tuberculosis (TB) are two major public health problems. They can coexist or appear sequentially. In patients with TB, lung cancer risk is increased. However, vice versa is not crystal clear. In this study, we aimed to determine the development of TB in patients with resectabled non-small cel...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Yakar F,Yakar A,Büyükpınarbaşılı N,Erelel M

更新日期：2016-04-11 00:00:00

abstract：BACKGROUND:It is well established that there is a reduction in the skin blood flow (SBF) in response to heat with age and diabetes. While it is known that high BMI creates a stress on the cardiovascular system and increases the risk of all cause of morbidity and mortality, little is known of the effect of high BMI on S...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Petrofsky JS,Alshammari F,Bains GS,Khowailed IA,Lee H,Kuderu YN,Lodha RD,Rodrigues S,Nguyen D,Potnis PA,Deshpande PP,Yim JE,Berk L

更新日期：2013-04-10 00:00:00

abstract：:BACKGROUND We studied the expression and effect of miR-26a-5p in synovial fibroblast in patients with rheumatoid arthritis (RA). MATERIAL AND METHODS The synovial tissues of 55 RA patients with total knee arthroplasty performed from January 2016 to December 2016 were collected as the RA group, and 62 patients without ...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Zhang W,Chen L,Jiang Y,Shen Y

更新日期：2018-07-26 00:00:00

abstract：:BACKGROUND Hesperidin (HPD) is a bioflavonoid found in citrus fruits. This study aimed to investigate the effects of HPD on cerebral morphology and cognitive behavior in sevoflurane anesthetized neonatal rats and the molecular mechanisms involved. MATERIAL AND METHODS Sixty neonatal Sprague-Dawley rats were divided in...

journal_title：Medical science monitor : international medical journal of experimental and clinical research

authors： Huang H,Hu C,Xu L,Zhu X,Zhao L,Min J

更新日期：2020-04-16 00:00:00