Endoscopic evaluation of esophago-gastro-jejunostomy in rat model of Barrett's esophagus.

Abstract:

:Endoscopy can be used to monitor the onset of metaplastic transformation and to observe the progression of neoplasia in small animal models of Barrett's esophagus. By avoiding animal sacrifice, the natural history of this disease can be studied in a longitudinal fashion. We aim to characterize the endoscopic features of esophageal mucosa at various stages of the metaplasia-dysplasia-carcinoma sequence in a rat reflux model of Barrett's for comparison with histology. Acid and bile reflux was produced by introducing a side-to-side esophago-gastro-jejunostomy in Sprague-Dawley rats. Endoscopic examination of the distal esophagus was performed in 24 surgically altered and 4 control rats, between weeks 24 and 36 after the operation in 4-week intervals, and all rats were biopsied and sacrificed at 36 weeks. Endoscopic images were classified based on the surface mucosal patterns of the distal esophagus and then compared with histology. The endoscopic appearance was classified as: (i) normal, characterized by a smooth surface; (ii) intestinal metaplasia, defined as elevated plaques/ridges, deep grooves, and thin linear folds; (iii) dysplasia, indicated by coarse folds/grooves, meshlike villi, and foveolar appearance; and (iv) carcinoma, suggested by irregular-shaped mass lesions with ulcerations. The endoscopic criteria for intestinal metaplasia yielded a sensitivity of 100% in comparison with histology. Intestinal metaplasia with high-grade dysplasia was found in two rats and with low-grade dysplasia in three rats. Both focally invasive squamous cell carcinoma and invasive adenocarcinoma were found in one rat. Small animal endoscopy in a rat model of Barrett's esophagus can be used to perform surveillance, classify mucosal patterns, observe the onset of intestinal metaplasia, and monitor the progression of neoplastic transformation, representing a useful tool for studying the natural history of this disease.

journal_name

Dis Esophagus

authors

Lu S,Lowe AW,Triadafilopoulos G,Hsiung PL,Hao Y,Crawford JM,Wang TD

doi

10.1111/j.1442-2050.2008.00909.x

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

323-30

issue

4

eissn

1120-8694

issn

1442-2050

pii

DES909

journal_volume

22

pub_type

杂志文章
  • Tuberculosis of the esophagus.

    abstract::We report a case of a patient with esophageal tuberculosis, a very uncommon form of extrapulmonar tuberculosis. Initially, because of constitutional symptomatology and radiological findings of mediastinal lymph node enlargement, lymphoma was considered. However, the endoscopic findings of ulcerative masses and a sinus...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:

    authors: Perdomo JA,Naomoto Y,Haisa M,Yamatsuji T,Kamikawa Y,Tanaka N

    更新日期:1998-01-01 00:00:00

  • Thoracic esophageal perforation: one surgeon's experience.

    abstract::Recognition of the importance of early diagnosis and aggressive, definitive surgical intervention has brought about a dramatic decline in mortality related to distal esophageal perforation. In the following retrospective analysis, we have examined all cases of thoracic esophageal perforations diagnosed, consulted, and...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2006.00533.x

    authors: Kiernan PD,Sheridan MJ,Hettrick V,Vaughan B,Graling P

    更新日期:2006-01-01 00:00:00

  • Endoscopic stent suture fixation for prevention of esophageal stent migration during prolonged dilatation for achalasia treatment.

    abstract::The aim of this study is to compare endoscopic stent suture fixation with endoscopic clip attachment or the use of partially covered stents (PCS) regarding their capability to prevent stent migration during prolonged dilatation in achalasia. Large-diameter self-expanding metal stents (30 mm × 80 mm) were placed across...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/dow002

    authors: Rieder E,Asari R,Paireder M,Lenglinger J,Schoppmann SF

    更新日期:2017-04-01 00:00:00

  • Noncardiac chest pain: diagnostic evaluation.

    abstract::Noncardiac chest pain (NCCP) is a common and challenging clinical problem. It is estimated that more than 70 million Americans (23% of the population) suffer from this condition yearly. Patients with NCCP represent a diagnostic dilemma. Their chest pain is often indistinguishable from cardiac pain leading to extensive...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,评审

    doi:10.1111/j.1442-2050.2011.01225.x

    authors: Fass R,Achem SR

    更新日期:2012-02-01 00:00:00

  • Reporting outcomes of definitive radiation-based treatment for esophageal cancer: a review of the literature.

    abstract::Accurate evaluation of radical radiotherapy requires well designed research with valid and appropriate outcomes. This study reviewed standards of outcome reporting and study design in randomized controlled trials (RCTs) of radiation-based therapy for esophageal cancer and made recommendations for future work. Randomiz...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,评审

    doi:10.1111/dote.12168

    authors: Main BG,Strong S,McNair AG,Falk SJ,Crosby T,Blazeby JM

    更新日期:2015-02-01 00:00:00

  • How many lymph nodes should be dissected in esophagectomy with or without neoadjuvant therapy to get accurate staging?

    abstract::It is essential to dissect an adequate number of lymph nodes (LNs) to ensure staging accuracy during esophagectomy with or without neoadjuvant therapy. We developed a statistical model to quantify the probability of precise nodal staging based on previous studies. Esophageal cancer patients who underwent esophagectomy...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doz009

    authors: Zhan C,Shi Y,Jiang W,Sun F,Li M,Lu T,Yin J,Ma K,Yang X,Wang Q

    更新日期:2020-01-16 00:00:00

  • Early diagnosis of mucosal squamous cell carcinoma of the esophagus: including two interesting cases of superficial spreading-type and multicentric-type squamous cell carcinomas.

    abstract::We reviewed 10 patients with esophageal mucosal carcinoma in order to improve the early diagnosis of the disease. Histologically seven of the 14 lesions were carcinomas in situ (epithelial cancer), and the other seven lesions were carcinomas confined to the mucosa other than epithelial cancer (muscularis mucosae cance...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/10.3.201

    authors: Kimura H,Konishi K,Earashi M,Satou T,Nojima N,Inoue T,Maeda K,Yabushita K,Kuroda Y,Tsuji M,Miwa A

    更新日期:1997-07-01 00:00:00

  • Prognostic relevance of serial endoscopic ultrasound after chemoradiation in esophageal cancer.

    abstract::The objective of this study is the feasibility of sequential endoscopic and endosonographic measurement of locoregional tumor load for the prediction of tumor recurrence in patients after neoadjuvant or definitive chemoradiotherapy, treated in curative intent for locally advanced esophageal carcinoma. In 67 patients w...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/dox065

    authors: Bohle W,Kasper M,Zoller WG

    更新日期:2017-10-01 00:00:00

  • Decision analysis supports the use of drain amylase-based enhanced recovery method after esophagectomy.

    abstract::Postesophagectomy anastomotic leak is a common postsurgical complication. The current standard method of detecting leak is esophagram usually late in the postoperative period. Perianastomotic drain amylase level had shown promising results in early detection anastomosis leak. Previous studies have shown that postopera...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doy041

    authors: Jiang B,Ho VP,Ginsberg J,Fu SJ,Perry Y,Argote-Greene L,Linden PA,Towe CW

    更新日期:2018-10-01 00:00:00

  • Circumferential and axial distribution of esophageal mucosal damage in reflux disease.

    abstract::The aim of this study was to evaluate the axial and radial distribution of histological markers including hyperplasia of the basal cell layer, elongation of the papillae and dilatation of the intercellular spaces of the squamous epithelium in patients with nonerosive reflux disease compared to controls and to relate t...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2007.00678.x

    authors: Edebo A,Vieth M,Tam W,Bruno M,van Berkel AM,Stolte M,Schoeman M,Tytgat G,Dent J,Lundell L

    更新日期:2007-01-01 00:00:00

  • Risk of malignant progression in Barrett's esophagus indefinite for dysplasia.

    abstract::Barrett's esophagus is a well-recognized risk factor for esophageal adenocarcinoma. The natural history of Barrett's esophagus classified as ‘indefinite for dysplasia’ (IND) is poorly characterized. The aim of this study is to characterize the natural history of IND by determining the rate of neoplastic progression an...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/dow025

    authors: Ma M,Shroff S,Feldman M,DeMarshall M,Price C,Tierney A,Falk GW

    更新日期:2017-03-01 00:00:00

  • Health-related quality of life in long-term survivors after high-dose chemoradiotherapy followed by surgery in esophageal cancer.

    abstract::Curative treatment of esophageal cancer with definitive or preoperative high-dose chemoradiotherapy inflicts a major strain on the patients with potentially severe physical, emotional, and social consequences. The aim of this study was to assess various aspects of quality of life and fatigue in long-term survivors fol...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2010.01104.x

    authors: Hurmuzlu M,Aarstad HJ,Aarstad AK,Hjermstad MJ,Viste A

    更新日期:2011-01-01 00:00:00

  • Delivering esophago-gastric cancer care during the COVID-19 pandemic in the United Kingdom: a surgical perspective.

    abstract:BACKGROUND:The COVID-19 pandemic continues to have a significant impact on the provision of medical care. Planning to ensure there is capability to treat those that become ill with the virus has led to an almost complete moratorium on elective work. This study evaluates the impact of COVID-19 on cancer, in particular s...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa091

    authors: Wahed S,Chmelo J,Navidi M,Hayes N,Phillips AW,Immanuel A

    更新日期:2020-09-04 00:00:00

  • Esophageal cancer after distal gastrectomy.

    abstract::The effect of gastrectomy on the subsequent development of esophageal cancer was investigated. Duodenogastroesophageal reflux is thought to be common in patients after distal gastrectomy, but whether this contributes to the development of esophageal cancer in such patients is controversial. We retrospectively evaluate...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2006.00599.x

    authors: Hashimoto N,Inayama M,Fujishima M,Ho H,Shinkai M,Hirai N,Kawanishi K,Imano M,Shigeoka H,Imamoto H,Shiozaki H

    更新日期:2006-01-01 00:00:00

  • Laparoscopic-assisted left thoracoabdominal esophagectomy (LLTA): an innovative approach for locally advanced tumors of the gastroesophageal junction.

    abstract:PURPOSE:To report a novel approach for locally advanced tumors located at the gastroesophageal junction (GEJ) using a laparoscopic abdominal phase and open left thoracotomy with the patient in a single right lateral decubitus position. BACKGROUND:The standard open left thoracoabdominal approach offers excellent exposu...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa014

    authors: Reyhani A,Zylstra J,Davies AR,Gossage JA

    更新日期:2020-11-18 00:00:00

  • Evaluation of clinical significance of 18F-fluorodeoxyglucose positron emission tomography in superficial squamous cell carcinomas of the thoracic esophagus.

    abstract::(18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is used for pre-treatment staging and evaluation of response to pre-operative therapy in advanced thoracic esophageal cancers. To evaluate the clinical significance of PET diagnosis of superficial thoracic esophageal cancers, FDG-PET was conducted preop...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2007.00743.x

    authors: Miyata H,Doki Y,Yasuda T,Yamasaki M,Higuchi I,Makari Y,Matsuyama J,Hirao T,Takiguchi S,Fujiwara Y,Monden M

    更新日期:2008-01-01 00:00:00

  • Technical aspects and results of the transhiatal resection in adenocarcinomas of the gastroesophageal junction.

    abstract::The distribution of lymph node metastases of adenocarcinomas of the gastroesophageal junction is classified into three types. The R0 resection with complete lymphadenectomy therefore requires different resection methods for type 1 and type 2/3 tumors. Comparing the subtotal esophagectomy and the extended gastrectomy, ...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1046/j.1442-2050.2001.00167.x

    authors: Ulrich B,Zahedi A

    更新日期:2001-01-01 00:00:00

  • Psychological impact of esophageal atresia: review of the research and clinical evidence.

    abstract::Esophageal atresia (EA) occurs in one out of 2500 to 4500 live births. As the vast majority of infants are now surviving neonatal corrective surgery, the focus has shifted from mortality to morbidity associated with EA. However, little is known about its psychological morbidity. This paper synthesizes research and cli...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,评审

    doi:10.1111/dote.12056

    authors: Caplan A

    更新日期:2013-05-01 00:00:00

  • The impact of the speed of food intake on gastroesophageal reflux events in obese female patients.

    abstract::Obesity increases the risk of gastroesophageal reflux disease (GERD). The majority of the reflux attacks occur postprandially. The influence of the speed of food intake on gastroesophageal reflux events is unclear in obese patients. To determine the influence of the speed of food intake on intraesophageal reflux event...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/dote.12499

    authors: Bor S,Erdogan A,Bayrakci B,Yildirim E,Vardar R

    更新日期:2017-01-01 00:00:00

  • CYFRA 21-1 as a tumor marker for squamous cell carcinoma of the esophagus.

    abstract::This study assessed the clinical value of CYFRA 21-1 in comparison with squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) in patients with esophageal squamous cell carcinoma. In 112 primary cancer patients, the diagnostic sensitivity of CYFRA 21-1 (33.9%) ...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/11.1.35

    authors: Nakamura T,Ide H,Eguchi R,Hayashi K,Takasaki K,Watanabe S

    更新日期:2017-11-01 00:00:00

  • Viruses and esophageal cancer.

    abstract::Esophageal adenocarcinoma (EAC) has had the fastest increasing incidence of any solid tumor in the United States in the last 30 years. Long standing gastroesophageal reflux disease is a well-established risk factor with strong associations with obesity, alcohol and tobacco. However, there are likely additional contrib...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/doaa036

    authors: Chang C,Worrell SG

    更新日期:2020-12-07 00:00:00

  • Same-day discharge in benign esophageal surgery: a prospective cohort study.

    abstract::Day-case esophageal surgery has been demonstrated to be safe in small prospective cohorts and only for laparoscopic fundoplication. The aims of this study are to assess the feasibility and safety of a large series of esophageal day-case surgeries, including laparoscopic Nissen fundoplication (LNF), Zenker diverticulec...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/dow036

    authors: Desbeaux A,Gronnier C,Piessen G,Vanderbeken M,Ruolt N,Triboulet JP,Mariette C

    更新日期:2017-04-01 00:00:00

  • Heller's esophagomyotomy with or without a 360 degrees floppy Nissen fundoplication for achalasia. Long-term results from a prospective randomized study.

    abstract::Heller's esophagomyotomy relieves dysphagia but does not restore esophageal peristalsis. The myotomy may induce reflux and the addition of a 360 degrees fundoplication may be hazardous with regard to the remaining aperistaltic esophagus. The aim of this prospectively randomized clinical trial was to compare the outcom...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1442-2050.2003.00348.x

    authors: Falkenback D,Johansson J,Oberg S,Kjellin A,Wenner J,Zilling T,Johnsson F,Von Holstein CS,Walther B

    更新日期:2003-01-01 00:00:00

  • Omission of preoperative esophageal manometry does not alter operative approach or postoperative dysphagia following laparoscopic paraesophageal hernia repair.

    abstract::Routine esophageal manometry for surgical planning before laparoscopic paraesophageal hernia (PEH) has been advocated in an effort to reduce the likelihood of postoperative dysphagia. The purpose of this study is to investigate whether omitting routine preoperative esophageal manometry is associated with a change in t...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1093/dote/dox044

    authors: Zevin B,Jones EL,Martin Del Campo SE,Perry KA

    更新日期:2017-07-01 00:00:00

  • FA01.02: THE EFFECT OF POSTOPERATIVE COMPLICATIONS AFTER MIE ON LONG-TERM SURVIVAL: A RETROSPECTIVE, MULTI-CENTER COHORT STUDY.

    abstract:Background:Esophagectomy has a high incidence of postoperative morbidity. Complications lead to a decreased short-term survival, however the influence of those complications on long-term survival is still unclear. Most of the performed studies are small, single center cohort series with inconclusive or conflicting resu...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,多中心研究

    doi:10.1093/dote/doy089.FA01.02

    authors: Fransen L,Berkelmans G,Asti E,Van Berge Henegouwen M,Berlth F,Bonavina L,Brown A,Bruns C,Gisbertz S,Grimminger P,Gutschow C,Hölscher A,Kauppi J,Lagarde SM,Mercer S,Moons J,Nafteux P,Nilsson M,Palazzo F,Pattyn P,Ph

    更新日期:2018-09-01 00:00:00

  • Risk factors for surgical site infection after surgery for esophageal perforation.

    abstract::Esophageal perforations carry a high potential for morbidity and mortality. The prognosis depends on rapid and precise diagnosis and management. Surgical site infections (SSIs) are very common following the surgical treatment of esophageal lesions. We aimed identify significant risk factors for SSI after surgery for e...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2007.00779.x

    authors: Breigeiron R,de Souza HP,Sidou JP

    更新日期:2008-01-01 00:00:00

  • Changing role of in vivo models in columnar-lined lower esophagus.

    abstract::Columnar-lined lower esophagus (CLE) or Barrett's esophagus (BE) is caused by chronic reflux of the gastrointestinal tract and can progress to invasive adenocarcinoma. However, the pathophysiology, cell of origin, and management of this condition is incompletely understood. This review evaluates the role of in vivo mo...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,评审

    doi:10.1046/j.1442-2050.2002.00268.x

    authors: Koak Y,Winslet M

    更新日期:2002-01-01 00:00:00

  • Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals.

    abstract::We report analytic and consensus processes that produced recommendations for neoadjuvant pathologic stage groups (ypTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration provided data for 22,654 patients with epitheli...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1111/dote.12538

    authors: Rice TW,Ishwaran H,Kelsen DP,Hofstetter WL,Apperson-Hansen C,Blackstone EH,Worldwide Esophageal Cancer Collaboration Investigators.

    更新日期:2016-11-01 00:00:00

  • Outcome of floppy Nissen fundoplication with intraoperative manometry to treat sliding hiatal hernia.

    abstract::The aim of this study was to evaluate the effectiveness of floppy Nissen fundoplication with intraoperative esophageal manometry. Between February 1992 and July 2004, there were 102 patients with sliding hiatal hernia undergoing transabdominal Nissen fundoplication. They were divided into three groups: 27 patients wer...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章

    doi:10.1111/j.1442-2050.2007.00777.x

    authors: Lei Y,Li JY,Jiang J,Wang J,Zhang QY,Wang TY,Krasna MJ

    更新日期:2008-01-01 00:00:00

  • Gastroesophageal reflux disease in obese patients: the role of obesity in management.

    abstract::Gastroesophageal reflux disease (GERD) is common in obese patients. The implications of obesity in the etiology, management and outcomes in treatment for GERD have become increasingly important due to an epidemic of obesity. The increasing prevalence of patients with both obesity and GERD merits evaluation of the appr...

    journal_title:Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

    pub_type: 杂志文章,评审

    doi:10.1111/j.1442-2050.2006.00540.x

    authors: Kendrick ML,Houghton SG

    更新日期:2006-01-01 00:00:00