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What is more damaging to vascular endothelial function: Diabetes, age, high BMI, or all of the above?

Abstract：

BACKGROUND:It is well established that there is a reduction in the skin blood flow (SBF) in response to heat with age and diabetes. While it is known that high BMI creates a stress on the cardiovascular system and increases the risk of all cause of morbidity and mortality, little is known of the effect of high BMI on SBF response to heat. Since diabetes is associated with age and a higher BMI, the interrelationship between age, BMI and SBF needs to be investigated to better understand the contribution diabetes alone has to endothelial impairment. MATERIAL AND METHODS:This study examined the SBF to heat in young and old people with low and high BMI and people with diabetes with high BMI to determine the contribution these variables have on SBF. Subjects were ten young and older people with BMI <20 and ten young and older people with BMI >20 and ten subjects with diabetes with BMI >20. The SBF response, above the quadriceps, was determined during a 6 minutes exposure to heat at 44°C. RESULTS:Even in young people, SBF after the stress of heat exposure was reduced in subjects with a high BMI. The effect of BMI was greatest in young people and lowest in older people and people with diabetes; in people with diabetes, BMI was a more significant variable than diabetes in causing impairment of blood flow to heat. BMI, for example, was responsible for 49% of the reduction in blood flow after stress heat exposure (R=-0.7) while ageing only accounted for 16% of the blood flow reduction (R=-0.397). CONCLUSIONS:These results would suggest the importance of keeping BMI low not only in people with diabetes to minimize further circulatory vascular damage, but also in young people to diminish long term circulatory vascular compromise.

journal_name

Med Sci Monit

journal_title

Medical science monitor : international medical journal of experimental and clinical research

authors

Petrofsky JS,Alshammari F,Bains GS,Khowailed IA,Lee H,Kuderu YN,Lodha RD,Rodrigues S,Nguyen D,Potnis PA,Deshpande PP,Yim JE,Berk L

doi

10.12659/MSM.883878

subject

Has Abstract

pub_date

2013-04-10 00:00:00

pages

257-63

eissn

1234-1010

issn

1643-3750

pii

883878

journal_volume

pub_type

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What is more damaging to vascular endothelial function: Diabetes, age, high BMI, or all of the above?