Antibiotic prophylaxis for hernia repair.

Abstract:

BACKGROUND:The use of antibiotic prophylaxis for hernia repair is currently a controversial issue given the disparity among study results in this area. OBJECTIVES:The objective of this systematic review was to clarify the effectiveness of antibiotic prophylaxis in reducing postoperative wound infection rates in elective open inguinal hernia repair. SEARCH STRATEGY:Searches in the Cochrane Colorectal Cancer Group specialized register were conducted crossing the terms herni* and inguinal or groin and the terms antimicr* or antibiot*, as free text and MeSH terms. A similar search in Medline (WebSPIRS from Silver Platter, January/1966 to November/2002) and Embase (1976 to December/2002) were conducted using the following terms: #1 antibiotic* or antimicrob* or anti infecti* or antiinfecti*; #2 prophyla* or prevent*; #3 #1 and #2; #4 clean and (surgery or tech* or proced*); #5 herni*; #6 (wound infection) and #4; #7 #3 and (#4 or #5 or #6). Reference lists of the included studies were checked to identify additional studies. SELECTION CRITERIA:Only randomized clinical trials were included. DATA COLLECTION AND ANALYSIS:Seven randomized clinical trials were identified. Two of them used prosthetic material for hernia repair (hernioplasty) whereas the remaining studies did not (herniorraphy). Pooled and subgroup analysis were conducted depending on whether prosthetic material was or not used. A random effects model was used in the analysis. MAIN RESULTS:The total number of patients included was 2660 (treatment group: 1297, control group: 1363). Overall infection rates were 3.08% and 4.69% in the prophylaxis and control groups, respectively (OR 0.61, 95%CI 0.32 - 1.17). The number of patients who need to be treated with prophylaxis (NNT) to prevent one infection in at least 30 days was 50 (95%CI 25 to infinite). The subgroup of patients with herniorrhaphy had infection rates of 3.78% and 4.87% in the prophylaxis and control groups, respectively (OR 0.84, 95%CI 0.53 - 1.34). NNT was 100 (95%CI 34 - infinite). The subgroup of patients with hernioplasty had infection rates of 1.3% and 4.2% in the prophylaxis and control groups, respectively (OR 0.28, 95%CI 0.02 - 3.14). NNT is 25 (IC95% NNH 25 to NNT 8). REVIEWER'S CONCLUSIONS:Based on the results of this meta-analysis, there was no clear evidence that routine administration of antibiotic prophylaxis for elective inguinal hernia repair reduced infection rates.

authors

Sanchez-Manuel FJ,Seco-Gil JL

doi

10.1002/14651858.CD003769

keywords:

subject

Has Abstract

pub_date

2003-01-01 00:00:00

pages

CD003769

issue

2

issn

1469-493X

pub_type

杂志文章,meta分析,评审
  • Interventions for treating constipation in pregnancy.

    abstract:BACKGROUND:Circulating progesterone may be the cause of slower gastrointestinal movement in mid and late pregnancy. OBJECTIVES:The objective of this review was to assess the effects of different methods for treating constipation in pregnancy. SEARCH STRATEGY:We searched the Cochrane Pregnancy and Childbirth Group tri...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001142

    authors: Jewell DJ,Young G

    更新日期:2000-01-01 00:00:00

  • Self-management for bronchiectasis.

    abstract:BACKGROUND:Bronchiectasis is a long term respiratory condition with an increasing rate of diagnosis. It is associated with persistent symptoms, repeated infective exacerbations, and reduced quality of life, imposing a burden on individuals and healthcare systems. The main aims of therapeutic management are to reduce ex...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD012528.pub2

    authors: Kelly C,Grundy S,Lynes D,Evans DJ,Gudur S,Milan SJ,Spencer S

    更新日期:2018-02-07 00:00:00

  • Oral contraceptives containing drospirenone for premenstrual syndrome.

    abstract:BACKGROUND:Premenstrual syndrome (PMS) is a common problem. Premenstrual dysphoric disorder (PMDD) is a severe form of premenstrual syndrome. Combined oral contraceptives, which provide both progestin and estrogen, have been examined for their ability to relieve premenstrual symptoms. An oral contraceptive containing d...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD006586.pub4

    authors: Lopez LM,Kaptein AA,Helmerhorst FM

    更新日期:2012-02-15 00:00:00

  • Interventions for treating scabies.

    abstract:BACKGROUND:Scabies is an intensely itchy parasitic infection of the skin caused by the Sarcoptes scabiei mite. It is a common public health problem with an estimated global prevalence of 300 million cases. Serious adverse effects have been reported for some drugs used to treat scabies. OBJECTIVES:To evaluate topical a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000320.pub2

    authors: Strong M,Johnstone P

    更新日期:2007-07-18 00:00:00

  • Antibiotics for acute maxillary sinusitis in adults.

    abstract:BACKGROUND:Sinusitis is one of the most common diagnoses among adults in ambulatory care, accounting for 15% to 21% of all adult outpatient antibiotic prescriptions. However, the role of antibiotics for sinusitis is controversial. OBJECTIVES:To assess the effects of antibiotics in adults with acute maxillary sinusitis...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000243.pub3

    authors: Ahovuo-Saloranta A,Rautakorpi UM,Borisenko OV,Liira H,Williams JW Jr,Mäkelä M

    更新日期:2014-02-11 00:00:00

  • Interventions for treating traumatised permanent front teeth: avulsed (knocked out) and replanted.

    abstract:BACKGROUND:Traumatic dental injuries are common. One of the most severe injuries is when a permanent tooth is knocked completely out of the mouth (avulsed). In most circumstances the tooth should be replanted as quickly as possible. There is uncertainty on which interventions will maximise the survival and repair of th...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD006542.pub3

    authors: Day PF,Duggal M,Nazzal H

    更新日期:2019-02-05 00:00:00

  • Interventions to reduce weight gain in schizophrenia.

    abstract:BACKGROUND:Weight gain is common for people with schizophrenia and this has serious implications for health and well being. OBJECTIVES:To determine the effects of both pharmacological (excluding medication switching) and non pharmacological strategies for reducing or preventing weight gain in people with schizophrenia...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005148.pub2

    authors: Faulkner G,Cohn T,Remington G

    更新日期:2007-01-24 00:00:00

  • Early surfactant administration with brief ventilation vs selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome.

    abstract:BACKGROUND:Both prophylactic and early surfactant replacement therapy, compared with later selective surfactant administration, reduce mortality and pulmonary complications in ventilated infants with respiratory distress syndrome (RDS). However, continued post-surfactant intubation and ventilation are risk factors for ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003063.pub2

    authors: Stevens TP,Blennow M,Soll RF

    更新日期:2004-01-01 00:00:00

  • Psychological therapies for the treatment of anxiety disorders in chronic obstructive pulmonary disease.

    abstract:BACKGROUND:Chronic obstructive pulmonary disease (COPD) (commonly referred to as chronic bronchitis and emphysema) is a chronic lung condition characterised by the inflammation of airways and irreversible destruction of pulmonary tissue leading to progressively worsening dyspnoea. It is a leading international cause of...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010673.pub2

    authors: Usmani ZA,Carson KV,Heslop K,Esterman AJ,De Soyza A,Smith BJ

    更新日期:2017-03-21 00:00:00

  • Interventions for treating oral mucositis for patients with cancer receiving treatment.

    abstract:BACKGROUND:Treatment of cancer is increasingly effective but associated with short and long term side effects. Oral side effects, including oral mucositis (mouth ulceration), remain a major source of illness despite the use of a variety of agents to treat them. OBJECTIVES:To assess the effectiveness of interventions f...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001973.pub4

    authors: Clarkson JE,Worthington HV,Furness S,McCabe M,Khalid T,Meyer S

    更新日期:2010-08-04 00:00:00

  • Caffeine versus theophylline for apnea in preterm infants.

    abstract:BACKGROUND:Recurrent apnea is common in preterm infants, particularly at very early gestational ages. These episodes of loss of effective breathing can lead to hypoxemia and bradycardia which may be severe enough to require resuscitation including use of positive pressure ventilation. Two forms of methylxanthine (caffe...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000273

    authors: Steer PA,Henderson-Smart DJ

    更新日期:2000-01-01 00:00:00

  • Blood pressure lowering efficacy of angiotensin receptor blockers for primary hypertension.

    abstract:BACKGROUND:Angiotensin receptor blockers (ARBs) are widely prescribed for hypertension so it is essential to determine and compare their effects on blood pressure (BP), heart rate and withdrawals due to adverse effects (WDAE). OBJECTIVES:To quantify the dose-related systolic and/or diastolic BP lowering efficacy of AR...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003822.pub2

    authors: Heran BS,Wong MM,Heran IK,Wright JM

    更新日期:2008-10-08 00:00:00

  • Extracorporeal photopheresis versus standard treatment for acute graft-versus-host disease after haematopoietic stem cell transplantation in paediatric patients.

    abstract:BACKGROUND:Acute graft-versus-host disease (aGvHD) is a major cause of morbidity and mortality after haematopoietic stem cell transplantation (HSCT) occurring in 8% to 59% of the recipients. Currently, the therapeutic mainstay for aGvHD is corticosteroids. However, there is no established standard treatment for steroid...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009759.pub3

    authors: Weitz M,Strahm B,Meerpohl JJ,Schmidt M,Bassler D

    更新日期:2015-12-15 00:00:00

  • Benzodiazepines for delirium.

    abstract:BACKGROUND:Delirium occurs in 30% of hospitalised patients and is associated with prolonged hospital stay and increased morbidity and mortality. The results of uncontrolled studies have been unclear, with some suggesting that benzodiazepines may be useful in controlling non-alcohol related delirium. OBJECTIVES:To dete...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006379.pub2

    authors: Lonergan E,Luxenberg J,Areosa Sastre A,Wyller TB

    更新日期:2009-01-21 00:00:00

  • Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus.

    abstract:BACKGROUND:Patients with type 2 diabetes mellitus (T2D) have an increased risk of cardiovascular disease and mortality compared to the background population. Observational studies report an association between reduced blood glucose and reduced risk of both micro- and macrovascular complications in patients with T2D. Ou...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD008143.pub3

    authors: Hemmingsen B,Lund SS,Gluud C,Vaag A,Almdal TP,Hemmingsen C,Wetterslev J

    更新日期:2013-11-11 00:00:00

  • Dressings for the prevention of surgical site infection.

    abstract:BACKGROUND:Surgical wounds (incisions) heal by primary intention when the wound edges are brought together and secured - often with sutures, staples, clips or glue. Wound dressings, usually applied after wound closure, provide physical support, protection from bacterial contamination and absorb exudate. Surgical site i...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003091.pub2

    authors: Dumville JC,Walter CJ,Sharp CA,Page T

    更新日期:2011-07-06 00:00:00

  • Urodynamic investigations for management of urinary incontinence in adults.

    abstract:BACKGROUND:Urodynamic tests are used to investigate people who have urinary incontinence or other urinary symptoms in order to make a definitive objective diagnosis. The aim is to help to select the treatment most likely to be successful. The investigations are invasive and time consuming. OBJECTIVES:The objective of ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003195

    authors: Glazener CM,Lapitan MC

    更新日期:2002-01-01 00:00:00

  • Garlic for preventing pre-eclampsia and its complications.

    abstract:BACKGROUND:The suggestion that garlic may lower blood pressure, inhibit platelet aggregation, and reduce oxidative stress has led to the hypothesis that it may have a role in preventing pre-eclampsia and its complications. OBJECTIVES:To assess the effects of garlic on prevention of pre-eclampsia and its complications....

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006065

    authors: Meher S,Duley L

    更新日期:2006-07-19 00:00:00

  • Pharmacological treatments for psychosis-related polydipsia.

    abstract:BACKGROUND:Polydipsia is the intake of more than three litres of fluids per day. Primary polydipsia occurs when excessive drinking cannot be explained by an identified medical condition, and is not secondary to polyuria. The prevalence of this problem in psychiatric inpatients has been estimated at between 6 and 17%. I...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003544

    authors: Brookes G,Ahmed AG

    更新日期:2002-01-01 00:00:00

  • Pars plana vitrectomy versus scleral buckling for repairing simple rhegmatogenous retinal detachments.

    abstract:BACKGROUND:Rhegmatogenous retinal detachment (RRD) is a separation of neurosensory retina from the underlying retinal pigment epithelium. It is caused by retinal tears, which let fluid pass from the vitreous cavity to the subretinal space. Pars plana vitrectomy (PPV), scleral buckling surgery and pneumatic retinopexy a...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD009562.pub2

    authors: Znaor L,Medic A,Binder S,Vucinovic A,Marin Lovric J,Puljak L

    更新日期:2019-03-08 00:00:00

  • Olanzapine alone or in combination for acute mania.

    abstract:BACKGROUND:Olanzapine, an atypical antipsychotic, is used in the treatment of mania both as monotherapy and combined with other medicines. OBJECTIVES:To review the efficacy and tolerability of olanzapine in the treatment of mania SEARCH STRATEGY:The Cochrane Collaboration Depression, Anxiety and Neurosis Controlled T...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004040

    authors: Rendell JM,Gijsman HJ,Keck P,Goodwin GM,Geddes JR

    更新日期:2003-01-01 00:00:00

  • Servo-control for maintaining abdominal skin temperature at 36C in low birth weight infants.

    abstract:BACKGROUND:Randomized trials have shown that the neonatal mortality rate of low birth-weight babies can be reduced by keeping them warm. For low birth-weight babies nursed in incubators, warm conditions may be achieved either by heating the air to a desired temperature, or by servo-controlling the baby's body temperatu...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001074

    authors: Sinclair JC

    更新日期:2002-01-01 00:00:00

  • Decision aids for people facing health treatment or screening decisions.

    abstract:BACKGROUND:Decision aids are interventions designed to help people make specific and deliberative choices among options (including status quo) by providing (at a minimum) information on the options and outcomes relevant to a person's health status. A systematic review is needed to summarize what is known about their ef...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001431

    authors: O'Connor AM,Stacey D,Rovner D,Holmes-Rovner M,Tetroe J,Llewellyn-Thomas H,Entwistle V,Rostom A,Fiset V,Barry M,Jones J

    更新日期:2001-01-01 00:00:00

  • Haloperidol versus placebo for schizophrenia.

    abstract:BACKGROUND:Haloperidol was developed in the late 1950s for use in the field of analgesia. Research subsequently demonstrated effects on hallucinations, delusions, aggressiveness, impulsiveness and states of excitement and led to the introduction of haloperidol as an antipsychotic. OBJECTIVES:To evaluate the clinical e...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003082

    authors: Joy CB,Adams CE,Lawrie SM

    更新日期:2001-01-01 00:00:00

  • Deworming drugs for treating soil-transmitted intestinal worms in children: effects on growth and school performance.

    abstract:BACKGROUND:In areas where intestinal worm infections occur, the World Health Organization recommends treating all school children at regular intervals with deworming drugs to improve growth and school performance. The evidence base for this policy needs to be established for countries to commit resources to implement t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000371.pub3

    authors: Taylor-Robinson DC,Jones AP,Garner P

    更新日期:2007-10-17 00:00:00

  • Infection control strategies for preventing the transmission of meticillin-resistant Staphylococcus aureus (MRSA) in nursing homes for older people.

    abstract:BACKGROUND:Nursing homes for older people provide an environment likely to promote the acquisition and spread of meticillin-resistant Staphylococcus aureus (MRSA), putting residents at increased risk of colonisation and infection. It is recognised that infection control strategies are important in preventing and contro...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD006354.pub2

    authors: Hughes CM,Smith MB,Tunney MM

    更新日期:2008-01-23 00:00:00

  • Elective repeat caesarean section versus induction of labour for women with a previous caesarean birth.

    abstract:BACKGROUND:When a woman has had a previous caesarean birth and requires induction of labour in a subsequent pregnancy there are two options for her care, an elective repeat caesarean or planned induction of labour. While there are risks and benefits for both elective repeat caesarean birth and planned induction of labo...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004906.pub4

    authors: Dodd JM,Crowther CA,Grivell RM,Deussen AR

    更新日期:2014-12-19 00:00:00

  • Lower versus higher oxygen concentrations titrated to target oxygen saturations during resuscitation of preterm infants at birth.

    abstract:BACKGROUND:Initial resuscitation with air is well tolerated by most infants born at term. However, the optimal fractional inspired oxygen concentration (FiO2 - proportion of the breathed air that is oxygen) targeted to oxygen saturation (SpO2 - an estimate of the amount of oxygen in the blood) for infants born preterm ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD010239.pub2

    authors: Lui K,Jones LJ,Foster JP,Davis PG,Ching SK,Oei JL,Osborn DA

    更新日期:2018-05-04 00:00:00

  • Gene therapy for sickle cell disease.

    abstract:BACKGROUND:Sickle cell disease encompasses a group of genetic disorders characterized by the presence of at least one hemoglobin S (Hb S) allele, and a second abnormal allele that could allow abnormal hemoglobin polymerisation leading to a symptomatic disorder.Autosomal recessive disorders (such as sickle cell disease)...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD007652.pub2

    authors: Olowoyeye A,Okwundu CI

    更新日期:2010-08-04 00:00:00

  • Improving health professionals' management and the organisation of care for overweight and obese people.

    abstract:BACKGROUND:Obesity is increasing throughout the industrialised world. If left unchecked it will have major implications for both population health and costs to health services. OBJECTIVES:To assess whether health professionals' management or the organisation of care for overweight and obese people could be improved. ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000984

    authors: Harvey EL,Glenny A,Kirk SF,Summerbell CD

    更新日期:2001-01-01 00:00:00