Abstract:
:The aim of this paper is to investigate the diagnostic value of histopathologic score and the dilated intercellular space (DIS) in patients with gastroesophageal reflux disease (GERD) and functional heartburn (FH). Participants with GERD symptoms including reflux esophagitis, non-erosive reflux disease (NERD), Barrett's esophagus (BE), functional heartburn (FH), along with a control group with atypical GERD-like symptom (Sym-C), and asymptomatic healthy volunteers (H-C) were administered GERD questionnaire, and subjected to endoscopy and biopsies, as well as 24-hour pH-impedance monitoring. Biopsies were evaluated using standards from the 2011 Esohisto Project after Hematoxylin-Eosin staining. DIS was measured quantitatively under light microscopy. Among the total of 565 participants with qualified biopsy specimens, the mean DIS of the reflux esophagitis (RE) group was significantly wider compared with the other five groups. DIS in patients with GERD-like symptoms was significantly wider compared with the H-C. No significant differences were observed between NERD and FH. Results from 24-hour pH-impedance monitoring indicated that only the DIS of patients with acid reflux or the amount of acid reflux episodes in patients with DIS was significantly wider compared with patients with nonacid reflux or patients without DIS (P < 0.001). With DIS = 0.9 μm as the cutoff value, the sensitivity and specificity were 62.6% and 54.1%, respectively. Using the total histopathologic score > 3 as the diagnostic criterion, the sensitivity and specificity were 71.7% and 47.4%. DIS is closely associated with GERD and acid reflux. The diagnostic value of histological scores in lower esophagus in GERD is very similar to that of the quantitative measurement of DIS.
journal_name
Dis Esophagusjournal_title
Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagusauthors
Cui R,Zhang H,Zhou L,Lu J,Xue Y,Wang Y,Yan X,Lin L,Lin Sdoi
10.1111/dote.12256subject
Has Abstractpub_date
2015-08-01 00:00:00pages
530-7issue
6eissn
1120-8694issn
1442-2050journal_volume
28pub_type
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type: 杂志文章
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
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