Epigenetic events in medulloblastoma development.

Abstract:

:Over the last decade, the analysis of genetic defects in primary tumors has been central to the identification of molecular events and biological pathways involved in the pathogenesis of medulloblastoma, the most common malignant brain tumor of childhood. Despite this, understanding of the molecular basis of the majority of cases remains poor. In recent years, the emerging field of epigenetics, which describes heritable alterations in gene expression that occur in the absence of DNA sequence changes, has forced a revision of the understanding of the mechanisms of gene disruption in cancer. Accumulating evidence indicates a significant involvement for epigenetic events in medulloblastoma development. Recent studies have identified a series of candidate tumor suppressor genes (for example, RASSF1A, CASP8, and HIC1) that are each specifically epigenetically inactivated in a large proportion (> 30%) of medulloblastomas by promoter hypermethylation, leading to the silencing of their gene expression. These findings shed new light on medulloblastoma and offer great potential for an improved understanding of its molecular pathology. The authors review the current understanding of epigenetic events in cancer and their contribution to medulloblastoma development. Their nature, origins, and functional role(s) in tumorigenesis are considered, and the authors assess the potential utility of these events as a basis for novel diagnostic and therapeutic approaches.

journal_name

Neurosurg Focus

journal_title

Neurosurgical focus

authors

Lindsey JC,Anderton JA,Lusher ME,Clifford SC

doi

10.3171/foc.2005.19.5.11

subject

Has Abstract

pub_date

2005-11-15 00:00:00

pages

E10

issue

5

issn

1092-0684

pii

190510

journal_volume

19

pub_type

杂志文章,评审
  • Pretemporal trans-Meckel's cave transtentorial approach for large petroclival meningiomas.

    abstract::OBJECTIVE Despite the advances in skull base techniques, large petroclival meningiomas (PCMs) still pose a challenge to neurosurgeons. The authors' objective of this study was to describe a pretemporal trans-Meckel's cave transtentorial approach for large PCMs and to report the surgical outcomes. METHODS From 2014 to ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2018.1.FOCUS17733

    authors: Liao CH,Wang JT,Lin CF,Chen SC,Lin CJ,Hsu SPC,Chen MH

    更新日期:2018-04-01 00:00:00

  • Arachnoid cysts: case series and review of the literature.

    abstract:OBJECT:Arachnoid cysts are commonly encountered fluid collections in the central nervous system. Recent advances in neuroimaging have translated into an increased detection of these cysts; that is, diagnoses can be made more frequently at earlier stages. Significant advances have also been made in the surgical manageme...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/foc.2007.22.2.7

    authors: Pradilla G,Jallo G

    更新日期:2007-02-15 00:00:00

  • Stereotactic robot-assisted MRI-guided laser thermal ablation of radiation necrosis in the posterior cranial fossa: technical note.

    abstract::Laser interstitial thermal therapy (LITT) is a minimally invasive procedure used to treat a variety of intracranial lesions. Utilization of robotic assistance with stereotactic procedures has gained attention due to potential for advantages over conventional techniques. The authors report the first case in which robot...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2016.4.FOCUS1622

    authors: Chan AY,Tran DK,Gill AS,Hsu FP,Vadera S

    更新日期:2016-10-01 00:00:00

  • Multimodal navigation in the functional microsurgical resection of intrinsic brain tumors located in eloquent motor areas: role of tractography.

    abstract:OBJECT:Nowadays the role of microsurgical management of intrinsic brain tumors is to maximize the volumetric resection of the tumoral tissue, minimizing the postoperative morbidity. The purpose of this paper was to study the benefits of an original protocol developed for the microsurgical treatment of tumors located in...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2009.11.FOCUS09234

    authors: González-Darder JM,González-López P,Talamantes F,Quilis V,Cortés V,García-March G,Roldán P

    更新日期:2010-02-01 00:00:00

  • Phototherapy in peripheral nerve regeneration: From basic science to clinical study.

    abstract:OBJECT:This review summarizes the continuous study of low-power laser radiation treatment of a severely injured peripheral nerve. Laser phototherapy was applied as a supportive factor for accelerating and enhancing axonal growth and regeneration after injury or a reconstructive peripheral nerve procedure. In nerve cell...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/FOC.2009.26.2.E8

    authors: Rochkind S

    更新日期:2009-02-01 00:00:00

  • Imaging of primary central nervous system lymphoma.

    abstract::Primary central nervous system lymphoma (PCNSL) is an aggressive neoplastic process that occurs in both immunocompetent and immunocompromised patients. Over the past 30 years there has been a steady increase in the number of cases in both patient populations. The imaging features for the disease and demographic charac...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/foc.2006.21.5.5

    authors: Go JL,Lee SC,Kim PE

    更新日期:2006-11-15 00:00:00

  • Comparison of conscious sedation and general anesthesia for motor mapping and resection of tumors located near motor cortex.

    abstract:OBJECT:The surgical treatment of tumors located near eloquent cortex carries a high risk of inducing worsening neurological deficits. Intraoperative electrocorticography techniques have been developed to help identify these areas at the time of surgery in an effort to minimize such risks. The optimal anesthetic techniq...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2003.15.1.8

    authors: Vitaz TW,Marx W,Victor JD,Gutin PH

    更新日期:2003-07-15 00:00:00

  • Retropleural thoracotomy. Technical note.

    abstract::Herniated thoracic discs, unlike their lumbar counterparts, are difficult to read and safely resect using traditional posterior approaches. Historically, the use of a laminectomy for thoracic disc resection has yielded poor clinical outcomes. Posterolateral and anterolateral approaches have become the standard surgica...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2001.10.1.9

    authors: Angevin PD,McCormick PC

    更新日期:2001-01-15 00:00:00

  • Outcomes after a purely endoscopic transsphenoidal resection of growth hormone-secreting pituitary adenomas.

    abstract:OBJECT:Using strict biochemical remission criteria, the authors assessed surgical outcomes after endoscopic transsphenoidal resection of growth hormone (GH)-secreting pituitary adenomas and identified preoperative factors that significantly influence the rate of remission. METHODS:A retrospective review of a prospecti...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2010.7.FOCUS10153

    authors: Campbell PG,Kenning E,Andrews DW,Yadla S,Rosen M,Evans JJ

    更新日期:2010-10-01 00:00:00

  • Indications for fusion following decompression for lumbar spinal stenosis.

    abstract::Degenerative lumbar spinal stenosis is a common condition affecting middle-aged and elderly people. Significant controversy exists concerning the appropriate indications for fusion following decompressive surgery. The purpose of this report is to compare the clinical outcomes of patients who were and were not treated ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.1997.3.2.5

    authors: Fox MW,Onofrio BM

    更新日期:1997-08-15 00:00:00

  • Improved restoration of thoracic kyphosis using a rod construct with differentiated rigidity in the surgical treatment of adolescent idiopathic scoliosis.

    abstract::OBJECTIVE The objective of this study was to compare postoperative sagittal alignment among 3 rod constructs with different rigidity profiles. METHODS This was a dual-center retrospective cohort study involving 2 consecutive cohorts in which patients were surgically treated for adolescent idiopathic scoliosis. Lenke T...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,多中心研究

    doi:10.3171/2017.7.FOCUS17351

    authors: Ohrt-Nissen S,Dragsted C,Dahl B,Ferguson JAI,Gehrchen M

    更新日期:2017-10-01 00:00:00

  • Comparison of minimally invasive transspinous and open approaches for thoracolumbar intradural-extramedullary spinal tumors.

    abstract::OBJECT Spinal tumor resection has historically been performed via open approaches, although minimally invasive approaches have recently been found to be effective in small cohort series. The authors compare surgical characteristics and clinical outcomes of surgery in patients undergoing mini-open and open approaches f...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2015.5.FOCUS15187

    authors: Raygor KP,Than KD,Chou D,Mummaneni PV

    更新日期:2015-08-01 00:00:00

  • Topectomy versus leukotomy: J. Lawrence Pool's contribution to psychosurgery.

    abstract::Surgery of the mind has a rather checkered past. Though its history begins with the prehistoric trephination of skulls to allow "evil spirits" to escape, the early- to mid-20th century saw a surge in the popularity of psychosurgery. The 2 prevailing operations were topectomy and leukotomy for the treatment of certain ...

    journal_title:Neurosurgical focus

    pub_type: 历史文章,杂志文章

    doi:10.3171/2017.6.FOCUS17259

    authors: Holland R,Kopel D,Carmel PW,Prestigiacomo CJ

    更新日期:2017-09-01 00:00:00

  • Minimal tethered cord syndrome: what's necessary to justify a new surgical indication?

    abstract::Traditionally, surgical division of the terminal filum (filum terminale) has been reserved for patients with imaging-apparent spinal cord tethering. The occurrence of medically refractory voiding dysfunction of neurogenic origin, without magnetic resonance (MR) imaging documentation of abnormality in the spine, has be...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/FOC-07/08/E1

    authors: Selden NR

    更新日期:2007-01-01 00:00:00

  • Transcortical surgery for lateral ventricular tumors.

    abstract:OBJECT:Tumors of the lateral ventricle can be removed via two major approaches: the transcallosal or the transcortical route. The purpose of this study is to discuss the techniques and outcomes in transcortical surgery of tumors located in the lateral ventricle. METHODS:An experience with 29 consecutive lateral ventri...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2001.10.6.3

    authors: Ellenbogen RG

    更新日期:2001-06-15 00:00:00

  • Resection of uncovertebral joints and posterior longitudinal ligament for cervical disc arthroplasty.

    abstract::The most commonly accepted indications for cervical disc arthroplasty (CDA) are 1- and 2-level cervical disc herniation or spondylosis causing radiculopathy or myelopathy that is refractory to medical management. Unlike anterior cervical discectomy and fusion (ACDF), which eliminates motion, CDA aims to restore the ph...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2017.1.FocusVid.16380

    authors: Tu TH,Chang CC,Wu JC,Fay LY,Huang WC,Cheng H

    更新日期:2017-01-01 00:00:00

  • Decision making for patients with multiple brain metastases: radiosurgery, radiotherapy, or resection?

    abstract:OBJECT:Multiple brain metastases are a common health problem, frequently found in patients with cancer. The prognosis, even after treatment with whole-brain radiation therapy (WBRT), is poor, with an average expected survival time of less than 6 months. Investigators at numerous centers have evaluated the role of stere...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,随机对照试验

    doi:10.3171/foc.2000.9.2.5

    authors: Kondziolka D,Patel A,Lunsford LD,Flickinger JC

    更新日期:2000-08-15 00:00:00

  • Radiosurgery for nonfunctioning pituitary adenoma.

    abstract:OBJECT:Nonfunctioning pituitary adenomas comprise approximately 30% of all pituitary tumors. The purpose of this retrospective study was to evaluate the efficacy and role of gamma knife surgery (GKS) in the treatment of these lesions. METHODS:The authors conducted a review of cases in which GKS was performed at the Un...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2003.14.5.10

    authors: Sheehan JP,Kondziolka D,Flickinger J,Lunsford LD

    更新日期:2003-05-15 00:00:00

  • Significance of cerebrospinal fluid inflammatory markers for diagnosing external ventricular drain-associated ventriculitis in patients with severe traumatic brain injury.

    abstract:Objective:The aim of this study was to investigate the diagnostic potential of the inflammatory markers interleukin-6 (IL-6), total leukocyte count (TLC), and protein in the CSF and IL-6, C-reactive protein, and white blood cell count in the serum for the early diagnosis of ventriculitis in patients with traumatic brai...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2019.8.FOCUS19407

    authors: Lenski M,Biczok A,Neufischer K,Tonn JC,Briegel J,Thon N

    更新日期:2019-11-01 00:00:00

  • Distribution and stability of antisense phosphorothioate oligonucleotides in rodent brain following direct intraparenchymal controlled-rate infusion.

    abstract::High-flow microinfusion is a novel technique for delivery of compounds directly into the brain parenchyma, bypassing the blood-brain barrier. The feasibility of this technique has been demonstrated with low-molecular-weight compounds, macromolecular dyes, and proteins. Delivery of antisense oligonucleotides into the b...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.1997.3.5.7

    authors: Broaddus WC,Prabhu SS,Gillies GT,Neal J,Conrad WS,Chen ZJ,Fillmore H,Young HF

    更新日期:1997-11-15 00:00:00

  • Transarterial embolization of an internal maxillary artery arteriovenous fistula presenting with pulsatile tinnitus.

    abstract::Arteriovenous fistulae of the internal maxillary artery are exceedingly rare, with less than 30 cases reported in the literature. Most of these lesions are congenital, iatrogenic, or posttraumatic. The most common presentation of internal maxillary artery fistulae is pulsatile tinnitus and headache. Because these lesi...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2019.1.FocusVid.18479

    authors: Brinjikji W,Cloft HJ,Lanzino G,Rangel-Castilla L,Morris PP

    更新日期:2019-01-01 00:00:00

  • Treatment of patients with a pituitary adenoma: one clinician's experience.

    abstract::The diagnosis and treatment of a patient with a pituitary adenoma or another type of pituitary lesion requires a team approach involving the neurosurgeon, endocrinologist, primary care physician, and, in some patients, an ophthalmologist and radiation therapist. The diagnosis of excessive pituitary hormone secretion a...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/foc.2004.16.4.2

    authors: Vance ML

    更新日期:2004-04-15 00:00:00

  • High flow EC-IC bypass for a giant left MCA aneurysm.

    abstract::Giant cerebral aneurysms may be treated through a variety of options, including aneurysm trapping with concurrent bypass. This video describes the case of a large, recurrent, left middle cerebral artery aneurysm that was treated using a high flow, radial artery bypass graft, from the external carotid artery to the lef...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2015.V1.FOCUS14548

    authors: Arias EJ,Zipfel GJ

    更新日期:2015-01-01 00:00:00

  • Concussion in professional football: summary of the research conducted by the National Football League's Committee on Mild Traumatic Brain Injury.

    abstract::PIn 1994 the National Football League (NFL) initiated a comprehensive clinical and biomechanical research study of mild traumatic brain injury (TBI), a study that is ongoing. Data on mild TBIs sustained between 1996 and 2001 were collected and submitted by NFL team physicians and athletic trainers, and these data were...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/foc.2006.21.4.13

    authors: Pellman EJ,Viano DC,National Football League's Committee on Mild Traumatic Brain Injury.

    更新日期:2006-10-15 00:00:00

  • Pathophysiology and genetic factors in moyamoya disease.

    abstract::Moyamoya disease is an uncommon cerebrovascular condition characterized by progressive stenosis of the bilateral internal carotid arteries with compensatory formation of an abnormal network of perforating blood vessels providing collateral circulation. The etiology and pathogenesis of moyamoya disease remain unclear. ...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章,评审

    doi:10.3171/2009.1.FOCUS08302

    authors: Achrol AS,Guzman R,Lee M,Steinberg GK

    更新日期:2009-04-01 00:00:00

  • Spinal dural arteriovenous fistulas: outcome and prognostic factors.

    abstract::The aim of this study is to review the clinical outcome of patients treated for spinal dural arteriovenous malformations and investigate the presence of pretreatment indicators of outcome after short- and midterm follow-up. The authors retrospectively reviewed the records of 65 consecutive patients treated either surg...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2012.2.FOCUS1218

    authors: Cenzato M,Debernardi A,Stefini R,D'Aliberti G,Piparo M,Talamonti G,Coppini M,Versari P

    更新日期:2012-05-01 00:00:00

  • Frailty predicts worse outcomes after intracranial meningioma surgery irrespective of existing prognostic factors.

    abstract:OBJECTIVE:Frailty has been recognized as a predictor of adverse surgical outcomes across multiple surgical disciplines, but until now the relationship between frailty and intracranial meningioma surgery has not been studied. The goal of the present study was to determine the relationship between increasing frailty (det...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2020.7.FOCUS20324

    authors: Theriault BC,Pazniokas J,Adkoli AS,Cho EK,Rao N,Schmidt M,Cole C,Gandhi C,Couldwell WT,Al-Mufti F,Bowers CA

    更新日期:2020-10-01 00:00:00

  • Comparison of intraoperative MR imaging and 3D-navigated ultrasonography in the detection and resection control of lesions.

    abstract:OBJECT:The authors undertook a study to compare two intraoperative imaging modalities, low-field magnetic resonance (MR) imaging and a prototype of a three-dimensional (3D)-navigated ultrasonography in terms of imaging quality in lesion detection and intraoperative resection control. METHODS:Low-field MR imaging was u...

    journal_title:Neurosurgical focus

    pub_type: 临床试验,杂志文章

    doi:10.3171/foc.2001.10.2.4

    authors: Tronnier VM,Bonsanto MM,Staubert A,Knauth M,Kunze S,Wirtz CR

    更新日期:2001-02-15 00:00:00

  • Comparison of manually shaped and computer-shaped titanium mesh for repairing large frontotemporoparietal skull defects after traumatic brain injury.

    abstract:OBJECT:The object of this study was to compare the effects and complications of manual and computer-aided shaping of titanium meshes for repairing large frontotemporoparietal skull defects following traumatic brain injury. METHODS:From March 2005 to June 2011, 161 patients with frontotemporoparietal skull defects were...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2012.2.FOCUS129

    authors: Luo J,Liu B,Xie Z,Ding S,Zhuang Z,Lin L,Guo Y,Chen H,Yu X

    更新日期:2012-07-01 00:00:00

  • A stepwise illustration of the retrosigmoid approach for resection of a cerebellopontine meningioma.

    abstract::The retrosigmoid approach is a work-horse approach to the cerebellopontine angle (CPA), providing access from the foremen magnum to the tentorium. Indications for this approach are variable such as resection of meningiomas, acoustic neuromas and epidermoid tumors, treatment of vascular lesions of vertebrobasilar syste...

    journal_title:Neurosurgical focus

    pub_type: 杂志文章

    doi:10.3171/2014.V1.FOCUS13445

    authors: Cıkla U,Kujoth GC,Başkaya MK

    更新日期:2014-01-01 00:00:00